FR2840299B1 - NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE - Google Patents

NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE

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Publication number
FR2840299B1
FR2840299B1 FR0206850A FR0206850A FR2840299B1 FR 2840299 B1 FR2840299 B1 FR 2840299B1 FR 0206850 A FR0206850 A FR 0206850A FR 0206850 A FR0206850 A FR 0206850A FR 2840299 B1 FR2840299 B1 FR 2840299B1
Authority
FR
France
Prior art keywords
cosmetics
preparation
receptor inhibitor
human medicine
rar receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0206850A
Other languages
English (en)
Other versions
FR2840299A1 (fr
Inventor
Thibaud Biadatti
Pascal Collette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0206850A priority Critical patent/FR2840299B1/fr
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Priority to MXPA04011972A priority patent/MXPA04011972A/es
Priority to BR0309896-6A priority patent/BR0309896A/pt
Priority to PCT/EP2003/005554 priority patent/WO2003101928A1/fr
Priority to CA2483817A priority patent/CA2483817C/fr
Priority to RU2004138294/04A priority patent/RU2004138294A/ru
Priority to JP2004509623A priority patent/JP2006511443A/ja
Priority to AU2003242583A priority patent/AU2003242583A1/en
Priority to DE60336312T priority patent/DE60336312D1/de
Priority to AT03755947T priority patent/ATE500866T1/de
Priority to PT03755947T priority patent/PT1513793E/pt
Priority to CN03813053XA priority patent/CN1659132A/zh
Priority to ES03755947T priority patent/ES2361303T3/es
Priority to EP03755947A priority patent/EP1513793B1/fr
Priority to SI200331968T priority patent/SI1513793T1/sl
Priority to PL03372556A priority patent/PL372556A1/xx
Priority to DK03755947.3T priority patent/DK1513793T3/da
Priority to ARP030101952A priority patent/AR040234A1/es
Publication of FR2840299A1 publication Critical patent/FR2840299A1/fr
Priority to US10/991,510 priority patent/US7468457B2/en
Publication of FR2840299B1 publication Critical patent/FR2840299B1/fr
Application granted granted Critical
Priority to CY20111100411T priority patent/CY1111485T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/28—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups having unsaturation outside the aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C07C65/36—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0206850A 2002-06-04 2002-06-04 NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE Expired - Fee Related FR2840299B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR0206850A FR2840299B1 (fr) 2002-06-04 2002-06-04 NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE
ES03755947T ES2361303T3 (es) 2002-06-04 2003-05-27 Nuevos ligandos que son inhibidores de los receptores rar, procedimiento para su preparación y su uso en medicina humana y en cosmética.
PCT/EP2003/005554 WO2003101928A1 (fr) 2002-06-04 2003-05-27 Nouveaux ligands etant des inhibiteurs de recepteurs rar, procede de fabrication et utilisation de ceux-ci dans la medecine humaine et en cosmetique
CA2483817A CA2483817C (fr) 2002-06-04 2003-05-27 Nouveaux ligands etant des inhibiteurs de recepteurs rar, procede de fabrication et utilisation de ceux-ci dans la medecine humaine et en cosmetique
RU2004138294/04A RU2004138294A (ru) 2002-06-04 2003-05-27 Новые лиганды, являющиеся ингибититорами рецепторов rar, способ их получения и их применение для лечения человека и в лечебной косметике
JP2004509623A JP2006511443A (ja) 2002-06-04 2003-05-27 Ｒａｒ受容体の阻害剤である新規のリガンド、その調製方法およびヒト用の医薬品および化粧品におけるその使用
AU2003242583A AU2003242583A1 (en) 2002-06-04 2003-05-27 Novel ligands that are inhibitors of the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics
DE60336312T DE60336312D1 (de) 2002-06-04 2003-05-27 Neue liganden als inhibitoren des rar rezeptor, verfahren zu ihrer herstellung und ihre verwendung in der humanmedizin und in der kosmetik
AT03755947T ATE500866T1 (de) 2002-06-04 2003-05-27 Neue liganden als inhibitoren des rar rezeptor, verfahren zu ihrer herstellung und ihre verwendung in der humanmedizin und in der kosmetik
PT03755947T PT1513793E (pt) 2002-06-04 2003-05-27 Novos ligandos inibidores dos receptores rar, processo para a sua prepara??o e a sua utiliza??o em medicina humana e em cosm?tica a inven??o refere-se a novos compostos
MXPA04011972A MXPA04011972A (es) 2002-06-04 2003-05-27 Nuevos ligandos inhibidores de los receptores rars, su procedimiento de preparacion y su uso en medicina humana asi como en cosmetica.
CN03813053XA CN1659132A (zh) 2002-06-04 2003-05-27 作为rar受体抑制剂的新型配体,制备它们的方法及其在人药物和化妆品方面的用途
PL03372556A PL372556A1 (en) 2002-06-04 2003-05-27 Novel ligands that are inhibitors of the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics
SI200331968T SI1513793T1 (sl) 2002-06-04 2003-05-27 Novi ligandi kot inhibitorji RAR receptorjev, postopek za pripravo in uporabo le-teh v humani medicini in kozmetiki
EP03755947A EP1513793B1 (fr) 2002-06-04 2003-05-27 Nouveaux ligands etant des inhibiteurs de recepteurs rar, procede de fabrication et utilisation de ceux-ci dans la medecine humaine et en cosmetique
DK03755947.3T DK1513793T3 (da) 2002-06-04 2003-05-27 Nye ligander som inhibitorer af RAR-receptorerne, fremgangsmåde til deres frembringelse og anvendelse deraf i humanmedicin og i kosmetik
BR0309896-6A BR0309896A (pt) 2002-06-04 2003-05-27 Compostos, uso em um composto, composição farmacêutica, composição cosmética, uso cosmético de uma composição
ARP030101952A AR040234A1 (es) 2002-06-04 2003-06-02 Ligandos inhibidores de los receptores rars y su utilizacion en medicina humana asi como en cosmetica
US10/991,510 US7468457B2 (en) 2002-06-04 2004-11-19 Ligand inhibitors of the RAR receptors, process for preparing same and therapeutic/cosmetic applications thereof
CY20111100411T CY1111485T1 (el) 2002-06-04 2011-04-21 Νεοι συνδετες οι οποιοι ειναι αναστολεις των υποδοχεων του ρετινοϊκου οξεος, μεθοδος για την παρασκευη τους και χρηση τους στην ιατρικη για τον ανθρωπο και στα καλλυντικα

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0206850A FR2840299B1 (fr) 2002-06-04 2002-06-04 NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE

Publications (2)

Publication Number Publication Date
FR2840299A1 FR2840299A1 (fr) 2003-12-05
FR2840299B1 true FR2840299B1 (fr) 2006-05-05

Family

ID=29558950

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0206850A Expired - Fee Related FR2840299B1 (fr) 2002-06-04 2002-06-04 NOUVEAUX LIGANDS INHIBITEURS DES RECEPTEURS RARs, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE

Country Status (9)

Country Link
AR (1) AR040234A1 (fr)
AT (1) ATE500866T1 (fr)
CY (1) CY1111485T1 (fr)
DE (1) DE60336312D1 (fr)
DK (1) DK1513793T3 (fr)
ES (1) ES2361303T3 (fr)
FR (1) FR2840299B1 (fr)
PT (1) PT1513793E (fr)
SI (1) SI1513793T1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU86387A1 (fr) * 1986-04-04 1987-12-07 Oreal Composes aromatiques,leur procede de preparation et leur utilisation en medicine humaine et veterinaire et en cosmetique
FR2764604B1 (fr) * 1997-06-13 1999-09-10 Cird Galderma Composes bi-aromatiques relies par un radical propynylene ou allenylene et compositions pharmaceutiques et cosmetiques les contenant

Also Published As

Publication number Publication date
AR040234A1 (es) 2005-03-23
ES2361303T3 (es) 2011-06-15
ATE500866T1 (de) 2011-03-15
CY1111485T1 (el) 2015-08-05
DE60336312D1 (de) 2011-04-21
SI1513793T1 (sl) 2011-06-30
FR2840299A1 (fr) 2003-12-05
DK1513793T3 (da) 2011-05-09
PT1513793E (pt) 2011-05-25

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