FR2592047A1 - Complexes organometalliques de produits steroides ayant une affinite pour les recepteurs progestogene et gluco-corticoide et leur application au dosage des recepteurs hormonaux - Google Patents

Complexes organometalliques de produits steroides ayant une affinite pour les recepteurs progestogene et gluco-corticoide et leur application au dosage des recepteurs hormonaux

Info

Publication number
FR2592047A1
FR2592047A1 FR8518838A FR8518838A FR2592047A1 FR 2592047 A1 FR2592047 A1 FR 2592047A1 FR 8518838 A FR8518838 A FR 8518838A FR 8518838 A FR8518838 A FR 8518838A FR 2592047 A1 FR2592047 A1 FR 2592047A1
Authority
FR
France
Prior art keywords
receptors
progestogen
affinity
assay
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8518838A
Other languages
English (en)
Other versions
FR2592047B1 (fr
Inventor
Gerard Jaouen
Anne Vessieres
Sylvie Tondu
Jean Georges Teutsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR8518838A priority Critical patent/FR2592047B1/fr
Publication of FR2592047A1 publication Critical patent/FR2592047A1/fr
Application granted granted Critical
Publication of FR2592047B1 publication Critical patent/FR2592047B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention a pour objet un complexe organométallique d'un produit stéroïde comportant au moins un des radicaux suivants : - aryle en position 11, - aryle en position 17, - alkynyle en position 17, et ayant une affinité pour l'un des récepteurs progestogène et glucocorticoïde avec une entité organométallique comportant au moins un ligand carbonyle libre.
FR8518838A 1985-12-19 1985-12-19 Complexes organometalliques de produits steroides ayant une affinite pour les recepteurs progestogene et gluco-corticoide et leur application au dosage des recepteurs hormonaux Expired FR2592047B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8518838A FR2592047B1 (fr) 1985-12-19 1985-12-19 Complexes organometalliques de produits steroides ayant une affinite pour les recepteurs progestogene et gluco-corticoide et leur application au dosage des recepteurs hormonaux

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8518838A FR2592047B1 (fr) 1985-12-19 1985-12-19 Complexes organometalliques de produits steroides ayant une affinite pour les recepteurs progestogene et gluco-corticoide et leur application au dosage des recepteurs hormonaux

Publications (2)

Publication Number Publication Date
FR2592047A1 true FR2592047A1 (fr) 1987-06-26
FR2592047B1 FR2592047B1 (fr) 1988-03-04

Family

ID=9325968

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8518838A Expired FR2592047B1 (fr) 1985-12-19 1985-12-19 Complexes organometalliques de produits steroides ayant une affinite pour les recepteurs progestogene et gluco-corticoide et leur application au dosage des recepteurs hormonaux

Country Status (1)

Country Link
FR (1) FR2592047B1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2353854A1 (fr) * 1976-05-31 1977-12-30 Technion Res & Dev Foundation Methode et reactif d'analyse par liaison specifique
EP0105785A1 (fr) * 1982-09-23 1984-04-18 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Complexes organométalliques d'oestrogènes et leur application au dosage des récepteurs hormonaux
EP0128839A2 (fr) * 1983-06-14 1984-12-19 Roussel-Uclaf Stéroides radioactifs, leur procédé et leurs intermédiaires de préparation, leur application à la mise en évidence des récepteurs de glucocorticoides et au dosage du nombre de sites de fixation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2353854A1 (fr) * 1976-05-31 1977-12-30 Technion Res & Dev Foundation Methode et reactif d'analyse par liaison specifique
EP0105785A1 (fr) * 1982-09-23 1984-04-18 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Complexes organométalliques d'oestrogènes et leur application au dosage des récepteurs hormonaux
EP0128839A2 (fr) * 1983-06-14 1984-12-19 Roussel-Uclaf Stéroides radioactifs, leur procédé et leurs intermédiaires de préparation, leur application à la mise en évidence des récepteurs de glucocorticoides et au dosage du nombre de sites de fixation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF INORGANIC AND NUCLEAR CHEMISTRY, vol. 42, 1980, paes 1659-1662, Pergamon Press, Oxford, GB; G. POUSKOULELI et al.: "Reactions of group VIB metal hexacarbonyls with arene hormonal steroids" *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 107, no. 16, 7 août 1985, pages 4778-4780, American Chemical Society, Washington, DC, US; G. JAOUEN et al.: "Metal carbonyl fragments as a new class of markers in molecular biology" *

Also Published As

Publication number Publication date
FR2592047B1 (fr) 1988-03-04

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