FR2399414A1 - Beta-blocking aminopropoxy benzimidazole(s) - for treating cardiovascular disorders and hypertension - Google Patents
Beta-blocking aminopropoxy benzimidazole(s) - for treating cardiovascular disorders and hypertensionInfo
- Publication number
- FR2399414A1 FR2399414A1 FR7812492A FR7812492A FR2399414A1 FR 2399414 A1 FR2399414 A1 FR 2399414A1 FR 7812492 A FR7812492 A FR 7812492A FR 7812492 A FR7812492 A FR 7812492A FR 2399414 A1 FR2399414 A1 FR 2399414A1
- Authority
- FR
- France
- Prior art keywords
- beta
- butylamino
- cardiovascular disorders
- treating cardiovascular
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Benzimidazoles of formula (I) and their acid-addition salts are new:- In the formula, R' is H, alkyl or cycloalkyl; R2 is alkyl or cycloalkyl; R3 is H, primary or secondary alkyl; Y is O or S; also new are the tautomeric thiols of (I) when Y is S. 16 Cpds. are specifically claimed 4-(2-hydroxy-3-methylaminopropoxy)-2-benzimidazolinone and 1-t-butylamino-3-(2-mercapto-7-methyl-4-benzimidazolyloxy)-2-prop- anol. (I) are beta-blockers with low intrinsic stimulating activity for treating cardiovascular disorders, also having antihypertensive activity. Daily adult dose 5-100 mg. A typical cpd., 4-(3-t-butylamino-2-hydroxypropoxy)-2-benzimidazolinone hydrochloride, was prepd. in 56.3% yield by hydrogenation of 1-t-butylamino-3-(2,3-dinitrophenoxy)-2-propanol and treating the diamino prod. with phosgene.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB18438/77A GB1595316A (en) | 1977-05-03 | 1977-05-03 | 4-(3-amino-2-hydroxy-propoxy)-benzimidazole derivatives and pharmaceutical compositions containing them |
GB4915677 | 1977-11-25 | ||
GB220878 | 1978-01-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2399414A1 true FR2399414A1 (en) | 1979-03-02 |
Family
ID=27254036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7812492A Pending FR2399414A1 (en) | 1977-05-03 | 1978-04-27 | Beta-blocking aminopropoxy benzimidazole(s) - for treating cardiovascular disorders and hypertension |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS53135979A (en) |
AR (2) | AR220335A1 (en) |
AU (1) | AU3569678A (en) |
DE (1) | DE2819458A1 (en) |
DK (1) | DK190378A (en) |
ES (1) | ES469353A1 (en) |
FI (1) | FI781349A (en) |
FR (1) | FR2399414A1 (en) |
GR (1) | GR73669B (en) |
IL (1) | IL54591A0 (en) |
IT (1) | IT1096276B (en) |
LU (1) | LU79591A1 (en) |
MC (1) | MC1192A1 (en) |
NL (1) | NL7804794A (en) |
NO (1) | NO781556L (en) |
NZ (1) | NZ187066A (en) |
PT (1) | PT67980A (en) |
SE (1) | SE7805140L (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0003758A1 (en) * | 1978-02-09 | 1979-09-05 | Ciba-Geigy Ag | Etherified hydroxy-benzodiheterocycles and their acid addition salts, process for their preparation and pharmaceutical compositions containing them |
FR2520358A1 (en) * | 1982-01-26 | 1983-07-29 | Oreal | NEW COMPOUNDS FOR HAIR STYLING, PROCESS FOR THEIR PREPARATION, DYE COMPOSITION CONTAINING SAME, AND METHOD FOR DYING HAIR CORRESPONDING |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2801980A1 (en) | 1978-01-18 | 1979-07-19 | Boehringer Mannheim Gmbh | 4-HYDROXY-2-BENZIMIDAZOLINE-THIONE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE2905877A1 (en) * | 1979-02-16 | 1980-08-28 | Boehringer Mannheim Gmbh | NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE3839743A1 (en) * | 1988-11-25 | 1990-05-31 | Hoechst Ag | METHOD FOR PRODUCING BENZIMIDAZOLONES |
US9784726B2 (en) | 2013-01-08 | 2017-10-10 | Atrogi Ab | Screening method, a kit, a method of treatment and a compound for use in a method of treatment |
GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR4161M (en) * | 1963-07-30 | 1966-05-16 | ||
FR2113192A5 (en) * | 1970-10-23 | 1972-06-23 | Hoechst Ag | |
FR2306696A1 (en) * | 1975-04-09 | 1976-11-05 | Abbott Lab | NEW MEDICINAL PRODUCTS USEFUL IN PARTICULAR AS AGENTS BLOCKING B-ADRENERGIC RECEPTORS AND THEIR PREPARATION PROCESS |
FR2337718A1 (en) * | 1976-01-08 | 1977-08-05 | Ciba Geigy Ag | NEW ETHERIFIED HYDROXY-BENZODIHETEROCYCLES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
-
1978
- 1978-04-26 NZ NZ187066A patent/NZ187066A/en unknown
- 1978-04-27 FR FR7812492A patent/FR2399414A1/en active Pending
- 1978-04-27 IL IL54591A patent/IL54591A0/en unknown
- 1978-05-02 PT PT67980A patent/PT67980A/en unknown
- 1978-05-02 FI FI781349A patent/FI781349A/en not_active Application Discontinuation
- 1978-05-02 JP JP5241778A patent/JPS53135979A/en active Pending
- 1978-05-02 ES ES469353A patent/ES469353A1/en not_active Expired
- 1978-05-02 MC MC781299A patent/MC1192A1/en unknown
- 1978-05-02 DK DK190378A patent/DK190378A/en not_active Application Discontinuation
- 1978-05-02 NO NO781556A patent/NO781556L/en unknown
- 1978-05-03 AU AU35696/78A patent/AU3569678A/en active Pending
- 1978-05-03 IT IT23000/78A patent/IT1096276B/en active
- 1978-05-03 SE SE7805140A patent/SE7805140L/en unknown
- 1978-05-03 LU LU79591A patent/LU79591A1/en unknown
- 1978-05-03 DE DE19782819458 patent/DE2819458A1/en not_active Withdrawn
- 1978-05-03 NL NL7804794A patent/NL7804794A/en not_active Application Discontinuation
- 1978-05-31 AR AR272019A patent/AR220335A1/en active
-
1979
- 1979-01-24 GR GR56130A patent/GR73669B/el unknown
- 1979-07-06 AR AR277226A patent/AR219173A1/en active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR4161M (en) * | 1963-07-30 | 1966-05-16 | ||
FR2113192A5 (en) * | 1970-10-23 | 1972-06-23 | Hoechst Ag | |
FR2306696A1 (en) * | 1975-04-09 | 1976-11-05 | Abbott Lab | NEW MEDICINAL PRODUCTS USEFUL IN PARTICULAR AS AGENTS BLOCKING B-ADRENERGIC RECEPTORS AND THEIR PREPARATION PROCESS |
FR2337718A1 (en) * | 1976-01-08 | 1977-08-05 | Ciba Geigy Ag | NEW ETHERIFIED HYDROXY-BENZODIHETEROCYCLES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0003758A1 (en) * | 1978-02-09 | 1979-09-05 | Ciba-Geigy Ag | Etherified hydroxy-benzodiheterocycles and their acid addition salts, process for their preparation and pharmaceutical compositions containing them |
FR2520358A1 (en) * | 1982-01-26 | 1983-07-29 | Oreal | NEW COMPOUNDS FOR HAIR STYLING, PROCESS FOR THEIR PREPARATION, DYE COMPOSITION CONTAINING SAME, AND METHOD FOR DYING HAIR CORRESPONDING |
AT387212B (en) * | 1982-01-26 | 1988-12-27 | Oreal | METHOD FOR PRODUCING PARTLY NEW AMINOPHENOXYPROPANOLAMINES, COLORING AGENTS THAT CONTAIN IT AND METHOD FOR COLORING HAIR |
Also Published As
Publication number | Publication date |
---|---|
IL54591A0 (en) | 1978-07-31 |
AR219173A1 (en) | 1980-07-31 |
FI781349A (en) | 1978-11-04 |
LU79591A1 (en) | 1979-06-13 |
PT67980B (en) | 1980-05-05 |
NO781556L (en) | 1978-11-06 |
GR73669B (en) | 1984-03-28 |
AU3569678A (en) | 1979-11-08 |
IT7823000A0 (en) | 1978-05-03 |
NL7804794A (en) | 1978-11-07 |
JPS53135979A (en) | 1978-11-28 |
NZ187066A (en) | 1981-02-11 |
DK190378A (en) | 1978-11-04 |
IT1096276B (en) | 1985-08-26 |
AR220335A1 (en) | 1980-10-31 |
SE7805140L (en) | 1978-11-04 |
DE2819458A1 (en) | 1978-11-16 |
ES469353A1 (en) | 1980-01-01 |
MC1192A1 (en) | 1979-02-23 |
PT67980A (en) | 1978-06-01 |
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