FR2387242A1 - Compositions purifiees d'urokinase et procede pour leur obtention - Google Patents
Compositions purifiees d'urokinase et procede pour leur obtentionInfo
- Publication number
- FR2387242A1 FR2387242A1 FR7711004A FR7711004A FR2387242A1 FR 2387242 A1 FR2387242 A1 FR 2387242A1 FR 7711004 A FR7711004 A FR 7711004A FR 7711004 A FR7711004 A FR 7711004A FR 2387242 A1 FR2387242 A1 FR 2387242A1
- Authority
- FR
- France
- Prior art keywords
- urokinase
- ion
- isolated
- exchange chromatography
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 title abstract 8
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 title abstract 8
- 229960005356 urokinase Drugs 0.000 title abstract 8
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 238000004255 ion exchange chromatography Methods 0.000 title 1
- 230000002537 thrombolytic effect Effects 0.000 title 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- 108010051456 Plasminogen Proteins 0.000 abstract 1
- 102000013566 Plasminogen Human genes 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000000337 buffer salt Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003527 fibrinolytic agent Substances 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 108010087750 lysyl-plasminogen Proteins 0.000 abstract 1
- 229960000103 thrombolytic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Urokinase de poids moléculaire de l'ordre de 54 000, sensiblement exempte d'une urokinase ayant un poids moléculaire de l'ordre de 33 000. L'urokinase de poids moléculaire de l'ordre de 54 000 est obtenue à partir d'une solution contenant cette urokinase de poids moléculaire de l'ordre de 54 000, une urokinase de poids moléculaire de l'ordre de 33 000 et un sel minéral, par un procédé comprenant la mise en contact de cette solution avec un gel ayant, du point de vue ionique, les caractéristiques d'une résine échangeuse d'ions, et permettant la fixation des deux types d'urokinase et les élutions des deux urokinases dans des conditions de développement permettant la séparation complète de l'urokinase de poids moléculaire 33 000. Application à la constitution de médicaments.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7711004A FR2387242A1 (fr) | 1977-04-12 | 1977-04-12 | Compositions purifiees d'urokinase et procede pour leur obtention |
JP4258078A JPS53130485A (en) | 1977-04-12 | 1978-04-11 | Separating method of urokinase and medicin containg urokinase as useful component |
DK159878A DK159878A (da) | 1977-04-12 | 1978-04-12 | Fremgangsmaade til fremstilling af urokinase |
BE186750A BE865926A (fr) | 1977-04-12 | 1978-04-12 | Compositions purifiees d'urokinase et procede pour leur obtention |
NL7803888A NL7803888A (nl) | 1977-04-12 | 1978-04-12 | Werkwijze voor het scheiden van een urokinase en een fractie, die een ander urokinase bevat, alsmede farma- ceutisch preparaat en werkwijze voor het bereiden daar- van. |
SE7804141A SE7804141L (sv) | 1977-04-12 | 1978-04-12 | Renade kompositioner av urokinas och forfarande for framstellning derav |
ES468720A ES468720A1 (es) | 1977-04-12 | 1978-04-12 | Un procedimiento de separacion de dos tipos de uroquinasa. |
LU79426A LU79426A1 (fr) | 1977-04-12 | 1978-04-12 | Compositions purifiees d'urokinase et procede pour leur obtention |
DE19782815853 DE2815853A1 (de) | 1977-04-12 | 1978-04-12 | Gereinigte urokinasepraeparate und verfahren zu ihrer herstellung |
IT48859/78A IT1156188B (it) | 1977-04-12 | 1978-04-12 | Composizioni furificate di urochinasi e procedimento per ottenerle |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7711004A FR2387242A1 (fr) | 1977-04-12 | 1977-04-12 | Compositions purifiees d'urokinase et procede pour leur obtention |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2387242A1 true FR2387242A1 (fr) | 1978-11-10 |
Family
ID=9189313
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7711004A Withdrawn FR2387242A1 (fr) | 1977-04-12 | 1977-04-12 | Compositions purifiees d'urokinase et procede pour leur obtention |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS53130485A (fr) |
BE (1) | BE865926A (fr) |
DE (1) | DE2815853A1 (fr) |
DK (1) | DK159878A (fr) |
ES (1) | ES468720A1 (fr) |
FR (1) | FR2387242A1 (fr) |
IT (1) | IT1156188B (fr) |
LU (1) | LU79426A1 (fr) |
NL (1) | NL7803888A (fr) |
SE (1) | SE7804141L (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0040238A1 (fr) * | 1979-11-13 | 1981-11-25 | Syed Shaukat Husain | Activateurs plasminogenes utilies comme agents therapeutiques et diagnostiques et leur isolation. |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5411219A (en) * | 1977-06-25 | 1979-01-27 | Green Cross Corp:The | Thrombolytic agent and its preparation |
JPS606191A (ja) * | 1983-06-02 | 1985-01-12 | Wakamoto Pharmaceut Co Ltd | 低分子ウロキナ−ゼと高分子ウロキナ−ゼの分離方法 |
DE3439980A1 (de) * | 1984-11-02 | 1986-05-07 | Behringwerke Ag, 3550 Marburg | Verfahren zur reinigung sowie pasteurisierung von urokinase |
DE3512910A1 (de) * | 1985-04-11 | 1986-10-16 | Behringwerke Ag, 3550 Marburg | Verfahren zur reinigung von plasminogenaktivatoren |
US20030040095A1 (en) * | 2001-03-16 | 2003-02-27 | Achille Arini | Method for the production of pharmaceutically active recombinant proteins |
-
1977
- 1977-04-12 FR FR7711004A patent/FR2387242A1/fr not_active Withdrawn
-
1978
- 1978-04-11 JP JP4258078A patent/JPS53130485A/ja active Pending
- 1978-04-12 DE DE19782815853 patent/DE2815853A1/de not_active Withdrawn
- 1978-04-12 BE BE186750A patent/BE865926A/fr unknown
- 1978-04-12 IT IT48859/78A patent/IT1156188B/it active
- 1978-04-12 LU LU79426A patent/LU79426A1/fr unknown
- 1978-04-12 SE SE7804141A patent/SE7804141L/xx unknown
- 1978-04-12 DK DK159878A patent/DK159878A/da not_active IP Right Cessation
- 1978-04-12 ES ES468720A patent/ES468720A1/es not_active Expired
- 1978-04-12 NL NL7803888A patent/NL7803888A/xx not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0040238A1 (fr) * | 1979-11-13 | 1981-11-25 | Syed Shaukat Husain | Activateurs plasminogenes utilies comme agents therapeutiques et diagnostiques et leur isolation. |
EP0040238A4 (fr) * | 1979-11-13 | 1982-07-13 | Syed Shaukat Husain | Activateurs plasminogenes utilies comme agents therapeutiques et diagnostiques et leur isolation. |
Also Published As
Publication number | Publication date |
---|---|
BE865926A (fr) | 1978-10-12 |
DK159878A (da) | 1978-10-13 |
IT1156188B (it) | 1987-01-28 |
JPS53130485A (en) | 1978-11-14 |
DE2815853A1 (de) | 1978-10-19 |
ES468720A1 (es) | 1978-12-16 |
IT7848859A0 (it) | 1978-04-12 |
LU79426A1 (fr) | 1978-11-28 |
SE7804141L (sv) | 1978-10-13 |
NL7803888A (nl) | 1978-10-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2387242A1 (fr) | Compositions purifiees d'urokinase et procede pour leur obtention | |
BE587325A (fr) | Purification de jus sucrés au moyen de résines échangeuses d'ions. | |
AU256395B2 (en) | 2, 2'dithio-bis-isobutyronitrile | |
AU249002B2 (en) | Improved'polymerization catalyst | |
CA628391A (en) | N,n'-ethylenebis (n-substituted 2-benzothiazolesulfenamides) | |
CA616580A (en) | Ski climber | |
CA611891A (en) | 3,3',5,5'-tetraalkyldiphenoquinones | |
CA602478A (en) | Rapidly hardenable compositions of epoxide-compounds and complexes of friedel-craft's catalysts | |
AU250265B2 (en) | 2, 2'alkylene bis-(5, 6-dialkylbenzimidazoles and their preparation | |
CA602952A (en) | Procede d'irrigation | |
CA605005A (en) | 6,8-dihydroxyoctanoic acid | |
AU262893B2 (en) | RECOVERY OFP, p'ISOPROPYLIDENEDIPHENOL | |
AU254941B2 (en) | ^-1'[5]- pyrazolino-[17,16-c]-pregn -4-ene-3,11,20-triones | |
CA578885A (fr) | Calculateur de machiniste | |
AU238165B2 (en) | "brassiere | |
CA612572A (en) | 5-o-acetyl-2-o-p-toluenesulfonyl-1,4: 3,6-dianhydro-d-glucitol | |
CA628015A (en) | Balai d'essuie-glace | |
CA580643A (fr) | Composition active pharmaceutiquement comprenant de la 3,5,3' l-tri-iodo-thyronine | |
CA644219A (en) | Composition containing 1(1,2-diphenylethyl)pyrrolidine | |
AU604361A (en) | 2, 2'alkylene bis-(5, 6-dialkylbenzimidazoles and their preparation | |
AU157661A (en) | The smackit" golf practice set | |
CA639082A (en) | 3,5-dinitro-o-toluic acid hydrazides | |
CA610395A (en) | Procede d'epilage et de confitage de peaux | |
AU262608B2 (en) | Therapeutic composition comprising 3, - diethyl - 5 - methyl - 2,4 - piperidinedione and 7 - chloro - 2- methylamino - 5- phenyl - 3h - 1,4 - benzodiazepine - 4- oxide or its acid salt | |
AU237927B2 (en) | Improvements in or relating to 4, 4'dichlorodiphenylsulphone |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |