FR2885905A1 - NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT - Google Patents

NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT

Info

Publication number
FR2885905A1
FR2885905A1 FR0505144A FR0505144A FR2885905A1 FR 2885905 A1 FR2885905 A1 FR 2885905A1 FR 0505144 A FR0505144 A FR 0505144A FR 0505144 A FR0505144 A FR 0505144A FR 2885905 A1 FR2885905 A1 FR 2885905A1
Authority
FR
France
Prior art keywords
chemical compounds
compounds
medicinal product
family
novel chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR0505144A
Other languages
French (fr)
Inventor
Rebecca Pruss
Laure Jamot
Cyrille Drouot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trophos SA
Original Assignee
Trophos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trophos SA filed Critical Trophos SA
Priority to FR0505144A priority Critical patent/FR2885905A1/en
Priority to PCT/FR2006/001107 priority patent/WO2006125887A1/en
Publication of FR2885905A1 publication Critical patent/FR2885905A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

La présente invention se place dans le domaine de la pharmacie, particulièrement dans le domaine du traitement des maladies neurodégénératives. Très particulièrement elle concerne une famille de composés chimiques pour lesquelles une activité neuroprotectrice a pu être démontrée.Certains membres de ladite famille étant des composés nouveaux jamais décrits, l'invention concerne ces produits nouveaux, leurs procédé de synthèse ainsi que certains intermédiaires de synthèse eux-mêmes nouveaux.La présente invention concerne également des compositions comprenant les composés de la famille, l'utilisation desdits composés à titre de médicaments, particulièrement dans la préparation d'un médicament destiné au traitement des maladies neurodégénératives.The present invention is in the field of pharmacy, particularly in the field of treatment of neurodegenerative diseases. In particular, it relates to a family of chemical compounds for which neuroprotective activity has been demonstrated.Some members of said family being new compounds never described, the invention relates to these novel products, their synthesis process as well as some synthesis intermediates them. The present invention also relates to compositions comprising the compounds of the family, the use of said compounds as medicaments, particularly in the preparation of a medicament for the treatment of neurodegenerative diseases.

FR0505144A 2005-05-23 2005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT Withdrawn FR2885905A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR0505144A FR2885905A1 (en) 2005-05-23 2005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT
PCT/FR2006/001107 WO2006125887A1 (en) 2005-05-23 2006-05-17 5h-pyrido[4,3-b]indole derivative compounds and uses thereof as medicine for treating polyglutamin neurodegenerative diseases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0505144A FR2885905A1 (en) 2005-05-23 2005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT

Publications (1)

Publication Number Publication Date
FR2885905A1 true FR2885905A1 (en) 2006-11-24

Family

ID=35709336

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0505144A Withdrawn FR2885905A1 (en) 2005-05-23 2005-05-23 NOVEL CHEMICAL COMPOUNDS AND THEIR USES AS A MEDICINAL PRODUCT

Country Status (2)

Country Link
FR (1) FR2885905A1 (en)
WO (1) WO2006125887A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1937263A2 (en) * 2005-10-04 2008-07-02 Medivation, Inc. Hydrogenated pyrido-indole compounds for the treatment of huntington ' s disease
CA2700160A1 (en) 2007-09-20 2009-03-26 D2E, Llc Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
US8932557B2 (en) 2008-02-14 2015-01-13 Eli Lilly And Company Imaging agents for detecting neurological dysfunction
CA2715390A1 (en) 2008-02-14 2009-08-20 Siemens Medical Solutions Usa, Inc. Imaging agents for detecting neurological dysfunction
CN101423517B (en) * 2008-11-28 2011-09-14 浙江大学 Gamma-carbolines derivates as well as preparation method and application thereof
KR101609504B1 (en) 2012-05-22 2016-04-05 일라이 릴리 앤드 캄파니 Carboline and carbazole based imaging agents for detecting neurological dysfunction

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238411A1 (en) * 1986-03-17 1987-09-23 Sanofi 1,2-Dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b) indoles and their preparation
EP0876818A2 (en) * 1995-10-23 1998-11-11 Nikolai Serafimovich Zefirov Agent for treating neuro-degenerative disorders
EP1015451B1 (en) * 1997-09-08 2003-06-18 Janssen Pharmaceutica N.V. Tetrahydro gamma-carbolines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238411A1 (en) * 1986-03-17 1987-09-23 Sanofi 1,2-Dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b) indoles and their preparation
EP0876818A2 (en) * 1995-10-23 1998-11-11 Nikolai Serafimovich Zefirov Agent for treating neuro-degenerative disorders
EP1015451B1 (en) * 1997-09-08 2003-06-18 Janssen Pharmaceutica N.V. Tetrahydro gamma-carbolines

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.J. COOKE, N.M. HAMILTON: "alpha-subunit selective modulators of GABAa receptor fonction as CNS therapeutics", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 12, no. 10, 2002, pages 1491 - 1501, XP002367045 *
CHI HUNG NGUYEN ET AL: "Synthesis of tricyclic analogs of ellipticines: 4-methyl-5H-pyrido[4,3- b]indoles (.gamma.-carbolines) with various substituents at their apexes 1,5 and 8", TETRAHEDRON , 43(3), 527-35 CODEN: TETRAB; ISSN: 0040-4020, 1987, XP002367046 *
KRICHEVSKII, E. S. ET AL: "Acetals of lactams and amides. 73. Synthesis and some properties of 6-nitro-.gamma.-carboline derivatives", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 28, no. 4, 1992, pages 420 - 423, XP009061474 *

Also Published As

Publication number Publication date
WO2006125887A1 (en) 2006-11-30

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Effective date: 20090119