FR2450825A1 - BENZODIAZEPINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION - Google Patents

BENZODIAZEPINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2450825A1
FR2450825A1 FR7906056A FR7906056A FR2450825A1 FR 2450825 A1 FR2450825 A1 FR 2450825A1 FR 7906056 A FR7906056 A FR 7906056A FR 7906056 A FR7906056 A FR 7906056A FR 2450825 A1 FR2450825 A1 FR 2450825A1
Authority
FR
France
Prior art keywords
radical
alcoxy
memory
alkylamino
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7906056A
Other languages
French (fr)
Other versions
FR2450825B1 (en
Inventor
Henry Najer
Philippe Michel Jacque Manoury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7906056A priority Critical patent/FR2450825A1/en
Priority to GB8007841A priority patent/GB2046254A/en
Priority to DE19803008852 priority patent/DE3008852A1/en
Priority to JP2971580A priority patent/JPS55122770A/en
Publication of FR2450825A1 publication Critical patent/FR2450825A1/en
Application granted granted Critical
Publication of FR2450825B1 publication Critical patent/FR2450825B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSES REPONDANT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN RADICAL HYDROXYALKYLE, ALKYLE OU ALCOXY CARBONYLE ET R EST UN RADICAL HYDROXYLE, UN RADICAL ALCOXY DROIT OU RAMIFIE DE 2 A 6ATOMES DE CARBONE ET POUVANT PORTER COMME SUBSTITUANTS DES HALOGENES, UN RADICAL ALCOXY PORTANT UN GROUPE PIPERIDINO, MORPHOLINO, PIPERAZINO OU PYRROLIDINO, UN RADICAL DIALKYLAMINO-ALCOXY, UN RADICAL AMINO, UN RADICAL ALKYLAMINO, UN RADICAL DIALKYLAMINO, UN RADICAL CYCLOALKYLAMINO OU UN RADICAL OME (MEMETAL ALCALIN OU ALCALINOTERREUX). APPLICATION EN THERAPEUTIQUE.COMPOUNDS RESPONSIBLE FOR THE FORMULA: (CF DRAWING IN BOPI) IN WHICH R IS A HYDROXYALKYL, ALKYL OR ALCOXY CARBONYL RADICAL AND R IS A HYDROXYL RADICAL, A STRAIGHT OR RAMIFIED RADICAL ALCOXY OF 2 TO 6 ATOMS OF CARBON AND POWENTU-CARBON SUBSTITUTE , A RADICAL ALCOXY BEARING A PIPERIDINO, MORPHOLINO, PIPERAZINO OR PYRROLIDINO GROUP, A RADICAL DIALKYLAMINO-ALCOXY, A RADICAL AMINO, A RADICAL ALKYLAMINO, A RADICAL ALKYLAMINO, A RADICAL ALKYLAMINO, A MEMORY RADICAL ALCINKYLAMINO OR A MEMORY RADICAL ALCINKYLAMINO OR A MEMORY RADICAL ALCINAL CYCLOALO. APPLICATION IN THERAPEUTICS.

FR7906056A 1979-03-09 1979-03-09 BENZODIAZEPINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION Granted FR2450825A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR7906056A FR2450825A1 (en) 1979-03-09 1979-03-09 BENZODIAZEPINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
GB8007841A GB2046254A (en) 1979-03-09 1980-03-07 Benzodiazepines
DE19803008852 DE3008852A1 (en) 1979-03-09 1980-03-07 BENZODIAZEPINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
JP2971580A JPS55122770A (en) 1979-03-09 1980-03-08 Benzodiazepine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7906056A FR2450825A1 (en) 1979-03-09 1979-03-09 BENZODIAZEPINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
FR2450825A1 true FR2450825A1 (en) 1980-10-03
FR2450825B1 FR2450825B1 (en) 1982-01-29

Family

ID=9222942

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7906056A Granted FR2450825A1 (en) 1979-03-09 1979-03-09 BENZODIAZEPINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION

Country Status (4)

Country Link
JP (1) JPS55122770A (en)
DE (1) DE3008852A1 (en)
FR (1) FR2450825A1 (en)
GB (1) GB2046254A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2491926A1 (en) * 1980-10-10 1982-04-16 Synthelabo Raubasine (ajmalicine or delta-yohimbine) anti-anoxic derivs. - used for treat cerebral vascular damage, cerebral sclerosis, cranial trauma disorders and depressive states

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071886A (en) * 1988-03-10 1991-12-10 Sumitomo Chemical Company, Limited Heat-shrinkable, tubular foam
US5043115A (en) * 1988-03-10 1991-08-27 Sumitomo Chemical Company, Limited Heat-shrinkable, tubular foam

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181697A1 (en) * 1972-01-31 1973-12-07 Fujisawa Pharmaceutical Co
FR2253501A1 (en) * 1973-12-05 1975-07-04 Synthelabo 2,3-Dihydro-1H-benzodiazepine-2-ones - as tranquillisers with an improved therapeutic index
FR2262037A1 (en) * 1974-02-27 1975-09-19 Sumitomo Chemical Co

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2181697A1 (en) * 1972-01-31 1973-12-07 Fujisawa Pharmaceutical Co
FR2253501A1 (en) * 1973-12-05 1975-07-04 Synthelabo 2,3-Dihydro-1H-benzodiazepine-2-ones - as tranquillisers with an improved therapeutic index
FR2262037A1 (en) * 1974-02-27 1975-09-19 Sumitomo Chemical Co

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2491926A1 (en) * 1980-10-10 1982-04-16 Synthelabo Raubasine (ajmalicine or delta-yohimbine) anti-anoxic derivs. - used for treat cerebral vascular damage, cerebral sclerosis, cranial trauma disorders and depressive states

Also Published As

Publication number Publication date
GB2046254A (en) 1980-11-12
DE3008852A1 (en) 1980-09-18
FR2450825B1 (en) 1982-01-29
JPS55122770A (en) 1980-09-20

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Legal Events

Date Code Title Description
ST Notification of lapse