FR2410641A1 - RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATION - Google Patents

RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATION

Info

Publication number
FR2410641A1
FR2410641A1 FR7833889A FR7833889A FR2410641A1 FR 2410641 A1 FR2410641 A1 FR 2410641A1 FR 7833889 A FR7833889 A FR 7833889A FR 7833889 A FR7833889 A FR 7833889A FR 2410641 A1 FR2410641 A1 FR 2410641A1
Authority
FR
France
Prior art keywords
propionamides
biphenylyl
racemic
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7833889A
Other languages
French (fr)
Other versions
FR2410641B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Menarini SAS
Original Assignee
Menarini SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini SAS filed Critical Menarini SAS
Publication of FR2410641A1 publication Critical patent/FR2410641A1/en
Application granted granted Critical
Publication of FR2410641B1 publication Critical patent/FR2410641B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel compounds useful as spasmolytic agents of the following formula: in which n is 2 or 3. In addition, salts of these novel compounds are provided which are suitable for parenteral and oral administration to animals and humans as spasmolytic agents. In compositions for oral and parenteral or rectal administration, about 5 to about 40 mg of active ingredient per dosage unit are used. The bromide and iodide salts of these novel compounds are particularly useful.
FR7833889A 1977-11-30 1978-11-30 RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATION Granted FR2410641A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT964377A IT1090782B (en) 1977-11-30 1977-11-30 2 4 BIPHENYLIL 2 DIETHYLAMIN ALCHYL PROPIONAMIDE ITS SALTS AND RELATED MANUFACTURING PROCEDURES

Publications (2)

Publication Number Publication Date
FR2410641A1 true FR2410641A1 (en) 1979-06-29
FR2410641B1 FR2410641B1 (en) 1983-04-15

Family

ID=11132874

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7833889A Granted FR2410641A1 (en) 1977-11-30 1978-11-30 RACEMIC AND OPTICALLY ACTIVE FORMS OF (BIPHENYLYL-4) -2 N- (DIETHYLAMINO ALKYL) PROPIONAMIDES AND THEIR SALTS USEFUL AS SPASMOLYTIC AGENTS AND METHODS FOR PREPARATION

Country Status (9)

Country Link
JP (1) JPS5490157A (en)
BE (1) BE872403A (en)
CA (1) CA1118446A (en)
CH (1) CH637370A5 (en)
DE (1) DE2851416A1 (en)
ES (1) ES475533A1 (en)
FR (1) FR2410641A1 (en)
IT (1) IT1090782B (en)
NL (1) NL7811698A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003029187A1 (en) * 2001-09-28 2003-04-10 Dompe S.P.A. Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them
WO2008017903A1 (en) * 2006-08-08 2008-02-14 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate
WO2008020270A1 (en) * 2006-08-15 2008-02-21 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
AU2013206218A1 (en) * 2006-08-15 2013-06-27 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
US9371284B2 (en) 2007-06-04 2016-06-21 Techfields Pharma Co., Ltd. Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses
US9872846B2 (en) 2006-07-09 2018-01-23 Techfields Pharma Co., Ltd. High penetration compositions and uses thereof
US11135153B2 (en) 2006-07-09 2021-10-05 Techfields Pharma Co., Ltd. High penetration composition and uses thereof
US11541029B2 (en) 2008-12-04 2023-01-03 Techfields Pharma Co., Ltd. High penetration compositions and their applications

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5940036B2 (en) * 2013-10-08 2016-06-29 テックフィールズ バイオケム カンパニー リミテッド Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin permeability
JP6290947B2 (en) * 2016-02-05 2018-03-07 テックフィールズ バイオケム カンパニー リミテッド Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin permeability

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584547A (en) * 1968-06-05 1969-12-26
FR1593024A (en) * 1968-09-18 1970-05-25
FR2119846A1 (en) * 1970-12-28 1972-08-11 Choay Sa N,n-diethylaminoethylamide of para isobutyl phenylacetic - acid - antiinflammatory and analgesic
FR2370723A1 (en) * 1976-11-12 1978-06-09 Upjohn Co NEW ARYL-ACYLAMIDES N- (2-AMINOCYCLOALIPHATICS), THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584547A (en) * 1968-06-05 1969-12-26
FR1593024A (en) * 1968-09-18 1970-05-25
FR2119846A1 (en) * 1970-12-28 1972-08-11 Choay Sa N,n-diethylaminoethylamide of para isobutyl phenylacetic - acid - antiinflammatory and analgesic
FR2370723A1 (en) * 1976-11-12 1978-06-09 Upjohn Co NEW ARYL-ACYLAMIDES N- (2-AMINOCYCLOALIPHATICS), THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026510B2 (en) 2001-09-28 2006-04-11 Dompé S.p.A. Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them
WO2003029187A1 (en) * 2001-09-28 2003-04-10 Dompe S.P.A. Quaternary ammonium salts of omega-aminoalkylamides of r-2-aryl-propionic acids and pharmaceutical compositions containing them
AU2002338784B2 (en) * 2001-09-28 2008-08-14 Dompe' Farmaceutici S.P.A. Quaternary ammonium salts of omega-aminoalkylamides of R-2-aryl-propionic acids and pharmaceutical compositions containing them
US9872846B2 (en) 2006-07-09 2018-01-23 Techfields Pharma Co., Ltd. High penetration compositions and uses thereof
US11135153B2 (en) 2006-07-09 2021-10-05 Techfields Pharma Co., Ltd. High penetration composition and uses thereof
WO2008017903A1 (en) * 2006-08-08 2008-02-14 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate
WO2008020270A1 (en) * 2006-08-15 2008-02-21 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
AU2013206218B2 (en) * 2006-08-15 2016-06-30 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
AU2013206218A1 (en) * 2006-08-15 2013-06-27 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
AU2006347391B2 (en) * 2006-08-15 2013-03-07 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
US9371284B2 (en) 2007-06-04 2016-06-21 Techfields Pharma Co., Ltd. Pro-drugs of NSAIAS with very high skin and membranes penetration rates and their new medicinal uses
US10233198B2 (en) 2007-06-04 2019-03-19 Techfields Pharma Co., Ltd. Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
US11541029B2 (en) 2008-12-04 2023-01-03 Techfields Pharma Co., Ltd. High penetration compositions and their applications

Also Published As

Publication number Publication date
JPS631286B2 (en) 1988-01-12
BE872403A (en) 1979-03-16
FR2410641B1 (en) 1983-04-15
DE2851416C2 (en) 1989-02-23
IT1090782B (en) 1985-06-26
ES475533A1 (en) 1980-01-16
DE2851416A1 (en) 1979-05-31
NL7811698A (en) 1979-06-01
JPS5490157A (en) 1979-07-17
CH637370A5 (en) 1983-07-29
CA1118446A (en) 1982-02-16

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