FR2812547B1 - Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete - Google Patents

Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete

Info

Publication number
FR2812547B1
FR2812547B1 FR0010362A FR0010362A FR2812547B1 FR 2812547 B1 FR2812547 B1 FR 2812547B1 FR 0010362 A FR0010362 A FR 0010362A FR 0010362 A FR0010362 A FR 0010362A FR 2812547 B1 FR2812547 B1 FR 2812547B1
Authority
FR
France
Prior art keywords
derivative
pharmaceutical composition
metformin
thiazolidinedionion
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0010362A
Other languages
English (en)
Other versions
FR2812547A1 (fr
Inventor
Gerard Moinet
Gerard Botton
Didier Mesangeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0010362A priority Critical patent/FR2812547B1/fr
Application filed by LIPHA SAS filed Critical LIPHA SAS
Priority to SK208-2003A priority patent/SK2082003A3/sk
Priority to US10/343,609 priority patent/US20040014797A1/en
Priority to PL01358791A priority patent/PL358791A1/xx
Priority to EP01960539A priority patent/EP1305025A1/fr
Priority to JP2002517057A priority patent/JP2004505915A/ja
Priority to CZ2003476A priority patent/CZ2003476A3/cs
Priority to HU0303684A priority patent/HUP0303684A2/hu
Priority to BR0112915-5A priority patent/BR0112915A/pt
Priority to CN01813685A priority patent/CN1446090A/zh
Priority to PCT/EP2001/008512 priority patent/WO2002011721A1/fr
Priority to MXPA03000975A priority patent/MXPA03000975A/es
Priority to KR1020027018026A priority patent/KR20030019470A/ko
Priority to RU2003105809/15A priority patent/RU2003105809A/ru
Priority to CA002417883A priority patent/CA2417883A1/fr
Priority to AU2001282010A priority patent/AU2001282010A1/en
Priority to ARP010103708A priority patent/AR030309A1/es
Publication of FR2812547A1 publication Critical patent/FR2812547A1/fr
Publication of FR2812547B1 publication Critical patent/FR2812547B1/fr
Application granted granted Critical
Priority to EC2003004463A priority patent/ECSP034463A/es
Priority to NO20030518A priority patent/NO20030518D0/no
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition pharmaceutique comprenant en tant que principes actifs de la metformine éventuellement sous la forme de l'un de ses sels pharmaceutiquement acceptables et un dérivé de type 5-phénoxyalcoyl-2, 4-thiazolidinedione, en association avec un ou plusieurs excipients pharmaceutiquement acceptables.Ces compositions sont particulièrement appropriées au traitement du diabète non-insulino dépendant.
FR0010362A 2000-08-04 2000-08-04 Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete Expired - Fee Related FR2812547B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR0010362A FR2812547B1 (fr) 2000-08-04 2000-08-04 Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
KR1020027018026A KR20030019470A (ko) 2000-08-04 2001-07-24 메트포르민과 ５-페녹시알킬-２,４-티아졸리딘디온형유도체를 포함하여 이루어지는 약제학적 조성물
MXPA03000975A MXPA03000975A (es) 2000-08-04 2001-07-24 Composicion farmaceutica.
EP01960539A EP1305025A1 (fr) 2000-08-04 2001-07-24 Composition pharmaceutique comprenant de la metformine et un derive de type 5-phenoxyalkyle-2,4-thiazolidinedione
JP2002517057A JP2004505915A (ja) 2000-08-04 2001-07-24 メトホルミンおよび５−フェノキシアルキル−２，４−チアゾリジンジオン型誘導体を含む薬剤組成物
CZ2003476A CZ2003476A3 (cs) 2000-08-04 2001-07-24 Farmaceutický prostředek obsahující metformin a derivát typu 5-fenoxyalkyl-2,4-thiazolidindionu
HU0303684A HUP0303684A2 (hu) 2000-08-04 2001-07-24 Metformint és 5-fenoxialkil-2,4-tiazolidindion típusú származékot tartalmazó gyógyászati készítmény
US10/343,609 US20040014797A1 (en) 2000-08-04 2001-07-24 Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative
CN01813685A CN1446090A (zh) 2000-08-04 2001-07-24 含有二甲双胍和5－苯氧基烷基－2,4－噻唑烷二酮类衍生物的药物组合物
RU2003105809/15A RU2003105809A (ru) 2000-08-04 2001-07-24 Фармацевтическая композиция, включающая метформин и производное 5-феноксиалкил-2, 4-тиазолидиндионного типа
SK208-2003A SK2082003A3 (en) 2000-08-04 2001-07-24 Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative
PL01358791A PL358791A1 (en) 2000-08-04 2001-07-24 Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative
PCT/EP2001/008512 WO2002011721A1 (fr) 2000-08-04 2001-07-24 Composition pharmaceutique comprenant de la metformine et un derive de type 5-phenoxyalkyle-2,4-thiazolidinedione
CA002417883A CA2417883A1 (fr) 2000-08-04 2001-07-24 Composition pharmaceutique comprenant de la metformine et un derive de type 5-phenoxyalkyle-2,4-thiazolidinedione
AU2001282010A AU2001282010A1 (en) 2000-08-04 2001-07-24 Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative
BR0112915-5A BR0112915A (pt) 2000-08-04 2001-07-24 Composição farmacêutica compreendendo metformina e um derivado do tipo 5-fenoxialquil-2,4-tiazolidinadiona
ARP010103708A AR030309A1 (es) 2000-08-04 2001-08-03 Composicion farmaceutica
EC2003004463A ECSP034463A (es) 2000-08-04 2003-02-03 Composicion farmaceutica
NO20030518A NO20030518D0 (no) 2000-08-04 2003-02-03 Farmasöytisk preparat som omfatter metformin og et derivat av 5-fenoksyalkyl-2,4-tiazolidindion-type

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0010362A FR2812547B1 (fr) 2000-08-04 2000-08-04 Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete

Publications (2)

Publication Number Publication Date
FR2812547A1 FR2812547A1 (fr) 2002-02-08
FR2812547B1 true FR2812547B1 (fr) 2002-10-31

Family

ID=8853342

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0010362A Expired - Fee Related FR2812547B1 (fr) 2000-08-04 2000-08-04 Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete

Country Status (19)

Country Link
US (1) US20040014797A1 (fr)
EP (1) EP1305025A1 (fr)
JP (1) JP2004505915A (fr)
KR (1) KR20030019470A (fr)
CN (1) CN1446090A (fr)
AR (1) AR030309A1 (fr)
AU (1) AU2001282010A1 (fr)
BR (1) BR0112915A (fr)
CA (1) CA2417883A1 (fr)
CZ (1) CZ2003476A3 (fr)
EC (1) ECSP034463A (fr)
FR (1) FR2812547B1 (fr)
HU (1) HUP0303684A2 (fr)
MX (1) MXPA03000975A (fr)
NO (1) NO20030518D0 (fr)
PL (1) PL358791A1 (fr)
RU (1) RU2003105809A (fr)
SK (1) SK2082003A3 (fr)
WO (1) WO2002011721A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003105809A1 (fr) 2002-06-17 2003-12-24 Themis Laboratories Private Limited Comprimes multicouche contenant des thiazolidinediones et des biguanides et procedes de production desdits comprimes
UA80991C2 (en) 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
CA2660029A1 (fr) * 2006-08-04 2008-02-07 Nastech Pharmaceutical Company Inc. Compositions pour administration intranasale d'insuline humaine et leurs utilisations
KR100926417B1 (ko) 2007-01-29 2009-11-12 한올제약주식회사 Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 초산염,그의 제조방법 및 그를 포함하는 약제학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749583B1 (fr) * 1996-06-07 1998-08-21 Lipha Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
PL195136B1 (pl) * 1997-06-18 2007-08-31 Smithkline Beecham Plc Kombinacja zawierająca 5-[4-[2-(N-metylo-N-(2-pirydylo)amino)etoksy]-benzylo] tiazolidyno-2,4-dion i jej zastosowanie
GB9715295D0 (en) * 1997-07-18 1997-09-24 Smithkline Beecham Plc Novel method of treatment

Also Published As

Publication number Publication date
HUP0303684A2 (hu) 2004-03-01
WO2002011721A1 (fr) 2002-02-14
KR20030019470A (ko) 2003-03-06
NO20030518L (no) 2003-02-03
NO20030518D0 (no) 2003-02-03
PL358791A1 (en) 2004-08-23
CA2417883A1 (fr) 2002-02-14
MXPA03000975A (es) 2003-06-09
FR2812547A1 (fr) 2002-02-08
AU2001282010A1 (en) 2002-02-18
CZ2003476A3 (cs) 2003-06-18
AR030309A1 (es) 2003-08-20
JP2004505915A (ja) 2004-02-26
BR0112915A (pt) 2003-07-08
RU2003105809A (ru) 2004-08-27
CN1446090A (zh) 2003-10-01
SK2082003A3 (en) 2003-07-01
EP1305025A1 (fr) 2003-05-02
US20040014797A1 (en) 2004-01-22
ECSP034463A (es) 2003-03-31

Similar Documents

Publication Publication Date Title
MA29550B1 (fr) Derives de n- (pyridine-2-yl) - sulfonamide
HUP0204122A2 (hu) Dioxo-tiazolidint és hetformint tartalmazó gyógyszerkészítmény és felhasználása
TNSN04095A1 (en) Pharmaceutical compositions comprising metformine and glibenclamide for the treatment of type-ii diabetes mellitus
IL139227A0 (en) N-substituted aminotetralins as ligands for the neuropeptide yy5 receptor useful in the treatment of obesity and other disorders
PE83199A1 (es) Composicion farmaceutica de tiazolidinadiona y biguanida para el tratamiento de la diabetes
HUP0301194A2 (hu) Dipeptidil-peptidáz IV. inhibitorokból és más antidiabetikus szerekből álló kombinációs készítmények és alkalmazásuk diabetes mellitus kezelésére
BR0213522A (pt) Composto, composição farmacêutica, métodos de inibir a hiv integrase e para prevenir ou tratar a infecção pelo hiv ou para prevenir, tratar ou retardar o inìcio da aids em um paciente, e, combinação útil para tratar ou prevenir a infecção pelo hiv ou para prevenir, tratar ou retardar o inìcio da aids
BR0009864A (pt) Composto, composição farmacêutica, métodos para o tratamento de doenças, para o tratamento e/ou prevenção de condições mediadas pelos receptores nucleares e para o tratamento e/ou prevenção de diabete e/ou obesidade, e, uso de um composto
AR035927A1 (es) Compuesto de lactama (n)-((s)-2-hidroxi-3-metilbutiril)-1-(l-alaninil)-(s)-1-amino-3-metil-4,5,6,7-tetrahidro-2h-3-benzazepin-2-ona , composicion farmaceutica que lo comprende, procedimiento para la inhibicion de la liberacion de peptido b-amiloide y/o su sintesis que lo emplea y su uso para la fabr
RU93043528A (ru) Моногидрат 5-(2-(4-(1,2-бензотиазол-3-ил)-1-пиперазинил)этил)-6-хлор-1,3-дигидро-2н-индол-2-он хлоргидрата, способ его получения, фармацевтическая композиция, способ лечения
DE60236541D1 (de) Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1
AU2002225772A1 (en) Therapeutic agents and methods of use thereof for treating an amyloidogenic disease
MA29744B1 (fr) Formulations posologiques solides de medicaments presentant une adsorption buccale amelioree
BR0212787A (pt) Composto ou sal farmaceuticamente aceitável do mesmo, métodos de tratamento ou prevenção de doenças e de preparação de um composto, uso de um composto ou sal, e, composição farmacêutica
DE60024491D1 (de) Schnell-wirkende, gefrier-trocknete, orale, pharmazeutische formulierung für die behandlung von migräne
TNSN00235A1 (fr) Derives d'heterocyclo-alkylsulfonylpyrazole nouveaux, procede pour leur preparation et compositions les contenant
BR0114196A (pt) Formas polimórficas de maleato de 5-[4-[2-[n-metil-n-(2-piridil) amino]etóxi]benzil]tiazolidina-2,4-diona e processo para a preparação das mesmas.
BR0210392A (pt) Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto
FR2812547B1 (fr) Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
GEP20043227B (en) 5HT1 Antagonists for Antidepressant Therapy
BR9913982A (pt) Derivado de piridil-4h-1,2,4-oxadiazina opticamente ativo e seu uso no tratamento de doenças vasculares
PE108199A1 (es) Composicion farmaceutica de tiazolidindiona y sulfonilurea
MA26744A1 (fr) Polymorphes d'un chlorhydrate d'azo-bicyclo-2,2,2-oct-3-ylamine cristallins et compositions pharmaceutiques les contenant
BR0208488A (pt) Agonistas de kapa-opiato para o tratamento de doenças da bexiga
SE0000303D0 (sv) Novel compounds

Legal Events

Date Code Title Description
ST Notification of lapse