FR2940651B1 - Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif - Google Patents
Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hifInfo
- Publication number
- FR2940651B1 FR2940651B1 FR0807474A FR0807474A FR2940651B1 FR 2940651 B1 FR2940651 B1 FR 2940651B1 FR 0807474 A FR0807474 A FR 0807474A FR 0807474 A FR0807474 A FR 0807474A FR 2940651 B1 FR2940651 B1 FR 2940651B1
- Authority
- FR
- France
- Prior art keywords
- pyrazol
- pyridin
- derivatives
- preparation
- therapeutic use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Priority Applications (37)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0807474A FR2940651B1 (fr) | 2008-12-29 | 2008-12-29 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif |
| KR1020117017676A KR20110099786A (ko) | 2008-12-29 | 2009-12-24 | ２-피리딘-２-일-피라졸-３（２ｈ）-온의 유도체, 그의 제조법 및 ｈｉｆ 활성화제로서의 치료 용도 |
| SG2011047503A SG172803A1 (en) | 2008-12-29 | 2009-12-24 | Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof as hif activators |
| CA2748411A CA2748411A1 (fr) | 2008-12-29 | 2009-12-24 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
| MA34027A MA32976B1 (fr) | 2008-12-29 | 2009-12-24 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
| MX2011007054A MX2011007054A (es) | 2008-12-29 | 2009-12-24 | Derivados de 2-il-pirazol-3(2h)-ona, su preparacion y su aplicacion en terapeutica como activadores de hif. |
| JP2011542886A JP5734870B2 (ja) | 2008-12-29 | 2009-12-24 | ２−ピリジン−２−イル−ピラゾール−３（２ｈ）−オンの誘導体、これらの調製およびｈｉｆ活性化剤としての治療用途 |
| EP09805789.6A EP2382205B1 (fr) | 2008-12-29 | 2009-12-24 | Dérivés de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur préparation et leur application en thérapeutique comme activateurs de hif |
| SI200930983T SI2382205T1 (sl) | 2008-12-29 | 2009-12-24 | Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba kot aktivatorji HIF |
| PT98057896T PT2382205E (pt) | 2008-12-29 | 2009-12-24 | Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, sua preparação e sua aplicação terapêutica como activadores de hif |
| NZ593751A NZ593751A (en) | 2008-12-29 | 2009-12-24 | Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof as hif activators |
| BRPI0924060A BRPI0924060A8 (pt) | 2008-12-29 | 2009-12-24 | derivados de 2-piridin-2-il-pirazol-3(2h)-ona, o respectivo preparo e a respectiva aplicação em terapêutica com ativadores de hif |
| ES09805789.6T ES2481042T3 (es) | 2008-12-29 | 2009-12-24 | Derivados de 2-piridin-2-il-pirazol-3(2H)-ona, su preparación y uso terapéutico como activadores de HIF |
| CN200980157590.6A CN102333769B (zh) | 2008-12-29 | 2009-12-24 | 2-吡啶-2-基-吡唑-3(2h)-酮的衍生物、其制备和作为hif激活剂的治疗用途 |
| AU2009334569A AU2009334569B2 (en) | 2008-12-29 | 2009-12-24 | Derivatives of 2-pyridin-2-yl-pyrazol-3(2H)-one, preparation and therapeutic use thereof as HIF activators |
| EA201170899A EA019591B1 (ru) | 2008-12-29 | 2009-12-24 | Производные 2-пиридин-2-ил-пиразол-3(2h)-она, их получение и применение в терапии в качестве активаторов hif |
| MYPI2011003012A MY179093A (en) | 2008-12-29 | 2009-12-24 | Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof as hif activators |
| DK09805789.6T DK2382205T3 (da) | 2008-12-29 | 2009-12-24 | 2-pyridin-2-yl-pyrazol-3(2h)-on-derivater, fremstilling deraf og terapeutisk anvendelse deraf som hif-aktivatorer |
| PCT/FR2009/052691 WO2010076524A2 (fr) | 2008-12-29 | 2009-12-24 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
| PE2011001292A PE20120416A1 (es) | 2008-12-29 | 2009-12-24 | Derivados de 2-piridin-2-il-pirazol-3(2h)-ona como activadores de hif y preparacion de los mismos |
| PL09805789T PL2382205T3 (pl) | 2008-12-29 | 2009-12-24 | Pochodne 2-pirydyn-2-ylopirazol-3(2H)-onu, ich wytwarzanie i ich zastosowanie w lecznictwie jako aktywatorów HIF |
| ARP090105126A AR074915A1 (es) | 2008-12-29 | 2009-12-28 | Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de trastornos del aparato cardiovascular, glaucoma y otras patologias. |
| TW098145336A TWI482763B (zh) | 2008-12-29 | 2009-12-28 | ２－吡啶－２－基－吡唑－３（２ｈ）－酮衍生物，其製備及其作為ｈｉｆ活化劑之醫療用途 |
| PA20098856201A PA8856201A1 (es) | 2008-12-29 | 2009-12-29 | Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparación y su aplicacion en terapeutica como activadores de hif" |
| UY0001032369A UY32369A (es) | 2008-12-29 | 2009-12-29 | Derivados de 2-piridin-2-il-pirazol-3-(2h)-ona, su preparación y su aplicación en terapéutica como activadores de hif |
| TN2011000267A TN2011000267A1 (fr) | 2008-12-29 | 2011-05-24 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
| CL2011001496A CL2011001496A1 (es) | 2008-12-29 | 2011-06-17 | Compuestos derivados de 2-piridin-2-il-pirazol-3(2h)-ona, activadores de hif; composicion farmaceutica que los comprende; procedimiento de preparacion de estos; y su uso en el tratamiento de enfermedades cardiacas perifericas de origen isquemico, entre otras. |
| EC2011011155A ECSP11011155A (es) | 2008-12-29 | 2011-06-22 | DERIVADOS DE 2-PIRIDIN-2-IL-PIRAZOL-3(2H)-ONA, SU PREPARACIÓN Y SU APLICACIÓN EN TERAPÉUTICA COMO ACTIVADORES de HIF |
| CR20110361A CR20110361A (es) | 2008-12-29 | 2011-06-23 | Derivados de 2-piridin-2-il-pirazol-3(2h)-ona, su preparación y su aplicación en terapeutica como activadores de hif |
| IL213789A IL213789A (en) | 2008-12-29 | 2011-06-27 | 2-Pyridine-2-Yl-Phospholizing-3 (2 h) Compound, Process for Preparation of the Compound, Drug, Pharmaceutical Preparation, Use of Compound in Preparation of Drug and Combination |
| NI201100133A NI201100133A (es) | 2008-12-29 | 2011-06-28 | Derivados de 2-piridin - 2 - il - pirazol - 3(2h) -ona, su preparación y su aplicación en terapéutica como activadores de hif. |
| ZA2011/04783A ZA201104783B (en) | 2008-12-29 | 2011-06-28 | Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one,preparation and therapeutic use thereof as hif activators |
| CO11081326A CO6400141A2 (es) | 2008-12-29 | 2011-06-29 | Derivados de 2-piridin - 2 il pirazol- 3 (2h)-ona, su preparación y su aplicación en terapeútica com activadores de hif |
| US13/172,305 US8541455B2 (en) | 2008-12-29 | 2011-06-29 | Derivatives of 2-pyridin-2-yl-pyrazol-3(2H)-one, preparation and therapeutic use thereof as HIF activators |
| HRP20140680AT HRP20140680T1 (hr) | 2008-12-29 | 2014-07-15 | Derivati 2-piridin-2-ilpirazol-3(2h)-ona, njihovo dobivanje i njihova upotreba u terapiji kao aktivatora hif |
| SM201400097T SMT201400097B (it) | 2008-12-29 | 2014-07-22 | Derivati di 2 piridin-2-il-pirazol-3(2H)-one, loropreparazione e loro applicazione in campo terapeu tico come attivatori di hif |
| CY20141100553T CY1115368T1 (el) | 2008-12-29 | 2014-07-23 | Παραγωγα της 2-πυριδιν-2-υλο-πυραζολ-3(2η)-ονης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη ως ενεργοποιητες του ηιf |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0807474A FR2940651B1 (fr) | 2008-12-29 | 2008-12-29 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2940651A1 FR2940651A1 (fr) | 2010-07-02 |
| FR2940651B1 true FR2940651B1 (fr) | 2013-05-03 |
Family
ID=40635747
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0807474A Expired - Fee Related FR2940651B1 (fr) | 2008-12-29 | 2008-12-29 | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique comme activateurs de hif |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2940651B1 (fr) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4023488A1 (de) * | 1990-07-24 | 1992-01-30 | Bayer Ag | 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide |
| DE102005019712A1 (de) * | 2005-04-28 | 2006-11-09 | Bayer Healthcare Ag | Dipyridyl-dihydropyrazolone und ihre Verwendung |
| DE102006050516A1 (de) * | 2006-10-26 | 2008-04-30 | Bayer Healthcare Ag | Substituierte Dihydropyrazolone und ihre Verwendung |
| WO2008121861A2 (fr) * | 2007-03-28 | 2008-10-09 | Xenon Pharmaceuticals Inc. | Composés à base de pyrazole et de pyrrole utiles dans le traitement de troubles du métabolisme du fer |
-
2008
- 2008-12-29 FR FR0807474A patent/FR2940651B1/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2940651A1 (fr) | 2010-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20160831 |