FR2741535A1 - Solutions for the mouth and throat to prevent infections - Google Patents

Solutions for the mouth and throat to prevent infections Download PDF

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Publication number
FR2741535A1
FR2741535A1 FR9514041A FR9514041A FR2741535A1 FR 2741535 A1 FR2741535 A1 FR 2741535A1 FR 9514041 A FR9514041 A FR 9514041A FR 9514041 A FR9514041 A FR 9514041A FR 2741535 A1 FR2741535 A1 FR 2741535A1
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agent
natural
therapeutic
preparation according
isotonic
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FR2741535B1 (en
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SUN TRADING Ltd
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SUN TRADING Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin

Abstract

Composition for the mouth and throat contains isotonic natural saline solution, a synthetic or natural antimicrobial agent, a natural flavouring, together with a non-toxic excipient or vehicle suitable for local administration. Saline solution is preferably obtained by diluting sea water to obtain isotonicity either before or after its filtration and optional partial deionisation or partial ion-exchange. Antimicrobial agent may be e.g. phenolic or dihydro aromatic derivative (e.g. guaiacol); biguanides (e.g. chlorhexidine); or boric acid salts. Flavouring is preferably plant essence from e.g. (wild) thyme, oregano, coriander etc. Composition may further contain quat. ammonium antibacterials (e.g. benzalkonium chloride.)

Description

NOUVELLES PREPARATIONS POLIR LA SPHERE BLCCO-PHARYNGEE
La présente invention se rapporte au domaine de la thérapeutique et notamment à celui de la prévention ou du traitement des infections bucco-pharyngées. NEW PREPARATIONS POLISHING THE BLCCO-PHARYNGEE SPHERE
The present invention relates to the field of therapy and in particular to that of the prevention or treatment of buccopharyngeal infections.

Elle a particulièrement pour objet une préparation thérapeutique destinée à la prévention ou le traitement des manifestations inflammatoires ou infectieuses de la sphère bucco-pharyngée.It relates in particular to a therapeutic preparation intended for the prevention or the treatment of inflammatory or infectious manifestations of the buccopharyngeal sphere.

Elle concerne spécifiquement de nouvelles compositions destinées à la sphère bucco-pharyngée caractérisées en ce qu'elles renferment une préparation saline naturelle isotonique, un agent antibactérien de synthèse ou naturel et un agent aromatisant naturel en association ou en mélange avec un excipient ou un véhicule inerte, non toxique, approprié pour l'administration locale.It relates specifically to new compositions intended for the buccopharyngeal sphere, characterized in that they contain an isotonic natural saline preparation, a synthetic or natural antibacterial agent and a natural flavoring agent in combination or in mixture with an inert excipient or vehicle. , non-toxic, suitable for local administration.

En effet, par suite de la présence de produits irritants dans l'atmosphère, de contaminations microbiennes dans les moyens de transport urbain ou de variations importantes de température liées au chauffage dans les locaux, les affections de la sphère bucco-pharyngée sont devenues très fréquentes ou même permanentes chez certaines personnes particulièrement fragiles.Indeed, as a result of the presence of irritants in the atmosphere, microbial contamination in urban means of transport or significant temperature variations related to heating in the premises, affections of the bucco-pharyngeal sphere have become very frequent or even permanent in some particularly fragile people.

La plus mauvaise thérapeutique consiste à administrer à de tels sujets des antibiotiques ou des antibactériens d'une manière prolongée car on tend ainsi à sélectionner les souches antibactériennes en ne conservant plus que celles qui sont résistantes aux agents thérapeutiques. De même, l'admhstration d'anti-inflammatoires si elle réduit les phénomènes d'irritation ou de douleur, tend à diminuer les possibilités de défense de l'organisme en déprimant les réactions immunitaires. De plus, beaucoup d'anti-inflammatoires entrainent des effets secondaires notamment dans le tube digestif. génants ou douloureux. The worst therapy consists in administering such subjects antibiotics or antibacterials in a prolonged manner because there is thus a tendency to select the antibacterial strains while keeping only those which are resistant to the therapeutic agents. Similarly, the admhstration of anti-inflammatory drugs if it reduces the phenomena of irritation or pain, tends to decrease the possibilities of defense of the organism by depressing the immune reactions. In addition, many anti-inflammatory drugs cause side effects, especially in the digestive tract. annoying or painful.

fi était donc important de disposer d'un agent thérapeutique permettant de lutter ou de prévenir les manifestations pathologiques de la sphère bucco-pharyngée à l'aide d'une préparation qui soit bien tolérée. qui soit efficace et qui n entraine pas d'effet indésirable, par administrations répétées à intervalles plus ou moins rapproches.  fi was therefore important to have a therapeutic agent to combat or prevent pathological manifestations of the buccopharyngeal sphere using a preparation which is well tolerated. which is effective and which does not cause any undesirable effect, by repeated administrations at more or less close intervals.

Cet objectif a été réalisé avec les compositions. selon l'invention, qui associent un agent décongestionnant - la solution saline naturelle -. un agent bactéricide d'origine naturelle ou d'origine synthétique, et un agent aromatisant. This objective was achieved with the compositions. according to the invention, which combine a decongestant agent - natural saline solution. a bactericidal agent of natural or synthetic origin, and a flavoring agent.

L'association de ces trois constituants permet de réaliser une préparation efficace, agréable et non susceptible d'amener des effets secondaires indésirables ou toxiques.The combination of these three constituents makes it possible to prepare an effective preparation, pleasant and not liable to bring about undesirable or toxic side effects.

Les préparations, selon l'invention, se caractérisent par le fait que la solution saline naturelle est de préférence une solution de chlorure de sodium et, en particulier. de l'eau de mer amenée à une dilution suffisante pour réaliser l'isotonie. L'eau de mer peut entre le produit naturel tel quel ou le produit après dilution ou après désionisation partielle ou après filtration pour éliminer les particules minérales ou végétales en suspension. L'eau de mer est stérilisée par filtration stérilisante. On peut également préparer des solutions salines ayant pratiquement la même composition que l'eau de mer. L'eau de mer peut, en outre, être partiellement désionisée par adsorption sélective du sodium et/ou remplacement du sodium par un autre ion métallique comme le calcium ou le magnésium. The preparations according to the invention are characterized in that the natural saline solution is preferably a solution of sodium chloride and, in particular. sea water brought to a sufficient dilution to achieve isotonia. Sea water can enter the natural product as it is or the product after dilution or after partial deionization or after filtration to remove mineral or vegetable particles in suspension. Sea water is sterilized by sterilizing filtration. It is also possible to prepare saline solutions having practically the same composition as sea water. Sea water can also be partially deionized by selective adsorption of sodium and / or replacement of sodium by another metal ion such as calcium or magnesium.

L'agent antibactérien - naturel ou synthétique - peut être une substance chimique ou un extrait végétal contenant une telle substance. Cet agent antibactérien sera de préférence une substance aromatique phénolique ou un composé dihydroaromatique. Des exemples de tels composés sont le gaiacol et ses ethers, le clofoctol, le biclothymol, I'amylmetacresol, les salicylates de métal alcalin ou de bases organiques, I'anethol ou bien l'eucalyptol, le terpinéol, le menthol, les dérivés de l'acide benzoique, des agents colorants ou colorés comme l'éthacridine ou le methylthioninium, des biguanides comme la chlorhexidine, I'hexetidine ou l'hexamidine, ou bien encore des sels d'acide borique.The antibacterial agent - natural or synthetic - can be a chemical substance or a plant extract containing such a substance. This antibacterial agent will preferably be a phenolic aromatic substance or a dihydroaromatic compound. Examples of such compounds are gaiacol and its ethers, clofoctol, biclothymol, amylmetacresol, salicylates of alkali metal or organic bases, dill or eucalyptol, terpineol, menthol, derivatives of benzoic acid, coloring or colored agents such as ethacridine or methylthioninium, biguanides such as chlorhexidine, hexetidine or hexamidine, or even boric acid salts.

L'agent aromatisant sera de préférence une essence de plante comme le thym, le serpollet, l'origan, la badiane, I'anis, le coriandre, le neroli, la bergamote. la girofle; la marjolaine, la mélisse, I'eucalyptus, le romarin ou la rose ou un des constituants aromatisants de ces essences comme le thyrnol. la pulegone ou la vetivone. The flavoring agent will preferably be a plant essence such as thyme, wild thyme, oregano, star anise, anise, coriander, neroli, bergamot. cloves; marjoram, lemon balm, eucalyptus, rosemary or rose or one of the flavoring constituents of these essences such as thyrnol. pulegone or vetivone.

La solution peut également renfermer un agent antibactérien du type ammonium quaternaire comme le chlorure de benzalkonium le bromure de dodecalinium. le dodeclonium ou le chlorure de miristalkonium. The solution may also contain an antibacterial agent of the quaternary ammonium type such as benzalkonium chloride dodecalinium bromide. dodeclonium or miristalkonium chloride.

D'une manière préférée les compositions thérapeutiques selon l'invention renferment de 80 a 99 % de solution saline naturelle, de 0,01 à 0,5 % d'agent bactéricide et de 0X 1 a 2 % d'agent aromatisant. La solution peut, en outre, être additionnée d'un agent épaississant comme le glycérol ou le propylène glycol et/ou d'un agent d'adhésion comme un carbomère.Preferably, the therapeutic compositions according to the invention contain from 80 to 99% of natural saline solution, from 0.01 to 0.5% of bactericidal agent and from 0X 1 to 2% of flavoring agent. The solution can, in addition, be added with a thickening agent such as glycerol or propylene glycol and / or with an adhesion agent such as a carbomer.

Les préparations, selon l'invention, trouvent un emploi dans la prévention des surinfections pharyngées chez les jeunes enfants lorsque ceux-ci sont enrhumés ou lorsque la muqueuse nasale est congestionnée. En effet, les jeunes enfants ne savent pas toujours se moucher de telle sorte que les mucosités résultant d'une hypersécrétion des muqueuses ont tendance à s'accumuler dans l'arrière-gorge et à former un bouchon qui gène une respiration normale. Les préparations, selon l'invention, lorsqu'elles sont pulvérisées dans l'carrière gorge contribuent à dissocier ou à provoquer la désintégration de ce bouchon et permettent ainsi le retour à une respiration normale.The preparations according to the invention find use in the prevention of pharyngeal superinfections in young children when they are cold or when the nasal mucosa is congested. In fact, young children do not always know how to blow their nose so that the phlegm resulting from hypersecretion of the mucous membranes tends to accumulate in the back of the throat and to form a plug which interferes with normal breathing. The preparations according to the invention, when sprayed into the throat quarry contribute to dissociate or cause the disintegration of this plug and thus allow the return to normal breathing.

Les préparations, selon l'invention, sont utiles également pour l'hygiène buccale soit en permettant des lavages de bouche après une extraction dentaire soit pour dissocier la plaque dentaire soit encore pour les fumeurs en contribuant à faire disparaître l'odeur de tabac.The preparations according to the invention are also useful for oral hygiene either by allowing mouth washes after dental extraction or for dissociating dental plaque or for smokers by helping to make the smell of tobacco disappear.

La multiplicité des utilisations que les préparations, selon l'invention, ont pu trouver, apparait donc nettement.The multiplicity of uses that the preparations according to the invention have been able to find, therefore appears clearly.

La solution peut être appliquée sur les muqueuses par badigeonnage ou ser-ir de gargarisme.The solution can be applied to the mucous membranes by brushing or using gargle.

EUe pourra être également pulvérisée à l'aide d'un gaz propulseur ou de 1' air à l'aide d'un embout monté sur un flacon pressurisé ou sur un flacon pompe.It can also be sprayed using a propellant gas or air using a nozzle mounted on a pressurized bottle or on a pump bottle.

La préparation pourra également ètre munie de deux embouts. I un court pour des pulvérisations dans le nez et la bouche. I'autre long destiné à des pulsérisations dans la gorge.The preparation can also be provided with two tips. I a short for sprays in the nose and mouth. The other long intended for pulsations in the throat.

Le gaz propulseur peut ètre l'air. le gaz carbonique. I'azote ou des Foeous
Les préparations selon l'invention sont destinées a entre pulvérisées ou appliquées de une a Slx fois par jour selon les besoins et de préférence de 2 à 4 fois par jour.The propellant can be air. carbon dioxide. Nitrogen or Foeous
The preparations according to the invention are intended to be sprayed or applied one to one time per day as needed and preferably 2 to 4 times per day.

Les exemples suivants illustrent l'invention sans toutefois la limiter
EXEMPLE 1:
PREPARATION POUR LA GORGE
Eau de mer isotonique et stérilisée 45 ml
Glycerol 5 g
Salicylate de diethanolamine 0,1 g
Coccine nouvelle 0,02 g
Arome de menthe 0,05 g
Extrait de réglisse 0,05 g
Alcool 8ml
Cyclamate de sodium 0,1 g
Cette sohition est destinée à être pulvérisée dans la gorge.The following examples illustrate the invention without, however, limiting it
EXAMPLE 1:
PREPARATION FOR THE THROAT
Isotonic and sterilized seawater 45 ml
Glycerol 5 g
Diethanolamine salicylate 0.1 g
New beetle 0.02 g
Mint flavor 0.05 g
Licorice extract 0.05 g
Alcohol 8ml
Sodium cyclamate 0.1 g
This sohition is intended to be sprayed into the throat.

Gaz propulseur: anhydride carbonique.Propellant gas: carbon dioxide.

EXEMPLE II:
SOLUTION NASALE A PULVERISER
Chlorure de sodium 0,9 g
Essence d'eucalyptus 0,01 g
Chlorure de benzalkonium 0,025 g
Propylène glycol 2 g
Benzoate de sodium 1.25 g
Eau purifiée q.s.p. 100 ml
EXEMPLE 111:
SOLUTION POUR PULVERISATION BUCCALE
Eau de mer purifiée et stérilisée rendue isotonique 96 g
Carboxymethyl cellulose sodique 1,0 I g
Sorbitol 0,340 g
Benzoate de sodium 0,55 g
Acide sorbique I g
Eucalyptol 0,25 g
Gaz pulseur: anhydride carbonique.EXAMPLE II:
NASAL SPRAY SOLUTION
Sodium chloride 0.9 g
Eucalyptus oil 0.01 g
Benzalkonium chloride 0.025 g
Propylene glycol 2 g
Sodium benzoate 1.25 g
Purified water qs 100 ml
EXAMPLE 111:
SOLUTION FOR ORAL SPRAYING
Purified and sterilized sea water made isotonic 96 g
Carboxymethyl cellulose sodium 1.0 I g
Sorbitol 0.340 g
Sodium benzoate 0.55 g
Sorbic acid I g
Eucalyptol 0.25 g
Pulsing gas: carbon dioxide.

EXEMPLE IV:
SOLUTION A PULVERISER DANS LA GORGE
Eau de mer purifiée et stérilisée 85 g
Menthol 0,01 g
Veratrol 0,01 g
Essence de géranium 0,02 g
Essence de cedrat 0,01 g
Alcool éthylique à 950 4 mil
Eau purifiée q.s.p. 100 ml
Gaz propulseur: azote. EXAMPLE IV:
SOLUTION TO SPRAY IN THE THROAT
Purified and sterilized seawater 85 g
Menthol 0.01 g
Veratrol 0.01 g
Geranium essence 0.02 g
Citron essence 0.01 g
950 ethyl alcohol 4 mil
Purified water qs 100 ml
Propellant gas: nitrogen.

Claims (10)

REVENDICATIONS excipient ou un véhicule inerte non toxique approprié pour l'administration locale. excipient or inert non-toxic vehicle suitable for local administration. synthèse ou naturel, un agent aromatisant naturel, en association ou en mélange avec un synthetic or natural, a natural flavoring agent, in combination or in mixture with a qu'elles renferment une préparation saline naturelle isotonique, un agent antimicrobien de that they contain an isotonic natural saline preparation, an antimicrobial agent of I Nouvelles préparations thérapeutiques pour la sphère buccopharyngee caractérisées en ceI New therapeutic preparations for the buccopharyngeal sphere characterized in that 2. Une préparation thérapeutique, selon la revendication 1, dans laquelle la préparation saline2. A therapeutic preparation according to claim 1, wherein the saline preparation isotonique est une solution de chlorure de sodium. isotonic is a solution of sodium chloride. 3. Une préparation thérapeutique, selon la revendication I, dans laquelle la préparation saline3. A therapeutic preparation according to claim I, wherein the saline preparation isotonique est de l'eau de mer prélevée dans les mers tempérées. isotonic is seawater taken from temperate seas. 4. Une préparation thérapeutique, selon la revendication 1, dans laquelle la préparation saline4. A therapeutic preparation according to claim 1, wherein the saline preparation isotonique est de l'eau de mer filtrée et stérilisée. isotonic is filtered and sterilized seawater. 5. Une préparation thérapeutique, selon la revendication 1, dans laquelle la préparation saline5. A therapeutic preparation according to claim 1, wherein the saline preparation isotonique est de l'eau de mer filtrée et stérilisée amenée à l'isotonie par dilution ou par isotonic is filtered and sterilized seawater brought to isotonia by dilution or by désionisation. deionization. 6. Une préparation thérapeutique, selon l'une des revendications I à 5, dans laquelle l'agent6. A therapeutic preparation according to one of claims I to 5, in which the agent antimicrobien est une substance chimique ou un extrait végétal contenant une telle antimicrobial is a chemical or plant extract containing such substance. substance. 7. Une préparation thérapeutique, selon la revendication 6, dans laquelle l'agent antirnicrobien 7. A therapeutic preparation according to claim 6, wherein the anti-microbial agent est un composé phénolique ou dihydro aromatique ou du type biguanide ou du type is a phenolic or aromatic dihydro compound or of the biguanide type or of the type ammonium quaternaire. quaternary ammonium. 8. Une préparation thérapeutique, selon l'une des revendications 1 å 7. dans laquelle l'agent8. A therapeutic preparation according to one of claims 1 to 7. in which the agent aromatisant est une essence de plante. flavoring is a plant essence. incorpore en outre un agent épaississant ou un agent d'adhésion.  additionally incorporates a thickening agent or an adhesion agent. 9 Une preparation thérapeutique. selon l'une des revendications I a 8. dans laquelle on9 A therapeutic preparation. according to one of claims I to 8. wherein 10. Une préparation thérapeutique, selon l'une des revendications I à 9, présentée sous forme10. A therapeutic preparation according to one of claims I to 9, presented in the form de solution, de lotions ou de pulvérisations avec un gaz propulseur.  of solution, lotions or sprays with a propellant.
FR9514041A 1995-11-28 1995-11-28 NEW PREPARATIONS FOR THE BUCCO-PHARYNGEE SPHERE Expired - Fee Related FR2741535B1 (en)

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WO1999058095A2 (en) * 1998-05-14 1999-11-18 Sephra S.A.R.L. Pharmaceutical and/or cosmetic compositions containing sea water
FR2785189A1 (en) * 1998-11-02 2000-05-05 Agrosol Sa Dissolution of carbon dioxide in sea water for lowering pH to obtain better skin tolerance in thalassotherapy
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FR2777187A1 (en) * 1998-04-14 1999-10-15 Yves Theodore Stephane Tillet COMPOSITION FOR FACILITATING THE ACTION OF LEVOMENTHOL ON THERMORECEPTORS OF THE CONGENTED MUCOSA OF THE NASAL VESTIBULE AND THE NATURAL REGENERATION OF THIS MUCOSA
WO1999052520A1 (en) * 1998-04-14 1999-10-21 Tillet Yves Theodore Ionic aqueous composition containing levomenthol
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WO1999058095A3 (en) * 1998-05-14 2000-06-08 Sephra S A R L Pharmaceutical and/or cosmetic compositions containing sea water
FR2785189A1 (en) * 1998-11-02 2000-05-05 Agrosol Sa Dissolution of carbon dioxide in sea water for lowering pH to obtain better skin tolerance in thalassotherapy
US6899903B2 (en) * 2002-06-25 2005-05-31 Patrick Quillin Composition for cleansing the sinuses
DE102006032233A1 (en) * 2006-07-12 2008-01-17 Ewabo Chemikalien Gmbh & Co. Kg Use of a preparation containing eucalyptol/menthol for the production of medicament for combating and preventing virus infection and secondary bacterial infection
WO2009066262A1 (en) * 2007-11-21 2009-05-28 The Procter & Gamble Company Preparations, methods and kits useful for treatment of cough

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