FR2806409B1 - NOVEL HETEROCYCLIC DERIVATIVES OF LIPOIC ACID, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

NOVEL HETEROCYCLIC DERIVATIVES OF LIPOIC ACID, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
FR2806409B1
FR2806409B1 FR0003355A FR0003355A FR2806409B1 FR 2806409 B1 FR2806409 B1 FR 2806409B1 FR 0003355 A FR0003355 A FR 0003355A FR 0003355 A FR0003355 A FR 0003355A FR 2806409 B1 FR2806409 B1 FR 2806409B1
Authority
FR
France
Prior art keywords
medicaments
preparation
pharmaceutical compositions
compositions containing
lipoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0003355A
Other languages
French (fr)
Other versions
FR2806409A1 (en
Inventor
Jeremiah Harnett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0003355A priority Critical patent/FR2806409B1/en
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority to AT01917143T priority patent/ATE286050T1/en
Priority to PT01917143T priority patent/PT1265891E/en
Priority to AU44244/01A priority patent/AU4424401A/en
Priority to RU2002127729/04A priority patent/RU2260005C2/en
Priority to US10/221,432 priority patent/US6936715B2/en
Priority to HU0303127A priority patent/HUP0303127A3/en
Priority to PCT/FR2001/000764 priority patent/WO2001068643A2/en
Priority to DE60108089T priority patent/DE60108089T2/en
Priority to JP2001567734A priority patent/JP2003527391A/en
Priority to ES01917143T priority patent/ES2234825T3/en
Priority to DK01917143T priority patent/DK1265891T3/en
Priority to PL01361850A priority patent/PL361850A1/en
Priority to CA002402898A priority patent/CA2402898A1/en
Priority to EP01917143A priority patent/EP1265891B1/en
Priority to CZ20023105A priority patent/CZ20023105A3/en
Publication of FR2806409A1 publication Critical patent/FR2806409A1/en
Application granted granted Critical
Publication of FR2806409B1 publication Critical patent/FR2806409B1/en
Priority to US11/147,561 priority patent/US7285664B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0003355A 2000-03-16 2000-03-16 NOVEL HETEROCYCLIC DERIVATIVES OF LIPOIC ACID, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Expired - Fee Related FR2806409B1 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR0003355A FR2806409B1 (en) 2000-03-16 2000-03-16 NOVEL HETEROCYCLIC DERIVATIVES OF LIPOIC ACID, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PL01361850A PL361850A1 (en) 2000-03-16 2001-03-15 Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
AU44244/01A AU4424401A (en) 2000-03-16 2001-03-15 Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
RU2002127729/04A RU2260005C2 (en) 2000-03-16 2001-03-15 Lipoic acid derivatives, production thereof (variants) and pharmaceutical composition
US10/221,432 US6936715B2 (en) 2000-03-16 2001-03-15 Lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
HU0303127A HUP0303127A3 (en) 2000-03-16 2001-03-15 Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
PCT/FR2001/000764 WO2001068643A2 (en) 2000-03-16 2001-03-15 Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
DE60108089T DE60108089T2 (en) 2000-03-16 2001-03-15 Heterocyclic or benzene derivatives of lipoic acid, their production and Ederen use as a cure
AT01917143T ATE286050T1 (en) 2000-03-16 2001-03-15 HETEROCYCLIC OR BENZENE DERIVATIVES OF LIPONIC ACID, THEIR PRODUCTION AND THEIR USE AS REMEDIES
ES01917143T ES2234825T3 (en) 2000-03-16 2001-03-15 NEW HETEROCICLIC OR BENCENIC DERIVATIVES OF LIPOIC ACID, ITS PREPARATION AND ITS APPLICATION AS MEDICINES.
DK01917143T DK1265891T3 (en) 2000-03-16 2001-03-15 Heterocyclic or benzene-containing lipoic acid derivatives and their preparation and use as medicaments
PT01917143T PT1265891E (en) 2000-03-16 2001-03-15 NEW HETEROCYCLIC OR BENZENIC DERIVATIVES OF LIPOIC ACID ITS PREPARATION AND ITS APPLICATION TO TITLE OF MEDICINES
CA002402898A CA2402898A1 (en) 2000-03-16 2001-03-15 Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
EP01917143A EP1265891B1 (en) 2000-03-16 2001-03-15 Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
CZ20023105A CZ20023105A3 (en) 2000-03-16 2001-03-15 Novel heterocyclic or benzene derivatives of lipoic acid, process of their preparation and their use as medicaments
JP2001567734A JP2003527391A (en) 2000-03-16 2001-03-15 Novel heterocyclic or benzene derivative of lipoic acid, its production method and its use as a medicament
US11/147,561 US7285664B2 (en) 2000-03-16 2005-06-08 Heterocyclic or benzenic derivatives of lipoic acid, their preparation and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0003355A FR2806409B1 (en) 2000-03-16 2000-03-16 NOVEL HETEROCYCLIC DERIVATIVES OF LIPOIC ACID, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
FR2806409A1 FR2806409A1 (en) 2001-09-21
FR2806409B1 true FR2806409B1 (en) 2002-04-19

Family

ID=8848145

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0003355A Expired - Fee Related FR2806409B1 (en) 2000-03-16 2000-03-16 NOVEL HETEROCYCLIC DERIVATIVES OF LIPOIC ACID, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (1)

Country Link
FR (1) FR2806409B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123887A0 (en) * 1997-04-02 1998-10-30 Sankyo Co Dithiolan derivatives their use and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
FR2806409A1 (en) 2001-09-21

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Effective date: 20101130