FR2901478B1 - Forme pharmaceutique orale multimicroparticulaire a liberation prolongee - Google Patents
Forme pharmaceutique orale multimicroparticulaire a liberation prolongeeInfo
- Publication number
- FR2901478B1 FR2901478B1 FR0604685A FR0604685A FR2901478B1 FR 2901478 B1 FR2901478 B1 FR 2901478B1 FR 0604685 A FR0604685 A FR 0604685A FR 0604685 A FR0604685 A FR 0604685A FR 2901478 B1 FR2901478 B1 FR 2901478B1
- Authority
- FR
- France
- Prior art keywords
- multimicroparticulated
- oral pharmaceutical
- pharmaceutical form
- prolonged release
- prolonged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/745—Polymers of hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0604685A FR2901478B1 (fr) | 2006-05-24 | 2006-05-24 | Forme pharmaceutique orale multimicroparticulaire a liberation prolongee |
PCT/EP2007/055069 WO2007135193A2 (fr) | 2006-05-24 | 2007-05-24 | Forme pharmaceutique orale multimicroparticulaire a liberation prolongee comprenant des moyens anti-mesusage et resistant a l'alcool |
JP2009511528A JP5654750B2 (ja) | 2006-05-24 | 2007-05-24 | 持続性放出マルチ微粒子状経口医薬形態 |
EP07729498A EP2040685A2 (fr) | 2006-05-24 | 2007-05-24 | Forme pharmaceutique orale multimicroparticulaire a liberation prolongee comprenant des moyens anti-mesusage et resistant a l'alcool |
CNA200780018905XA CN101453994A (zh) | 2006-05-24 | 2007-05-24 | 延长释药的多微粒口服药物剂型 |
CA2651451A CA2651451C (fr) | 2006-05-24 | 2007-05-24 | Forme pharmaceutique orale multimicroparticulaire a liberation prolongee |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0604685A FR2901478B1 (fr) | 2006-05-24 | 2006-05-24 | Forme pharmaceutique orale multimicroparticulaire a liberation prolongee |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2901478A1 FR2901478A1 (fr) | 2007-11-30 |
FR2901478B1 true FR2901478B1 (fr) | 2015-06-05 |
Family
ID=37435577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0604685A Active FR2901478B1 (fr) | 2006-05-24 | 2006-05-24 | Forme pharmaceutique orale multimicroparticulaire a liberation prolongee |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2040685A2 (fr) |
JP (1) | JP5654750B2 (fr) |
CN (1) | CN101453994A (fr) |
CA (1) | CA2651451C (fr) |
FR (1) | FR2901478B1 (fr) |
WO (1) | WO2007135193A2 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003024429A1 (fr) | 2001-09-21 | 2003-03-27 | Egalet A/S | Systeme de liberation a base de polymere |
US20040253310A1 (en) | 2001-09-21 | 2004-12-16 | Gina Fischer | Morphine polymer release system |
ATE495732T1 (de) | 2003-03-26 | 2011-02-15 | Egalet As | Morphin-system mit kontrollierter freisetzung |
WO2008148798A2 (fr) | 2007-06-04 | 2008-12-11 | Egalet A/S | Compositions pharmaceutiques à libération contrôlée pour un effet prolongé |
JP2011506318A (ja) * | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 経口医薬製剤 |
BRPI0913724B8 (pt) * | 2008-09-18 | 2021-05-25 | Purdue Pharma Lp | formas farmacêuticas de liberação prolongada compreendendo naltrexona e poli (e-caprolactona) e seu preparo |
US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
CA2751667C (fr) | 2009-02-06 | 2016-12-13 | Egalet Ltd. | Composition a liberation immediate resistant a une maltraitance par prise d'alcool |
AU2010265213B2 (en) | 2009-06-24 | 2012-08-23 | Egalet Ltd. | Controlled release formulations |
MX347753B (es) * | 2010-02-24 | 2017-05-10 | Cima Labs Inc | Formulaciones resistentes al abuso. |
DK4011364T3 (da) * | 2011-03-23 | 2024-03-18 | Ironshore Pharmaceuticals & Dev Inc | Fremgangsmåder og sammensætninger til behandling af ADD (Attention Deficit Disorder) |
CN102516473B (zh) * | 2011-12-14 | 2013-07-24 | 华南理工大学 | 细胞片智能分离用共聚纳米复合水凝胶及其制备方法与应用 |
MX2014015880A (es) | 2012-07-06 | 2015-08-05 | Egalet Ltd | Composiciones farmaceuticas disuasivas de abuso para liberacion controlada. |
WO2014144975A1 (fr) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions ayant un agent de modification rhéologique pour réduire une variabilité de dissolution |
CA3042642A1 (fr) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Comprime extrude anti-abus a liberation immediate |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US9707184B2 (en) | 2014-07-17 | 2017-07-18 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
CA2936746C (fr) * | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methodes et compositions destinees au traitement du trouble de deficit d'attention |
CA3010636A1 (fr) | 2016-06-29 | 2018-01-04 | CannScience Innovations Inc. | Resines de cannabis decarboxylees, leurs utilisations et leurs procedes de fabrication |
EP3473246A1 (fr) | 2017-10-19 | 2019-04-24 | Capsugel Belgium NV | Formulations anti-abus à libération immédiate |
CN111841508B (zh) * | 2020-07-28 | 2021-08-17 | 南昌航空大学 | 一种磺基水杨酸修饰壳聚糖/二氧化硅微球及其制备方法和应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2007181C (fr) * | 1989-01-06 | 1998-11-24 | Angelo Mario Morella | Compose pharmaceutique a liberation continue |
JP3677156B2 (ja) * | 1997-09-05 | 2005-07-27 | 武田薬品工業株式会社 | 医薬 |
JP2002003366A (ja) * | 2000-06-23 | 2002-01-09 | Freunt Ind Co Ltd | 固形薬剤用水系コーティング剤組成物 |
MXPA04001206A (es) * | 2001-08-06 | 2004-07-08 | Euro Celtique Sa | Composiciones y metodos para prevenir el abuso de opioides. |
US20030059397A1 (en) * | 2001-09-17 | 2003-03-27 | Lyn Hughes | Dosage forms |
US20030068276A1 (en) * | 2001-09-17 | 2003-04-10 | Lyn Hughes | Dosage forms |
SI1578350T1 (sl) * | 2002-03-26 | 2009-10-31 | Euro Celtique Sa | Z gelom obloženi sestavki z zadržanim sproščanjem |
CA2499994C (fr) * | 2002-09-23 | 2012-07-10 | Verion, Inc. | Compositions pharmaceutiques n'induisant pas l'abus |
DE10250084A1 (de) * | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
US20040110781A1 (en) * | 2002-12-05 | 2004-06-10 | Harmon Troy M. | Pharmaceutical compositions containing indistinguishable drug components |
JP5296314B2 (ja) * | 2003-07-17 | 2013-09-25 | バナー ファーマキャップス,インコーポレイティド | 制御放出製剤 |
DE10336400A1 (de) * | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
TWI350762B (en) * | 2004-02-12 | 2011-10-21 | Euro Celtique Sa | Particulates |
FR2872044B1 (fr) * | 2004-06-28 | 2007-06-29 | Flamel Technologies Sa | Formulation pharmaceutique a base d'antibiotique sous forme microcapsulaire |
CA2572352A1 (fr) * | 2004-07-01 | 2006-01-12 | Gruenenthal Gmbh | Forme posologique anti-abus pour administration par voie orale contenant du (1r, 2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
JP5046946B2 (ja) * | 2004-10-15 | 2012-10-10 | スパーナス ファーマシューティカルズ インコーポレイテッド | 低乱用性薬学的製剤 |
FR2892937B1 (fr) * | 2005-11-10 | 2013-04-05 | Flamel Tech Sa | Forme pharmaceutique orale microparticulaire anti-mesusage |
-
2006
- 2006-05-24 FR FR0604685A patent/FR2901478B1/fr active Active
-
2007
- 2007-05-24 WO PCT/EP2007/055069 patent/WO2007135193A2/fr active Application Filing
- 2007-05-24 JP JP2009511528A patent/JP5654750B2/ja not_active Expired - Fee Related
- 2007-05-24 CA CA2651451A patent/CA2651451C/fr not_active Expired - Fee Related
- 2007-05-24 CN CNA200780018905XA patent/CN101453994A/zh active Pending
- 2007-05-24 EP EP07729498A patent/EP2040685A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2651451C (fr) | 2013-08-20 |
CA2651451A1 (fr) | 2007-11-29 |
CN101453994A (zh) | 2009-06-10 |
JP2009537610A (ja) | 2009-10-29 |
EP2040685A2 (fr) | 2009-04-01 |
JP5654750B2 (ja) | 2015-01-14 |
WO2007135193A2 (fr) | 2007-11-29 |
WO2007135193A3 (fr) | 2008-06-26 |
FR2901478A1 (fr) | 2007-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PLFP | Fee payment |
Year of fee payment: 10 |
|
TP | Transmission of property |
Owner name: FLAMEL IRELAND LIMITED, IE Effective date: 20151119 |
|
PLFP | Fee payment |
Year of fee payment: 11 |
|
PLFP | Fee payment |
Year of fee payment: 12 |