FR2887549B1 - Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation - Google Patents

Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation

Info

Publication number
FR2887549B1
FR2887549B1 FR0506382A FR0506382A FR2887549B1 FR 2887549 B1 FR2887549 B1 FR 2887549B1 FR 0506382 A FR0506382 A FR 0506382A FR 0506382 A FR0506382 A FR 0506382A FR 2887549 B1 FR2887549 B1 FR 2887549B1
Authority
FR
France
Prior art keywords
iminosucres
family
preparation
treatment
novel compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0506382A
Other languages
English (en)
Other versions
FR2887549A1 (fr
Inventor
Olivier Richard Martin
Philippe Compain
Charlotte Boucheron
Naoki Asano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite dOrleans
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite dOrleans
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite dOrleans filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0506382A priority Critical patent/FR2887549B1/fr
Priority to EP06764817A priority patent/EP1893201A1/fr
Priority to US11/993,880 priority patent/US20080269285A1/en
Priority to JP2008517539A priority patent/JP2008546744A/ja
Priority to CA002613213A priority patent/CA2613213A1/fr
Priority to PCT/FR2006/001425 priority patent/WO2006136714A1/fr
Publication of FR2887549A1 publication Critical patent/FR2887549A1/fr
Application granted granted Critical
Publication of FR2887549B1 publication Critical patent/FR2887549B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FR0506382A 2005-06-23 2005-06-23 Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation Expired - Fee Related FR2887549B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR0506382A FR2887549B1 (fr) 2005-06-23 2005-06-23 Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation
EP06764817A EP1893201A1 (fr) 2005-06-23 2006-06-22 Nouveaux composes de la famille des iminosucres, leurs utilisations pour le traitement de maladies lysosomales, ainsi que leur procede de preparation
US11/993,880 US20080269285A1 (en) 2005-06-23 2006-06-22 Novel Compounds of the Family of Iminosugars, Uses Thereof for Trewating Lysosomal Diseases, and Method for Preparing Same
JP2008517539A JP2008546744A (ja) 2005-06-23 2006-06-22 イミノ糖ファミリーの新規な化合物、リソソーム病の治療のためのその使用、及び、その製造方法
CA002613213A CA2613213A1 (fr) 2005-06-23 2006-06-22 Nouveaux composes de la famille des iminosucres, leurs utilisations pour le traitement de maladies lysosomales, ainsi que leur procede de preparation
PCT/FR2006/001425 WO2006136714A1 (fr) 2005-06-23 2006-06-22 Nouveaux composes de la famille des iminosucres, leurs utilisations pour le traitement de maladies lysosomales, ainsi que leur procede de preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0506382A FR2887549B1 (fr) 2005-06-23 2005-06-23 Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation

Publications (2)

Publication Number Publication Date
FR2887549A1 FR2887549A1 (fr) 2006-12-29
FR2887549B1 true FR2887549B1 (fr) 2009-07-10

Family

ID=35677398

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0506382A Expired - Fee Related FR2887549B1 (fr) 2005-06-23 2005-06-23 Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation

Country Status (6)

Country Link
US (1) US20080269285A1 (fr)
EP (1) EP1893201A1 (fr)
JP (1) JP2008546744A (fr)
CA (1) CA2613213A1 (fr)
FR (1) FR2887549B1 (fr)
WO (1) WO2006136714A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101747259B (zh) * 2008-12-18 2012-02-15 北京大学 氮杂糖类化合物及其合成方法及应用
CN103373955B (zh) * 2012-04-23 2016-04-06 北京大学 多价氮杂糖衍生物及其合成方法
CA2906675A1 (fr) * 2013-03-15 2014-09-18 Unither Virology, Llc Composes antibacteriens
EP3088389A1 (fr) * 2015-04-28 2016-11-02 Dorphan S.A. Dérivés de 4-epi-isofagomine
EP4146623A4 (fr) * 2020-05-07 2024-05-01 Alectos Therapeutics Inc. Inhibiteurs de glucosylcéramidases non lysosomales et leurs utilisations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772271A (en) * 1953-12-01 1956-11-27 Commerical Solvents Corp Addition of olefins and amines
FR2168851A1 (en) * 1972-01-24 1973-09-07 Synthelabo 2-substituted propyl-1-methyl piperidines - bronchodilators and spasmolytics
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
JPS6135788A (ja) * 1984-07-27 1986-02-20 Ss Pharmaceut Co Ltd 生理活性物質ｓｓ２０８４６ａ及びその製造法
US6274597B1 (en) * 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
US20040082641A1 (en) * 2002-10-28 2004-04-29 Rytved Klaus Asger Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
EP1528056A1 (fr) * 2003-10-29 2005-05-04 Academisch Ziekenhuis bij de Universiteit van Amsterdam Dérives de desoxynojirimycine et leurs utilisations en tant qu'inhibiteurs de glucosylceramidase
AU2004283631A1 (en) * 2003-10-29 2005-05-06 Genzyme Corporation Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof
BRPI0416217A8 (pt) * 2003-11-12 2018-05-08 Amicus Therapeutics Inc composto derivado de hidroxipiperidina, métodos para a síntese de um composto derivado de hidroxipiperidina para inibir glicocerebrosidase, para aumentar a atividade de glicocerebrosidase numa célula de mamífero e para estabilizar glicocerebrosidade, composição farmacêutica, métodos para inibir beta-glicosidade, e para tratar doença de gaucher e derivado hidroxipiperidina com ligante flexível curto

Also Published As

Publication number Publication date
JP2008546744A (ja) 2008-12-25
US20080269285A1 (en) 2008-10-30
EP1893201A1 (fr) 2008-03-05
WO2006136714A1 (fr) 2006-12-28
CA2613213A1 (fr) 2006-12-28
FR2887549A1 (fr) 2006-12-29

Similar Documents

Publication Publication Date Title
MA31245B1 (fr) Amides de 4-aryl-1,4-dihydro-1,6-naphthyridine substitués et utilisation de ceux-ci
MA33123B1 (fr) 2-acetamido-5-aryl-1,2,4-triazolones substitues et leur utilisation
DE502005006149D1 (de) Hetaryloxy-substituierte phenylaminopyrimidine als rho-kinasehemmer
MA34721B1 (fr) Acides carboxyliques 1-benzylcycloalkyle substitués et leur utilisation
HK1122803A1 (fr)
TW200833330A (en) Substituted dihydropyrazolones and their use
WO2010037066A3 (fr) Unités posologiques d'acide 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-méthylpyridin-2-yl)benzoïque
WO2007038459A3 (fr) Composes de carboxyamine et leurs methodes d'utilisation
WO2007022529A3 (fr) Méthode pour traiter des maladies inflammatoires
MA38060A1 (fr) Imidazo[1,2-a]pyridincarboxamides amino-substitués et leur utilisation
WO2010017196A3 (fr) Anticorps monoclonaux contre l'inhibiteur de la voie du facteur tissulaire (tfpi)
WO2009153496A3 (fr) Composes agonistes ppar, preparation et utilisations pour le traitement du diabete et/ou des dyslipidemies
EP2772260A3 (fr) Compositions thérapeutiques comprenant de l'hyaluronane et des anticorps thérapeutiques ainsi que des procédés de traitement
ATE453642T1 (de) Substituierte phenylaminopyrimidine
WO2007105015A3 (fr) DÉRIVES D'ACIDE 18ß-GLYCYRRHETINIQUE
WO2008119457A3 (fr) Acides dicarboxyliques à substitution lactame et leur utilisation
MA33290B1 (fr) Pipéridines substituées
FR2904557B1 (fr) Nouvel extrait d'eucalyptus, son procede de preparation et ses utilisations therapeutiques
EA201101643A1 (ru) ВАРИАНТЫ ПРИМЕНЕНИЯ IL-1β АНТИТЕЛ И ИХ СВЯЗЫВАЮЩИХ ФРАГМЕНТОВ В СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЕ
TW200745132A (en) Novel, acyclically substituted furopyrimidine derivatives and use thereof
FR2887549B1 (fr) Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation
ATE475651T1 (de) Aryl-substituierte heterozyklen und ihre verwendung
ATE500253T1 (de) 3-cyano-5-thiazaheteroaryl-dihydropyridine und ihre verwendung zur behandlung kardiovaskulärer erkrankungen
MA33291B1 (fr) Pipéridines substituées
WO2007017146A3 (fr) Utilisation de la collismycine et de derives de celle-ci comme inhibiteurs du stress oxydatif

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20140228