FR2442844A1 - Analogues de la prostaglandine i1 et compositions pharmaceutiques les contenant - Google Patents

Analogues de la prostaglandine i1 et compositions pharmaceutiques les contenant

Info

Publication number
FR2442844A1
FR2442844A1 FR7929261A FR7929261A FR2442844A1 FR 2442844 A1 FR2442844 A1 FR 2442844A1 FR 7929261 A FR7929261 A FR 7929261A FR 7929261 A FR7929261 A FR 7929261A FR 2442844 A1 FR2442844 A1 FR 2442844A1
Authority
FR
France
Prior art keywords
prostaglandin
analogs
ethylene
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7929261A
Other languages
English (en)
Other versions
FR2442844B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP14763778A external-priority patent/JPS5573678A/ja
Priority claimed from JP15920778A external-priority patent/JPS5587785A/ja
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of FR2442844A1 publication Critical patent/FR2442844A1/fr
Application granted granted Critical
Publication of FR2442844B1 publication Critical patent/FR2442844B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne de nouveaux analogues de la prostaglandine I1 . Ces composés ont la formule ci-dessous, dans laquelle A = noyau pentagonal de type prostaglandinique, B = noyau pentagonal ou hexagonal incluant un atome de soufre, Y = éthylène, vinylène ou éthylène, Z = chaînon hydrocarboné, R**1 = groupe carboxy, ester, amide ou hydroxyméthyle éventuellement estérifié, R**2 = H, méthyle, éthyle, R**3 = liaison simple ou alcoylène, R** 4 = H, alcoyle, alcoxy, ou, phényle ou phénoxy éventuellement substitués. Applications pharmacologiques dans le domaine obstétrical et gynécologique.
FR7929261A 1978-11-29 1979-11-28 Analogues de la prostaglandine i1 et compositions pharmaceutiques les contenant Granted FR2442844A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14763778A JPS5573678A (en) 1978-11-29 1978-11-29 Simultated compound of thio-prostaglandin i1, its preparation and drug composition containing it as active ingredient
JP15920778A JPS5587785A (en) 1978-12-26 1978-12-26 Mestruation inducer and abortifacient containing thio-prostaglandin i1 or its analog

Publications (2)

Publication Number Publication Date
FR2442844A1 true FR2442844A1 (fr) 1980-06-27
FR2442844B1 FR2442844B1 (fr) 1983-01-28

Family

ID=26478118

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7929261A Granted FR2442844A1 (fr) 1978-11-29 1979-11-28 Analogues de la prostaglandine i1 et compositions pharmaceutiques les contenant

Country Status (6)

Country Link
US (1) US4367237A (fr)
CH (1) CH643254A5 (fr)
DE (1) DE2947526A1 (fr)
FR (1) FR2442844A1 (fr)
GB (1) GB2038815B (fr)
IT (1) IT1126402B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58164512A (ja) * 1982-03-25 1983-09-29 Ono Pharmaceut Co Ltd プロスタグランジン類似化合物を有効成分として含有する肝臓疾患治療剤
US4595692A (en) * 1985-05-17 1986-06-17 E. R. Squibb & Sons, Inc. 7-thiabicycloheptane substituted ethers
DE4339475A1 (de) * 1993-11-19 1995-05-24 Wolff Walsrode Ag Knisterfreie, antistatische Polyurethanfolie mit hoher Atmungsaktivität sowie ihre Verwendung
BRPI0200751B1 (pt) * 2002-02-06 2018-10-23 Univ Minas Gerais complexos de inclusão de benzaldeído semicabazona em ciclodextrinas e seu método de preparação
ES2567328T3 (es) 2009-07-28 2016-04-21 Ono Pharmaceutical Co., Ltd. Compuesto bicíclico y uso del mismo para fines médicos
JP5835236B2 (ja) 2011-01-27 2015-12-24 小野薬品工業株式会社 二環式化合物およびその医薬用途
ES2581852T3 (es) * 2011-01-27 2016-09-07 Ono Pharmaceutical Co., Ltd. Compuesto bicíclico y uso del mismo para fines médicos
CA2927788C (fr) * 2013-10-25 2022-09-06 Insmed Incorporated Composes de prostacycline, compositions en contenant et leurs procedes d'utilisation
WO2016081658A1 (fr) 2014-11-18 2016-05-26 Insmed Incorporated Procédés de fabrication de tréprostinil et promédicaments dérivés de tréprostinil
US10899729B2 (en) 2016-06-30 2021-01-26 Ono Pharmaceutical Co.. Ltd. Method for producing bicyclic compound
CA3138530A1 (fr) 2019-04-29 2020-11-05 Insmed Incorporated Compositions de poudre seche de promedicaments de treprostinil et methodes d'utilisation de celles-ci

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000744A1 (fr) * 1978-03-13 1979-10-04 Research Corp Produits analogues et derives pharmaceutiquement actifs de la 6,9-thiaprostacycline

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4187381A (en) * 1973-08-06 1980-02-05 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4158667A (en) * 1976-02-04 1979-06-19 The Upjohn Company 6-Keto PGF analogs
FI71138C (fi) * 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
JPS6022708B2 (ja) * 1977-07-14 1985-06-03 小野薬品工業株式会社 プロスタグランジン類似化合物
US4180512A (en) * 1977-08-03 1979-12-25 The Upjohn Company Pyran analogs of 4,5,13,14-tetradehydro-PGI1 compounds
US4258199A (en) * 1978-03-13 1981-03-24 Research Corporation Method for preparing cyclic ethers and thioethers including oxygen isomers and sulfur analogs of prostacyclin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000744A1 (fr) * 1978-03-13 1979-10-04 Research Corp Produits analogues et derives pharmaceutiquement actifs de la 6,9-thiaprostacycline

Also Published As

Publication number Publication date
FR2442844B1 (fr) 1983-01-28
CH643254A5 (fr) 1984-05-30
IT1126402B (it) 1986-05-21
IT7927602A0 (it) 1979-11-27
DE2947526A1 (de) 1980-06-12
US4367237A (en) 1983-01-04
GB2038815B (en) 1983-09-14
GB2038815A (en) 1980-07-30

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Legal Events

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