FR2393310A1 - Composition diagnostique liquide stabilisee contenant un phosphate et procede de preparation de celle-ci - Google Patents

Composition diagnostique liquide stabilisee contenant un phosphate et procede de preparation de celle-ci

Info

Publication number
FR2393310A1
FR2393310A1 FR7817693A FR7817693A FR2393310A1 FR 2393310 A1 FR2393310 A1 FR 2393310A1 FR 7817693 A FR7817693 A FR 7817693A FR 7817693 A FR7817693 A FR 7817693A FR 2393310 A1 FR2393310 A1 FR 2393310A1
Authority
FR
France
Prior art keywords
composition
phosphate
substrate
composition containing
stabilized liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7817693A
Other languages
English (en)
Other versions
FR2393310B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MODROVICH IVAN
Original Assignee
MODROVICH IVAN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MODROVICH IVAN filed Critical MODROVICH IVAN
Publication of FR2393310A1 publication Critical patent/FR2393310A1/fr
Application granted granted Critical
Publication of FR2393310B1 publication Critical patent/FR2393310B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/10—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases p-Nitrophenol derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention a pour objet une composition diagnostique liquide stabilisée contenant un phosphate, généralement un substrat phosphatique utilisable pour le dosage d'enzymes phosphatases alcaline et acide. La composition comprend en fait une composition tampon contenant un ion magnésium pour l'activation de l'enzyme et une composition de substrat, qui sont mélangés au moment du dosage. La composition tampon est d'un pH approprié de maniere que, lorsque la composition tampon et la composition de substrat sont mélangées, le mélange qui en résulte prenne le pH de la composition tampon. La substance stabilisante utilisé sera telle qu'elle empêche l'hydrolyse du phosphate à partir du substrat organique, par exemple le phénol et des composés phénoliques, l'imidazole et des composés aliphatiques nitrés ayant de un jusqu'à six atomes de carbone.
FR7817693A 1977-06-03 1978-06-05 Composition diagnostique liquide stabilisee contenant un phosphate et procede de preparation de celle-ci Granted FR2393310A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/803,036 US4132598A (en) 1977-06-03 1977-06-03 Stabilized liquid phosphate containing diagnostic compositions and method of preparing same

Publications (2)

Publication Number Publication Date
FR2393310A1 true FR2393310A1 (fr) 1978-12-29
FR2393310B1 FR2393310B1 (fr) 1982-10-22

Family

ID=25185401

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817693A Granted FR2393310A1 (fr) 1977-06-03 1978-06-05 Composition diagnostique liquide stabilisee contenant un phosphate et procede de preparation de celle-ci

Country Status (8)

Country Link
US (1) US4132598A (fr)
JP (1) JPS5412796A (fr)
CA (1) CA1110527A (fr)
CH (1) CH642456A5 (fr)
DE (1) DE2823824A1 (fr)
FR (1) FR2393310A1 (fr)
GB (1) GB1593949A (fr)
SE (1) SE447123B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1108964B (it) * 1978-01-20 1985-12-16 Sclavo Inst Sieroterapeut Composizione adatta all'analisi della fosfatasi alcalina e metodo utilizzante la stessa
DE3023485A1 (de) * 1980-06-24 1982-01-07 Merck Patent Gmbh, 6100 Darmstadt Verfahren und mittel sowie deren verwendung zur stabilisierung der alkalischen phosphatase
US4472499A (en) * 1982-01-22 1984-09-18 American Hoechst Corporation Reagents for the determination of enzymes
US4555484A (en) * 1983-07-25 1985-11-26 Eastman Kodak Company Analytical element and method for alkaline phosphatase assay
JPS60237999A (ja) * 1984-05-11 1985-11-26 Konishiroku Photo Ind Co Ltd アルカリホスフアタ−ゼ用乾式分析素子
JPS61110058A (ja) * 1984-11-02 1986-05-28 Fuji Photo Film Co Ltd アルカリ性ホスフアタ−ゼ活性測定用一体型多層分析要素
DE4037764A1 (de) * 1990-11-28 1992-06-04 Behringwerke Ag Waschloesung fuer festphasen-immunometrische verfahren, die stabilisatoren fuer das markierungssystem enthaelt und ihre verwendung
US7001717B2 (en) * 2003-12-05 2006-02-21 Biofx Laboratories, Inc. Charcoal stabilization of phenyl phosphates

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3466306A (en) * 1965-08-06 1969-09-09 Warner Lambert Pharmaceutical Process for the stabilization of organic esters of phosphoric acid
GB1211721A (en) * 1966-11-14 1970-11-11 Smith Kline French Lab Laboratory reagent for assay of acid or alkaline phosphatase
US3595756A (en) * 1968-11-26 1971-07-27 Smith Kline French Lab Laboratory reagent for assay of alkaline phosphatase
BE849701A (fr) * 1976-03-26 1977-04-15 Werkwijze voor het bereiden van een gestabiliseerd conserveringsmiddel voor haematologische reagentia
FR2344568A1 (fr) * 1976-03-17 1977-10-14 Modrovich Ivan Procede de stabilisation d'un enzyme labile

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3540984A (en) * 1966-06-30 1970-11-17 Calbiochem Reagent material and method for creative kinase assay

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3466306A (en) * 1965-08-06 1969-09-09 Warner Lambert Pharmaceutical Process for the stabilization of organic esters of phosphoric acid
GB1211721A (en) * 1966-11-14 1970-11-11 Smith Kline French Lab Laboratory reagent for assay of acid or alkaline phosphatase
US3595756A (en) * 1968-11-26 1971-07-27 Smith Kline French Lab Laboratory reagent for assay of alkaline phosphatase
FR2344568A1 (fr) * 1976-03-17 1977-10-14 Modrovich Ivan Procede de stabilisation d'un enzyme labile
BE849701A (fr) * 1976-03-26 1977-04-15 Werkwijze voor het bereiden van een gestabiliseerd conserveringsmiddel voor haematologische reagentia
FR2345164A1 (fr) * 1976-03-26 1977-10-21 Coulter Diagnostics Inc Solutions reactives hematologiques stabilisees

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1948 *

Also Published As

Publication number Publication date
DE2823824A1 (de) 1978-12-07
CH642456A5 (fr) 1984-04-13
DE2823824C2 (fr) 1989-12-28
US4132598A (en) 1979-01-02
SE7805887L (sv) 1978-12-04
JPS5412796A (en) 1979-01-30
JPS5618199B2 (fr) 1981-04-27
SE447123B (sv) 1986-10-27
FR2393310B1 (fr) 1982-10-22
GB1593949A (en) 1981-07-22
CA1110527A (fr) 1981-10-13

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