FR2986232B1 - Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique - Google Patents
Derives heterocycliques bicycliques, leur preparation et leur application en therapeutiqueInfo
- Publication number
- FR2986232B1 FR2986232B1 FR1250768A FR1250768A FR2986232B1 FR 2986232 B1 FR2986232 B1 FR 2986232B1 FR 1250768 A FR1250768 A FR 1250768A FR 1250768 A FR1250768 A FR 1250768A FR 2986232 B1 FR2986232 B1 FR 2986232B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- bicyclic heterocyclic
- therapeutic application
- heterocyclic derivatives
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Priority Applications (26)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1250768A FR2986232B1 (fr) | 2012-01-26 | 2012-01-26 | Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique |
ARP130100196A AR089782A1 (es) | 2012-01-26 | 2013-01-23 | Derivados heterociclicos biciclicos, su preparacion y su aplicacion en terapeutica |
HUE13712331A HUE031917T2 (en) | 2012-01-26 | 2013-01-25 | Pyrimidooxazocin derivatives as mTOR inhibitors |
RU2014134640A RU2627269C2 (ru) | 2012-01-26 | 2013-01-25 | Бициклические гетероциклические производные, их получение и применение |
SG11201404325VA SG11201404325VA (en) | 2012-01-26 | 2013-01-25 | Pyrimidooxazocine derivatives as mtor - inhibitors |
CA2862747A CA2862747A1 (fr) | 2012-01-26 | 2013-01-25 | Derives de pyrimidooxazocine utiles comme inhibiteurs de mtor |
LTEP13712331.1T LT2807172T (lt) | 2012-01-26 | 2013-01-25 | Pirimidooksazocino dariniai kaip mtor slopikliai |
JP2014553846A JP6068508B2 (ja) | 2012-01-26 | 2013-01-25 | Mtor阻害剤としてのピリミドオキサゾシン誘導体 |
BR112014018226A BR112014018226A8 (pt) | 2012-01-26 | 2013-01-25 | Derivados de pirimidooxazocina como inibidores de mtor |
EP13712331.1A EP2807172B1 (fr) | 2012-01-26 | 2013-01-25 | DÉRIVÉS DE PYRIMIDOOXAZOCINE UTILES COMME INHIBITEURS DE mTOR |
DK13712331.1T DK2807172T3 (en) | 2012-01-26 | 2013-01-25 | PYRIMIDOOXAZOCINE DERIVATIVES AS MTOR INHIBITORS |
KR1020147023238A KR20140125389A (ko) | 2012-01-26 | 2013-01-25 | Mtor-저해제로서 피리미도옥사조신 유도체 |
PL13712331T PL2807172T3 (pl) | 2012-01-26 | 2013-01-25 | Pochodne pirymidooksazocyny jako inhibitory mTOR |
US14/374,838 US9120812B2 (en) | 2012-01-26 | 2013-01-25 | Pyrimidooxazocine derivatives as mTOR-inhibitors |
MX2014009084A MX348841B (es) | 2012-01-26 | 2013-01-25 | Derivados de pirimidooxazocina como inhibidores de mtor. |
AU2013213261A AU2013213261B2 (en) | 2012-01-26 | 2013-01-25 | Pyrimidooxazocine derivatives as mTOR - inhibitors |
CN201380016539.XA CN104203958B (zh) | 2012-01-26 | 2013-01-25 | 二环杂环衍生物、其制备及治疗用途 |
PCT/IB2013/050656 WO2013111106A1 (fr) | 2012-01-26 | 2013-01-25 | DÉRIVÉS DE PYRIMIDOOXAZOCINE UTILES COMME INHIBITEURS DE mTOR |
PT137123311T PT2807172T (pt) | 2012-01-26 | 2013-01-25 | Derivados de pirimidooxazocina como inibidores de mtor |
TW102102986A TWI572608B (zh) | 2012-01-26 | 2013-01-25 | 雙環雜環衍生物、其製備方法及醫療用途 |
UY0001034594A UY34594A (es) | 2012-01-26 | 2013-01-25 | Derivados heterocíclicos bicíclicos, su preparación y su aplicación en terapéutica |
SI201330547A SI2807172T1 (sl) | 2012-01-26 | 2013-01-25 | Derivati pirimidooksazocina kot inhibitorji MTOR |
ES13712331.1T ES2617880T3 (es) | 2012-01-26 | 2013-01-25 | Derivados de pirimidooxazocina como inhibidores de mTOR |
IL233774A IL233774A (en) | 2012-01-26 | 2014-07-23 | Pyrimidooxazosin derivatives as mtor inhibitors |
HRP20170288TT HRP20170288T1 (hr) | 2012-01-26 | 2017-02-21 | DERIVATI PIRIMIDOOKSAZOCINA KAO INHIBITORI mTOR |
CY20171100270T CY1118852T1 (el) | 2012-01-26 | 2017-02-28 | Παραγωγα πυριμιδοοξαζοσινης ως αναστολεις της mtor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1250768A FR2986232B1 (fr) | 2012-01-26 | 2012-01-26 | Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2986232A1 FR2986232A1 (fr) | 2013-08-02 |
FR2986232B1 true FR2986232B1 (fr) | 2014-02-14 |
Family
ID=47997597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1250768A Expired - Fee Related FR2986232B1 (fr) | 2012-01-26 | 2012-01-26 | Derives heterocycliques bicycliques, leur preparation et leur application en therapeutique |
Country Status (26)
Country | Link |
---|---|
US (1) | US9120812B2 (fr) |
EP (1) | EP2807172B1 (fr) |
JP (1) | JP6068508B2 (fr) |
KR (1) | KR20140125389A (fr) |
CN (1) | CN104203958B (fr) |
AR (1) | AR089782A1 (fr) |
AU (1) | AU2013213261B2 (fr) |
BR (1) | BR112014018226A8 (fr) |
CA (1) | CA2862747A1 (fr) |
CY (1) | CY1118852T1 (fr) |
DK (1) | DK2807172T3 (fr) |
ES (1) | ES2617880T3 (fr) |
FR (1) | FR2986232B1 (fr) |
HR (1) | HRP20170288T1 (fr) |
HU (1) | HUE031917T2 (fr) |
IL (1) | IL233774A (fr) |
LT (1) | LT2807172T (fr) |
MX (1) | MX348841B (fr) |
PL (1) | PL2807172T3 (fr) |
PT (1) | PT2807172T (fr) |
RU (1) | RU2627269C2 (fr) |
SG (1) | SG11201404325VA (fr) |
SI (1) | SI2807172T1 (fr) |
TW (1) | TWI572608B (fr) |
UY (1) | UY34594A (fr) |
WO (1) | WO2013111106A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015055071A1 (fr) * | 2013-10-16 | 2015-04-23 | 上海璎黎药业有限公司 | Composé hétérocyclique condensé, son procédé de préparation, composition pharmaceutique et leurs utilisations |
WO2016050201A1 (fr) * | 2014-09-29 | 2016-04-07 | 山东轩竹医药科技有限公司 | Pyrimidine substituée en tant qu'inhibiteur de pi3k à sélectivité élevée |
US10307707B2 (en) * | 2017-05-17 | 2019-06-04 | Thomas P. Daly | 1-amino-2-methyl-2-propanol derivatives |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2472835A1 (fr) * | 2002-01-18 | 2003-07-31 | Kyorin Pharmaceutical Co., Ltd. | Derives de pyrimidine fusionnes bicycliques |
RU2342388C2 (ru) * | 2002-11-22 | 2008-12-27 | Джапан Тобакко Инк. | Конденсированные бициклические азотсодержащие гетероциклы, обладающие dgat ингибирующим действием |
US8586582B2 (en) * | 2008-11-11 | 2013-11-19 | Xcovery Holding Company, Llc | PI3K/mTOR kinase inhibitors |
CN102459248A (zh) * | 2009-05-26 | 2012-05-16 | 埃克塞里艾克西斯公司 | 作为PI3K/mTOR抑制剂的苯并氧杂环庚三烯以及它们使用与制造方法 |
CA2799764A1 (fr) * | 2010-05-19 | 2011-11-24 | Xcovery Holding Company, Llc. | Inhibiteurs selectifs de la mtor kinase |
-
2012
- 2012-01-26 FR FR1250768A patent/FR2986232B1/fr not_active Expired - Fee Related
-
2013
- 2013-01-23 AR ARP130100196A patent/AR089782A1/es unknown
- 2013-01-25 KR KR1020147023238A patent/KR20140125389A/ko active IP Right Grant
- 2013-01-25 LT LTEP13712331.1T patent/LT2807172T/lt unknown
- 2013-01-25 MX MX2014009084A patent/MX348841B/es active IP Right Grant
- 2013-01-25 PT PT137123311T patent/PT2807172T/pt unknown
- 2013-01-25 ES ES13712331.1T patent/ES2617880T3/es active Active
- 2013-01-25 JP JP2014553846A patent/JP6068508B2/ja active Active
- 2013-01-25 UY UY0001034594A patent/UY34594A/es not_active Application Discontinuation
- 2013-01-25 CN CN201380016539.XA patent/CN104203958B/zh active Active
- 2013-01-25 SI SI201330547A patent/SI2807172T1/sl unknown
- 2013-01-25 US US14/374,838 patent/US9120812B2/en active Active
- 2013-01-25 PL PL13712331T patent/PL2807172T3/pl unknown
- 2013-01-25 SG SG11201404325VA patent/SG11201404325VA/en unknown
- 2013-01-25 WO PCT/IB2013/050656 patent/WO2013111106A1/fr active Application Filing
- 2013-01-25 EP EP13712331.1A patent/EP2807172B1/fr active Active
- 2013-01-25 DK DK13712331.1T patent/DK2807172T3/en active
- 2013-01-25 RU RU2014134640A patent/RU2627269C2/ru not_active IP Right Cessation
- 2013-01-25 TW TW102102986A patent/TWI572608B/zh not_active IP Right Cessation
- 2013-01-25 BR BR112014018226A patent/BR112014018226A8/pt not_active Application Discontinuation
- 2013-01-25 CA CA2862747A patent/CA2862747A1/fr not_active Abandoned
- 2013-01-25 HU HUE13712331A patent/HUE031917T2/en unknown
- 2013-01-25 AU AU2013213261A patent/AU2013213261B2/en not_active Ceased
-
2014
- 2014-07-23 IL IL233774A patent/IL233774A/en active IP Right Grant
-
2017
- 2017-02-21 HR HRP20170288TT patent/HRP20170288T1/hr unknown
- 2017-02-28 CY CY20171100270T patent/CY1118852T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PLFP | Fee payment |
Year of fee payment: 5 |
|
PLFP | Fee payment |
Year of fee payment: 6 |
|
PLFP | Fee payment |
Year of fee payment: 7 |
|
PLFP | Fee payment |
Year of fee payment: 8 |
|
ST | Notification of lapse |
Effective date: 20200910 |