FR2387216A2 - Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenant - Google Patents
Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenantInfo
- Publication number
- FR2387216A2 FR2387216A2 FR7810581A FR7810581A FR2387216A2 FR 2387216 A2 FR2387216 A2 FR 2387216A2 FR 7810581 A FR7810581 A FR 7810581A FR 7810581 A FR7810581 A FR 7810581A FR 2387216 A2 FR2387216 A2 FR 2387216A2
- Authority
- FR
- France
- Prior art keywords
- methylene
- compounds
- pharmaceutical compositions
- compositions containing
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 2
- -1 p-substituted phenyl esters Chemical class 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000002831 pharmacologic agent Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des nouveaux dérivés substitués de prostaglandines et des compositions pharmaceutiques en contenant. Elle couvre en particulier des nouveaux dérivés amido, cycloamido, carbonylamido et sulfonylamido ainsi que les esters phényliques p-substitués de composés du type 9-déoxy-9-méthylène-PGF. Ces nouveaux amides ont une action prolongée comme agents pharmacologiques comparativement aux composés connus précédemment du type 9-déoxy-9-méthylène-PGF. En outre, les nouveaux esters phényliques p-substitués donnent des formules pharmaceutiques plus stables comparativement aux esters connus du type 9-déoxy-9-méthylène-PGF. Au surplus, ces composés sont sous forme d'acides libres, d'esters, d'alcools en C1 et d'amines en C1 . Application des composés pour leur action pharmacologique du type prostaglandine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/786,249 US4118584A (en) | 1977-04-11 | 1977-04-11 | 9-Deoxy-9-methylene-16-phenyl-PGF compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2387216A2 true FR2387216A2 (fr) | 1978-11-10 |
| FR2387216B2 FR2387216B2 (fr) | 1980-08-08 |
Family
ID=25138053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7810581A Granted FR2387216A2 (fr) | 1977-04-11 | 1978-04-10 | Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenant |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US4118584A (fr) |
| JP (1) | JPS53135957A (fr) |
| BE (1) | BE865881A (fr) |
| CH (1) | CH634832A5 (fr) |
| DE (1) | DE2814711A1 (fr) |
| FR (1) | FR2387216A2 (fr) |
| GB (1) | GB1568017A (fr) |
| NL (1) | NL7803433A (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387217A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derives |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4277612A (en) * | 1979-05-01 | 1981-07-07 | The Upjohn Company | ω-Aryl-9-deoxy-9-methylene-5,6-didehydro-PGF1 compounds |
| US4695647A (en) * | 1984-03-22 | 1987-09-22 | Drug Science Foundation | Aromatic derivatives of 13-azaprostanoic acid |
| AU6513294A (en) * | 1993-05-26 | 1994-12-20 | Taisho Pharmaceutical Co., Ltd. | Prostaglandin e1 analog |
| US20050158461A1 (en) * | 2004-01-21 | 2005-07-21 | 3M Innovative Properties Company | Methods of making reflective elements |
| SG185939A1 (en) * | 2007-11-01 | 2012-12-28 | Acucela Inc | Amine derivative compounds for treating ophthalmic diseases and disorders |
| HU231175B1 (hu) * | 2015-12-04 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387217A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931299A (en) * | 1974-09-13 | 1976-01-06 | American Home Products Corporation | 9β-Formyl prostaglandin derivatives |
| US3950363A (en) * | 1975-03-10 | 1976-04-13 | The Upjohn Company | Prostaglandin cyclic ethers |
| US4060534A (en) * | 1976-01-23 | 1977-11-29 | The Upjohn Company | 9-Deoxy-9-methylene-PGF compounds |
-
1977
- 1977-04-11 US US05/786,249 patent/US4118584A/en not_active Expired - Lifetime
-
1978
- 1978-03-09 GB GB9339/78A patent/GB1568017A/en not_active Expired
- 1978-03-31 NL NL7803433A patent/NL7803433A/xx not_active Application Discontinuation
- 1978-04-05 DE DE19782814711 patent/DE2814711A1/de not_active Withdrawn
- 1978-04-10 CH CH384478A patent/CH634832A5/de not_active IP Right Cessation
- 1978-04-10 FR FR7810581A patent/FR2387216A2/fr active Granted
- 1978-04-11 BE BE186716A patent/BE865881A/fr not_active IP Right Cessation
- 1978-04-11 JP JP4184578A patent/JPS53135957A/ja active Pending
- 1978-07-12 US US05/924,036 patent/US4145561A/en not_active Expired - Lifetime
- 1978-07-12 US US05/923,832 patent/US4156782A/en not_active Expired - Lifetime
- 1978-07-12 US US05/924,034 patent/US4138578A/en not_active Expired - Lifetime
- 1978-07-12 US US05/923,833 patent/US4159385A/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387217A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derives |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387217A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derives |
Also Published As
| Publication number | Publication date |
|---|---|
| BE865881A (fr) | 1978-10-11 |
| GB1568017A (en) | 1980-05-21 |
| JPS53135957A (en) | 1978-11-28 |
| NL7803433A (nl) | 1978-10-13 |
| US4145561A (en) | 1979-03-20 |
| US4118584A (en) | 1978-10-03 |
| CH634832A5 (de) | 1983-02-28 |
| US4159385A (en) | 1979-06-26 |
| US4156782A (en) | 1979-05-29 |
| DE2814711A1 (de) | 1978-10-19 |
| FR2387216B2 (fr) | 1980-08-08 |
| US4138578A (en) | 1979-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2416216A1 (fr) | Nouvelles acyl anilines et leur application fongicide | |
| FR2416234A1 (fr) | Derives de metronidazole et compositions pharmaceutiques en contenant | |
| ES542322A0 (es) | Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina | |
| DE69311361D1 (de) | Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten | |
| DE69017786D1 (de) | Den Augeninnendruck vermindernde 11-Acylprostaglandine. | |
| FR2356424A1 (fr) | Compositions pharmaceutiques a base d'acide phophono-formique utiles pour lutter contre les infections virales | |
| ES2164877T3 (es) | Reduccion del crecimiento del pelo. | |
| FR2453851A1 (fr) | Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant | |
| DE69526353D1 (de) | Immunologische aktivität der rhamnolipide | |
| FR2387217A2 (fr) | Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derives | |
| FR2387216A2 (fr) | Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenant | |
| RU2000103224A (ru) | Лишенные побочных эффектов производные простагландинов для лечения глаукомы | |
| FR2418214A1 (fr) | Compose de formule 1-(2',6',6'-trimethylcyclohexyl)-hexane-3-ol utilise notamment comme fixateur pour compositions de parfums | |
| FR2389375A1 (fr) | ||
| FR2361380A1 (fr) | Nouveaux analogues de prostaglandines et leur preparation | |
| FR2404005A1 (fr) | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant | |
| GB1161349A (en) | New Capillary Product | |
| KR910007503A (ko) | 모노퍼옥시산-함유 구강 조성물 | |
| FR2419312A1 (fr) | Composition ignifuge parfumee | |
| FR2441617A1 (fr) | Nouveaux derives de s-triazine, leur procede de preparation et compositions pharmaceutiques les contenant | |
| FR2428436A1 (fr) | Nouvelles compositions cosmetiques pour le traitement de l'etat gras des cheveux et de la peau, composes nouveaux et leur procede de preparation | |
| FR2447375A1 (fr) | Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant | |
| FR2385681A1 (fr) | Monofluorophosphate d'amine a longue chaine, son procede de preparation et composition dentifrice le contenant | |
| FR2415635A1 (fr) | Nouveaux derives de 3-(n-(acetoxyacetyl)-n-phenyl)amino-tetrahydro-2-furanone, leur preparation et leur application en tant qu'agents microbicides | |
| FR2435945A1 (fr) | Perfectionnements a des compositions contenant de l'etomidate |