FR2421891A1 - Prepn. of pyrrolidino- ethyl-di:phenyl acetamide - by condensing di:phenyl acetic acid and pyrrolidino- ethylamine - Google Patents

Prepn. of pyrrolidino- ethyl-di:phenyl acetamide - by condensing di:phenyl acetic acid and pyrrolidino- ethylamine

Info

Publication number
FR2421891A1
FR2421891A1 FR7731396A FR7731396A FR2421891A1 FR 2421891 A1 FR2421891 A1 FR 2421891A1 FR 7731396 A FR7731396 A FR 7731396A FR 7731396 A FR7731396 A FR 7731396A FR 2421891 A1 FR2421891 A1 FR 2421891A1
Authority
FR
France
Prior art keywords
pyrrolidino
phenyl
ethylamine
acetic acid
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7731396A
Other languages
French (fr)
Other versions
FR2421891B1 (en
Inventor
B Bonnaud
G Mouzin
H Gousse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7731396A priority Critical patent/FR2421891A1/en
Publication of FR2421891A1 publication Critical patent/FR2421891A1/en
Application granted granted Critical
Publication of FR2421891B1 publication Critical patent/FR2421891B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ethyl alpha, alpha-diphenyl acetamide of formula (I) is prepd. by the condensation of diphenyl acetic acid (II) with pyrrolidino ethylamine (III). Usually 10-30% excess of (IIe is used, and the reaction is effected at 120-200 (150) degrees C. Water evolved during the reaction is preferably removed as it forms, giving a measure of the progress of the reaction which is usually complete within 2-10 hours. (I) is a known agent for the treatment of respiratory disorders. The process is easier to carry out than the known method of making (I).
FR7731396A 1977-10-17 1977-10-17 Prepn. of pyrrolidino- ethyl-di:phenyl acetamide - by condensing di:phenyl acetic acid and pyrrolidino- ethylamine Granted FR2421891A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7731396A FR2421891A1 (en) 1977-10-17 1977-10-17 Prepn. of pyrrolidino- ethyl-di:phenyl acetamide - by condensing di:phenyl acetic acid and pyrrolidino- ethylamine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7731396A FR2421891A1 (en) 1977-10-17 1977-10-17 Prepn. of pyrrolidino- ethyl-di:phenyl acetamide - by condensing di:phenyl acetic acid and pyrrolidino- ethylamine

Publications (2)

Publication Number Publication Date
FR2421891A1 true FR2421891A1 (en) 1979-11-02
FR2421891B1 FR2421891B1 (en) 1980-08-14

Family

ID=9196666

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7731396A Granted FR2421891A1 (en) 1977-10-17 1977-10-17 Prepn. of pyrrolidino- ethyl-di:phenyl acetamide - by condensing di:phenyl acetic acid and pyrrolidino- ethylamine

Country Status (1)

Country Link
FR (1) FR2421891A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187700A1 (en) * 1985-01-10 1986-07-16 H. Lundbeck A/S Novel aminoalkyl substituted urea derivatives, acid addition salts thereof and enatiomers
EP0367040A1 (en) * 1988-11-04 1990-05-09 Kabi Pharmacia AB Compounds for the treatment of urinary incontinence
US5236956A (en) * 1988-11-04 1993-08-17 Kabi Pharmacia Aktiebolag Compounds for the treatment of urinary incontinence
EP0569802A1 (en) * 1992-05-09 1993-11-18 MERCK PATENT GmbH Arylacetamides
US7960429B2 (en) 2007-03-30 2011-06-14 Tioga Pharmaceuticals, Inc Kappa-opiate agonists for the treatment of diarrhea-predominant irritable bowel syndrome

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187700A1 (en) * 1985-01-10 1986-07-16 H. Lundbeck A/S Novel aminoalkyl substituted urea derivatives, acid addition salts thereof and enatiomers
EP0367040A1 (en) * 1988-11-04 1990-05-09 Kabi Pharmacia AB Compounds for the treatment of urinary incontinence
US5236956A (en) * 1988-11-04 1993-08-17 Kabi Pharmacia Aktiebolag Compounds for the treatment of urinary incontinence
EP0569802A1 (en) * 1992-05-09 1993-11-18 MERCK PATENT GmbH Arylacetamides
US5532266A (en) * 1992-05-09 1996-07-02 Merck Patent Gesellschaft Mit Beschrankter Haftung Acrylacetamides
US7960429B2 (en) 2007-03-30 2011-06-14 Tioga Pharmaceuticals, Inc Kappa-opiate agonists for the treatment of diarrhea-predominant irritable bowel syndrome
US8877800B2 (en) 2007-03-30 2014-11-04 Tioga Pharmaceuticals, Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant irritable bowel syndrome

Also Published As

Publication number Publication date
FR2421891B1 (en) 1980-08-14

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