FR2434151A1 - PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE - Google Patents

PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE

Info

Publication number
FR2434151A1
FR2434151A1 FR7914907A FR7914907A FR2434151A1 FR 2434151 A1 FR2434151 A1 FR 2434151A1 FR 7914907 A FR7914907 A FR 7914907A FR 7914907 A FR7914907 A FR 7914907A FR 2434151 A1 FR2434151 A1 FR 2434151A1
Authority
FR
France
Prior art keywords
ones
pyrroline
producing
pyrrolidine
necessary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7914907A
Other languages
French (fr)
Other versions
FR2434151B3 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mundipharma AG
Original Assignee
Mundipharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mundipharma AG filed Critical Mundipharma AG
Publication of FR2434151A1 publication Critical patent/FR2434151A1/en
Application granted granted Critical
Publication of FR2434151B3 publication Critical patent/FR2434151B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne la synthèse de composés hétérocycliques doués d'une activité biologique. On soumet des N-aroylméthylacétamides à une cyclisation sous N2 en milieu basique pour obtenir des 3-pyrroline-2-ones qu'une hydrogénation catalytique transforme en les pyrrolidine-2-ones correspondantes. Les composés ainsi obtenus agissent sur le système nerveux central ou ont une action analogue à celle des prostaglandines.The invention relates to the synthesis of heterocyclic compounds endowed with biological activity. N-aroylmethylacetamides are subjected to cyclization under N2 in a basic medium to obtain 3-pyrrolin-2-ones which catalytic hydrogenation transforms into the corresponding pyrrolidine-2-ones. The compounds thus obtained act on the central nervous system or have an action analogous to that of prostaglandins.

FR7914907A 1978-06-12 1979-06-11 PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE Granted FR2434151A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91468278A 1978-06-12 1978-06-12
US1249679A 1979-02-15 1979-02-15

Publications (2)

Publication Number Publication Date
FR2434151A1 true FR2434151A1 (en) 1980-03-21
FR2434151B3 FR2434151B3 (en) 1982-04-30

Family

ID=26683628

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7914907A Granted FR2434151A1 (en) 1978-06-12 1979-06-11 PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE

Country Status (19)

Country Link
AR (1) AR222997A1 (en)
AT (1) ATA386679A (en)
AU (1) AU529479B2 (en)
CA (1) CA1108628A (en)
CH (1) CH650772A5 (en)
DE (3) DE2954236C2 (en)
DK (1) DK157847C (en)
ES (1) ES481315A1 (en)
FI (1) FI70209C (en)
FR (1) FR2434151A1 (en)
GB (1) GB2028307B (en)
GR (1) GR68438B (en)
IL (1) IL57266A (en)
IT (1) IT1116891B (en)
NL (1) NL7904584A (en)
NO (1) NO791943L (en)
NZ (1) NZ190705A (en)
PT (1) PT69716A (en)
SE (1) SE431644B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943640A (en) * 1983-10-14 1990-07-24 The Dow Chemical Company Preparation of 5-(1-alkyl-carbonyloxy)alkylpyrrolidin-2-one
WO1990007499A1 (en) * 1988-12-27 1990-07-12 Ici Americas Inc. Process for the preparation of 3-carboalkoxypyrrolidones
US5021587A (en) * 1990-01-24 1991-06-04 Petrolite Corporation Synthesis of N,3,4-trisubstituted-3-azoline-2-ones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272842A (en) * 1965-06-25 1966-09-13 Lilly Co Eli Novel pyrrolinones
GB1350582A (en) * 1970-07-24 1974-04-18 Ucb Sa Cerivatives of 2-pyrrolidinone
DE2413935A1 (en) 1974-03-20 1975-10-16 Schering Ag 4- (POLYALCOXY-PHENYL) -2-PYRROLIDONE

Also Published As

Publication number Publication date
FR2434151B3 (en) 1982-04-30
CA1108628A (en) 1981-09-08
ATA386679A (en) 1983-12-15
FI791866A (en) 1979-12-13
IL57266A (en) 1982-12-31
AR222997A1 (en) 1981-07-15
DK241779A (en) 1979-12-13
CH650772A5 (en) 1985-08-15
AU529479B2 (en) 1983-06-09
GB2028307B (en) 1983-01-19
NZ190705A (en) 1981-10-19
SE7905079L (en) 1979-12-13
DK157847B (en) 1990-02-26
NO791943L (en) 1979-12-13
IT7949373A0 (en) 1979-06-11
NL7904584A (en) 1979-12-14
DE2923553C2 (en) 1988-06-01
PT69716A (en) 1979-07-01
FI70209B (en) 1986-02-28
SE431644B (en) 1984-02-20
DK157847C (en) 1990-09-17
DE2954236C2 (en) 1988-10-06
GR68438B (en) 1981-12-30
IT1116891B (en) 1986-02-10
ES481315A1 (en) 1980-08-16
IL57266A0 (en) 1979-09-30
DE2954237C2 (en) 1989-09-21
FI70209C (en) 1986-09-15
AU4767079A (en) 1979-12-20
GB2028307A (en) 1980-03-05
DE2923553A1 (en) 1979-12-20

Similar Documents

Publication Publication Date Title
MA21896A1 (en) PROCESS FOR THE PREPATRATION OF IMIDAZOLYL - ALKENOIC ACIDS.
FR2515203B1 (en) DISTILLATION PROCESS FOR THE PRODUCTION OF DEHYDRATED ETHANOL
MY131442A (en) Excitatory amino acid receptor antagonists
PT74827B (en) PROCESS FOR THE PHOSPHATION OF METALS UTILIZABLE TO PRE-TREATMENT FOR CATAPHORESIS ESPECIALLY FOR CATHODIC CATAPHODESIS
BE808116A (en) PROCESS AND CATALYSTS FOR THE PRODUCTION OF MULTIGRADE OILS OF IMPROVED QUALITIES
FR2498621B1 (en) PROCESS FOR THE CONVERSION OF HEAVY HYDROCARBON OILS TO LIGHT HYDROCARBON OILS
DE69530933D1 (en) USE OF 5- (TETRADECYLOXY) -2-FURANIC CARBONIC ACID FOR THE TREATMENT OF ALZHEIMER DISEASE OR PSYCHOSIS
LU81297A1 (en) MICROBIOLOGICAL ENZYMATIC PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE AMINOACIDS FROM HYDANTOINS AND / OR RACEMIC CARBAMOYL DERIVATIVES
IT8819009A0 (en) IMPROVED PROCESS FOR THE PRODUCTION OF HYBRID RICE.
FR2434151A1 (en) PROCESS FOR PRODUCING PYRROLIDINE-2-ONES FROM 3-PYRROLINE-2-ONES AND PROCESS FOR PRODUCING 3-PYRROLINE-2-ONES NECESSARY FOR THIS PURPOSE
BE885090A (en) PROCESS FOR PRODUCING PROTEIN ISOLATE HAVING BETTER WHITENESS
DE69404306D1 (en) METHOD FOR THE PRODUCTION AND OPTICAL RESOLUTION OF 2-PHENYL-3-AMINOPIPERIDINE
BE889625A (en) ELECTROCHEMICAL PROCESS FOR THE SYNTHESIS OF ORGANIC COMPOUNDS
BE851597A (en) PROCESS FOR HYDROGENATION OF OLEFINE POLYMERS FOR THE PRODUCTION OF WHITE OILS
FR2618423B1 (en) PROCESS AND INSTALLATION FOR MAKING BRIQUETTES OF A RAW MATERIAL FOR THE PRODUCTION OF SILICON OR SILICON CARBIDE OR FERROSILICIUM
FR2668795B1 (en) METHOD FOR PROMOTING THE PRODUCTION OF EFFLUENTS FROM A PRODUCTION AREA.
BE888562A (en) PROCESS FOR PRODUCING AN ENZYMATIC PREPARATION OF FRUCTOSYL-TRANSFERASE,
FR2321537A1 (en) IMPROVED PROCESS FOR THE REFINING OF OILS, FATS OR CRUDE WAXES OF ANIMAL OR VEGETABLE ORIGIN
DE3751362D1 (en) 5-aryl-3H-1,2,4-triazol-3-one and its use as anticonvulsants.
FI872195A (en) FOERFARANDE FOER FRAMSTAELLNING AV PENEMDERIVAT.
ATE116851T1 (en) 5-ARYL-3H-1,2,4-TRIAZOLE-3-ONE AND ITS USE IN THE TREATMENT OF NEURODEGENERATIVE CONDITIONS.
FR2490508B1 (en) PROCESS FOR THE PRODUCTION OF CATALYSTS
PT85570B (en) PROCESS FOR THE PREPARATION OF 2,3-DIHYDRO FURANES DERIVATIVES AS INTERMEDIATES FOR THE PREPARATION OF TETRAHYDROFURAN
FR2414040A1 (en) 5-CYANO-1-HYDROCARBYLPYRROLE-2-ACETIC ACIDS THEIR PREPARATION AND APPLICATION TO THE PRODUCTION OF CORRESPONDING 5-ACYL ACIDS
ES8306997A1 (en) 5 Fluoro PGI compounds.

Legal Events

Date Code Title Description
ST Notification of lapse