FR2401134A1 - PROCESS FOR THE PREPARATION OF THYMOSIN A1 AND AN ANALOGUE - Google Patents
PROCESS FOR THE PREPARATION OF THYMOSIN A1 AND AN ANALOGUEInfo
- Publication number
- FR2401134A1 FR2401134A1 FR7811686A FR7811686A FR2401134A1 FR 2401134 A1 FR2401134 A1 FR 2401134A1 FR 7811686 A FR7811686 A FR 7811686A FR 7811686 A FR7811686 A FR 7811686A FR 2401134 A1 FR2401134 A1 FR 2401134A1
- Authority
- FR
- France
- Prior art keywords
- glu
- asn
- thr
- lys
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne la synthèse de la thymosine alpha 1 . Il s'agit d'un procédé pour la préparation de thymosine alpha 1 ou de son analogue (Asn**2) et de leurs sels pharmaceutiquement acceptables, selon lequel on élimine les groupes protecteurs d'un octacosapeptide protégé de la séquence : H3 C - CO - Ser(R**1) - X - Ala - Ala- Val - Asp(OR**2) -Thr(R**3) - Ser(R**1) - Ser(R**1) - Glu(OR**4) - Ile - Thr(R** 3) - Thr(R**3) - Lys(R**5) - As- p(OR**2) - Leu - Lys(R** 5) - Glu(OR**4) - Lys(R**5) - Glu(OR**4)- Val - Val - Glu(OR** 4) - Glu(OR**4) - Ala - Glu(OR**4) - Asn - OR**6 où X est Asn ou Asp(OR**2); et R1 , R2 , R3 , R 4 , R5 et R6 sont des groupes protecteurs. Le peptide obtenu est un immuno-stimulateur.The invention relates to the synthesis of thymosin alpha 1. This is a process for the preparation of thymosin alpha 1 or its analogue (Asn ** 2) and their pharmaceutically acceptable salts, according to which the protective groups of a protected octacosapeptide of the sequence: H3 C are removed - CO - Ser (R ** 1) - X - Ala - Ala- Val - Asp (OR ** 2) -Thr (R ** 3) - Ser (R ** 1) - Ser (R ** 1) - Glu (OR ** 4) - Ile - Thr (R ** 3) - Thr (R ** 3) - Lys (R ** 5) - As- p (OR ** 2) - Leu - Lys (R ** 5) - Glu (OR ** 4) - Lys (R ** 5) - Glu (OR ** 4) - Val - Val - Glu (OR ** 4) - Glu (OR ** 4) - Ala - Glu (OR ** 4) - Asn - OR ** 6 where X is Asn or Asp (OR ** 2); and R1, R2, R3, R 4, R5 and R6 are protecting groups. The peptide obtained is an immunostimulator.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78989877A | 1977-04-22 | 1977-04-22 | |
US05/871,563 US4116951A (en) | 1977-04-22 | 1978-01-23 | [Asn2 ]-thymosin α1 and analogs thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2401134A1 true FR2401134A1 (en) | 1979-03-23 |
FR2401134B1 FR2401134B1 (en) | 1983-09-30 |
Family
ID=27120967
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7811686A Granted FR2401134A1 (en) | 1977-04-22 | 1978-04-20 | PROCESS FOR THE PREPARATION OF THYMOSIN A1 AND AN ANALOGUE |
FR7835404A Granted FR2405926A1 (en) | 1977-04-22 | 1978-12-15 | (ASN2) -THYMOSIN A1 AND METHOD OF PREPARATION |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7835404A Granted FR2405926A1 (en) | 1977-04-22 | 1978-12-15 | (ASN2) -THYMOSIN A1 AND METHOD OF PREPARATION |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS53137914A (en) |
AT (1) | AT364470B (en) |
CA (1) | CA1113088A (en) |
CH (3) | CH641152A5 (en) |
DE (1) | DE2817082A1 (en) |
DK (1) | DK147918C (en) |
ES (1) | ES469016A1 (en) |
FI (1) | FI781241A (en) |
FR (2) | FR2401134A1 (en) |
GB (1) | GB1590668A (en) |
GR (1) | GR71886B (en) |
HU (1) | HU180783B (en) |
IT (1) | IT1113134B (en) |
LU (1) | LU79488A1 (en) |
NL (1) | NL7804364A (en) |
NO (2) | NO781404L (en) |
PT (1) | PT67937B (en) |
SE (1) | SE447262B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4116951A (en) * | 1977-04-22 | 1978-09-26 | Hoffmann-La Roche Inc. | [Asn2 ]-thymosin α1 and analogs thereof |
DE2919592A1 (en) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | METHOD FOR PRODUCING THYMOSINE ALPHA 1 AND DERIVATIVES THEREOF |
EP0033384B1 (en) * | 1980-01-18 | 1984-02-15 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Medicaments containing fragments of thymosin-alpha-1 with immunostimulating activity, and thymosin-alpha-1 fragments |
US4339427A (en) * | 1980-04-14 | 1982-07-13 | Hoffmann-La Roche Inc. | Radioimmunoassay of thymosinα |
EP0056594B1 (en) * | 1981-01-14 | 1984-09-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Thymosin-alpha-1 fragments and pharmaceutical compositions with immunoregulating action containing them |
CN1058500C (en) * | 1993-02-03 | 2000-11-15 | 施塞克龙药品公司 | Thymosin alpha-1 derivatives |
US6262230B1 (en) * | 1994-01-28 | 2001-07-17 | Sciclone Pharmaceuticals Inc. | Analogs of thymosin α1 |
-
1978
- 1978-04-17 CH CH408878A patent/CH641152A5/en not_active IP Right Cessation
- 1978-04-18 DK DK169478A patent/DK147918C/en not_active IP Right Cessation
- 1978-04-19 DE DE19782817082 patent/DE2817082A1/en not_active Ceased
- 1978-04-20 FR FR7811686A patent/FR2401134A1/en active Granted
- 1978-04-20 GR GR56036A patent/GR71886B/el unknown
- 1978-04-21 NO NO781404A patent/NO781404L/en unknown
- 1978-04-21 PT PT67937A patent/PT67937B/en unknown
- 1978-04-21 CA CA301,643A patent/CA1113088A/en not_active Expired
- 1978-04-21 IT IT22629/78A patent/IT1113134B/en active
- 1978-04-21 AT AT0286178A patent/AT364470B/en not_active IP Right Cessation
- 1978-04-21 JP JP4673978A patent/JPS53137914A/en active Pending
- 1978-04-21 LU LU79488A patent/LU79488A1/en unknown
- 1978-04-21 HU HU78HO2067A patent/HU180783B/en unknown
- 1978-04-21 GB GB1574/78A patent/GB1590668A/en not_active Expired
- 1978-04-21 FI FI781241A patent/FI781241A/en not_active Application Discontinuation
- 1978-04-21 ES ES469016A patent/ES469016A1/en not_active Expired
- 1978-04-21 SE SE7804612A patent/SE447262B/en not_active IP Right Cessation
- 1978-04-24 NL NL7804364A patent/NL7804364A/en not_active Application Discontinuation
- 1978-12-15 FR FR7835404A patent/FR2405926A1/en active Granted
-
1982
- 1982-05-13 NO NO821608A patent/NO148924C/en unknown
- 1982-11-05 CH CH645082A patent/CH641153A5/en not_active IP Right Cessation
- 1982-11-05 CH CH644982A patent/CH640218A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATA286178A (en) | 1981-03-15 |
IT7822629A0 (en) | 1978-04-21 |
PT67937B (en) | 1980-04-07 |
JPS53137914A (en) | 1978-12-01 |
CA1113088A (en) | 1981-11-24 |
CH641153A5 (en) | 1984-02-15 |
SE447262B (en) | 1986-11-03 |
DK147918B (en) | 1985-01-07 |
FR2401134B1 (en) | 1983-09-30 |
NO821608L (en) | 1978-10-24 |
GR71886B (en) | 1983-08-04 |
NO148924B (en) | 1983-10-03 |
GB1590668A (en) | 1981-06-03 |
DE2817082A1 (en) | 1978-11-02 |
NO148924C (en) | 1984-01-11 |
SE7804612L (en) | 1978-12-20 |
DK147918C (en) | 1985-08-19 |
LU79488A1 (en) | 1979-05-25 |
NL7804364A (en) | 1978-10-24 |
FI781241A (en) | 1978-10-23 |
FR2405926A1 (en) | 1979-05-11 |
NO781404L (en) | 1978-10-24 |
IT1113134B (en) | 1986-01-20 |
PT67937A (en) | 1978-05-01 |
AT364470B (en) | 1981-10-27 |
HU180783B (en) | 1983-04-29 |
ES469016A1 (en) | 1980-01-01 |
DK169478A (en) | 1978-10-23 |
FR2405926B1 (en) | 1983-09-09 |
CH640218A5 (en) | 1983-12-30 |
CH641152A5 (en) | 1984-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |