FR2407941A1 - NEW CHOLESTEROL DERIVATIVES - Google Patents

NEW CHOLESTEROL DERIVATIVES

Info

Publication number
FR2407941A1
FR2407941A1 FR7630450A FR7630450A FR2407941A1 FR 2407941 A1 FR2407941 A1 FR 2407941A1 FR 7630450 A FR7630450 A FR 7630450A FR 7630450 A FR7630450 A FR 7630450A FR 2407941 A1 FR2407941 A1 FR 2407941A1
Authority
FR
France
Prior art keywords
cholesterol derivatives
new cholesterol
alcoxy
compounds
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7630450A
Other languages
French (fr)
Other versions
FR2407941B1 (en
Inventor
John Joseph Partridge Jr
Milan Radoje Uskokovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/621,319 external-priority patent/US3994878A/en
Priority claimed from US05/623,859 external-priority patent/US4038272A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2407941A1 publication Critical patent/FR2407941A1/en
Application granted granted Critical
Publication of FR2407941B1 publication Critical patent/FR2407941B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENTION CONCERNE DES COMPOSES CHIMIQUES NOUVEAUX. IL S'AGIT DE COMPOSE DE LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN GROUPE HYDROXY ALCOXY INFERIEUR, PHENYL ALCOXY INFERIEUR, ALCANOYLOXY INFERIEUR OU BENZOYLOXY. CES COMPOSES SONT UTILES DANS LE DOMAINE BIOLOGIQUE ET THERAPEUTIQUE.THE PRESENT INVENTION RELATES TO NEW CHEMICAL COMPOUNDS. THIS IS A COMPOUND OF THE FORMULA: (CF DRAWING IN BOPI) IN WHICH R IS A GROUP HYDROXY LOWER ALCOXY, PHENYL ALCOXY LOWER, ALCANOYLOXY INFERIEUR OR BENZOYLOXY. THESE COMPOUNDS ARE USEFUL IN THE BIOLOGICAL AND THERAPEUTIC FIELD.

FR7630450A 1975-10-10 1976-10-11 NEW CHOLESTEROL DERIVATIVES Granted FR2407941A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/621,319 US3994878A (en) 1975-10-10 1975-10-10 Syntheses of 24R,25- and 24S,25-dihydroxycholesterol and alkanoyl derivatives thereof
US05/623,859 US4038272A (en) 1975-10-20 1975-10-20 Stereospecific syntheses of 24r,25- and 24s,25-dihydroxycholesterol and alkanoyl derivatives thereof

Publications (2)

Publication Number Publication Date
FR2407941A1 true FR2407941A1 (en) 1979-06-01
FR2407941B1 FR2407941B1 (en) 1980-05-16

Family

ID=27088923

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7630450A Granted FR2407941A1 (en) 1975-10-10 1976-10-11 NEW CHOLESTEROL DERIVATIVES
FR7712223A Granted FR2351998A1 (en) 1975-10-10 1977-04-22 NEW CHOLESTEROL DERIVATIVES AND PROCESS FOR THEIR PREPARATION

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7712223A Granted FR2351998A1 (en) 1975-10-10 1977-04-22 NEW CHOLESTEROL DERIVATIVES AND PROCESS FOR THEIR PREPARATION

Country Status (8)

Country Link
JP (1) JPS5246061A (en)
AT (1) AT355236B (en)
CH (1) CH628907A5 (en)
DE (1) DE2645527A1 (en)
FR (2) FR2407941A1 (en)
GB (5) GB1564806A (en)
IT (1) IT1068692B (en)
NL (1) NL7611155A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH644873A5 (en) * 1980-02-12 1984-08-31 Hoffmann La Roche METHOD FOR PRODUCING CHOLESTEROL DERIVATIVES.
BR112015022174B1 (en) 2013-03-13 2022-07-05 Sage Therapeutics, Inc NEUROACTIVE STEROID COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITION AND THEIR USE
ES2884086T3 (en) 2015-07-06 2021-12-10 Sage Therapeutics Inc Oxysteroles and their procedures for use
US10696712B2 (en) * 2015-07-06 2020-06-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
ES2921010T3 (en) 2016-04-01 2022-08-16 Sage Therapeutics Inc Oxysterols and procedures for their use
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
RS62222B1 (en) 2016-07-07 2021-09-30 Sage Therapeutics Inc 11-substituted 24-hydroxysterols for use in the treatment of nmda related conditions
AU2017337121B2 (en) 2016-09-30 2022-01-27 Sage Therapeutics, Inc. C7 substituted oxysterols and methods as NMDA modulators
CN115181153A (en) 2016-10-18 2022-10-14 萨奇治疗股份有限公司 Oxysterol and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7402846A (en) * 1973-03-02 1974-09-04
US3822254A (en) * 1973-05-21 1974-07-02 Hoffmann La Roche Synthesis of 25-hydroxycholesterol

Also Published As

Publication number Publication date
CH628907A5 (en) 1982-03-31
FR2351998A1 (en) 1977-12-16
FR2351998B1 (en) 1980-04-25
DE2645527A1 (en) 1977-04-21
GB1564806A (en) 1980-04-16
NL7611155A (en) 1977-04-13
GB1564809A (en) 1980-04-16
GB1564810A (en) 1980-04-16
GB1564807A (en) 1980-04-16
GB1564808A (en) 1980-04-16
ATA751376A (en) 1979-07-15
FR2407941B1 (en) 1980-05-16
AT355236B (en) 1980-02-25
JPS5246061A (en) 1977-04-12
IT1068692B (en) 1985-03-21

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Legal Events

Date Code Title Description
ST Notification of lapse