FR2417508A2 - 2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention - Google Patents

2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention

Info

Publication number
FR2417508A2
FR2417508A2 FR7804822A FR7804822A FR2417508A2 FR 2417508 A2 FR2417508 A2 FR 2417508A2 FR 7804822 A FR7804822 A FR 7804822A FR 7804822 A FR7804822 A FR 7804822A FR 2417508 A2 FR2417508 A2 FR 2417508A2
Authority
FR
France
Prior art keywords
alkyl
phenyl
atheroma
thione
analgesics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7804822A
Other languages
French (fr)
Other versions
FR2417508B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7804822A priority Critical patent/FR2417508A2/en
Priority to NL7802514A priority patent/NL7802514A/en
Priority to DE19782810052 priority patent/DE2810052A1/en
Priority to ES467648A priority patent/ES467648A1/en
Priority to JP2714278A priority patent/JPS53127488A/en
Priority to US05/884,732 priority patent/US4188387A/en
Priority to GB9393/78A priority patent/GB1565767A/en
Priority to CH258578A priority patent/CH629194A5/en
Publication of FR2417508A2 publication Critical patent/FR2417508A2/en
Application granted granted Critical
Publication of FR2417508B2 publication Critical patent/FR2417508B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

2-Alkyl-5-phenyl-6-(4-dialkylamino-phenyl)-1,2,4-triazin -3-one and 3-thione derivs. fo formula (I) and their acid addn. salts are new (where R is lower alkyl; R1 is opt. branched lowr alkyl, alkenyl alkynyl or -(Ch2)n-NR2R3; R n is 2-4; R2, R3 are lower alkyl or together with the N atom form a heterocyclic ring; Y is H, halo, lower alkyl, alkoxy or -N(R)2 and X is O or S. Used as analgesics and blood platelet aggregation inhibitor used to treat rheumatic troubles, various pains and in the prevention of atheroma. (I) is administered orally, parenterally or rectally in classical formulations e.g. unit doses of 50-200 mg are administered orally to give a max. daily dose of 1000mg.
FR7804822A 1977-03-09 1978-02-17 2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention Granted FR2417508A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR7804822A FR2417508A2 (en) 1978-02-17 1978-02-17 2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention
DE19782810052 DE2810052A1 (en) 1977-03-09 1978-03-08 AMINOARYL-1,2,4-TRIAZINE, THE METHOD FOR MANUFACTURING IT AND THE MEDICINAL PRODUCTS CONTAINING IT
NL7802514A NL7802514A (en) 1977-03-09 1978-03-08 5,6-DIARYL-1,2,4-TRIAZINE DERIVATIVES AND METHOD FOR PREPARING THESE COMPOUNDS.
JP2714278A JPS53127488A (en) 1977-03-09 1978-03-09 Aminoaryll1*2*44triazine derivative*method for its production and arthritic drugs containing said derivative
ES467648A ES467648A1 (en) 1977-03-09 1978-03-09 Amino-aryl 1,24-triazines useful in the treatment of diverse pain
US05/884,732 US4188387A (en) 1977-03-09 1978-03-09 Amino-aryl 1,24-triazines useful in the treatment of diverse pain
GB9393/78A GB1565767A (en) 1977-03-09 1978-03-09 Substituted 1,2,4 - triazines processes for their preparation and pharmaceutical compositions containing them
CH258578A CH629194A5 (en) 1977-03-09 1978-03-09 AMINO ARYL TRIAZINES-1,2,4 FOR USE IN THE TREATMENT OF VARIOUS ALGIA.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7804822A FR2417508A2 (en) 1978-02-17 1978-02-17 2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention

Publications (2)

Publication Number Publication Date
FR2417508A2 true FR2417508A2 (en) 1979-09-14
FR2417508B2 FR2417508B2 (en) 1983-08-19

Family

ID=9204808

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7804822A Granted FR2417508A2 (en) 1977-03-09 1978-02-17 2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention

Country Status (1)

Country Link
FR (1) FR2417508A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036357A1 (en) * 1980-03-14 1981-09-23 Pierre Fabre S.A. Antalgic and antiagregant cetonic derivatives of 5,6-diaryl-1,2,4-triazines, usable in the treatment of migraine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/55 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036357A1 (en) * 1980-03-14 1981-09-23 Pierre Fabre S.A. Antalgic and antiagregant cetonic derivatives of 5,6-diaryl-1,2,4-triazines, usable in the treatment of migraine

Also Published As

Publication number Publication date
FR2417508B2 (en) 1983-08-19

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