FR2377994A1 - 3-Ortho-hydroxyphenyl-3-phenyl:propionic acid - used as intermediate for biologically active propylamine derivs., is prepd. from cinnamate ester and phenol - Google Patents
3-Ortho-hydroxyphenyl-3-phenyl:propionic acid - used as intermediate for biologically active propylamine derivs., is prepd. from cinnamate ester and phenolInfo
- Publication number
- FR2377994A1 FR2377994A1 FR7701449A FR7701449A FR2377994A1 FR 2377994 A1 FR2377994 A1 FR 2377994A1 FR 7701449 A FR7701449 A FR 7701449A FR 7701449 A FR7701449 A FR 7701449A FR 2377994 A1 FR2377994 A1 FR 2377994A1
- Authority
- FR
- France
- Prior art keywords
- hydroxyphenyl
- phenyl
- propylamine
- biologically active
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
3-o-Hydroxyphenyl-3-phenylpropionic acid of formula (I) is new. (I) is usd in the synthesis of biologically active cpds., e.g. 3-o-hydroxyphenyl-3-phenyl-N-(diphenylpropyl)-propylamine (II) and 3-o-hydroxyphenyl-3-phenyl-N- (3,4-dimethoxyphenyl)ethyl propylamine (III). The hydrochloride of (II) and (III), in concn. of 0.05 mu mole/ml, affect the sympathicolytic and adrenolytic contraction activity of the isolated spermatic duct of the rat e.g. redn. in amplitude of contraction, caused by intramural electric stimulation, after 10 minutes, as % of control: (II), 90%; (III) 72%; caused by 10-5 g/ml adrenalin, after 10 minutes, as % of control: (II), 81%; (III) 1%.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7701449A FR2377994A1 (en) | 1977-01-19 | 1977-01-19 | 3-Ortho-hydroxyphenyl-3-phenyl:propionic acid - used as intermediate for biologically active propylamine derivs., is prepd. from cinnamate ester and phenol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7701449A FR2377994A1 (en) | 1977-01-19 | 1977-01-19 | 3-Ortho-hydroxyphenyl-3-phenyl:propionic acid - used as intermediate for biologically active propylamine derivs., is prepd. from cinnamate ester and phenol |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2377994A1 true FR2377994A1 (en) | 1978-08-18 |
FR2377994B1 FR2377994B1 (en) | 1979-05-11 |
Family
ID=9185672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7701449A Granted FR2377994A1 (en) | 1977-01-19 | 1977-01-19 | 3-Ortho-hydroxyphenyl-3-phenyl:propionic acid - used as intermediate for biologically active propylamine derivs., is prepd. from cinnamate ester and phenol |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2377994A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0537954A1 (en) * | 1991-10-15 | 1993-04-21 | Takeda Chemical Industries, Ltd. | Process of preparing diphenylmethane derivatives |
-
1977
- 1977-01-19 FR FR7701449A patent/FR2377994A1/en active Granted
Non-Patent Citations (1)
Title |
---|
NEANT * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0537954A1 (en) * | 1991-10-15 | 1993-04-21 | Takeda Chemical Industries, Ltd. | Process of preparing diphenylmethane derivatives |
Also Published As
Publication number | Publication date |
---|---|
FR2377994B1 (en) | 1979-05-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |