FR2694694A1 - Compsn for treating psoriasis partic of the scalp - can be used as a shampoo and is effective, odourless and free of side effects - Google Patents

Compsn for treating psoriasis partic of the scalp - can be used as a shampoo and is effective, odourless and free of side effects Download PDF

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FR2694694A1
FR2694694A1 FR9210114A FR9210114A FR2694694A1 FR 2694694 A1 FR2694694 A1 FR 2694694A1 FR 9210114 A FR9210114 A FR 9210114A FR 9210114 A FR9210114 A FR 9210114A FR 2694694 A1 FR2694694 A1 FR 2694694A1
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Jean-Noel Thorel
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof

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Abstract

Active compsn. for the treatment of psoriasis, partic. of the scalp, comprises: (a) an antiseptic and/or (b) an antiseborrhoeic fraction consisting of at least one tar arising from distn. of organic matter (living or fossil, vegetable or animal); (c) an agent active against pityriasis comprising at least one 1-hydroxy-2-pyridone, pref. pitoctone olamine; and (d) a keratolytic agent, pref. salicylic acid. USE/ADVANTAGE - The compsn. is useful for the treatment of psoriasis, partic. of the scalp, by topical application, or as a shampoo. Topical treatments of prior art are difficult to apply to the scalp because of the hair, require care in use because of possible side-effects and may have an unpleasant odour as a result of the tar used. The claimed compsn. does not have these disadvantages and does not require medical supervision in use. The use of the agent (c) allows a large redn. in the tar-based antiseborrhoeic cpd. Use of a 1-hydroxy-2-pyridone allows use of a reduced amount of an optional selenium cpd., which reduces toxicity problems.

Description

Composition active pour le traitement du psoriasis,
notamment le psoriasis du cuir chevelu
La présente invention concerne le traitement du psoriasis, et plus particulièrement, quoique non exclusivement, le psoriasis du cuir chevelu. A cette fin, l'invention concerne des compositions actives vis-à-vis du psoriasis, que celles-ci soient considérées en tant que médicaments à usage externe, ou en tant que préparations dermo-cosmétiques.Active composition for the treatment of psoriasis,
including scalp psoriasis
The present invention relates to the treatment of psoriasis, and more particularly, although not exclusively, psoriasis of the scalp. To this end, the invention relates to active compositions with respect to psoriasis, whether these are considered as medicaments for external use, or as dermo-cosmetic preparations.

Le psoriasis est une dermatose fréquente, d'étio- logie inconnue, à évolution chronique, caractérisée par des taches rouges plus ou moins étendues, bien circonscrites, recouvertes de squames sèches, abondantes et friables. Les lésions correspondantes siègent surtout aux coudes, aux genoux, au cuir chevelu, mais peuvent aussi envahir tout le corps. Psoriasis is a frequent dermatosis, of unknown etiology, with chronic evolution, characterized by more or less extensive, well circumscribed red spots, covered with dry, profuse and brittle scales. The corresponding lesions are located mainly on the elbows, knees, scalp, but can also invade the whole body.

S'agissant du psoriasis du cuir chevelu, on estime que 0,5 à 1 % de la population est atteinte par cette affection, particulièrement déplaisante et très difficile à traiter en raison de la présence des cheveux. Regarding scalp psoriasis, it is estimated that 0.5 to 1% of the population is affected by this condition, which is particularly unpleasant and very difficult to treat due to the presence of hair.

Très souvent, le psoriasis du cuir chevelu provoque des squames épaisses et des plaques érythémateuses. Very often, scalp psoriasis causes thick scales and erythematous plaques.

Comme tout autre psoriasis, celui du cuir chevelu se définit histologiquement par une hyperkératose, localement parakératosique, une acanthose régulière avec un allongement des papilles dermiques. Des inclusions PAS positives sont visibles dans l'épiderme du cuir chevelu, et on retrouve également des micro-abcès dans la couche cornée, ainsi qu'un aspect spongiforme de cette dernière, avec éventuellement une exocytose à cellules polynucléaires neutrophiles.Like any other psoriasis, that of the scalp is defined histologically by hyperkeratosis, locally parakeratotic, regular acanthosis with lengthening of the dermal papillae. PAS positive inclusions are visible in the epidermis of the scalp, and micro-abscesses are also found in the stratum corneum, as well as a spongiform aspect of the latter, possibly with exocytosis of neutrophilic polynuclear cells.

Le psoriasis du cuir chevelu doit être distingué, quant à son diagnostic, des différentes formes de pityriasis, ou états pélliculaires du cuir chevelu, et de la dermite séborrhéique.  Psoriasis of the scalp should be distinguished, as for its diagnosis, from the various forms of pityriasis, or pelicular states of the scalp, and from seborrheic dermatitis.

Différents traitements locaux ont déjà été proposés, vis-à-vis du psoriasis du cuir chevelu, mais sont difficiles à appliquer en raison du l'existence ou de la présence des cheveux. Notamment diverses préparations topiques sont disponibles, et comportent pour la plupart d'entre elles de l'acide salicylique associé à différents agents réducteurs, comme du goudron de houille, de l'anthraline, et/ou comportent différents dermo-corticoïdes. Different local treatments have already been proposed for psoriasis of the scalp, but are difficult to apply because of the existence or presence of the hair. In particular, various topical preparations are available, and most of them include salicylic acid combined with different reducing agents, such as coal tar, anthralin, and / or contain different dermo-corticoids.

Tous ces produits sont d'un usage délicat, car de nombreux effets secondaires peuvent apparaître, au rang desquels on peut noter une atrophie cutanée, des vergetures, un retard de cicatrisation des plaies, différents phénomènes de dessication cutanée, des folliculites, des éruptions acnéiformes, voire une dépigmentation du cuir chevelu. All of these products are delicate to use, because many side effects can appear, among which one can note atrophy of the skin, stretch marks, delayed healing of wounds, different phenomena of skin dessication, folliculitis, acneiform eruptions. , or even a depigmentation of the scalp.

La présente invention a pour objet de remédier aux inconvénients précités. The object of the present invention is to remedy the aforementioned drawbacks.

Plus précisément, l'invention a pour objet une composition active pour le traitement du psoriasis et préférentiellement le psoriasis du cuir chevelu, à usage dermo-cosmétique ou pharmaceutique, sans effets secondaires particuliers et ne requérant pas de ce fait un contrôle médical lors de son utilisation. More specifically, the subject of the invention is an active composition for the treatment of psoriasis and preferably psoriasis of the scalp, for dermo-cosmetic or pharmaceutical use, without any particular side effects and therefore not requiring medical control during its use.

Selon l'invention, une composition active associe
(a) un agent antiseptique, par exemple de l'essence de cade, et/ou
(b) une fraction lourde antiséborrhéique, comprenant au moins un goudron résultant de la distillation d'une matière organique, vivante ou fossile, telle que végétale ou animale, par exemple un coaltar
(c) un agent actif à l'état isolé contre le pityriasis, comprenant au moins une l-hydroxy-2 pyridone, notamment la piroctone olamine
(d) un agent kératolytique, autre que la fraction lourde, notamment l'acide salicylique. According to the invention, an active composition combines
(a) an antiseptic agent, for example cade essence, and / or
(b) a heavy antiseborrheic fraction, comprising at least one tar resulting from the distillation of an organic matter, living or fossil, such as vegetable or animal, for example a coaltar
(c) an active agent in an isolated state against pityriasis, comprising at least one 2-hydroxy-pyridone, in particular piroctone olamine
(d) a keratolytic agent, other than the heavy fraction, in particular salicylic acid.

Préférentiellement la 1-hydroxy-2 pyridone répond à la formule générale

Figure img00030001

- dans laquelle le groupement R1 est un substituant alkyle
et/ou aryle, sans liaisons oléfiniques ou acétyléniques - dans laquelle l'un des groupements R2 et R4 est un atome
d'hydrogène, et l'autre est de l'hydrogène, ou un sub
stituant méthyle ou éthyle - et dans laquelle R3 est un substituant alkyle ayant jus
qu'à deux atomes de carbone.Preferably 1-hydroxy-2 pyridone corresponds to the general formula
Figure img00030001

- in which the group R1 is an alkyl substituent
and / or aryl, without olefinic or acetylenic bonds - in which one of the groups R2 and R4 is an atom
hydrogen, and the other is hydrogen, or a sub
methyl or ethyl stituant - and in which R3 is an alkyl substituent having juice
than two carbon atoms.

Avantageusement, l'agent de traitement du pityriasis comprend un composé de sélénium, par exemple du disulfure de sélénium. Advantageously, the pityriasis treatment agent comprises a selenium compound, for example selenium disulfide.

Une composition selon l'invention comprend par exemple un poids - de 0,01 à 8 %, préférentiellement de 0,25 à 0,3 % de
coaltar - de 0,001 à 1 %, préférentiellement de 0,05 à 0,3 % d'es
sence de cade - de 0,01 à 2 %, préférentiellement de 0,15 à 0,80 % de 1
hydroxy-2 pyridone - de 0,01 à 2 %, préférentiellement de 0,2 à 0,8 % d'acide
salicylique - de 0,01 à 1 %, préférentiellement de 0,75 à 0,35 % d'un
composé de sélénium.A composition according to the invention comprises for example a weight - from 0.01 to 8%, preferably from 0.25 to 0.3% of
coaltar - from 0.001 to 1%, preferably from 0.05 to 0.3% of es
sade of cade - from 0.01 to 2%, preferably from 0.15 to 0.80% of 1
2-hydroxy pyridone - from 0.01 to 2%, preferably from 0.2 to 0.8% of acid
salicylic - from 0.01 to 1%, preferably from 0.75 to 0.35% of a
composed of selenium.

La composition selon l'invention présente encore les avantages déterminants suivants. The composition according to the invention also has the following determining advantages.

Tout d'abord la présence de l'agent actif à l'état isolé contre le pityriasis, permet de diminuer dans une large mesure la proportion de la fraction lourde antiséborrhéique, à base de goudron, et éventuellement la proportion pondérale du composé de sélénium. Ceci permet de limiter les inconvénients liés à l'éventuelle toxicité de ces produits. First of all, the presence of the active agent in the isolated state against pityriasis makes it possible to reduce to a large extent the proportion of the heavy antiseborrheic fraction, based on tar, and possibly the weight proportion of the selenium compound. This makes it possible to limit the drawbacks linked to the possible toxicity of these products.

Ensuite la composition selon l'invention évite tout inconvénient lié à l'odeur désagréable et permanente de la fraction lourde à base de goudron, souvent incommodante pour le patient et son entourage. Then the composition according to the invention avoids any drawback linked to the unpleasant and permanent odor of the heavy tar-based fraction, often inconvenient for the patient and his entourage.

Pour terminer, différents essais cliniques effectués selon l'invention ont démontré une amélioration de l'état des patients, là en particulier ou des produits traditionnels n'apportaient aucun résultat substantiel. Finally, various clinical trials carried out according to the invention have shown an improvement in the condition of the patients, there in particular where traditional products did not bring any substantial result.

A partir d'une composition active selon l'invention, on peut formuler tout médicament approprié à usage externe, avec un excipient adapté à une application topique, et éventuellement un additif favorisant la pénétration systémique du principe actif, en l'occurrence la composition identifiée comme précédemment. From an active composition according to the invention, any drug suitable for external use can be formulated, with an excipient suitable for topical application, and optionally an additive promoting the systemic penetration of the active principle, in this case the identified composition. like before.

S'agissant du traitement du psoriasis du cuir chevelu, le médicament sera présenté et formulé sous la forme d'un shampooing, l'excipient comprenant alors au moins un agent tensio-actif. With regard to the treatment of scalp psoriasis, the medicament will be presented and formulated in the form of a shampoo, the excipient then comprising at least one surfactant.

Et à partir de la même composition active, on peut formuler différentes préparations dermo-cosmétiques, favorisant le traitement du psoriasis, notamment du psoriasis du cuir chevelu, comprenant à titre de matière active une composition telle que définie précédemment, ainsi qu'un véhicule adapté à une application topique. De telles préparations peuvent être des crèmes, pommades, lotions, onguents, gels, et autres solutions alcooliques, usuelles en matière de cosmétique. And from the same active composition, different dermo-cosmetic preparations can be formulated, favoring the treatment of psoriasis, in particular scalp psoriasis, comprising as active material a composition as defined above, as well as a suitable vehicle to a topical application. Such preparations may be creams, ointments, lotions, ointments, gels, and other alcoholic solutions, customary in the field of cosmetics.

S'agissant du psoriasis cuir chevelu, bien entendu la forme préférée pour la préparation précitée sera un shampooing, dont le véhicule comprendra au moins un agent tensio-actif et un agent de viscosité. With regard to scalp psoriasis, of course the preferred form for the aforementioned preparation will be a shampoo, the vehicle of which will comprise at least one surfactant and one viscosity agent.

Un shampooing à usage dermo-cosmétique, comprenant une composition active, telle que définie précédemment, a fait l'objet d'une étude multicentrique, en consultation hospitalière, vis-à-vis du psoriasis du cuir chevelu, à partir de 16 sujets de 18 à 64 ans, dans quatre centres hospitaliers. A dermo-cosmetic shampoo, comprising an active composition, as defined above, was the subject of a multicenter study, in hospital consultation, with respect to scalp psoriasis, from 16 subjects of 18 to 64 years old, in four hospitals.

Tous les sujets présentaient au départ un érythème, des squames, une infiltration, et la plupart un prurit au niveau du cuir chevelu. All subjects initially presented with erythema, dander, infiltration, and most with pruritus in the scalp.

Le traitement a duré huit semaines, et le shampooing selon l'invention a été utilisé par chaque patient un jour sur deux, pendant les quinze premiers jours, puis un jour sur trois pendant la durée restante du traitement. The treatment lasted eight weeks, and the shampoo according to the invention was used by each patient every other day, for the first fifteen days, then every other day for the remainder of the treatment.

L'efficacité d'un tel shampooing s'est révélée importante et rapide, puisqu'on constate, d'une part une amélioration significative vis-à-vis des quatre signes diagnostics du psoriasis, dans 80 % des cas, et un blanchiment complet, dans 40 % des cas. The effectiveness of such a shampoo has proven to be important and rapid, since there is, on the one hand, a significant improvement with respect to the four diagnostic signs of psoriasis, in 80% of the cases, and complete whitening. , in 40% of cases.

La tolérance d'un tel shampooing a été parfaite dans 100 % des cas, aucune réaction indésirable n'ayant été constatée. The tolerance of such a shampoo was perfect in 100% of the cases, no adverse reaction having been observed.

Les qualités d'un tel shampooing ont été particu lièrement appréciées par les utilisateurs, puisqu'on a constaté
- aucune rémanence d'odeur du shampooing sur les cheveux, dans 98 % des cas,
- une absence d'hyperséborrhée réactionnelle, dans 50 % des cas,
- ainsi qu'un effet coiffant et volumateur dans 71 % des cas. The qualities of such a shampoo have been particularly appreciated by the users, since it has been found
- no persistence of shampoo odor on the hair, in 98% of cases,
- an absence of reaction hyperseborrhea, in 50% of cases,
- as well as a styling and volumizing effect in 71% of the cases.

Claims (10)

REVENDICATIONS 1) Composition active pour le traitement du psoriasis, notamment le psoriasis du cuir chevelu, caractérisée en ce qu'elle associe 1) Active composition for the treatment of psoriasis, in particular psoriasis of the scalp, characterized in that it combines (a) un agent antiseptique, et/ou (b) une fraction antiséborrhéique, comprenant au moins un goudron résultant de la distillation d'une matière organique, vivante ou fossile, telle que végétale ou animale (a) an antiseptic agent, and / or (b) an antiseborrheic fraction, comprising at least one tar resulting from the distillation of an organic matter, living or fossil, such as vegetable or animal (c) un agent actif à l'état isolé contre le pityriasis, comprenant au moins une 1-hydroxy-2 pyridone, notamment la piroctone olamine (c) an active agent in an isolated state against pityriasis, comprising at least one 1-hydroxy-2 pyridone, in particular piroctone olamine (d) un agent keratolytique, autre que la fraction lourde, notamment l'acide salicylique. (d) a keratolytic agent, other than the heavy fraction, in particular salicylic acid. 2) Composition selon la revendication 1, caractérisée en ce que la 1-hydroxy-2 pyridone répond à la formule générale 2) Composition according to claim 1, characterized in that 1-hydroxy-2 pyridone corresponds to the general formula
Figure img00060001
Figure img00060001
 - dans laquelle le groupement R1 est un substituant alkyle - in which the group R1 is an alkyl substituent et/ou aryle, sans liaisons oléfiniques ou acétyléniques - dans laquelle l'un des groupements R2 et R4 est un atome and / or aryl, without olefinic or acetylenic bonds - in which one of the groups R2 and R4 is an atom d'hydrogène, et l'autre est de l'hydrogène, ou un sub hydrogen, and the other is hydrogen, or a sub stituant méthyle ou éthyle - et dans laquelle R3 est un substituant alkyle ayant jus methyl or ethyl stituant - and in which R3 is an alkyl substituent having juice qu'à deux atomes de carbone. than two carbon atoms. 3) Composition selon la revendication 1, caractérisée en ce que l'agent de traitement du pityriasis comprend un composé de sélénium, par exemple du disulfure de sélénium. 3) Composition according to claim 1, characterized in that the pityriasis treatment agent comprises a selenium compound, for example selenium disulfide. 4) Composition selon la revendication 1, caractérisée en ce que la fraction lourde antiséborrhéique comprend un coaltar.  4) Composition according to claim 1, characterized in that the heavy antiseborrheic fraction comprises a coaltar. 5) Composition selon la revendication 1, caractérisée en ce que l'agent antiseptique comprend de l'essence de cade. 5) Composition according to claim 1, characterized in that the antiseptic agent comprises cade essence. 6) Composition selon les revendications 1 à 5, comprenant en poids - de 0,01 à 8 %, préférentiellement de 0,25 à 0,3 % de 6) Composition according to claims 1 to 5, comprising by weight - from 0.01 to 8%, preferably from 0.25 to 0.3% of coaltar - de 0,001 à 1 %, préférentiellement de 0,05 à 0,3 % d'es coaltar - from 0.001 to 1%, preferably from 0.05 to 0.3% of es sence de cade - de 0,01 à 2 %, préférentiellement de 0,15 à 0,80 % de 1 sade of cade - from 0.01 to 2%, preferably from 0.15 to 0.80% of 1 hydroxy-2 pyridone - de 0,01 à 2 %, préférentiellement de 0,2 à 0,8 % d'acide 2-hydroxy pyridone - from 0.01 to 2%, preferably from 0.2 to 0.8% of acid salicylique - de 0,01 à 1 %, préférentiellement de 0,75 à 0,35 % d'un salicylic - from 0.01 to 1%, preferably from 0.75 to 0.35% of a composé de sélénium. composed of selenium. 7) Médicament à usage externe pour le traitement du psoriasis, notamment du psoriasis du cuir chevelu, caractérisé en ce qu'il comprend à titre de principe actif une composition selon l'une quelconque des revendications 1 à 6, un excipient adapté à une application topique, et éventuellement un additif favorisant la pénétration systémique du principe actif. 7) Medication for external use for the treatment of psoriasis, in particular scalp psoriasis, characterized in that it comprises, as active principle, a composition according to any one of claims 1 to 6, an excipient suitable for application topical, and possibly an additive promoting the systemic penetration of the active ingredient. 8) Médicament pour le traitement du psoriasis du cuir chevelu selon la revendication 7, présenté sous forme de shampooing, caractérisé en que l'excipient comprend au moins un agent tensio-actif. 8) Medication for the treatment of scalp psoriasis according to claim 7, presented in the form of a shampoo, characterized in that the excipient comprises at least one surfactant. 9) Préparation dermo-cosmétique favorisant le traitement du psoriasis, notamment du psoriasis du cuir chevelu, caractérisée en ce qu'elle comprend à titre de matière active une composition selon l'une quelconque des revendications 1 à 6, et un véhicule adapté à une application topique. 9) Dermo-cosmetic preparation favoring the treatment of psoriasis, in particular psoriasis of the scalp, characterized in that it comprises, as active material, a composition according to any one of claims 1 to 6, and a vehicle suitable for topical application. 10) Préparation selon la revendication 9, pour le traitement du psoriasis du cuir chevelu, présentée sous forme de shampooing, caractérisée en ce que le véhicule comprend au moins un agent tensio-actif, et un agent de viscosité.  10) Preparation according to claim 9, for the treatment of psoriasis of the scalp, presented in the form of shampoo, characterized in that the vehicle comprises at least one surfactant, and a viscosity agent.
FR9210114A 1992-08-13 1992-08-13 Active composition for the treatment of psoriasis, in particular psoriasis of the scalp. Expired - Lifetime FR2694694B1 (en)

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EP0680745A2 (en) * 1994-05-05 1995-11-08 L'oreal Use of antifungals and or halogenated antibacterial agents for diminishing hair loss
US6469033B1 (en) 1996-09-27 2002-10-22 Aventis Pharma Deutschland Gmbh Use of 1-hydroxy-2-pyridones for the treatment of skin diseases
US7018656B2 (en) 1996-09-27 2006-03-28 Aventis Pharma Deutschland Gmbh Antimycotic gel with high active substance release
EP1682083A1 (en) * 2003-11-03 2006-07-26 Stiefel Laboratories, Inc. Antimicrobial shampoo compositions
WO2007020328A1 (en) * 2005-08-12 2007-02-22 Lumene Oy Cosmetic product for the treatment of scalp
US7981909B2 (en) 1996-09-27 2011-07-19 Medicis Pharmaceutical Corporation Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
EP3421093A1 (en) * 2017-06-27 2019-01-02 Daxxin AB Liquid composition for wash of scalp and hair, or for wash of skin comprising piroctone olamine

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0680745A2 (en) * 1994-05-05 1995-11-08 L'oreal Use of antifungals and or halogenated antibacterial agents for diminishing hair loss
FR2719481A1 (en) * 1994-05-05 1995-11-10 Oreal Composition based on antifungal compounds and halogenated antibacterial compounds to reduce hair loss.
EP0680745A3 (en) * 1994-05-05 1997-03-26 Oreal Use of antifungals and or halogenated antibacterial agents for diminishing hair loss.
US5650145A (en) * 1994-05-05 1997-07-22 L'oreal Dermatological/cosmetic compositions comprising antifungal and antibacterial compounds and reduction of hair loss therewith
US5919438A (en) * 1994-05-05 1999-07-06 Societe L'oreal S.A. Dermatological/cosmetic compositions comprising antifungal and antibacterial compounds and reduction of hair loss therewith
US6121254A (en) * 1994-05-05 2000-09-19 Societe L'oreal S.A. Dermatological/cosmetic compositions comprising antifungal and antibacterial compounds and reduction of hair loss therewith
US6469033B1 (en) 1996-09-27 2002-10-22 Aventis Pharma Deutschland Gmbh Use of 1-hydroxy-2-pyridones for the treatment of skin diseases
US7018656B2 (en) 1996-09-27 2006-03-28 Aventis Pharma Deutschland Gmbh Antimycotic gel with high active substance release
US7026337B2 (en) 1996-09-27 2006-04-11 Aventis Pharma Deutschland Gmbh Antimycotic gel having high active compound release
US7981909B2 (en) 1996-09-27 2011-07-19 Medicis Pharmaceutical Corporation Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
EP1682083A1 (en) * 2003-11-03 2006-07-26 Stiefel Laboratories, Inc. Antimicrobial shampoo compositions
EP1682083A4 (en) * 2003-11-03 2007-08-01 Stiefel Laboratories Antimicrobial shampoo compositions
WO2007020328A1 (en) * 2005-08-12 2007-02-22 Lumene Oy Cosmetic product for the treatment of scalp
EP3421093A1 (en) * 2017-06-27 2019-01-02 Daxxin AB Liquid composition for wash of scalp and hair, or for wash of skin comprising piroctone olamine
US10668054B2 (en) 2017-06-27 2020-06-02 Daxxin AB Liquid composition for wash of scalp and and hair, or for wash of skin

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