FR2806262A1 - Nutritional supplement for protection against premenstrual symptoms, menopausal problems, osteoporosis, and cancers comprises evening primrose and borage oils - Google Patents

Nutritional supplement for protection against premenstrual symptoms, menopausal problems, osteoporosis, and cancers comprises evening primrose and borage oils Download PDF

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FR2806262A1
FR2806262A1 FR0003463A FR0003463A FR2806262A1 FR 2806262 A1 FR2806262 A1 FR 2806262A1 FR 0003463 A FR0003463 A FR 0003463A FR 0003463 A FR0003463 A FR 0003463A FR 2806262 A1 FR2806262 A1 FR 2806262A1
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nutritional supplement
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evening primrose
prostaglandins
osteoporosis
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Hatem Smaoui
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

Nutritional supplement comprising evening primrose and borage oils, rich in OMICRON 6 fatty acids, and psi linolenic acid carriers, is new. An Independent claim is included for nutritional supplements containing tomato lycopene, vitamin D, and curcuma, optionally with vitamin E.

Description

NOUVEAU COMPLEMENT NUTRITIONNEL A BASE DE LYCOPENE DE TOMATE, D'HUILES D'ONAGRE, DE BOURRACHE. D'UN COMPLEXE MULTIVITAMINIQVE ET DE CURCUMA. La présente invention concerne une formulation renfermant des nutriments apportant à l'organisme humain une protection. Cette protection concerne aussi bien la femme pré ménopausée que post ménopausée. NEW NUTRITIONAL SUPPLEMENT BASED ON LYCOPENE TOMATO, OIL ONAGRE, BOURRACHE. MULTIVITAMINIC COMPLEX AND CURCUMA. The present invention relates to a formulation containing nutrients providing the human body with protection. This protection concerns both pre-menopausal and post-menopausal women.

Elle a plus particulièrement pour objet d'apporter à l'organisme humain un complexe huileux riche en acides gras de la série S2 6, du lycopène de tomate, de Ici vitamine E, C, B3, ô6 ainsi que des actifs naturels possédant des propriétés contre la prolifération cellulaire. It is more particularly intended to provide the human body with an oily complex rich in fatty acids of the S2 6 series, tomato lycopene, Vitamin E, C, B3 and O6, as well as natural active ingredients possessing properties against cell proliferation.

D'une manière générale, les formulations utilisant des phytonutriments utilisés en supplémentation alimentaire, et ayant pour but d'apporter les acides gras gamma linoléiques ne renferment pas de vitamines C, B3 et B6. In general, formulations using phytonutrients used in food supplementation and intended to provide gamma linoleic fatty acids do not contain vitamins C, B3 and B6.

L'originalité de cette formulation réside dans le fait qu'elle apporte l'acide gras gamma linoléique (GLA) avec les vitamines qui permettent à l'organisme de synthétiser les prostaglandines PG E1 et PGF 1 a. The originality of this formulation lies in the fact that it brings gamma linoleic fatty acid (GLA) with the vitamins that allow the body to synthesize the PG E1 and PGF 1 a prostaglandins.

Cette formulation renferme un nutriment qui a pour rôle de protéger contre les radicaux libres. Il est aussi protecteur contre les syndromes malins : le lycopène de tomate. This formulation contains a nutrient whose role is to protect against free radicals. It is also protective against malignant syndromes: tomato lycopene.

La vitamine D, dans ce supplément nutritionnel, possède un double rôle : elle coopère avec le lycopène contre les processus malins et permet de renforcer la charpente osseuse en fixant le calcium et le phosphore alimentaires, prévenant contre l'ostéoporose. Vitamin D, in this nutritional supplement, has a dual role: it cooperates with lycopene against malignant processes and helps strengthen the bone structure by fixing dietary calcium and phosphorus, preventing against osteoporosis.

Le curcuma possède aussi une action sur les cellules cancéreuses : il est protecteur. Turmeric also has an action on cancer cells: it is protective.

INGREDIENTS <B><U>Le</U></B> 1ycopène <B><U>de tomate</U></B> est un excellent anti-radicaux libres et protecteur contre certaines pathologies malignes. Le lycopène piège les radicaux libres et participe à la lutte contre la formation de peroxydes toxiques pour l'organisme. I) agit beaucoup plus efficacement que les autres caroténdides dans le processus d'antioxydation.  INGREDIENTS <B> <U> </ B> </ B> </ B> </ B> 1 </ b> Tomato ycopene <B> </ B> </ B> is an excellent anti-free radicals and protective against certain malignant diseases. Lycopene traps free radicals and helps fight against the formation of toxic peroxides for the body. I) acts much more effectively than other carotenes in the process of antioxidation.

Plusieurs rapports scientifiques ont démontré l'effet du lycopène dans la protection contre les cancers du sein et de l'utérus chez la femme. Les femmes qui possèdent un taux sérique élevé de lycopène sont mieux protégées contre le cancer du sein et de l'endomètre. Several scientific reports have demonstrated the effect of lycopene in the protection against breast and uterine cancers in women. Women with high serum lycopene levels are better protected against breast and endometrial cancer.

NAGASAWA, <I><U>H. et al,</U></I> Effects <I>of</I> lycopene <I>on</I> spontaneous mammary tumor in 5HN virgin mice. <B><I>A</I></B><I>n</I> ticancer Res, <I>15: 1173-1178, 1995)</I> PALAN <I><U>P. R and al.</U> Plasma</I> level <I>of<B>6</B></I> carotene, Lycopene, Canthaxanthin, Retinol, <I>and</I> Tocopherol <I>in Cervical</I> Intraepithelial Neoplasia <I>and</I> Cancer.  NAGASAWA, <i> <u> H. et al, </ i> </ i> Effects <i> of </ i> lycopene <I> one </ i> spontaneous mammary tumor in 5HN virgin mice. <B> <I> A </ I> </ B> <I> n </ I> ticancer Res, <I> 15: 1173-1178, 1995) </ I> PALAN <I> <U> P. R et al. </ U> Plasma </ i> level <I> of <B> 6 </ i> carotene, Lycopene, Canthaxanthin, Retinol, <i> and </ I> Tocopherol <I> in Cervical </ I> Intraepithelial Neoplasia <I> and </ I> Cancer.

Clinical <I>Cancer Research. Vol 2, 181-185 (1996)</I> sENSUPTA <I><U>A and a</U>l. The</I> anti=carcinogenic role <I>of</I> lycopene, abundantly present <I>in</I> tomato. Eur. <I>J. Cancer</I> Pre <I>v.. 8, (4) : 325-330 (1999)</I> <B>L'huile de bourrache</B> riche en acides gras essentiels, elle renferme 22 fo d'acide gamma linoléique. Elle assure une hydratation intense de la peau et permet de lutter contre le dessèchement cutané et d'optimiser le métabolisme cellulaire.  Clinical <I> Cancer Research. Vol 2, 181-185 (1996) </ I> SENSUPTA <I> <U> A and a </ U> l. The </ I> anti-carcinogenic role <i> of </ i> lycopene, abundantly present <i> in </ i> tomato. Eur. <I> J. Cancer </ I> Pre <I> v. 8, (4): 325-330 (1999) </ I> <B> Borage oil </ B> rich in essential fatty acids, it contains 22% of gamma linoleic acid. It ensures intense hydration of the skin and helps fight against skin dryness and optimize cellular metabolism.

Cette huile est précieuse quant à son action contre le vieillissement de la peau et la formation des rides. This oil is precious for its action against the aging of the skin and the formation of wrinkles.

<B>L'huile d'onagre</B> est riche en acide gamma linolénique (série des oméga 6) à l'origine de prostaglandines physiologiquement active. <B> Evening primrose oil </ B> is rich in gamma-linolenic acid (omega-6 series), which is the origin of physiologically active prostaglandins.

Elle régule l'action des hormones sexuelles, le maintien de l'élasticité des organes et hutte contre le vieillissement. Elle a une action sur l'irritabilité, les troubles dû à la menstruation et les risques cardio-vasculaires. It regulates the action of sex hormones, maintaining the elasticity of organs and hut against aging. It has an action on irritability, disorders due to menstruation and cardiovascular risks.

L'huile d'onagre est administrée comme précurseur de prostaglandines de par son contenu en acide gamma linolénique. bes études ont montré que l'huile d'onagre régule le système hormonal. Prise pendant la deuxième moitié du cycle menstruel, elle diminue nettement le syndrome prémenstruel en agissant sur toutes ses manifestations : dépression, irritabilité, tension mammaire, douleurs abdominales, rétention d'eau et céphalées. Evening primrose oil is administered as a precursor of prostaglandins by its content in gamma linolenic acid. Studies have shown that evening primrose oil regulates the hormonal system. Taken during the second half of the menstrual cycle, it significantly reduces premenstrual syndrome by acting on all its manifestations: depression, irritability, breast tenderness, abdominal pain, water retention and headache.

<B>Vitamine E</B> ou a,-tocophérol est nécessaire à l'activité de plusieurs enzymes. C'est un excellent antioxydant et inhibiteur de Ici formation de nitrosamines. La vitamine E aide à lutter contre le vieillissement cutané. <B> Vitamin E </ B> or a, -tocopherol is necessary for the activity of several enzymes. It is an excellent antioxidant and inhibitor of nitrosamine formation. Vitamin E helps fight against skin aging.

<B><U>Le complexe</U></B> vitaminé <B><U>C. B3 et B6</U></B> Les vitamines B3 et B6 et C sont nécessaires à Ici synthèse des prostaglandines bénéfiques. En effet, sans leurs concours, les enzymes qui transforment les GLA en prostaglandines sont inactives. La vitamine B6 est nécessaire à la transformation de l'acide gamma linoléique, apporté par les huiles d'onagre et de bourrache, en acide dihommo linolénique. <B> <U> The complex </ U> </ B> vitamin <B> <U> C. B3 and B6 Vitamins B3 and B6 and C are needed for synthesis of beneficial prostaglandins. Indeed, without their help, the enzymes that transform GLA into prostaglandins are inactive. Vitamin B6 is necessary for the transformation of gamma linoleic acid, provided by evening primrose and borage oils, into dihommo linolenic acid.

Les vitamines C et<B>83</B> participent ensuite à la synthèse de prostaglandines (PGE 1 et PGF 1 a) La Vitamine C est par excellence la vitamine réductrice agissant dans les phénomènes d'oxydoréduction cellulaires, elle possède un pouvoir anti asthénique et protège les vitamines A et E de l'oxydation. Vitamins C and <B> 83 </ B> then participate in the synthesis of prostaglandins (PGE 1 and PGF 1a) Vitamin C is par excellence the reducing vitamin acting in cellular redox phenomena, it has an anti asthenic and protects vitamins A and E from oxidation.

<B><U>La Vitamine b</U></B> : est apportée par l'huile de foie de flétan. Des travaux effectués sur des cultures cellulaires cancéreuses, ont démontré que la synergie lycopène - vitamine D inhibe la multiplication des cellules cancéreuses. <B> <U> Vitamin B </ U> </ B>: is brought by halibut liver oil. Work carried out on cancerous cell cultures has shown that lycopene - vitamin D synergy inhibits the multiplication of cancer cells.

AMIR H <B><U>and al</U>.</B> Lycopene and 1,25-Dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.  AMIR H <B> <U> et al </ U>. </ B> Lycopene and 1,25-Dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.

<I>Nutrition and Cancer Research. 33 (I), 105 -112 (1999)</I> De plus, La vitamine D renforce l'action du calcium alimentaire et prévient de l'ostéoporose. <I> Nutrition and Cancer Research. 33 (I), 105 -112 (1999) </ I> In addition, vitamin D enhances the action of dietary calcium and prevents osteoporosis.

<U>Le curcuma</U> Le curcuma, très connu en Inde, possède des propriétés anti- prolifératives.

Figure img00030024

<U>Le sélénium ;</U> est un antioxydant, et est doté d'activités anti cancéreuses. RECAPITULATIF ET DOSAGES 1) Les molécules directement antiradicalaires (piégeurs <U>)</U> - Lycopène naturel de tomate (1 à 10 mg) - vitamine E (2 à 15 mg) - vitamine C (20 à 80 mg) - vitamine B3 (2 à 30 mg) - vitamine Bb (2 à 15 mg) <U>2) Les molécules venant renforcer les systèmes</U> enzymatiques <U>de défense</U> antiradicalaire. <U> Turmeric </ U> Turmeric, well known in India, has anti-proliferative properties.
Figure img00030024

<U>Selenium;</U> is an antioxidant, and has anti-cancer activities. SUMMARY AND ASSAYS 1) The molecules directly antiradical (scavengers <U>) </ U> - Lycopene natural tomato (1 to 10 mg) - vitamin E (2 to 15 mg) - vitamin C (20 to 80 mg) - vitamin B3 (2 to 30 mg) - vitamin Bb (2 to 15 mg) <U> 2) Molecules that strengthen the <U> antiradical defense </ U> enzymatic systems.

- sélénium ( 20 à 100 mcg) <U>3) Les</U> ingrédients apportant <U>l'acide gras gamma linoléique.</U> - Huile de bourrache (20 à 500 mg) - huile d'onagre (20 à 500 mg) <U>4) les ingrédients à</U> activité anti proliférative <U>cellulaire</U> - le curcuma (1 à 50 mg) - la vitamine D (2 à 50 pg) selenium (20 to 100 mcg) <U> 3) </ U> ingredients supplying <U> gamma linoleic fatty acid. </ U> - Borage oil (20 to 500 mg) - evening primrose oil ( 20 to 500 mg) <U> 4) <U> U </ U> anti-proliferative activity - Turmeric (1 to 50 mg) - Vitamin D (2 to 50 μg)

Claims (1)

REVENDICATIONS 1)- Complément nutritionnel caractérisé par la présence d'huiles d'onagre et de bourrache, riches en acide gras de la série S2 6 et vectrices d'acide gamma linolénique, qui permet de combler la carence en prostaglandines, cause du syndrome prémenstruel chez la femme et de problèmes liés à la ménopause. 2)- Complément nutritionnel contenant, selon la revendication 1, un précurseur direct des prostaglandines soulageant la femme pendant (a période prémenstruelle et pendant la ménopause. 3)- complément nutritionnel, selon la revendication 2, renfermant un complexe vitaminique permettant de faciliter la synthèse des prostaglandines dans l'organisme. 4)- Complément nutritionnel apportant du lycopène de tomate, de la vitamine D et du curcuma, permettant un meilleur confort chez la femme, selon la revendication 3, et protégeant contre les syndromes malins. 5)- Complément nutritionnel, selon la revendication 4, additionné de vitamine E, antioxydante 6)- utilisation d'un complément nutritionnel, selon les revendications 1 à 5, pour la préparation d'une composition alimentaire destinée à améliorer la protection et le confort à la femme pré et post ménopausée. 1) - Nutritional supplement characterized by the presence of evening primrose oils and borage, rich in fatty acid of the series S2 6 and vectors of gamma linolenic acid, which makes up for the deficiency of prostaglandins, cause of the premenstrual syndrome in women and problems related to menopause. 2) - Nutritional supplement containing, according to claim 1, a direct precursor prostaglandins relieving the woman during (premenstrual period and during menopause.) 3) - nutritional supplement, according to claim 2, containing a vitamin complex to facilitate synthesis prostaglandins in the body. 4) - Nutritional supplement providing tomato lycopene, vitamin D and turmeric, allowing a better comfort in women, according to claim 3, and protecting against malignant syndromes. 5) - nutritional supplement, according to claim 4, supplemented with vitamin E, antioxidant 6) - use of a nutritional supplement, according to claims 1 to 5, for the preparation of a food composition intended to improve the protection and comfort to the woman before and after menopause.
FR0003463A 2000-03-17 2000-03-17 Nutritional supplement for protection against premenstrual symptoms, menopausal problems, osteoporosis, and cancers comprises evening primrose and borage oils Withdrawn FR2806262A1 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068200A2 (en) * 2002-02-15 2003-08-21 Touche Marie-Jose Novel therapeutic application for a composition
WO2004103388A2 (en) * 2003-05-22 2004-12-02 Bioniche Life Sciences Inc. Insect repellent
WO2005092355A1 (en) * 2004-03-26 2005-10-06 Velez-Rivera Hector Phyto-composition for the treatment of articular diseases
EP1618800A1 (en) * 2004-07-24 2006-01-25 Cognis IP Management GmbH Active compositions comprising lycopene, cytidin and fatty acids
EP2808026A1 (en) 2013-05-31 2014-12-03 Ems S.A. Composition for treatment or reduction of symptoms related to premenstrual syndrome (pms), premenstrual disphoric disorder (pmdd), premenopause, menopause or female hormonal disorders in a pharmaceutical composition containing said form, and process for producing said pharmaceutical form and use of said composition

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* Cited by examiner, † Cited by third party
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FR2836046A1 (en) * 2002-02-15 2003-08-22 Marie Jose Touche NOVEL THERAPEUTIC APPLICATION OF COMPOUND A: BUTOFORM OR SCUROFORM ASSOCIATED WITH PRODUCT B: EUGENOL AND PRODUCT C: ZINC OXIDE, ADDED TO LYCOPENE
WO2003068200A3 (en) * 2002-02-15 2004-03-25 Marie-Jose Touche Novel therapeutic application for a composition
WO2003068200A2 (en) * 2002-02-15 2003-08-21 Touche Marie-Jose Novel therapeutic application for a composition
US7381431B2 (en) 2003-05-22 2008-06-03 Bioniche Life Sciences, Inc. Insect repellent
WO2004103388A2 (en) * 2003-05-22 2004-12-02 Bioniche Life Sciences Inc. Insect repellent
WO2004103388A3 (en) * 2003-05-22 2005-04-07 Bioniche Life Sciences Inc Insect repellent
US7985432B2 (en) 2003-05-22 2011-07-26 Bioniche Life Sciences, Inc. Insect repellent
AU2004241797B2 (en) * 2003-05-22 2011-03-17 Bioniche Life Sciences Inc. Insect repellent
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