FR2402655A1 - FLAVON PREPARATION PROCESS - Google Patents

FLAVON PREPARATION PROCESS

Info

Publication number
FR2402655A1
FR2402655A1 FR7825878A FR7825878A FR2402655A1 FR 2402655 A1 FR2402655 A1 FR 2402655A1 FR 7825878 A FR7825878 A FR 7825878A FR 7825878 A FR7825878 A FR 7825878A FR 2402655 A1 FR2402655 A1 FR 2402655A1
Authority
FR
France
Prior art keywords
flavon
preparation process
isolation
prepared
hesperdidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7825878A
Other languages
French (fr)
Other versions
FR2402655B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of FR2402655A1 publication Critical patent/FR2402655A1/en
Application granted granted Critical
Publication of FR2402655B1 publication Critical patent/FR2402655B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Flavones are prepared by dissolving a flavanone in a basic solvent, dehydrogenating without isolation of an intermediate using iodine and then isolation of the flavone formed. Preferably, diosmin is prepared from hesperdidin. The process is easy to carry out and gives the final products in high yield and great purity.
FR7825878A 1977-09-10 1978-09-08 FLAVON PREPARATION PROCESS Granted FR2402655A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772740950 DE2740950A1 (en) 1977-09-10 1977-09-10 METHOD OF MANUFACTURING FLAVONS

Publications (2)

Publication Number Publication Date
FR2402655A1 true FR2402655A1 (en) 1979-04-06
FR2402655B1 FR2402655B1 (en) 1983-01-28

Family

ID=6018705

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7825878A Granted FR2402655A1 (en) 1977-09-10 1978-09-08 FLAVON PREPARATION PROCESS

Country Status (5)

Country Link
CH (1) CH636869A5 (en)
DE (1) DE2740950A1 (en)
ES (1) ES473195A1 (en)
FR (1) FR2402655A1 (en)
IT (1) IT1107693B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052086A1 (en) * 1980-11-11 1982-05-19 BONOMELLI S.p.A. Process for producing flavone derivatives with medicinal activity
FR2782518A1 (en) * 1998-08-19 2000-02-25 Innokem Sarl Preparation of vasotropic diosmin from hesperidin by anhydrous reaction with iodine and pyridine with solid mineral base
EP1086953A1 (en) * 1999-09-24 2001-03-28 Isochem Process for the purification of diosmine

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ193316A (en) * 1979-04-10 1984-07-31 Hoffmann La Roche 3-alkoxyflavone derivatives and pharmaceutical compositions
AU8045382A (en) * 1981-12-14 1983-06-23 Pennwalt Corp. Chromones
WO2010092592A2 (en) * 2009-02-11 2010-08-19 Elder Pharmaceuticals Ltd. Process for the preparation of diosmin
CN102875621A (en) * 2012-10-26 2013-01-16 成都澜绮制药有限公司 Synthesis method of diosmin
CN103833810A (en) * 2014-02-12 2014-06-04 李玉山 New preparation technology of apigenin-7-neohesperidoside
EP3053930A1 (en) * 2015-02-03 2016-08-10 Interquim, S.A. Process for the preparation of diosmin
CN113583063A (en) * 2021-08-18 2021-11-02 陕西嘉禾生物科技股份有限公司 Method for synthesizing cosmosiin by using naringin
CN114306363B (en) * 2022-01-05 2022-11-08 成都亚中生物制药有限责任公司 Method for industrially preparing citrus flavone bulk drug

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES465156A1 (en) * 1977-12-16 1978-10-01 Merck Quimica S A Procedure for preparing glycosides with an unsaturated aglicon. (Machine-translation by Google Translate, not legally binding)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052086A1 (en) * 1980-11-11 1982-05-19 BONOMELLI S.p.A. Process for producing flavone derivatives with medicinal activity
FR2782518A1 (en) * 1998-08-19 2000-02-25 Innokem Sarl Preparation of vasotropic diosmin from hesperidin by anhydrous reaction with iodine and pyridine with solid mineral base
WO2000011009A2 (en) * 1998-08-19 2000-03-02 Innokem, S.A.R.L. Method for industrial production of diosmin from hesperidin by reaction with iodine and pyridine
WO2000011009A3 (en) * 1998-08-19 2000-06-29 Innokem Sarl Method for industrial production of diosmin from hesperidin by reaction with iodine and pyridine
EP1086953A1 (en) * 1999-09-24 2001-03-28 Isochem Process for the purification of diosmine
FR2798932A1 (en) * 1999-09-24 2001-03-30 Isochem Sa DIOSMINE PURIFICATION PROCESS

Also Published As

Publication number Publication date
DE2740950A1 (en) 1979-03-22
IT7851027A0 (en) 1978-09-08
IT1107693B (en) 1985-11-25
DE2740950C2 (en) 1987-10-22
CH636869A5 (en) 1983-06-30
FR2402655B1 (en) 1983-01-28
ES473195A1 (en) 1979-11-16

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Legal Events

Date Code Title Description
ST Notification of lapse