FR2620451B1 - Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments - Google Patents

Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments

Info

Publication number
FR2620451B1
FR2620451B1 FR8811952A FR8811952A FR2620451B1 FR 2620451 B1 FR2620451 B1 FR 2620451B1 FR 8811952 A FR8811952 A FR 8811952A FR 8811952 A FR8811952 A FR 8811952A FR 2620451 B1 FR2620451 B1 FR 2620451B1
Authority
FR
France
Prior art keywords
medicines
preparation
renin inhibitors
novel renin
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR8811952A
Other languages
English (en)
Other versions
FR2620451A1 (fr
Inventor
Weidmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2620451A1 publication Critical patent/FR2620451A1/fr
Application granted granted Critical
Publication of FR2620451B1 publication Critical patent/FR2620451B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
FR8811952A 1987-09-15 1988-09-12 Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments Expired - Fee Related FR2620451B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3730895 1987-09-15

Publications (2)

Publication Number Publication Date
FR2620451A1 FR2620451A1 (fr) 1989-03-17
FR2620451B1 true FR2620451B1 (fr) 1993-12-24

Family

ID=6336013

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8811952A Expired - Fee Related FR2620451B1 (fr) 1987-09-15 1988-09-12 Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments

Country Status (8)

Country Link
US (1) US5045537A (fr)
JP (1) JPH01151544A (fr)
BE (1) BE1003071A5 (fr)
CH (1) CH677672A5 (fr)
DE (1) DE3830825A1 (fr)
FR (1) FR2620451B1 (fr)
GB (1) GB2209752B (fr)
IT (1) IT1224742B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0326364B1 (fr) * 1988-01-26 1994-06-22 Sankyo Company Limited Polypeptide inhibant la rénine, sa fabrication et son utilisation
WO1990012804A2 (fr) * 1989-04-18 1990-11-01 The Upjohn Company Peptides avec des groupes n-terminaux polaires
US5098924A (en) * 1989-09-15 1992-03-24 E. R. Squibb & Sons, Inc. Diol sulfonamide and sulfinyl renin inhibitors
US5614522A (en) * 1990-11-19 1997-03-25 G.D. Searle & Co. Retroviral protease inhibitors
US5482947A (en) 1990-11-19 1996-01-09 Talley; John J. Retroviral protease inhibitors
US5475013A (en) * 1990-11-19 1995-12-12 Monsanto Company Retroviral protease inhibitors
AU662114B2 (en) * 1990-11-19 1995-08-24 Monsanto Company Retroviral protease inhibitors
US5583238A (en) * 1990-11-19 1996-12-10 G. D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
DE69132423T2 (de) * 1990-11-19 2001-04-26 Monsanto Co., St. Louis Inhibitoren retroviraler Proteasen
US5475027A (en) * 1990-11-19 1995-12-12 G.D. Searle & Co. Retroviral protease inhibitors
ATE170169T1 (de) * 1990-11-19 1998-09-15 Monsanto Co Retrovirale protease inhibitoren
US5648511A (en) * 1990-11-19 1997-07-15 G.D. Searle & Co. Method for making intermediates useful in the synthesis of retroviral protease inhibitors
US5708004A (en) * 1990-11-19 1998-01-13 Monsanto Company Retroviral protease inhibitors
US5869605A (en) * 1992-10-30 1999-02-09 Rhone-Poulencchimie Protected compound comprising a protective group removably attached to a compound to be protected
US6359113B1 (en) 1990-12-31 2002-03-19 Rhodia Chimie Protective group, compound protected by said group and device for grafting the protective group on the compound to protect it
JPH07508020A (ja) 1992-05-21 1995-09-07 ジー．ディー．サール　アンド　カンパニー レトロウイルスプロテアーゼインヒビター
US6022994A (en) 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5463104A (en) * 1992-08-25 1995-10-31 G. D. Searle & Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6743929B1 (en) 1992-08-25 2004-06-01 G. D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
RU2146668C1 (ru) 1992-08-25 2000-03-20 Джи Ди Сирл энд Компани Сульфонилалканоиламино-гидроксиэтиламино-сульфонамидное соединение, фармацевтические композиции и способы лечения и ингибирования ретровирусных протеаз
DK0656887T3 (da) 1992-08-25 1999-07-05 Searle & Co Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
US7141609B2 (en) 1992-08-25 2006-11-28 G.D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5968942A (en) 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6046190A (en) * 1992-08-25 2000-04-04 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US5760076A (en) * 1992-08-25 1998-06-02 G.D Searle & Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5830897A (en) * 1992-08-27 1998-11-03 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
WO1994010133A1 (fr) * 1992-10-30 1994-05-11 G.D. Searle & Co. Derives d'acide succinoylamino hydroxyethylamino sulfamique utiles comme inhibiteurs de proteases retrovirales
US5578606A (en) 1992-10-30 1996-11-26 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US6337398B1 (en) 1992-10-30 2002-01-08 G.D. Searle & Co. Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US5756498A (en) * 1992-10-30 1998-05-26 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
DE69331421T2 (de) 1992-10-30 2002-08-01 G.D. SEARLE & CO., CHICAGO N-substituierte Hydroxyethylaminosulfamidsäure-Derivate verwendbar als Inhibitoren retroviraler Proteasen
ES2134924T3 (es) * 1992-10-30 1999-10-16 Searle & Co Acidos sulfonilalcanoilamino-hidroxietilamino-sulfamicos utiles como inhibidores de proteasas retrovirales.
US5514801A (en) 1992-12-29 1996-05-07 Monsanto Company Cyclic sulfone containing retroviral protease inhibitors
US5830888A (en) * 1993-04-16 1998-11-03 Monsanto Company Macrocyclic retroviral protease inhibitors
US5750648A (en) * 1993-08-20 1998-05-12 G.D. Searle & Co. Retroviral protease inhibitors and combinations thereof
US5602119A (en) * 1993-10-29 1997-02-11 Vazquez; Michael L. Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5831117A (en) 1995-01-20 1998-11-03 G. D. Searle & Co. Method of preparing retroviral protease inhibitor intermediates
JP4014220B2 (ja) 1995-01-20 2007-11-28 ジー．ディー．サール アンド カンパニー ビス−スルホンアミドヒドロキシエチルアミノ レトロ ウイルスプロテアーゼインヒビター
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6140505A (en) 1995-03-10 2000-10-31 G. D. Searle & Co. Synthesis of benzo fused heterocyclic sulfonyl chlorides
EP1188766A1 (fr) 1995-03-10 2002-03-20 G.D. Searle & Co. Hydroxyethylamino sulfonamide de bis-aminoacide comme inhibiteurs de proteases de retrovirus
US5985870A (en) * 1995-03-10 1999-11-16 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
JP4124818B2 (ja) * 1995-03-10 2008-07-23 ジー．ディー．サール アンド カンパニー ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6667307B2 (en) 1997-12-19 2003-12-23 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6169085B1 (en) 1995-03-10 2001-01-02 G. D. Searle & Company Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
CA2236236A1 (fr) * 1995-11-15 1997-05-22 G.D. Searle & Co. Inhibiteurs de proteases retrovirales a base de sulfonylalcanoylamino hydroxyethylamino sulfonamides substitues
US5760019A (en) * 1996-07-12 1998-06-02 The Research Foundation Of State University Of New York Silanol enzyme inhibitors
WO1999062511A1 (fr) * 1998-06-02 1999-12-09 Bristol-Myers Squibb Company Agents de difluoroamide neurotrophiques
EP1095022A1 (fr) 1998-07-08 2001-05-02 G.D. Searle & Co. Inhibiteurs de la protease retrovirale
US7012086B1 (en) 2000-06-30 2006-03-14 The Foundation For Innovative Therapies, Inc. Treatment of retrovirus induced derangements with niacin compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104041B1 (fr) * 1982-09-15 1988-07-27 Aktiebolaget Hässle Inhibiteurs d'enzyme

Also Published As

Publication number Publication date
FR2620451A1 (fr) 1989-03-17
GB8821442D0 (en) 1988-10-12
DE3830825A1 (de) 1989-03-23
JPH01151544A (ja) 1989-06-14
GB2209752A (en) 1989-05-24
US5045537A (en) 1991-09-03
BE1003071A5 (fr) 1991-11-12
IT8848347A0 (it) 1988-09-17
GB2209752B (en) 1991-06-05
IT1224742B (it) 1990-10-18
CH677672A5 (fr) 1991-06-14

Similar Documents

Publication Publication Date Title
FR2620451B1 (fr) Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments
FR2531083B1 (fr) Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2615191B1 (fr) Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
FR2551064B1 (fr) Nouveaux esters et amides aromatiques, leur preparation et leur utilisation comme medicaments
FR2629825B1 (fr) Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments
FR2561651B1 (fr) Nouveaux derives de la cyclosporine, leur preparation et leur utilisation comme medicaments
FR2575750B1 (fr) Derives de la piperidine et de la pyrrolidine, leur preparation et leur utilisation comme medicaments
FR2501199B1 (fr) Nouveaux polypeptides, leur preparation et leur application comme medicaments
FR2606018B1 (fr) Nouveaux a-aminoacides substitues, leur preparation et leur utilisation en therapeutique comme medicaments
FR2590902B1 (fr) Nouveaux derives de la calcitonine, leur preparation et leur utilisation comme medicaments
FR2617171B1 (fr) Nouveaux derives de la somatostatine, leur preparation et leur utilisation comme medicaments
FR2511003B1 (fr) Alacaloides ergopeptidiques, leur preparation et leur utilisation comme medicaments
FR2531962B1 (fr) Nouveaux derives de la desoxyuridine, leur preparation et leur utilisation comme medicaments
FR2560196B1 (fr) Nouvelles 8a-acylaminoergolines, leur preparation et leur utilisation comme medicaments
BE896590A (fr) Nouveaux azepino-indoles leur preparation et leur utilisation comme medicaments
FR2540112B1 (fr) Nouveaux derives de la benzo(g)quinoleine, leur preparation et leur utilisation comme medicaments
FR2640271B1 (fr) Nouveaux derives de l'adenosine, leur preparation et leur utilisation comme medicaments
FR2527608B1 (fr) Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments
FR2596051B1 (fr) Nouveaux derives de la purine, leur preparation et leur utilisation comme medicaments
FR2549058B1 (fr) Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
FR2527206B1 (fr) Nouveaux derives de la 2(1h)-pyridinone, leur preparation et leur utilisation comme medicaments
FR2528431B1 (fr) Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
FR2532308B1 (fr) Nouveaux polypeptides, leur preparation et leur application comme medicaments
FR2536072B1 (fr) Nouveaux derives de la quinazoline, leur preparation et leur utilisation comme medicaments
FR2530634B1 (fr) Derives du carbapeneme, leur preparation et leur utilisation comme medicaments

Legal Events

Date Code Title Description
ST Notification of lapse