FR2439177A1 - METHOD FOR SYNTHESIS OF KETONIC ACIDS AND ESTERS - Google Patents

METHOD FOR SYNTHESIS OF KETONIC ACIDS AND ESTERS

Info

Publication number
FR2439177A1
FR2439177A1 FR7925756A FR7925756A FR2439177A1 FR 2439177 A1 FR2439177 A1 FR 2439177A1 FR 7925756 A FR7925756 A FR 7925756A FR 7925756 A FR7925756 A FR 7925756A FR 2439177 A1 FR2439177 A1 FR 2439177A1
Authority
FR
France
Prior art keywords
esters
acid
ketonic acids
organic solvent
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7925756A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of FR2439177A1 publication Critical patent/FR2439177A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

ON PREPARE DES ACIDES OU DES ESTERS CETONIQUES, OU LEURS PRECURSEURS, PAR EXEMPLE LES DIESTERS DE L'ACIDE ACETONE DICARBOXYLIQUE, EN FAISANT REAGIR UN ACIDE A-HYDROXYLE, PAR EXEMPLE L'ACIDE CITRIQUE, OU UN DERIVE DE CET ACIDE, AVEC UN ACIDE MINERAL ANHYDRE OU UN ANHYDRIDE D'ACIDE CARBOXYLIQUE EN PRESENCE D'UN SOLVANT ORGANIQUE INERTE ET NON MISCIBLE A L'EAU. IL EST POSSIBLE DE DIMINUER LES DIFFICULTES DE FABRICATION QUAND ON PREPARE LES ACIDES OU ESTERS CETONIQUES DANS UN MILIEU REACTIONNEL CONTENANT UN TEL SOLVANT ORGANIQUE. LES ESTERS DE L'ACIDE ACETONE DICARBOXYLIQUE SONT UTILES COMME CATALYSEURS POUR LA POLYMERISATION DU CHLOROPRENE, ET ON PEUT EGALEMENT LES FAIRE REAGIR AVEC DES AMINES PRIMAIRES ET UNE HALOACETONE POUR FORMER DES ESTERS DE PYRROLE SUBSTITUES QUI SONT DES PRODUITS PHARMACEUTIQUES.KETONIC ACIDS OR ESTERS, OR THEIR PRECURSORS, FOR EXAMPLE ACETONE DICARBOXYLIC ACID DIESTERS, ARE PREPARED BY REACTING AN A-HYDROXYL ACID, FOR EXAMPLE CITRIC ACID, OR A DERIVATIVE OF THIS ACID, WITH AN ACID. MINERAL ANHYDROUS OR A CARBOXYLIC ACID ANHYDRIDE IN THE PRESENCE OF AN INERT ORGANIC SOLVENT AND NOT MISCIBLE TO WATER. IT IS POSSIBLE TO REDUCE MANUFACTURING DIFFICULTIES WHEN PREPARING KETONIC ACIDS OR ESTERS IN A REACTIONAL MEDIUM CONTAINING SUCH ORGANIC SOLVENT. ACETONE DICARBOXYLIC ACID ESTERS ARE USEFUL AS CATALYSTS FOR POLYMERIZATION OF CHLOROPRENE, AND CAN ALSO BE REACTED WITH PRIMARY AMINES AND HALOACETONE TO FORM PYRROLE ESTERS SUBSTITUTE FOR PHARMACEUTICALS.

FR7925756A 1978-10-19 1979-10-17 METHOD FOR SYNTHESIS OF KETONIC ACIDS AND ESTERS Withdrawn FR2439177A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95268178A 1978-10-19 1978-10-19

Publications (1)

Publication Number Publication Date
FR2439177A1 true FR2439177A1 (en) 1980-05-16

Family

ID=25493135

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7925756A Withdrawn FR2439177A1 (en) 1978-10-19 1979-10-17 METHOD FOR SYNTHESIS OF KETONIC ACIDS AND ESTERS

Country Status (8)

Country Link
JP (1) JPS5594336A (en)
BE (1) BE879537A (en)
DE (1) DE2942105A1 (en)
FI (1) FI793220A (en)
FR (1) FR2439177A1 (en)
GB (1) GB2033391A (en)
NL (1) NL7907734A (en)
SE (1) SE7908597L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE57912T1 (en) * 1986-08-29 1990-11-15 American Cyanamid Co PROCESS FOR THE PREPARATION OF ANILINOFUMARATE AND 2,3-QUINOLINDICARBONIC ACID.
WO2004089867A2 (en) * 2003-04-10 2004-10-21 EGIS Gyógyszergyár Rt. Process for the preparation of dialkyl 3-oxoglutarates
WO2014043182A2 (en) * 2012-09-14 2014-03-20 Bioamber Inc. Alternative pathways to adipates and adipic acid by combined fermentation and catalytic methods
CN103288628B (en) * 2013-06-09 2016-06-01 重庆邮电大学 Citric acid hydrogen peroxide oxidation prepares the method for 1,3-��-ketoglutaric acid diester and intermediate thereof
CN109053413A (en) * 2018-08-04 2018-12-21 许昌恒生制药有限公司 A kind of preparation method of cholinolytic class pharmaceutical intermediate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2848480A (en) * 1953-02-19 1958-08-19 Smith New York Co Inc Production of keto esters
US2887508A (en) * 1958-07-17 1959-05-19 Pfizer & Co C Lower alkyl ester of acetonedicarboxylic acid
FR1203748A (en) * 1957-11-21 1960-01-20 Pfizer & Co C Improvements to the processes for preparing acetonedicarboxylic acid and its esters
DE1160841B (en) * 1961-01-16 1964-01-09 Boehringer Sohn Ingelheim Process for the preparation of acetone dicarboxylic acid and its alkyl esters from citric acid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2848480A (en) * 1953-02-19 1958-08-19 Smith New York Co Inc Production of keto esters
FR1203748A (en) * 1957-11-21 1960-01-20 Pfizer & Co C Improvements to the processes for preparing acetonedicarboxylic acid and its esters
US2887508A (en) * 1958-07-17 1959-05-19 Pfizer & Co C Lower alkyl ester of acetonedicarboxylic acid
DE1160841B (en) * 1961-01-16 1964-01-09 Boehringer Sohn Ingelheim Process for the preparation of acetone dicarboxylic acid and its alkyl esters from citric acid

Also Published As

Publication number Publication date
SE7908597L (en) 1980-04-20
FI793220A (en) 1980-04-20
NL7907734A (en) 1980-04-22
DE2942105A1 (en) 1980-04-30
GB2033391A (en) 1980-05-21
JPS5594336A (en) 1980-07-17
BE879537A (en) 1980-02-15

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