FR2399414A1 - Beta-blocking aminopropoxy benzimidazole(s) - for treating cardiovascular disorders and hypertension - Google Patents

Beta-blocking aminopropoxy benzimidazole(s) - for treating cardiovascular disorders and hypertension

Info

Publication number
FR2399414A1
FR2399414A1 FR7812492A FR7812492A FR2399414A1 FR 2399414 A1 FR2399414 A1 FR 2399414A1 FR 7812492 A FR7812492 A FR 7812492A FR 7812492 A FR7812492 A FR 7812492A FR 2399414 A1 FR2399414 A1 FR 2399414A1
Authority
FR
France
Prior art keywords
beta
butylamino
cardiovascular disorders
treating cardiovascular
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7812492A
Other languages
French (fr)
Inventor
Roger Edward Markwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB18438/77A external-priority patent/GB1595316A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2399414A1 publication Critical patent/FR2399414A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Benzimidazoles of formula (I) and their acid-addition salts are new:- In the formula, R' is H, alkyl or cycloalkyl; R2 is alkyl or cycloalkyl; R3 is H, primary or secondary alkyl; Y is O or S; also new are the tautomeric thiols of (I) when Y is S. 16 Cpds. are specifically claimed 4-(2-hydroxy-3-methylaminopropoxy)-2-benzimidazolinone and 1-t-butylamino-3-(2-mercapto-7-methyl-4-benzimidazolyloxy)-2-prop- anol. (I) are beta-blockers with low intrinsic stimulating activity for treating cardiovascular disorders, also having antihypertensive activity. Daily adult dose 5-100 mg. A typical cpd., 4-(3-t-butylamino-2-hydroxypropoxy)-2-benzimidazolinone hydrochloride, was prepd. in 56.3% yield by hydrogenation of 1-t-butylamino-3-(2,3-dinitrophenoxy)-2-propanol and treating the diamino prod. with phosgene.
FR7812492A 1977-05-03 1978-04-27 Beta-blocking aminopropoxy benzimidazole(s) - for treating cardiovascular disorders and hypertension Pending FR2399414A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB18438/77A GB1595316A (en) 1977-05-03 1977-05-03 4-(3-amino-2-hydroxy-propoxy)-benzimidazole derivatives and pharmaceutical compositions containing them
GB4915677 1977-11-25
GB220878 1978-01-19

Publications (1)

Publication Number Publication Date
FR2399414A1 true FR2399414A1 (en) 1979-03-02

Family

ID=27254036

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7812492A Pending FR2399414A1 (en) 1977-05-03 1978-04-27 Beta-blocking aminopropoxy benzimidazole(s) - for treating cardiovascular disorders and hypertension

Country Status (18)

Country Link
JP (1) JPS53135979A (en)
AR (2) AR220335A1 (en)
AU (1) AU3569678A (en)
DE (1) DE2819458A1 (en)
DK (1) DK190378A (en)
ES (1) ES469353A1 (en)
FI (1) FI781349A (en)
FR (1) FR2399414A1 (en)
GR (1) GR73669B (en)
IL (1) IL54591A0 (en)
IT (1) IT1096276B (en)
LU (1) LU79591A1 (en)
MC (1) MC1192A1 (en)
NL (1) NL7804794A (en)
NO (1) NO781556L (en)
NZ (1) NZ187066A (en)
PT (1) PT67980A (en)
SE (1) SE7805140L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003758A1 (en) * 1978-02-09 1979-09-05 Ciba-Geigy Ag Etherified hydroxy-benzodiheterocycles and their acid addition salts, process for their preparation and pharmaceutical compositions containing them
FR2520358A1 (en) * 1982-01-26 1983-07-29 Oreal NEW COMPOUNDS FOR HAIR STYLING, PROCESS FOR THEIR PREPARATION, DYE COMPOSITION CONTAINING SAME, AND METHOD FOR DYING HAIR CORRESPONDING

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801980A1 (en) 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-HYDROXY-2-BENZIMIDAZOLINE-THIONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE2905877A1 (en) * 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3839743A1 (en) * 1988-11-25 1990-05-31 Hoechst Ag METHOD FOR PRODUCING BENZIMIDAZOLONES
US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4161M (en) * 1963-07-30 1966-05-16
FR2113192A5 (en) * 1970-10-23 1972-06-23 Hoechst Ag
FR2306696A1 (en) * 1975-04-09 1976-11-05 Abbott Lab NEW MEDICINAL PRODUCTS USEFUL IN PARTICULAR AS AGENTS BLOCKING B-ADRENERGIC RECEPTORS AND THEIR PREPARATION PROCESS
FR2337718A1 (en) * 1976-01-08 1977-08-05 Ciba Geigy Ag NEW ETHERIFIED HYDROXY-BENZODIHETEROCYCLES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4161M (en) * 1963-07-30 1966-05-16
FR2113192A5 (en) * 1970-10-23 1972-06-23 Hoechst Ag
FR2306696A1 (en) * 1975-04-09 1976-11-05 Abbott Lab NEW MEDICINAL PRODUCTS USEFUL IN PARTICULAR AS AGENTS BLOCKING B-ADRENERGIC RECEPTORS AND THEIR PREPARATION PROCESS
FR2337718A1 (en) * 1976-01-08 1977-08-05 Ciba Geigy Ag NEW ETHERIFIED HYDROXY-BENZODIHETEROCYCLES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003758A1 (en) * 1978-02-09 1979-09-05 Ciba-Geigy Ag Etherified hydroxy-benzodiheterocycles and their acid addition salts, process for their preparation and pharmaceutical compositions containing them
FR2520358A1 (en) * 1982-01-26 1983-07-29 Oreal NEW COMPOUNDS FOR HAIR STYLING, PROCESS FOR THEIR PREPARATION, DYE COMPOSITION CONTAINING SAME, AND METHOD FOR DYING HAIR CORRESPONDING
AT387212B (en) * 1982-01-26 1988-12-27 Oreal METHOD FOR PRODUCING PARTLY NEW AMINOPHENOXYPROPANOLAMINES, COLORING AGENTS THAT CONTAIN IT AND METHOD FOR COLORING HAIR

Also Published As

Publication number Publication date
IL54591A0 (en) 1978-07-31
AR219173A1 (en) 1980-07-31
FI781349A (en) 1978-11-04
LU79591A1 (en) 1979-06-13
PT67980B (en) 1980-05-05
NO781556L (en) 1978-11-06
GR73669B (en) 1984-03-28
AU3569678A (en) 1979-11-08
IT7823000A0 (en) 1978-05-03
NL7804794A (en) 1978-11-07
JPS53135979A (en) 1978-11-28
NZ187066A (en) 1981-02-11
DK190378A (en) 1978-11-04
IT1096276B (en) 1985-08-26
AR220335A1 (en) 1980-10-31
SE7805140L (en) 1978-11-04
DE2819458A1 (en) 1978-11-16
ES469353A1 (en) 1980-01-01
MC1192A1 (en) 1979-02-23
PT67980A (en) 1978-06-01

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