FR2785543B1 - Exosomes modifies et utilisations - Google Patents

Exosomes modifies et utilisations

Info

Publication number
FR2785543B1
FR2785543B1 FR9813946A FR9813946A FR2785543B1 FR 2785543 B1 FR2785543 B1 FR 2785543B1 FR 9813946 A FR9813946 A FR 9813946A FR 9813946 A FR9813946 A FR 9813946A FR 2785543 B1 FR2785543 B1 FR 2785543B1
Authority
FR
France
Prior art keywords
modified exosomes
exosomes
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9813946A
Other languages
English (en)
Other versions
FR2785543A1 (fr
Inventor
Christian Bonnerot
Philippe Benaroch
Sebastian Amigorena
Schneider Helene Vincent
Pamela Stumptner
Graca Raposo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9813946A priority Critical patent/FR2785543B1/fr
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to AU10514/00A priority patent/AU772451B2/en
Priority to EP99954055A priority patent/EP1127110A1/fr
Priority to PCT/FR1999/002691 priority patent/WO2000028001A1/fr
Priority to JP2000581168A priority patent/JP2002529074A/ja
Priority to CA002349679A priority patent/CA2349679A1/fr
Priority to EA200100509A priority patent/EA004428B1/ru
Priority to CN99812879A priority patent/CN1325441A/zh
Priority to IL14263499A priority patent/IL142634A0/xx
Priority to TW088119348A priority patent/TWI224138B/zh
Publication of FR2785543A1 publication Critical patent/FR2785543A1/fr
Application granted granted Critical
Publication of FR2785543B1 publication Critical patent/FR2785543B1/fr
Priority to AU2004203482A priority patent/AU2004203482A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
FR9813946A 1998-11-05 1998-11-05 Exosomes modifies et utilisations Expired - Fee Related FR2785543B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR9813946A FR2785543B1 (fr) 1998-11-05 1998-11-05 Exosomes modifies et utilisations
IL14263499A IL142634A0 (en) 1998-11-05 1999-11-04 Modified exosomes and uses
PCT/FR1999/002691 WO2000028001A1 (fr) 1998-11-05 1999-11-04 Exosomes modifies et utilisations
JP2000581168A JP2002529074A (ja) 1998-11-05 1999-11-04 改変エキソソーム及び使用
CA002349679A CA2349679A1 (fr) 1998-11-05 1999-11-04 Exosomes modifies et utilisations
EA200100509A EA004428B1 (ru) 1998-11-05 1999-11-04 Модифицированные экзосомы и их применение
AU10514/00A AU772451B2 (en) 1998-11-05 1999-11-04 Modified exosomes and uses
EP99954055A EP1127110A1 (fr) 1998-11-05 1999-11-04 Exosomes modifies et utilisations
CN99812879A CN1325441A (zh) 1998-11-05 1999-11-04 经修饰的胞外体及其用途
TW088119348A TWI224138B (en) 1998-11-05 1999-12-16 Membrane vesicles, method for producing the same, composition containing the same, uses thereof, method for producing antibodies and method for detection of the presence of t-lymphocytes specific to antigen-MHC complexes in a biological sample
AU2004203482A AU2004203482A1 (en) 1998-11-05 2004-07-29 Modified exosomes and uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9813946A FR2785543B1 (fr) 1998-11-05 1998-11-05 Exosomes modifies et utilisations

Publications (2)

Publication Number Publication Date
FR2785543A1 FR2785543A1 (fr) 2000-05-12
FR2785543B1 true FR2785543B1 (fr) 2003-02-28

Family

ID=9532412

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9813946A Expired - Fee Related FR2785543B1 (fr) 1998-11-05 1998-11-05 Exosomes modifies et utilisations

Country Status (10)

Country Link
EP (1) EP1127110A1 (fr)
JP (1) JP2002529074A (fr)
CN (1) CN1325441A (fr)
AU (2) AU772451B2 (fr)
CA (1) CA2349679A1 (fr)
EA (1) EA004428B1 (fr)
FR (1) FR2785543B1 (fr)
IL (1) IL142634A0 (fr)
TW (1) TWI224138B (fr)
WO (1) WO2000028001A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040241176A1 (en) * 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
AU2002331244B2 (en) 2001-08-17 2007-02-15 Exothera L.L.C. Methods and compounds for the targeting of protein to exosomes
KR100519384B1 (ko) * 2002-08-13 2005-10-06 (주)누백스 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도
CN1313151C (zh) * 2002-11-04 2007-05-02 杭州浙大康泰生物技术有限公司 一种新型高效非细胞性疫苗的制备及其用途
US7914792B2 (en) 2003-02-14 2011-03-29 Exothera L.L.C. Methods and compounds for raising antibodies and for screening antibody repertoires
JPWO2005094571A1 (ja) * 2004-03-31 2008-02-14 独立行政法人科学技術振興機構 遺伝子改変ヘテロ動物及び該動物を用いたエキソサイトシスの計測方法
WO2006089572A1 (fr) * 2005-02-28 2006-08-31 Charité - Universitätsmedizin Berlin Capsules polyelectrolytiques de detection des reactions entre antigenes et anticorps
CN1322115C (zh) * 2005-07-06 2007-06-20 清华大学 载有外源配体分子的胞外体及其制备方法与应用
US9085778B2 (en) * 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
CA2676143A1 (fr) 2007-01-26 2008-07-31 University Of Louisville Research Foundation, Inc. Modification de composants a base d' exosome utilises comme vaccin
WO2010119256A1 (fr) * 2009-04-17 2010-10-21 Isis Innovation Limited Composition pour la distribution de matériel génétique
CN102596177B (zh) * 2009-07-01 2014-05-28 阿昂梅迪克斯公司 来源于有核哺乳动物细胞的微囊泡及其应用
CN102470167A (zh) * 2009-07-02 2012-05-23 Ith免疫治疗控股公司 基于外泌体的癌症治疗
ES2362589B1 (es) 2009-12-28 2012-05-16 Centre De Recerca En Salut Internacional De Barcelona Exosomas derivados de reticulocitos infectados con plasmodium sp., método para su obtención y su uso.
JP2015500013A (ja) 2011-11-30 2015-01-05 ユニバーシティ オブ ブレーメン 胎盤組織におけるｍｉＲＮＡの発現
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
EP3052616A4 (fr) * 2013-10-02 2017-03-29 Paradigm Biopharmaceuticals Limited Procédé de production d'exosomes
EP2862874B1 (fr) * 2013-10-15 2018-12-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Procédé de production d'anticorps polyclonaux à l'aide d'une composition antigénique comprenant des vésicules de membrane contenant des protéines
DE102014113688A1 (de) * 2014-09-22 2016-03-24 Jacobs University Bremen Ggmbh Antigenspezifische immunfärbung von t-zellen
CA3017571A1 (fr) * 2015-03-16 2016-09-22 Duncan Ross Procede de traitement comprenant des vesicules logees dans une membrane
MX2017015279A (es) * 2015-06-03 2018-05-15 Innovex Therapeutics S L Exasomas y su uso como vacunas.
NZ738149A (en) 2015-06-10 2024-02-23 Univ Texas Use of exosomes for the treatment of disease
AU2017226956A1 (en) 2016-03-03 2018-10-11 Institut Gustave Roussy PTPS-based vaccines against cancer
WO2017175253A1 (fr) * 2016-04-04 2017-10-12 国立研究開発法人医薬基盤・健康・栄養研究所 Vaccin à adn ciblant l'exosome
GB201717446D0 (en) 2017-10-24 2017-12-06 Evox Therapeutics Ltd Affinity purification of engineering extracellular vesicles
WO2020231700A1 (fr) * 2019-05-11 2020-11-19 Youngsuk Yi Compositions à base de neurotoxines et méthodes
CN110938670B (zh) * 2019-11-07 2023-11-07 南方医科大学南方医院 微生物菌液与血清囊泡反应在检测微生物感染中的应用
JP2021000093A (ja) * 2020-08-05 2021-01-07 国立研究開発法人医薬基盤・健康・栄養研究所 エキソソーム標的ｄｎａワクチン

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69635895D1 (de) * 1995-08-03 2006-05-04 Rijksuniversiteit Te Leiden Le Antigen presentierende bläschen, die von zellen ableiten

Also Published As

Publication number Publication date
AU2004203482A1 (en) 2004-08-26
EP1127110A1 (fr) 2001-08-29
IL142634A0 (en) 2002-03-10
EA004428B1 (ru) 2004-04-29
CA2349679A1 (fr) 2000-05-18
WO2000028001A1 (fr) 2000-05-18
AU772451B2 (en) 2004-04-29
CN1325441A (zh) 2001-12-05
AU1051400A (en) 2000-05-29
TWI224138B (en) 2004-11-21
FR2785543A1 (fr) 2000-05-12
JP2002529074A (ja) 2002-09-10
EA200100509A1 (ru) 2001-12-24

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ST Notification of lapse

Effective date: 20070731