FR2760972B1 - Utilisation de l-citrulline en medecine orthomoleculaire pour la vasoprotection, le tonus relaxatif des muscles lisses et la protection cellulaires - Google Patents
Utilisation de l-citrulline en medecine orthomoleculaire pour la vasoprotection, le tonus relaxatif des muscles lisses et la protection cellulairesInfo
- Publication number
- FR2760972B1 FR2760972B1 FR9802433A FR9802433A FR2760972B1 FR 2760972 B1 FR2760972 B1 FR 2760972B1 FR 9802433 A FR9802433 A FR 9802433A FR 9802433 A FR9802433 A FR 9802433A FR 2760972 B1 FR2760972 B1 FR 2760972B1
- Authority
- FR
- France
- Prior art keywords
- vasoprotection
- relaxative
- tonus
- citrulline
- smooth muscles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 210000002460 smooth muscle Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/807,757 US6028107A (en) | 1997-02-27 | 1997-02-27 | Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection |
US08/961,639 US5874471A (en) | 1997-02-27 | 1997-10-30 | Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2760972A1 FR2760972A1 (fr) | 1998-09-25 |
FR2760972B1 true FR2760972B1 (fr) | 2003-01-10 |
Family
ID=27123037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9802433A Expired - Fee Related FR2760972B1 (fr) | 1997-02-27 | 1998-02-27 | Utilisation de l-citrulline en medecine orthomoleculaire pour la vasoprotection, le tonus relaxatif des muscles lisses et la protection cellulaires |
Country Status (5)
Country | Link |
---|---|
US (1) | US5874471A (fr) |
AP (1) | AP841A (fr) |
CA (1) | CA2229746C (fr) |
FR (1) | FR2760972B1 (fr) |
GB (1) | GB2322551B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6425881B1 (en) * | 1994-10-05 | 2002-07-30 | Nitrosystems, Inc. | Therapeutic mixture useful in inhibiting lesion formation after vascular injury |
US9486429B2 (en) * | 1999-06-01 | 2016-11-08 | Vanderbilt University | Therapeutic methods employing nitric oxide precursors |
US6346382B1 (en) * | 1999-06-01 | 2002-02-12 | Vanderbilt University | Human carbamyl phosphate synthetase I polymorphism and diagnostic methods related thereto |
JP3843298B2 (ja) * | 2001-02-05 | 2006-11-08 | 国立大学法人 奈良先端科学技術大学院大学 | シトルリンを含有する活性酸素消去剤 |
JP2004518712A (ja) | 2001-02-14 | 2004-06-24 | ラート・マティアス | 細胞の生体エネルギー代謝に関与する生化学的化合物の組成物及びそれの使用法 |
US6864242B2 (en) * | 2001-03-05 | 2005-03-08 | Stephen P. Ernest | Enteral formulation |
EP1564220A4 (fr) * | 2002-11-21 | 2010-03-17 | Chugai Pharmaceutical Co Ltd | Excipient pour medicament a liberation retardee |
WO2006002096A2 (fr) * | 2004-06-18 | 2006-01-05 | Vivo Therapeutics, Inc. | Faibles doses de l-citrulline pour traiter des maladies |
US20060046982A1 (en) * | 2004-08-26 | 2006-03-02 | Waugh William H | Orthomolecular medical use of L-citrulline for capillary endothelial protection and adjacent cell protection in neurodegenerative disease |
EP2679223A1 (fr) * | 2006-04-04 | 2014-01-01 | Nestec S.A. | Traitements utilisant de la citrulline |
CN101415414B (zh) * | 2006-04-04 | 2013-06-12 | 雀巢产品技术援助有限公司 | 瓜氨酸在制备治疗矫正脓毒症患者中精氨酸缺乏的药物中的用途 |
CA2709660C (fr) | 2008-01-04 | 2018-06-05 | Nestec S.A. | Compositions comprenant des acides gras insatures et des composes liberant de l'oxyde nitrique et leur utilisation pour ameliorer des fonctions cognitives et apparentees |
KR101932831B1 (ko) | 2008-01-31 | 2018-12-27 | 반더빌트유니버시티 | 관상과 동맥의 동맥류성 지주막하출혈의 치료를 위한 조성물 및 방법 |
PT2247297T (pt) * | 2008-01-31 | 2019-04-24 | Univ Vanderbilt | Tratamento terapêutico para estados pulmonares |
FR2937550B1 (fr) * | 2008-10-29 | 2010-12-10 | Univ Paris Descartes | Utilisation de la citrulline pour le traitement et la prevention du syndrome d'ischemie-reperfusion |
FR2943901B1 (fr) | 2009-04-01 | 2017-11-17 | E(Ye)Brain | Procede et systeme de detection d'anomalies oculomotrices. |
WO2012027277A2 (fr) * | 2010-08-21 | 2012-03-01 | Hydropep, Llc | Compositions permettant de réduire les effets délétères du stress et du vieillissement |
JP5748441B2 (ja) * | 2010-09-27 | 2015-07-15 | 株式会社明治 | シトルリンを有効成分として含有する骨量低下改善剤 |
FR2970414B1 (fr) * | 2011-01-14 | 2013-03-22 | Univ Paris Descartes | Action preventive de la citrulline sur le developpement spontane des tumeurs |
AT511776B1 (de) * | 2011-07-26 | 2014-03-15 | Gonadosan Gmbh | Verwendung von citrullin und ein kombinationspräparat zur verbesserung der männlichen fertilität |
EP2805730A1 (fr) * | 2013-05-21 | 2014-11-26 | Bergen Teknologioverforing AS | Donneurs d'oxyde nitrique pour le traitement du syndrome de fatigue chronique |
AR111082A1 (es) * | 2017-02-27 | 2019-05-29 | Univ Vanderbilt | Citrulina para el tratamiento de la crisis de células falciformes |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5411757A (en) * | 1989-11-09 | 1995-05-02 | Buist; Neil R. M. | Palatable balanced amino acid-modified diet |
US5449688A (en) * | 1993-03-30 | 1995-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating chronic inflammatory diseases |
GB2281207A (en) * | 1993-08-28 | 1995-03-01 | Univ Sheffield | Treatment of laminitis with l-arginine |
DE4341000A1 (de) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Verwendung von L-Arginin, L-Ornithin oder L-Citrullin und topischen Zubereitungen mit diesen Stoffen |
DE19533330A1 (de) * | 1995-09-11 | 1997-03-13 | Beiersdorf Ag | Gegen Hautkrebs wirksame topische Zubereitungen |
-
1997
- 1997-10-30 US US08/961,639 patent/US5874471A/en not_active Expired - Lifetime
-
1998
- 1998-02-16 CA CA002229746A patent/CA2229746C/fr not_active Expired - Fee Related
- 1998-02-25 GB GB9804025A patent/GB2322551B/en not_active Expired - Fee Related
- 1998-02-26 AP APAP/P/1998/001208A patent/AP841A/en active
- 1998-02-27 FR FR9802433A patent/FR2760972B1/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2229746C (fr) | 2002-05-07 |
AP841A (en) | 2000-06-02 |
GB2322551A (en) | 1998-09-02 |
CA2229746A1 (fr) | 1998-08-27 |
GB9804025D0 (en) | 1998-04-22 |
AP9801208A0 (en) | 1998-03-31 |
FR2760972A1 (fr) | 1998-09-25 |
GB2322551B (en) | 1999-09-01 |
US5874471A (en) | 1999-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |
Effective date: 20111102 |