FR2403350A1 - Nouvelle anthracycline antibiotique contre les tumeurs - Google Patents
Nouvelle anthracycline antibiotique contre les tumeursInfo
- Publication number
- FR2403350A1 FR2403350A1 FR7729595A FR7729595A FR2403350A1 FR 2403350 A1 FR2403350 A1 FR 2403350A1 FR 7729595 A FR7729595 A FR 7729595A FR 7729595 A FR7729595 A FR 7729595A FR 2403350 A1 FR2403350 A1 FR 2403350A1
- Authority
- FR
- France
- Prior art keywords
- growth
- against tumors
- new antibiotic
- anthracycline against
- aclacynomycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/888—Streptomyces antibioticus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
L'invention concerne de nouveaux agents contre les tumeurs désignés par MA144-G1, -G2, -L, -N1, -S1, -S2, -U1, -U2, et Y qui sont des glycosides anthracycline et qui empêchent la croissance de bactéries Gram positif, comme Corynebactérium Bovis, Staphylococcus aureus, Micrococcus flavus et la croissance de tumeurs animales comme la leucémie L1210 chez les souris. Selon l'invention, les composés sont produits par fermentation d'un microorganisme appartenant à l'espèce Streptomyces et par conversion enzymatique ou chimique de l'aclacynomycine A, MA144-N1, MA144-M1, MA144-M2, la cinérubine A, MA144-Y, MA144-G1, MA144-G2, MA144-U1, MA144-U2, ou la rhodirubine A. La courbe jointe donne le spectre d'adsorption ultraviolet et de la lumière visible de MA144-G1 dans 90 % de méthanol. L'invention s'applique notamment à l'industrie pharmaceutique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12023776A JPS5344555A (en) | 1976-10-05 | 1976-10-05 | Anthracyclin.glycoside antibiotics |
JP6090877A JPS5463067A (en) | 1977-05-24 | 1977-05-24 | Oncostatic drugs and their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2403350A1 true FR2403350A1 (fr) | 1979-04-13 |
FR2403350B1 FR2403350B1 (fr) | 1981-04-30 |
Family
ID=26401967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7729595A Granted FR2403350A1 (fr) | 1976-10-05 | 1977-09-30 | Nouvelle anthracycline antibiotique contre les tumeurs |
Country Status (18)
Country | Link |
---|---|
US (2) | US4207313A (fr) |
AU (1) | AU505971B2 (fr) |
CA (1) | CA1100895A (fr) |
CH (1) | CH637160A5 (fr) |
DE (1) | DE2743654B2 (fr) |
DK (1) | DK145200C (fr) |
ES (1) | ES471823A1 (fr) |
FI (1) | FI57444C (fr) |
FR (1) | FR2403350A1 (fr) |
GB (1) | GB1589536A (fr) |
GR (1) | GR63996B (fr) |
HU (1) | HU181999B (fr) |
IE (1) | IE46236B1 (fr) |
LU (1) | LU78242A1 (fr) |
NL (1) | NL176004C (fr) |
NO (2) | NO148959C (fr) |
SE (1) | SE425798B (fr) |
YU (1) | YU40483B (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2398111A1 (fr) * | 1977-07-18 | 1979-02-16 | Bristol Myers Co | Nouvel antibiotique du type anthracycline produit par fermentation, son procede de production et medicament le contenant |
EP0022574A1 (fr) * | 1979-07-13 | 1981-01-21 | Sanraku-Ocean Co., Ltd. | Antibiotiques appartenant au groupe rhodomycine et procédé pour leur préparation |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5543012A (en) * | 1978-09-20 | 1980-03-26 | Sanraku Inc | Novel anthracycline derivatine and its preparation |
JPS5648893A (en) * | 1979-09-07 | 1981-05-02 | Sanraku Inc | Preparation of anthracycline glycoside |
DE3071391D1 (en) * | 1979-09-07 | 1986-03-13 | Sanraku Ocean Co | 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same |
CH648327A5 (de) * | 1980-10-16 | 1985-03-15 | Hoffmann La Roche | Anthracycline. |
JPS5874694A (ja) * | 1981-10-29 | 1983-05-06 | Sanraku Inc | アントラサイクリン誘導体 |
JPS5995891A (ja) * | 1982-11-26 | 1984-06-02 | Kitasato Inst:The | 新規な制癌性抗生物質80−217およびその製造法 |
JPS61236792A (ja) * | 1985-04-12 | 1986-10-22 | Sanraku Inc | 新規アントラサイクリン抗生物質 |
DE3524117A1 (de) * | 1985-07-05 | 1987-02-05 | Hoechst Ag | Neue anthracyclin-tetrasaccharide, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatik |
DE3641833A1 (de) * | 1986-12-08 | 1988-06-09 | Behringwerke Ag | Zytostatisch wirksame anthracyclinderivate |
US5013549A (en) * | 1989-02-16 | 1991-05-07 | Board Of Trustees Operating Michigan State University | Production, isolation, and identification of novel antifungal compounds |
US4977084A (en) * | 1989-02-16 | 1990-12-11 | Board Of Trustees Operating Michigan State University | Production, isolation, and identification of novel antifungal compounds |
US5066585A (en) * | 1990-07-09 | 1991-11-19 | Board Of Trustees Operating Michigan State University | Method of inhibiting fungus using novel antifungal compounds |
KR970000591B1 (ko) * | 1993-09-03 | 1997-01-14 | 동국제약 주식회사 | 신균주 스트렙토마이세스 라벤도폴리아 DKRS 및 이를 이용한 아클라시노마이신 A, B, Y 및 아글리콘(Aglycone)의 제조방법 |
US6589591B1 (en) * | 2001-07-10 | 2003-07-08 | Baylor College Of Medicine | Method for treating medical devices using glycerol and an antimicrobial agent |
US20040256561A1 (en) * | 2003-06-17 | 2004-12-23 | Allyson Beuhler | Wide band light sensing pixel array |
US20050059156A1 (en) * | 2003-08-06 | 2005-03-17 | Pharmacia Italia S.P.A. | Method for detecting contaminants in pharmaceutical products |
AU2005231417A1 (en) * | 2004-04-02 | 2005-10-20 | Baylor College Of Medicine | Novel modification of medical prostheses |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2227867A1 (fr) * | 1973-05-02 | 1974-11-29 | Farmaceutici Italia | |
FR2279413A1 (fr) * | 1974-07-27 | 1976-02-20 | Microbial Chem Res Found | Antibiotiques anti-tumoraux denommes aclacinomycines a et b |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB846130A (en) | 1956-03-23 | 1960-08-24 | Ciba Ltd | New antibiotic and derivatives and salts thereof, preparations containing the same and process for the manufacture of these substances |
US3092550A (en) * | 1957-10-29 | 1963-06-04 | Ciba Geigy Corp | Antibiotic danubomycin and process for its manufacture |
CH362490A (de) | 1957-10-29 | 1962-06-15 | Ciba Geigy | Verfahren zur Herstellung eines neuen Antibiotikums |
FR1533151A (fr) | 1962-05-18 | 1968-07-19 | Rhone Poulenc Sa | Nouvel antibiotique et sa préparation |
FR1527892A (fr) | 1967-03-15 | 1968-06-07 | Rhone Poulenc Sa | Nouveau procédé de préparation de l'antibiotique 13057 r.p. |
YU33730B (en) * | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
US3803124A (en) * | 1968-04-12 | 1974-04-09 | Farmaceutici It Soc | Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives |
US3686163A (en) * | 1968-05-14 | 1972-08-22 | Farmaceutici Italia | Dihydrodaunomycin antibiotic and derivatives thereof |
FR1593235A (fr) | 1968-11-18 | 1970-05-25 | ||
US3616624A (en) * | 1969-11-04 | 1971-11-02 | Becton Dickinson Co | Laminar flow work bench |
US3828021A (en) * | 1972-06-14 | 1974-08-06 | Merck & Co Inc | Gentamicin c1 derivatives |
GB1426637A (en) | 1973-12-04 | 1976-03-03 | Vnii Izyskaniju Novykh Antibio | Manthracyclic antibiotic and a method of production thereof |
US3864480A (en) * | 1974-05-06 | 1975-02-04 | Merck & Co Inc | Cinerubin A and B As Antiparasitic Agents |
US4009328A (en) * | 1975-05-02 | 1977-02-22 | Schering Corporation | Aminoglycoside 66-40C, method for its manufacture, method for its use as an intermediate in the preparation of known antibiotics and novel antibacterials |
JPS5231051A (en) * | 1975-09-03 | 1977-03-09 | Kowa Co | Preparation of amino sugar derivatives |
US4039736A (en) * | 1976-04-15 | 1977-08-02 | Bristol-Myers Company | Antibiotic compounds marcellomycin and musettamycin |
-
1977
- 1977-09-22 NL NLAANVRAGE7710380,A patent/NL176004C/xx not_active IP Right Cessation
- 1977-09-22 CH CH1159577A patent/CH637160A5/fr not_active IP Right Cessation
- 1977-09-28 DE DE2743654A patent/DE2743654B2/de active Granted
- 1977-09-30 SE SE7710972A patent/SE425798B/xx not_active IP Right Cessation
- 1977-09-30 NO NO773353A patent/NO148959C/no unknown
- 1977-09-30 CA CA287,886A patent/CA1100895A/fr not_active Expired
- 1977-09-30 FR FR7729595A patent/FR2403350A1/fr active Granted
- 1977-09-30 DK DK435577A patent/DK145200C/da not_active IP Right Cessation
- 1977-09-30 IE IE2007/77A patent/IE46236B1/en unknown
- 1977-09-30 HU HU77ZA402A patent/HU181999B/hu not_active IP Right Cessation
- 1977-10-03 GB GB41047/77A patent/GB1589536A/en not_active Expired
- 1977-10-03 YU YU2352/77A patent/YU40483B/xx unknown
- 1977-10-03 US US05/838,617 patent/US4207313A/en not_active Expired - Lifetime
- 1977-10-03 GR GR54487A patent/GR63996B/el unknown
- 1977-10-03 FI FI772915A patent/FI57444C/fi not_active IP Right Cessation
- 1977-10-04 LU LU78242A patent/LU78242A1/xx unknown
- 1977-10-04 AU AU29337/77A patent/AU505971B2/en not_active Expired
-
1978
- 1978-06-05 NO NO78781949A patent/NO147953C/no unknown
- 1978-07-17 ES ES471823A patent/ES471823A1/es not_active Expired
-
1979
- 1979-05-10 US US06/037,804 patent/US4245045A/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2227867A1 (fr) * | 1973-05-02 | 1974-11-29 | Farmaceutici Italia | |
FR2279413A1 (fr) * | 1974-07-27 | 1976-02-20 | Microbial Chem Res Found | Antibiotiques anti-tumoraux denommes aclacinomycines a et b |
Non-Patent Citations (1)
Title |
---|
NV2321/77 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2398111A1 (fr) * | 1977-07-18 | 1979-02-16 | Bristol Myers Co | Nouvel antibiotique du type anthracycline produit par fermentation, son procede de production et medicament le contenant |
EP0022574A1 (fr) * | 1979-07-13 | 1981-01-21 | Sanraku-Ocean Co., Ltd. | Antibiotiques appartenant au groupe rhodomycine et procédé pour leur préparation |
Also Published As
Publication number | Publication date |
---|---|
NL176004C (nl) | 1985-02-01 |
HU181999B (en) | 1983-11-28 |
AU505971B2 (en) | 1979-12-06 |
NL7710380A (nl) | 1978-04-07 |
DK145200C (da) | 1983-02-28 |
LU78242A1 (fr) | 1978-01-26 |
FI57444C (fi) | 1980-08-11 |
SE425798B (sv) | 1982-11-08 |
YU235277A (en) | 1982-06-30 |
IE46236L (en) | 1978-04-05 |
GR63996B (en) | 1980-01-18 |
GB1589536A (en) | 1981-05-13 |
DE2743654A1 (de) | 1978-04-06 |
DK435577A (da) | 1978-04-06 |
NO147953B (no) | 1983-04-05 |
CA1100895A (fr) | 1981-05-12 |
DK145200B (da) | 1982-10-04 |
FI57444B (fi) | 1980-04-30 |
US4207313A (en) | 1980-06-10 |
FI772915A (fi) | 1978-04-06 |
NL176004B (nl) | 1984-09-03 |
NO148959C (no) | 1984-01-18 |
US4245045A (en) | 1981-01-13 |
NO147953C (no) | 1983-07-20 |
FR2403350B1 (fr) | 1981-04-30 |
DE2743654B2 (de) | 1979-12-13 |
AU2933777A (en) | 1979-04-12 |
NO148959B (no) | 1983-10-10 |
NO781949L (no) | 1978-04-06 |
IE46236B1 (en) | 1983-04-06 |
NO773353L (no) | 1978-04-06 |
ES471823A1 (es) | 1979-02-01 |
DE2743654C3 (fr) | 1980-08-21 |
YU40483B (en) | 1986-02-28 |
SE7710972L (sv) | 1978-04-06 |
CH637160A5 (fr) | 1983-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |