FR2947547B1 - NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) - Google Patents

NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Info

Publication number
FR2947547B1
FR2947547B1 FR0903239A FR0903239A FR2947547B1 FR 2947547 B1 FR2947547 B1 FR 2947547B1 FR 0903239 A FR0903239 A FR 0903239A FR 0903239 A FR0903239 A FR 0903239A FR 2947547 B1 FR2947547 B1 FR 2947547B1
Authority
FR
France
Prior art keywords
pkb
pyrimidin
dihydro
oxo
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0903239A
Other languages
French (fr)
Other versions
FR2947547A1 (en
Inventor
Jean Christophe Carry
Victor Certal
Frank Halley
Andreas Karlsson
Laurent Schio
Fabienne Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0903239A priority Critical patent/FR2947547B1/en
Priority to JP2012518120A priority patent/JP5680638B2/en
Priority to PE2012000004A priority patent/PE20120640A1/en
Priority to AU2010267816A priority patent/AU2010267816B2/en
Priority to MEP-2014-62A priority patent/ME01885B/en
Priority to MYPI2011006377 priority patent/MY153042A/en
Priority to DK10742014.3T priority patent/DK2448927T3/en
Priority to CA2767064A priority patent/CA2767064C/en
Priority to ES10742014.3T priority patent/ES2464125T3/en
Priority to MA34593A priority patent/MA33501B1/en
Priority to SI201030607T priority patent/SI2448927T1/en
Priority to SG10201402867TA priority patent/SG10201402867TA/en
Priority to SG2011097938A priority patent/SG177469A1/en
Priority to KR1020127002839A priority patent/KR20120106714A/en
Priority to ARP100102350A priority patent/AR077364A1/en
Priority to NZ597579A priority patent/NZ597579A/en
Priority to BRPI1015913-4A priority patent/BRPI1015913A2/en
Priority to PL10742014T priority patent/PL2448927T3/en
Priority to EP10742014.3A priority patent/EP2448927B1/en
Priority to CN201080039214.XA priority patent/CN102548970B/en
Priority to PCT/FR2010/051375 priority patent/WO2011001114A1/en
Priority to MX2012000094A priority patent/MX2012000094A/en
Priority to UAA201201036A priority patent/UA107357C2/en
Priority to RS20140306A priority patent/RS53317B/en
Priority to EA201270111A priority patent/EA021088B1/en
Priority to PT107420143T priority patent/PT2448927E/en
Priority to TW99121906A priority patent/TWI466883B/en
Priority to UY0001032755A priority patent/UY32755A/en
Publication of FR2947547A1 publication Critical patent/FR2947547A1/en
Priority to CR20110703A priority patent/CR20110703A/en
Priority to TNP2011000657A priority patent/TN2011000657A1/en
Priority to DO2011000407A priority patent/DOP2011000407A/en
Priority to US13/338,011 priority patent/US8791255B2/en
Priority to IL217295A priority patent/IL217295A/en
Priority to CO11180700A priority patent/CO6480974A2/en
Priority to HN2011003482A priority patent/HN2011003482A/en
Priority to IL217321A priority patent/IL217321A0/en
Priority to CL2012000003A priority patent/CL2012000003A1/en
Priority to EC2012011570A priority patent/ECSP12011570A/en
Priority to ZA2012/00026A priority patent/ZA201200026B/en
Priority to NI201200002A priority patent/NI201200002A/en
Priority to CR20120071A priority patent/CR20120071A/en
Application granted granted Critical
Publication of FR2947547B1 publication Critical patent/FR2947547B1/en
Priority to HK12109790.9A priority patent/HK1169110A1/en
Priority to HRP20140478AT priority patent/HRP20140478T1/en
Priority to CY20141100419T priority patent/CY1115626T1/en
Priority to US14/312,124 priority patent/US8993565B2/en
Priority to SM201400084T priority patent/SMT201400084B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
FR0903239A 2009-07-02 2009-07-02 NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) Expired - Fee Related FR2947547B1 (en)

Priority Applications (46)

Application Number Priority Date Filing Date Title
FR0903239A FR2947547B1 (en) 2009-07-02 2009-07-02 NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
JP2012518120A JP5680638B2 (en) 2009-07-02 2010-07-01 Novel (6-oxo-1,6-dihydropyrimidin-2-yl) amide derivatives, their preparation and their pharmaceutical use as AKT (PKB) phosphorylation inhibitors
PE2012000004A PE20120640A1 (en) 2009-07-02 2010-07-01 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDE, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS PHOSPHORILATION INHIBITORS OF AKT (PKB)
AU2010267816A AU2010267816B2 (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
MEP-2014-62A ME01885B (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
MYPI2011006377 MY153042A (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
DK10742014.3T DK2448927T3 (en) 2009-07-02 2010-07-01 HIS UNKNOWN (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, PREPARING THEREOF AND PHARMACEUTICAL USE THEREOF AS ACTIVE PHOSPHOROUSATION INHIBITORS
CA2767064A CA2767064C (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
ES10742014.3T ES2464125T3 (en) 2009-07-02 2010-07-01 New derivatives of (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide, its preparation and its pharmaceutical use as phosphorylation inhibitors of AKT
MA34593A MA33501B1 (en) 2009-07-02 2010-07-01 New derivatives (6-oxo-1,6-dihydro-pyridine-2 -yl) - amide, their preparation and pharmaceutical use as akt phosphorylation inhibitors (pkb)
SI201030607T SI2448927T1 (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
SG10201402867TA SG10201402867TA (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
SG2011097938A SG177469A1 (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
KR1020127002839A KR20120106714A (en) 2009-07-02 2010-07-01 Novel (6-oxo-1,6-dihydro-pyrimidin-2-yl)amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
ARP100102350A AR077364A1 (en) 2009-07-02 2010-07-01 DERIVATIVES OF 6-OXO-1,6- DIHIDRO -PIRIMIDIN-2-IL-) AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB)
NZ597579A NZ597579A (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
BRPI1015913-4A BRPI1015913A2 (en) 2009-07-02 2010-07-01 (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide derivatives, their preparation and their pharmaceutical use as inhibitors of akt phosphorylation (pkb)
PL10742014T PL2448927T3 (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
EP10742014.3A EP2448927B1 (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
CN201080039214.XA CN102548970B (en) 2009-07-02 2010-07-01 Novel (6-oxo-1,6-dihydro-pyrimidin-2-base) amide derivatives, its preparation method and its medicinal use as AKT (PKB) phosphorylation inhibitor
PCT/FR2010/051375 WO2011001114A1 (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
MX2012000094A MX2012000094A (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors.
UAA201201036A UA107357C2 (en) 2009-07-02 2010-07-01 (6-oxo-1,6-dihydropyrimidine-2-il)amide derivatives, their preparation and their pharmaceutical use as inhibitors of phosphorylation akt (pkb)
RS20140306A RS53317B (en) 2009-07-02 2010-07-01 Novel (6-oxo-1,6-dihydro-pyrimidin-2-yl)amide derivatives, prepration thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
EA201270111A EA021088B1 (en) 2009-07-02 2010-07-01 (6-oxo-1, 6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
PT107420143T PT2448927E (en) 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
TW99121906A TWI466883B (en) 2009-07-02 2010-07-02 Novel(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as inhibitors of akt (pkb) phosphorylation
UY0001032755A UY32755A (en) 2009-07-02 2010-07-02 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB).
CR20110703A CR20110703A (en) 2009-07-02 2011-12-21 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB)
TNP2011000657A TN2011000657A1 (en) 2009-07-02 2011-12-22 NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
DO2011000407A DOP2011000407A (en) 2009-07-02 2011-12-26 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB)
US13/338,011 US8791255B2 (en) 2009-07-02 2011-12-27 (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
IL217295A IL217295A (en) 2009-07-02 2011-12-29 (6-oxo-1,6 - dihydropyrimidin -2 - yl) amide derivatives, preparation thereof and pharmaceutical use thereof for the treatment of cancer
CO11180700A CO6480974A2 (en) 2009-07-02 2011-12-29 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB)
HN2011003482A HN2011003482A (en) 2009-07-02 2011-12-30 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB)
IL217321A IL217321A0 (en) 2009-07-02 2012-01-01 Novel (6-oxo-1,6 - dihydro - pyrimidin - 2 - yl) - amide derivatives, prepartion thereof, and pharamaceutical use thereof as akt (pkb) phosphorylation inhibitors
CL2012000003A CL2012000003A1 (en) 2009-07-02 2012-01-02 Compounds derived from substituted (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide; preparation procedure; pharmaceutical composition comprising them; intermediate compounds; and use of said compounds as akt (pkb) phosphorylation inhibitors for the treatment of cancer.
EC2012011570A ECSP12011570A (en) 2009-07-02 2012-01-03 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITORS (PKB)
ZA2012/00026A ZA201200026B (en) 2009-07-02 2012-01-03 Novel (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide derivatives,preparation thereof,and pharmaceutical use thereof as akt(pkb) phosphorylation inhibotors
NI201200002A NI201200002A (en) 2009-07-02 2012-01-05 NEW DERIVATIVES OF (6-OXO-1,6-DIHIDRO-PIRIMIDIN-2-IL) -AMIDE, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS PHOSPHORILATION INHIBITORS OF AKT (PKB).
CR20120071A CR20120071A (en) 2009-07-02 2012-02-10 OCTASACÁRIDOS N-ACILOS ACTIVADORES OF THE FGF RECEPTORS, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
HK12109790.9A HK1169110A1 (en) 2009-07-02 2012-10-05 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors (6--16--2-) akt
HRP20140478AT HRP20140478T1 (en) 2009-07-02 2014-05-28 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
CY20141100419T CY1115626T1 (en) 2009-07-02 2014-06-11 NEW PRODUCTS (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide, their preparation and pharmaceutical use as unrestricted phosphorus
US14/312,124 US8993565B2 (en) 2009-07-02 2014-06-23 (6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
SM201400084T SMT201400084B (en) 2009-07-02 2014-06-26 New derivatives of 6- (osso-1,6diiro-pyrimidin-2-yl) -amide, their preparation and their pharmaceutical use as akt phosphorylation inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903239A FR2947547B1 (en) 2009-07-02 2009-07-02 NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Publications (2)

Publication Number Publication Date
FR2947547A1 FR2947547A1 (en) 2011-01-07
FR2947547B1 true FR2947547B1 (en) 2012-05-18

Family

ID=41611847

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0903239A Expired - Fee Related FR2947547B1 (en) 2009-07-02 2009-07-02 NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Country Status (5)

Country Link
BR (1) BRPI1015913A2 (en)
CR (1) CR20120071A (en)
FR (1) FR2947547B1 (en)
TN (1) TN2011000657A1 (en)
UA (1) UA107357C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111393374A (en) * 2020-05-08 2020-07-10 张建蒙 Oxo-dihydropyridazine derivative and application thereof in antitumor drugs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2178866A2 (en) * 2007-07-09 2010-04-28 AstraZeneca AB Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases

Also Published As

Publication number Publication date
UA107357C2 (en) 2014-12-25
BRPI1015913A2 (en) 2020-08-18
TN2011000657A1 (en) 2013-05-24
CR20120071A (en) 2012-11-01
FR2947547A1 (en) 2011-01-07

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