FR2901554B1 - 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation - Google Patents

2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation

Info

Publication number
FR2901554B1
FR2901554B1 FR0604733A FR0604733A FR2901554B1 FR 2901554 B1 FR2901554 B1 FR 2901554B1 FR 0604733 A FR0604733 A FR 0604733A FR 0604733 A FR0604733 A FR 0604733A FR 2901554 B1 FR2901554 B1 FR 2901554B1
Authority
FR
France
Prior art keywords
alcoxy
benzazepine
alkylamide
trihydroxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0604733A
Other languages
English (en)
Other versions
FR2901554A1 (fr
Inventor
Jidong Zhang
Frederico Nardi
Alain Commercon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0604733A priority Critical patent/FR2901554B1/fr
Priority to TW096117596A priority patent/TW200812971A/zh
Priority to PE2007000622A priority patent/PE20080705A1/es
Priority to JP2009511545A priority patent/JP2009537614A/ja
Priority to EA200870565A priority patent/EA200870565A1/ru
Priority to MX2008014844A priority patent/MX2008014844A/es
Priority to CA002649336A priority patent/CA2649336A1/fr
Priority to EP07765942A priority patent/EP2035387A2/fr
Priority to KR1020087028521A priority patent/KR20090010071A/ko
Priority to PCT/FR2007/000866 priority patent/WO2007135293A2/fr
Priority to AU2007253196A priority patent/AU2007253196A1/en
Priority to CNA2007800189967A priority patent/CN101454290A/zh
Priority to BRPI0712925-4A priority patent/BRPI0712925A2/pt
Priority to ARP070102222A priority patent/AR061103A1/es
Priority to DO2007000104A priority patent/DOP2007000104A/es
Priority to UY30368A priority patent/UY30368A1/es
Publication of FR2901554A1 publication Critical patent/FR2901554A1/fr
Priority to TNP2008000402A priority patent/TNSN08402A1/en
Priority to CR10382A priority patent/CR10382A/es
Priority to IL194972A priority patent/IL194972A0/en
Priority to IL195148A priority patent/IL195148A0/en
Priority to US12/267,689 priority patent/US7994162B2/en
Priority to EC2008008893A priority patent/ECSP088893A/es
Priority to GT200800249A priority patent/GT200800249A/es
Priority to MA31458A priority patent/MA30561B1/fr
Priority to NO20085285A priority patent/NO20085285L/no
Application granted granted Critical
Publication of FR2901554B1 publication Critical patent/FR2901554B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR0604733A 2006-05-24 2006-05-24 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation Expired - Fee Related FR2901554B1 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR0604733A FR2901554B1 (fr) 2006-05-24 2006-05-24 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation
TW096117596A TW200812971A (en) 2006-05-24 2007-05-17 2-alkoxy-3,4,5-trihydroxy-alkylamido-benzazepines, preparation thereof, compositions containing them and use thereof
PE2007000622A PE20080705A1 (es) 2006-05-24 2007-05-21 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion
ARP070102222A AR061103A1 (es) 2006-05-24 2007-05-23 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion
MX2008014844A MX2008014844A (es) 2006-05-24 2007-05-23 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepina, su preparacion, composiciones que las contienen y utilizacion.
CA002649336A CA2649336A1 (fr) 2006-05-24 2007-05-23 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation
EP07765942A EP2035387A2 (fr) 2006-05-24 2007-05-23 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur préparation, compositions les contenant et utilisation
KR1020087028521A KR20090010071A (ko) 2006-05-24 2007-05-23 2-알콕시-3,4,5-트리히드록시-알킬아미드-벤즈아제핀, 그의제조 방법 및 용도, 및 그를 함유하는 조성물
PCT/FR2007/000866 WO2007135293A2 (fr) 2006-05-24 2007-05-23 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur préparation, compositions les contenant et utilisation
AU2007253196A AU2007253196A1 (en) 2006-05-24 2007-05-23 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof, and compositions containing the same
CNA2007800189967A CN101454290A (zh) 2006-05-24 2007-05-23 2-烷氧基-3,4,5-三羟基-烷基酰胺-苯并吖庚因，它们的制备，含有它们的组合物和用途
BRPI0712925-4A BRPI0712925A2 (pt) 2006-05-24 2007-05-23 2-alcàxi-3,4,5-triidràxi-alquilamida-benzazepina, sua preparaÇço, composiÇÕes que as contÊm, e utilizaÇço
JP2009511545A JP2009537614A (ja) 2006-05-24 2007-05-23 ２−アルコキシ−３，４，５−トリヒドロキシ−アルキルアミド−ベンズアゼピン、これの調製およびこれの使用ならびにこれを含有する組成物
EA200870565A EA200870565A1 (ru) 2006-05-24 2007-05-23 2-алкокси-3,4,5-тригидроксиалкиламидобензазепины, их получение, содержащие их композиции и применение
UY30368A UY30368A1 (es) 2006-05-24 2007-05-24 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion
DO2007000104A DOP2007000104A (es) 2006-05-24 2007-05-24 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su pre-paración, composiciones que las contienen y utilización
TNP2008000402A TNSN08402A1 (en) 2006-05-24 2008-10-15 Modular system for realising furnishing elements
CR10382A CR10382A (es) 2006-05-24 2008-10-20 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion
IL194972A IL194972A0 (en) 2006-05-24 2008-10-28 2-alkoxy-3,4,5-trihydroxy-alkylamide-
IL195148A IL195148A0 (en) 2006-05-24 2008-11-06 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof and compositions containing the same
US12/267,689 US7994162B2 (en) 2006-05-24 2008-11-10 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof, and compositions containing the same
EC2008008893A ECSP088893A (es) 2006-05-24 2008-11-17 2-alcoxi-3, 4,5-trihidroxi-alquilamida-benzazepinas, su preparación, composiciones que las contienen y utilización
GT200800249A GT200800249A (es) 2006-05-24 2008-11-19 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepinas, su preparacion, composiciones que las contienen y utilizacion
MA31458A MA30561B1 (fr) 2006-05-24 2008-12-05 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur préparation, compositions les contenant et utilisation.
NO20085285A NO20085285L (no) 2006-05-24 2008-12-17 2-alkosy-3,4,5-tnhydroksyalkylamidbenzazepiner, deres fremstilling og bruk samt preparater inneholdende disse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0604733A FR2901554B1 (fr) 2006-05-24 2006-05-24 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation

Publications (2)

Publication Number Publication Date
FR2901554A1 FR2901554A1 (fr) 2007-11-30
FR2901554B1 true FR2901554B1 (fr) 2011-04-01

Family

ID=37487536

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0604733A Expired - Fee Related FR2901554B1 (fr) 2006-05-24 2006-05-24 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation

Country Status (24)

Country Link
US (1) US7994162B2 (fr)
EP (1) EP2035387A2 (fr)
JP (1) JP2009537614A (fr)
KR (1) KR20090010071A (fr)
CN (1) CN101454290A (fr)
AR (1) AR061103A1 (fr)
AU (1) AU2007253196A1 (fr)
BR (1) BRPI0712925A2 (fr)
CA (1) CA2649336A1 (fr)
CR (1) CR10382A (fr)
DO (1) DOP2007000104A (fr)
EA (1) EA200870565A1 (fr)
EC (1) ECSP088893A (fr)
FR (1) FR2901554B1 (fr)
GT (1) GT200800249A (fr)
IL (2) IL194972A0 (fr)
MA (1) MA30561B1 (fr)
MX (1) MX2008014844A (fr)
NO (1) NO20085285L (fr)
PE (1) PE20080705A1 (fr)
TN (1) TNSN08402A1 (fr)
TW (1) TW200812971A (fr)
UY (1) UY30368A1 (fr)
WO (1) WO2007135293A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878528B1 (fr) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation
CN102924462B (zh) * 2012-10-24 2015-01-14 华东师范大学 1,2,3,4,5,9-取代苯并吖庚因类化合物的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4831135A (en) 1986-06-18 1989-05-16 The Regents Of The University Of California Bengamide anthelmintics
US5283241A (en) 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
GB9411841D0 (en) 1994-06-14 1994-08-03 Pharma Mar Sa New antitumoral compounds from jaspis sponge
JP2002241368A (ja) 1997-02-18 2002-08-28 Shionogi & Co Ltd 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物
CO5140099A1 (es) 1998-11-17 2002-03-22 Novartis Ag Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores
US6239127B1 (en) 1999-11-17 2001-05-29 Novartis Ag Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation
CA2405892C (fr) * 2000-05-11 2009-07-07 Frederick Ray Kinder Jr. Carbonates et ethers de caprolactame substitues et utilisation de ceux-ci comme agents anti tumoraux
JP2004514122A (ja) 2000-11-14 2004-05-13 ノバルティス　アクチエンゲゼルシャフト 抗増殖性化合物をスクリーニングしかつ腫瘍増殖を阻害する方法
US6545148B2 (en) 2001-03-12 2003-04-08 Novartis Ag Process for preparing certain substituted caprolactams
JP2004262793A (ja) 2003-02-28 2004-09-24 Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai 化合物ｎ−９０１１、その製造法及び用途
AU2004263287B2 (en) * 2003-07-25 2009-02-12 Novartis Ag Substituted lactams and their use as anti-cancer agents
DE10349669B3 (de) 2003-10-24 2005-05-25 Aventis Pharma Deutschland Gmbh Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US7153846B2 (en) 2003-10-24 2006-12-26 Sanofi-Aventis Deutschland Gmbh Bengamide derivatives, process for preparing them, and their use
FR2878525B1 (fr) 2004-11-29 2007-02-23 Aventis Pharma Sa Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation
FR2878528B1 (fr) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation

Also Published As

Publication number Publication date
IL195148A0 (en) 2009-09-22
IL194972A0 (en) 2009-08-03
CR10382A (es) 2009-02-26
GT200800249A (es) 2009-05-15
EA200870565A1 (ru) 2009-06-30
US7994162B2 (en) 2011-08-09
MA30561B1 (fr) 2009-07-01
UY30368A1 (es) 2008-01-02
CN101454290A (zh) 2009-06-10
BRPI0712925A2 (pt) 2013-01-08
WO2007135293A3 (fr) 2008-05-02
MX2008014844A (es) 2009-02-17
ECSP088893A (es) 2008-12-30
US20090099152A1 (en) 2009-04-16
DOP2007000104A (es) 2007-11-15
NO20085285L (no) 2008-12-17
JP2009537614A (ja) 2009-10-29
CA2649336A1 (fr) 2007-11-29
WO2007135293A2 (fr) 2007-11-29
TNSN08402A1 (en) 2010-04-14
AU2007253196A1 (en) 2007-11-29
EP2035387A2 (fr) 2009-03-18
PE20080705A1 (es) 2008-07-30
KR20090010071A (ko) 2009-01-28
TW200812971A (en) 2008-03-16
AR061103A1 (es) 2008-08-06
FR2901554A1 (fr) 2007-11-30

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20130131