FR2412312A1 - 3-fluoro-10-piperazino-10,11-dihydrodibenzo-(b,f)thiepines substituees en 8, leurs sels, et procede pour leur preparation - Google Patents
3-fluoro-10-piperazino-10,11-dihydrodibenzo-(b,f)thiepines substituees en 8, leurs sels, et procede pour leur preparationInfo
- Publication number
- FR2412312A1 FR2412312A1 FR7832559A FR7832559A FR2412312A1 FR 2412312 A1 FR2412312 A1 FR 2412312A1 FR 7832559 A FR7832559 A FR 7832559A FR 7832559 A FR7832559 A FR 7832559A FR 2412312 A1 FR2412312 A1 FR 2412312A1
- Authority
- FR
- France
- Prior art keywords
- thiepines
- dihydrodibenzo
- piperazino
- fluoro
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A.3-FLUORO-10-PIPERAZINO-10,11-DIHYDRODIBENZO-(B,F)THIEPINES SUBSTITUEES EN 8, LEURS SELS, ET PROCEDE POUR LEUR FABRICATION. B.CES PRODUITS SE CARACTERISENT PAR UNE ACTIVITE PSYCHOTROPIQUE ET PAR UNE TOXICITE RELATIVEMENT FAIBLE; UN EFFET CATALEPTIQUE, ANTI-APOMORPHINE ET DEPRESSANTE CENTRALE. C.APPLICATIONS NOTAMMENT DANS LA THERAPEUTIQUE DE LA SCHIZOPHRENIE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS778728A CS196893B1 (en) | 1977-12-22 | 1977-12-22 | 3-fluor-10-piperazino-8-substituted 10,11-dihydro-dibenzothiepines |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2412312A1 true FR2412312A1 (fr) | 1979-07-20 |
FR2412312B1 FR2412312B1 (fr) | 1982-10-29 |
Family
ID=5438253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7832559A Granted FR2412312A1 (fr) | 1977-12-22 | 1978-11-17 | 3-fluoro-10-piperazino-10,11-dihydrodibenzo-(b,f)thiepines substituees en 8, leurs sels, et procede pour leur preparation |
Country Status (13)
Country | Link |
---|---|
US (1) | US4243805A (fr) |
JP (1) | JPS5492979A (fr) |
AT (1) | AT368151B (fr) |
BE (1) | BE872496A (fr) |
CA (1) | CA1100134A (fr) |
CH (1) | CH642077A5 (fr) |
CS (1) | CS196893B1 (fr) |
DE (1) | DE2855703C2 (fr) |
DK (1) | DK521078A (fr) |
FI (1) | FI66374C (fr) |
FR (1) | FR2412312A1 (fr) |
GB (1) | GB2010843B (fr) |
SE (1) | SE442403B (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3029365A1 (de) * | 1980-08-01 | 1982-03-25 | Bayer Ag, 5090 Leverkusen | Verfahren zur (alpha)-bromierung von gegebenenfalls substituierten fluortoluolen und gemischen von in (alpha)-stellung verschieden hoch bromierten, gegebenenfalls substituierten fluortoluolen |
CS249455B1 (en) * | 1985-01-24 | 1987-03-12 | Miroslav Protiva | N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation |
US5700445A (en) * | 1994-12-12 | 1997-12-23 | Allelix Biopharmaceuticals, Inc. | N-methyl piperazine compounds having dopamine receptor affinity |
EP1350113A2 (fr) | 2000-08-30 | 2003-10-08 | Chemocentryx, Inc. | Inhibition de l'infection par cmv et de la dissemination de ce dernier |
US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
RU2336879C2 (ru) * | 2003-01-23 | 2008-10-27 | Акадиа Фармасьютикалз Инк. | Применение n-десметилклозапина для лечения нейропсихиатрических заболеваний у людей |
JP2007534656A (ja) | 2003-12-22 | 2007-11-29 | アカディア ファーマシューティカルズ,インコーポレーテッド | ムスカリンアゴニストとしてのアミノ置換ジアリール[a,d]シクロヘプテン類似体および精神神経疾患の治療方法 |
US20050282800A1 (en) * | 2004-04-01 | 2005-12-22 | Bo-Ragnar Tolf | Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof |
GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
DE102004049728A1 (de) * | 2004-10-11 | 2006-04-13 | Merck Patent Gmbh | Verfahren zur Herstellung von monosubstituierten Piperazinderivaten |
US20070105836A1 (en) * | 2005-10-31 | 2007-05-10 | Lars Pettersson | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
US10525376B2 (en) | 2015-07-20 | 2020-01-07 | W. L. Gore & Associates, Inc. | Affinity chromatography devices |
WO2019092044A1 (fr) * | 2017-11-08 | 2019-05-16 | Centre National De La Recherche Scientifique | Composés de dihydrobenzo[b][1]benzothiépine utiles en thérapie |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2223039A1 (fr) * | 1973-03-30 | 1974-10-25 | Hoffmann La Roche | |
JPS5634431A (en) * | 1979-08-31 | 1981-04-06 | Chuko Kasei Kogyo Kk | Preparation of inorganic-fiber woven fabric pipe with wave-form indented part on surface thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2412521A1 (de) * | 1973-03-30 | 1974-10-10 | Hoffmann La Roche | Tricyclische verbindungen |
FI753625A (fr) * | 1975-01-06 | 1976-07-07 | Spofa Vereinigte Pharma Werke |
-
1977
- 1977-12-22 CS CS778728A patent/CS196893B1/cs unknown
-
1978
- 1978-11-17 FR FR7832559A patent/FR2412312A1/fr active Granted
- 1978-11-22 DK DK521078A patent/DK521078A/da not_active Application Discontinuation
- 1978-11-24 FI FI783607A patent/FI66374C/fi not_active IP Right Cessation
- 1978-12-04 BE BE192114A patent/BE872496A/fr not_active IP Right Cessation
- 1978-12-14 GB GB7848581A patent/GB2010843B/en not_active Expired
- 1978-12-14 AT AT0892578A patent/AT368151B/de not_active IP Right Cessation
- 1978-12-20 SE SE7813114A patent/SE442403B/sv not_active IP Right Cessation
- 1978-12-21 CH CH1305178A patent/CH642077A5/de not_active IP Right Cessation
- 1978-12-21 CA CA318,360A patent/CA1100134A/fr not_active Expired
- 1978-12-22 US US05/972,323 patent/US4243805A/en not_active Expired - Lifetime
- 1978-12-22 DE DE2855703A patent/DE2855703C2/de not_active Expired
- 1978-12-22 JP JP15770178A patent/JPS5492979A/ja active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2223039A1 (fr) * | 1973-03-30 | 1974-10-25 | Hoffmann La Roche | |
JPS5634431A (en) * | 1979-08-31 | 1981-04-06 | Chuko Kasei Kogyo Kk | Preparation of inorganic-fiber woven fabric pipe with wave-form indented part on surface thereof |
Also Published As
Publication number | Publication date |
---|---|
DE2855703C2 (de) | 1987-02-26 |
US4243805A (en) | 1981-01-06 |
CH642077A5 (de) | 1984-03-30 |
AT368151B (de) | 1982-09-27 |
DE2855703A1 (de) | 1979-06-28 |
SE7813114L (sv) | 1979-06-23 |
CA1100134A (fr) | 1981-04-28 |
JPS5492979A (en) | 1979-07-23 |
CS196893B1 (en) | 1980-04-30 |
GB2010843A (en) | 1979-07-04 |
FI66374C (fi) | 1984-10-10 |
FI66374B (fi) | 1984-06-29 |
GB2010843B (en) | 1982-08-18 |
BE872496A (fr) | 1979-03-30 |
DK521078A (da) | 1979-06-23 |
FI783607A (fi) | 1979-06-23 |
FR2412312B1 (fr) | 1982-10-29 |
JPS638109B2 (fr) | 1988-02-19 |
SE442403B (sv) | 1985-12-23 |
ATA892578A (de) | 1982-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |