FR2739294A1 - Dispensing head for nozzle of nasal medication spray - Google Patents
Dispensing head for nozzle of nasal medication spray Download PDFInfo
- Publication number
- FR2739294A1 FR2739294A1 FR9511459A FR9511459A FR2739294A1 FR 2739294 A1 FR2739294 A1 FR 2739294A1 FR 9511459 A FR9511459 A FR 9511459A FR 9511459 A FR9511459 A FR 9511459A FR 2739294 A1 FR2739294 A1 FR 2739294A1
- Authority
- FR
- France
- Prior art keywords
- nasal
- collar
- nozzle
- tip
- spray head
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Mechanical Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
EMBOUT NASAL DE SECURITE
La présente invention concerne un embout nasal de sécurité destiné à introduire par jet ou pulvérisation, une solution ou une suspension médicamenteuse dans le nez d'un patient.NASAL SAFETY TIP
The present invention relates to a safety nasal tip intended to introduce by jet or spray, a drug solution or suspension into the nose of a patient.
Art antérieur
La pulvérisation nasale de médicaments se fait généralement à l'aide d'un pulvérisateur délivrant un aérosol, à partir d'un réservoir qui peut être soit pressurisé, soit muni d'un système de pompe.Prior art
The nasal spraying of drugs is generally carried out using a sprayer delivering an aerosol, from a reservoir which can be either pressurized, or fitted with a pump system.
L'embout introduit dans la cavité nasale se présente généralement sous forme d'une section conique, cylindrique ou cylindroconique équipée à son extrémité supérieure d'une buse de pulvérisation et à sa base d'un appui pour le ou les doigt(s) qui, au moyen d'une pression axiale, provoque(nt) I'arrivée de la solution. L'extrémité munie de la buse de pulvérisation doit être en matière plastique suffisamment rigide pour que le dispositif générateur d'aérosol fonctionne correctement. Cette nécessité, conjuguée au fait que la pulvérisation entraîne un mouvement axial de l'embout, provoque, souvent, un contact traumatisant entre l'extrémité de l'embout et les muqueuses nasales, ce qui a pour effet de provoquer également, en plus du désagrément, une irritation de la cavité nasale.Cet inconvénient, déjà peu agréable pour les adultes, devient préjudiciable à la facilité des soins quand il s'agit d'effectuer des pulvérisations nasales à de jeunes enfants ou des nourissons.The tip introduced into the nasal cavity is generally in the form of a conical, cylindrical or cylindroconical section equipped at its upper end with a spray nozzle and at its base with a support for the finger (s) which , by means of an axial pressure, causes (s) the arrival of the solution. The end with the spray nozzle must be of sufficiently rigid plastic material for the aerosol generating device to function properly. This need, combined with the fact that the spraying causes axial movement of the nozzle, often causes traumatic contact between the end of the nozzle and the nasal mucosa, which has the effect of also causing, in addition to inconvenience, irritation of the nasal cavity.This disadvantage, already unpleasant for adults, becomes detrimental to the ease of care when it comes to performing nasal sprays to young children or infants.
Objet de l'invention
La présente invention a pour objet de proposer une nouvelle solution technique, qui permet de limiter la pénétration de l'embout dans la cavité nasale et ainsi de réduire les contacts entre la buse de pulvérisation et la paroi interne nasale ou les muqueuses nasales.Subject of the invention
The object of the present invention is to propose a new technical solution which makes it possible to limit the penetration of the nozzle into the nasal cavity and thus to reduce the contacts between the spray nozzle and the nasal internal wall or the nasal mucous membranes.
Description
Selon l'invention, L'embout nasal est muni d'un dispositif qui vient en butée avec le pourtour de l'orifice nasal et qui permet de contrôler la longueur de l'embout introduite dans la cavité nasale.Description
According to the invention, the nasal endpiece is provided with a device which abuts with the periphery of the nasal orifice and which makes it possible to control the length of the endpiece introduced into the nasal cavity.
Ledit dispositif est de préférence en forme de collerette, en matière souple, de dimensions extérieures supérieures à l'orifice nasal, et situé sur l'embout, entre la buse de pulvérisation et la base dudit embout de façon à limiter, à une longueur prédéterminée, la partie de l'embout pénétrant dans la cavité nasale. Ainsi, la buse de pulvérisation ne vient pas en contact avec la paroi interne nasale, ce qui supprime ou limite les risques de traumatisme ou d'irritation. De plus, une meilleure répartition du brouillard dans la cavité nasale est obtenue grâce au fait qu'on peut ajuster la position de l'extrémité libre de l'embout à l'endroit le plus favorable de la cavité nasale.Said device is preferably in the form of a collar, of flexible material, of external dimensions greater than the nasal orifice, and situated on the nozzle, between the spray nozzle and the base of said nozzle so as to limit, to a predetermined length , the part of the mouthpiece entering the nasal cavity. Thus, the spray nozzle does not come into contact with the internal nasal wall, which eliminates or limits the risks of trauma or irritation. In addition, a better distribution of the mist in the nasal cavity is obtained by virtue of the fact that the position of the free end of the nozzle can be adjusted to the most favorable location in the nasal cavity.
Selon l'invention, le dispositif venant en butée avec l'orifice nasal se présente sous forme d'un anneau en forme de disque fixé sur l'embout nasal, entre l'orifice de la buse de pulvérisation et, de préférence, I'embase qui sert d'appui au(x) doigt(s). De préférence, afin de s'adapter à l'anatomie du nez, le passage de l'embout à travers le disque (qui peut être de forme ovale, circulaire ou elliptique) est excentré de façon à ce que la partie de disque située près de la lèvre au moment de l'emploi, soit très réduite suivant la direction appropriée qui est la direction du petit axe lorsque la collerette est de forme elliptique ou ovale. La longueur de l'embout comprise entre l'extrémité qui porte la buse de pulvérisation et la partie supérieure de la collerette correspond à la partie de 1' embout pénétrant dans la cavité nasale.De préférence cette longueur sera comprise, entre 4 et 14 mm, selon que l'embout est destiné à des nourissons ou à des adultes. Le dispositif peut être soit fabriqué indépendamment et fixé par emboîtement, soit surmoulé sur un embout standard, soit encore être obtenu directement par moulage ou injection de l'embout complet. Selon un mode préféré de l'invention, une collerette en forme de disque est surmoulée autour d'un embout standard, par exemple selon la technique de bi-injection: ce mode de réalisation permet d'utiliser une matière plastique rigide, comme par exemple du polyéthylène ou du polypropylène, qui conviennent bien pour réaliser la buse de pulvérisation et Embout standard, et d'utiliser une matière plastique souple pour la collerette afin de procurer un contact doux entre ladite collerette et l'orifice nasal. According to the invention, the device abutting the nasal orifice is in the form of a disc-shaped ring fixed on the nasal nozzle, between the orifice of the spray nozzle and, preferably, I ' base which serves as support for the finger (s). Preferably, in order to adapt to the anatomy of the nose, the passage of the tip through the disc (which may be oval, circular or elliptical) is eccentric so that the disc part located near of the lip at the time of use, or very reduced in the appropriate direction which is the direction of the minor axis when the flange is of elliptical or oval shape. The length of the nozzle between the end which carries the spray nozzle and the upper part of the collar corresponds to the part of the nozzle penetrating into the nasal cavity. Preferably this length will be between 4 and 14 mm , depending on whether the tip is intended for infants or adults. The device can either be manufactured independently and fixed by interlocking, or overmolded on a standard end-piece, or even be obtained directly by molding or injection of the complete end-piece. According to a preferred embodiment of the invention, a disc-shaped collar is molded around a standard end piece, for example according to the bi-injection technique: this embodiment makes it possible to use a rigid plastic material, such as for example polyethylene or polypropylene, which are well suited for making the spray nozzle and standard nozzle, and to use a flexible plastic material for the collar in order to provide a soft contact between said collar and the nasal orifice.
D'autres avantages et caractéristiques ressortiront mieux à la lecture de plusieurs modes de réalisation du dispositif selon l'invention, ainsi que des dessins annexés sur lesquels
La figure 1 est une vue en perspective du dispositif selon l'invention, dans lequel la collerette est surmoulée sur un type d'embout nasal.Other advantages and characteristics will emerge more clearly on reading several embodiments of the device according to the invention, as well as the appended drawings in which
Figure 1 is a perspective view of the device according to the invention, wherein the flange is molded onto a type of nose piece.
La figure 2 est une vue en perspective du dispositif selon l'invention, dans lequel la collerette est venue de moulage avec un autre type d' embout nasal. Figure 2 is a perspective view of the device according to the invention, wherein the flange is molded with another type of nose piece.
La figure 3 est une vue de dessus et à échelle agrandie de la collerette des figures 1 et 2. FIG. 3 is a top view and on an enlarged scale of the collar of FIGS. 1 and 2.
La figure 4 est une vue en perspective d'un ensemble avec collerette amovible. Figure 4 is a perspective view of an assembly with removable flange.
Sur la figure 1 est représenté un premier type d'embout 1 muni à sa base 2 d'une zone d'appui 3 pour le ou les doigts de l'utilisateur, l'embout 1 étant pourvu à son extrémité 4 d'une buse ou orifice d'évacuation 5 de la solution à injecter dans une cavité nasale d'un patient. L'embout 1 est cylindroconique et en polypropylène, la base 2 présentant un diamètre moyen d'environ 6 mm. In Figure 1 is shown a first type of tip 1 provided at its base 2 with a support zone 3 for the user's finger or fingers, the tip 1 being provided at its end 4 with a nozzle or discharge port 5 for the solution to be injected into a nasal cavity of a patient. The end piece 1 is cylindroconical and made of polypropylene, the base 2 having an average diameter of approximately 6 mm.
Une collerette 6 est disposée autour de l'embout 1, entre l'extrémité 4 et la base 2, et elle est constituée par une partie 7 de forme ovale ou elliptique, bien qu'une forme circulaire puisse convenir. Dans la partie 7 est ménagé un orifice 8 pour le passage de l'embout 1, ledit orifice étant excentré par rapport au centre de ladite partie 7, de manière à ménager une zone 9 de dimensions réduites entre le bord 10 dudit orifice et le bord 1 1 de la partie 7 qui lui est le plus proche. La largeur de la zone 9 est de l'ordre du millimètre de façon que, lors de l'introduction de l'embout 1 dans une cavité nasale, ladite collerette ne s'appuie que très peu sur la base de la narine du patient et évite ainsi tout désagrément ou inconfort. A collar 6 is arranged around the end piece 1, between the end 4 and the base 2, and it is constituted by a part 7 of oval or elliptical shape, although a circular shape may be suitable. In part 7 is formed an orifice 8 for the passage of the end piece 1, said orifice being eccentric relative to the center of said part 7, so as to provide an area 9 of reduced dimensions between the edge 10 of said orifice and the edge 1 1 of the closest part 7. The width of the zone 9 is of the order of a millimeter so that, during the introduction of the tip 1 into a nasal cavity, said collar rests very little on the base of the nostril of the patient and this avoids any inconvenience or discomfort.
Un manchon 12 est prévu d'un côté de la collerette 6 et il épouse parfaitement la forme de la partie dudit embout sur laquelle il est disposé. A sleeve 12 is provided on one side of the collar 6 and it perfectly matches the shape of the part of said tip on which it is arranged.
Dans le mode de réalisation de la figure 1 la collerette 6 avec son manchon 12 sont surmoulés sur l'embout 1 qui présente à cet effet de petites rainures ou entailles sur la surface pour que le surmoulage soit efficace. La partie 13 de l'embout qui doit pénétrer dans la cavité nasale, présente une longueur d'environ 6 mm. Dans l'exemple représenté, la collerette 6 est en forme d'ellipse dont les dimensions sont respectivement 12 et 15 mm pour le petit axe et le grand axe et une épaisseur d'environ 2 mm. La collerette est réalisée par injection d'une matière plastique souple, comme par exemple de l'Evoprène G 970 (Evode).L'embout nasal ainsi obtenu convient plus particulièrement pour procéder à des pulvérisations nasales chez les très jeunes enfants ; la présence de la collerette évite tout contact brutal entre l'embout et la muqueuse nasale, même dans le cas de mouvements mal contrôlés de l'enfant. In the embodiment of Figure 1 the collar 6 with its sleeve 12 are overmolded on the nozzle 1 which has for this purpose small grooves or notches on the surface for the overmolding to be effective. The part 13 of the endpiece which must enter the nasal cavity has a length of approximately 6 mm. In the example shown, the flange 6 is in the form of an ellipse whose dimensions are respectively 12 and 15 mm for the minor axis and the major axis and a thickness of approximately 2 mm. The collar is produced by injection of a flexible plastic material, such as for example Evoprene G 970 (Evode). The nasal tip thus obtained is more particularly suitable for carrying out nasal sprays in very young children; the presence of the collar avoids any brutal contact between the mouthpiece and the nasal mucosa, even in the case of poorly controlled movements of the child.
Selon un deuxième mode de réalisation, L'embout nasal comportant la collerette 6 est moulé par injection en une seule pièce, selon une forme représentée par la figure 2. On utilise une matière plastique assez souple et la buse de pulvérisation et son canal, réalisés en matière plastique dure, sont rapportés à l'intérieur de l'embout. According to a second embodiment, the nasal nozzle comprising the collar 6 is injection molded in one piece, in a shape shown in FIG. 2. A fairly flexible plastic material is used and the spray nozzle and its channel, made hard plastic, are reported inside the tip.
Selon ce mode de réalisation, la collerette 6 se présente sous forme ovale, de dimensions environ 20 mm x 15 mm et d'épaisseur environ 2 mm. La longueur de la partie 13 de l'embout 1 comprise entre la buse de pulvérisation 5 et la collerette 6 est d'environ 10 mm et le passage de l'embout est excentré près d'un bord à grand rayon de la collerette ovale. According to this embodiment, the collar 6 is in oval form, of dimensions approximately 20 mm × 15 mm and of thickness approximately 2 mm. The length of the part 13 of the nozzle 1 between the spray nozzle 5 and the flange 6 is approximately 10 mm and the passage of the nozzle is eccentric near an edge with a large radius of the oval flange.
Dans ce mode de réalisation, il n'y a pas de manchon 12 et l'embout 1 est muni de moyens 14 de préhension et d'appui pour les doigts de l'utilisateur. In this embodiment, there is no sleeve 12 and the end piece 1 is provided with means 14 for gripping and supporting the fingers of the user.
D'autres modes de réalisation sont également possibles, comme par exemple le moulage d'une collerette qui est ensuite fixée à l'aide d'une colle sur un embout standard, ou, comme représenté sur la figure 4, une collerette (6) moulée en élastomère souple, de forme elliptique ou ovale et dont l'orifice (8) vient coopérer avec l'une des gorges (15) moulées sur l'embout (1) pour former une butée de sécurité amovible réglable et adaptable à l'anatomie de l'utilisateur. Cette dernière disposition présente l'avantage de pouvoir accepter un capuchon de protection de l'embout si la collerette est retirée ou placée en position basse. Other embodiments are also possible, such as for example the molding of a collar which is then fixed with the aid of an adhesive on a standard end-piece, or, as shown in FIG. 4, a collar (6) molded in flexible elastomer, elliptical or oval in shape and the orifice (8) of which co-operates with one of the grooves (15) molded on the end piece (1) to form a removable safety stop adjustable and adaptable to the user anatomy. The latter arrangement has the advantage of being able to accept a protective cap for the end piece if the collar is removed or placed in the low position.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9511459A FR2739294B1 (en) | 1995-09-29 | 1995-09-29 | NASAL SAFETY TIP |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9511459A FR2739294B1 (en) | 1995-09-29 | 1995-09-29 | NASAL SAFETY TIP |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2739294A1 true FR2739294A1 (en) | 1997-04-04 |
| FR2739294B1 FR2739294B1 (en) | 1998-01-16 |
Family
ID=9483057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9511459A Expired - Fee Related FR2739294B1 (en) | 1995-09-29 | 1995-09-29 | NASAL SAFETY TIP |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2739294B1 (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998057690A1 (en) * | 1997-06-18 | 1998-12-23 | Valois S.A. | Nasal applicator and device for dispensing device comprising same |
| WO2000027430A2 (en) * | 1998-11-06 | 2000-05-18 | Schweiz. Serum- & Impfinstitut Bern | Composition consisting of influenza virus surface proteins and dispensing device |
| EP1092447A2 (en) * | 1999-10-14 | 2001-04-18 | Becton Dickinson and Company | Nasal delivery device including spray nozzle |
| GB2412326A (en) * | 2004-03-26 | 2005-09-28 | Bespak Plc | Hand-held dispenser |
| WO2010139883A1 (en) | 2009-06-03 | 2010-12-09 | Laboratoires Thea | Device that assists in supplying drops of a liquid contained in a sprayer and sprayer provided with one such device |
| EP2550986A1 (en) * | 2011-07-25 | 2013-01-30 | A & K Film und Touristik GmbH | Device for applying chemical substances |
| WO2021175841A1 (en) | 2020-03-03 | 2021-09-10 | Laboratoires Thea | Device and method for monitoring compliance with a therapeutic ophthalmic treatment |
| US20220160974A1 (en) * | 2015-06-12 | 2022-05-26 | Ap Pharma Systems Atomizadores E Dispensadores Ltda | Spray dispenser for nasal drugs |
| WO2022171969A1 (en) | 2021-02-15 | 2022-08-18 | Aptar France Sas | Dispensing head for a device for dispensing a fluid or powder product into the nose |
| US11446260B2 (en) | 2013-03-15 | 2022-09-20 | Janssen Pharmaceutica Nv | Pharmaceutical composition of S-ketamine hydrochloride |
| US11707440B2 (en) | 2017-12-22 | 2023-07-25 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| US11759586B1 (en) * | 2022-04-13 | 2023-09-19 | Ferrer Medical Innovations, LLC | Nasal spray bottle with improved nozzle and system of application |
| EP4039296A4 (en) * | 2019-10-01 | 2023-10-25 | Toko Yakuhin Kogyo Co., Ltd. | Nasal spray injection nozzle and rest product for administration of nasal drops |
| US11883526B2 (en) | 2019-03-05 | 2024-01-30 | Janssen Pharmaceutica Nv | Esketamine for the treatment of depression |
| US11980596B2 (en) | 2017-09-13 | 2024-05-14 | Janssen Pharmaceutica Nv | Delivery of esketamine for the treatment of depression |
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|---|---|---|---|---|
| US3255750A (en) * | 1963-12-13 | 1966-06-14 | Schwartzman Sam | Inhaler |
| EP0274415A2 (en) * | 1987-01-06 | 1988-07-13 | Howell, Richard Owen | Colonic irrigator |
| US5114415A (en) * | 1989-06-14 | 1992-05-19 | Susan Shedlock | Apparatus for suctioning secretions from upper airways |
| FR2692569A1 (en) * | 1992-06-18 | 1993-12-24 | Valois | Dispenser filling procedure - uses shutter with cavity which contains single does of fluid and transfers it to dispenser |
| WO1994017753A1 (en) * | 1993-02-12 | 1994-08-18 | Minnesota Mining And Manufacturing Company | Aerosol delivery apparatus |
-
1995
- 1995-09-29 FR FR9511459A patent/FR2739294B1/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3255750A (en) * | 1963-12-13 | 1966-06-14 | Schwartzman Sam | Inhaler |
| EP0274415A2 (en) * | 1987-01-06 | 1988-07-13 | Howell, Richard Owen | Colonic irrigator |
| US5114415A (en) * | 1989-06-14 | 1992-05-19 | Susan Shedlock | Apparatus for suctioning secretions from upper airways |
| FR2692569A1 (en) * | 1992-06-18 | 1993-12-24 | Valois | Dispenser filling procedure - uses shutter with cavity which contains single does of fluid and transfers it to dispenser |
| WO1994017753A1 (en) * | 1993-02-12 | 1994-08-18 | Minnesota Mining And Manufacturing Company | Aerosol delivery apparatus |
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6427680B1 (en) | 1997-06-18 | 2002-08-06 | Valois S.A. | Nasal applicator and a dispenser device including such an applicator |
| FR2764807A1 (en) * | 1997-06-18 | 1998-12-24 | Valois Sa | NASAL DISPENSING DEVICE FOR A FLUID OR POWDERY PRODUCT |
| WO1998057690A1 (en) * | 1997-06-18 | 1998-12-23 | Valois S.A. | Nasal applicator and device for dispensing device comprising same |
| WO2000027430A2 (en) * | 1998-11-06 | 2000-05-18 | Schweiz. Serum- & Impfinstitut Bern | Composition consisting of influenza virus surface proteins and dispensing device |
| WO2000027430A3 (en) * | 1998-11-06 | 2000-11-23 | Schweiz Serum & Impfinst | Composition consisting of influenza virus surface proteins and dispensing device |
| AU776669B2 (en) * | 1998-11-06 | 2004-09-16 | Berna Biotech Ag | Pharmaceutically active composition and dispensing device |
| JP4632510B2 (en) * | 1999-10-14 | 2011-02-16 | ベクトン・ディキンソン・アンド・カンパニー | Nose feeding device with spray nozzle |
| JP2001137344A (en) * | 1999-10-14 | 2001-05-22 | Becton Dickinson & Co | Intranasal delivery device provided with spray nozzle |
| EP1092447A3 (en) * | 1999-10-14 | 2001-05-09 | Becton Dickinson and Company | Nasal delivery device including spray nozzle |
| US7296566B2 (en) | 1999-10-14 | 2007-11-20 | Becton, Dickinson And Company | Nasal delivery device including spray nozzle |
| EP1092447A2 (en) * | 1999-10-14 | 2001-04-18 | Becton Dickinson and Company | Nasal delivery device including spray nozzle |
| GB2412326A (en) * | 2004-03-26 | 2005-09-28 | Bespak Plc | Hand-held dispenser |
| WO2010139883A1 (en) | 2009-06-03 | 2010-12-09 | Laboratoires Thea | Device that assists in supplying drops of a liquid contained in a sprayer and sprayer provided with one such device |
| EP2550986A1 (en) * | 2011-07-25 | 2013-01-30 | A & K Film und Touristik GmbH | Device for applying chemical substances |
| US11446260B2 (en) | 2013-03-15 | 2022-09-20 | Janssen Pharmaceutica Nv | Pharmaceutical composition of S-ketamine hydrochloride |
| US20220160974A1 (en) * | 2015-06-12 | 2022-05-26 | Ap Pharma Systems Atomizadores E Dispensadores Ltda | Spray dispenser for nasal drugs |
| US11980596B2 (en) | 2017-09-13 | 2024-05-14 | Janssen Pharmaceutica Nv | Delivery of esketamine for the treatment of depression |
| US11707440B2 (en) | 2017-12-22 | 2023-07-25 | Janssen Pharmaceuticals, Inc. | Esketamine for the treatment of depression |
| US11883526B2 (en) | 2019-03-05 | 2024-01-30 | Janssen Pharmaceutica Nv | Esketamine for the treatment of depression |
| EP4039296A4 (en) * | 2019-10-01 | 2023-10-25 | Toko Yakuhin Kogyo Co., Ltd. | Nasal spray injection nozzle and rest product for administration of nasal drops |
| FR3107828A1 (en) | 2020-03-03 | 2021-09-10 | Laboratoires Thea | Electronic module for a vial of a liquid ophthalmic product with a mechanical pump, assembly comprising a module and a vial, and a device for monitoring compliance with a treatment |
| WO2021175838A1 (en) | 2020-03-03 | 2021-09-10 | Laboratoires Thea | Electronic module for a vial containing a liquid ophthalmic product with a mechanical pump and assembly comprising a module and a vial |
| WO2021175841A1 (en) | 2020-03-03 | 2021-09-10 | Laboratoires Thea | Device and method for monitoring compliance with a therapeutic ophthalmic treatment |
| WO2022171969A1 (en) | 2021-02-15 | 2022-08-18 | Aptar France Sas | Dispensing head for a device for dispensing a fluid or powder product into the nose |
| FR3119772A1 (en) * | 2021-02-15 | 2022-08-19 | Aptar France Sas | Dispensing head for nasal dispensing device for a fluid or powdery product |
| US11759586B1 (en) * | 2022-04-13 | 2023-09-19 | Ferrer Medical Innovations, LLC | Nasal spray bottle with improved nozzle and system of application |
| WO2023200459A1 (en) * | 2022-04-13 | 2023-10-19 | Ferrer Medical Innovations, LLC | Nasal spray bottle with improved nozzle and system of application |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2739294B1 (en) | 1998-01-16 |
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