FR2364939A2 - Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol - Google Patents
Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycolInfo
- Publication number
- FR2364939A2 FR2364939A2 FR7628396A FR7628396A FR2364939A2 FR 2364939 A2 FR2364939 A2 FR 2364939A2 FR 7628396 A FR7628396 A FR 7628396A FR 7628396 A FR7628396 A FR 7628396A FR 2364939 A2 FR2364939 A2 FR 2364939A2
- Authority
- FR
- France
- Prior art keywords
- heparin
- contg
- polymers
- prepd
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0023—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a quaternized group or a protonated amine group of the substrate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/0804—Manufacture of polymers containing ionic or ionogenic groups
- C08G18/0809—Manufacture of polymers containing ionic or ionogenic groups containing cationic or cationogenic groups
- C08G18/0814—Manufacture of polymers containing ionic or ionogenic groups containing cationic or cationogenic groups containing ammonium groups or groups forming them
Abstract
Heparin is bonded to polymers contg. a quat. ammonium group in a polar aprotic solvent, the heparination being effected in the preference of water and dimethyl sulphoxide and/or diethyl glycol. Useful as anticoagulants. In an example, a polyurethane contg. 0.583 m.eq./g of tert. N was treated in DMF with CH3I to give 100% yield of quat. N. This was then treated with the Na salt of heparin in water and DMSO giving a polyurethane contg. 16.6% heparin.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7628396A FR2364939A2 (en) | 1976-09-16 | 1976-09-16 | Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7628396A FR2364939A2 (en) | 1976-09-16 | 1976-09-16 | Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2364939A2 true FR2364939A2 (en) | 1978-04-14 |
FR2364939B2 FR2364939B2 (en) | 1981-07-31 |
Family
ID=9177924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7628396A Granted FR2364939A2 (en) | 1976-09-16 | 1976-09-16 | Anticoagulant heparin contg. polymers - prepd. from a polymer and heparin in aq. di:methyl sulphoxide or di:ethylene glycol |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2364939A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4676975A (en) * | 1984-12-07 | 1987-06-30 | Becton, Dickinson And Company | Thermoplastic polyurethane anticoagulant alloy coating |
US4678660A (en) * | 1984-12-07 | 1987-07-07 | Deseret Medical, Inc. | Thermoplastic polyurethane anticoagulant alloy coating |
EP0495478A2 (en) * | 1991-01-16 | 1992-07-22 | Toyo Boseki Kabushiki Kaisha | A material compatible with blood |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2087506A5 (en) * | 1970-05-21 | 1971-12-31 | Rhone Poulenc Sa | |
US3755218A (en) * | 1970-08-14 | 1973-08-28 | California Inst Of Techn | Ionically bonded block elastomeric copolymers of a polyquaternary polyurethane and heparin |
-
1976
- 1976-09-16 FR FR7628396A patent/FR2364939A2/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2087506A5 (en) * | 1970-05-21 | 1971-12-31 | Rhone Poulenc Sa | |
US3755218A (en) * | 1970-08-14 | 1973-08-28 | California Inst Of Techn | Ionically bonded block elastomeric copolymers of a polyquaternary polyurethane and heparin |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4676975A (en) * | 1984-12-07 | 1987-06-30 | Becton, Dickinson And Company | Thermoplastic polyurethane anticoagulant alloy coating |
US4678660A (en) * | 1984-12-07 | 1987-07-07 | Deseret Medical, Inc. | Thermoplastic polyurethane anticoagulant alloy coating |
EP0495478A2 (en) * | 1991-01-16 | 1992-07-22 | Toyo Boseki Kabushiki Kaisha | A material compatible with blood |
EP0495478A3 (en) * | 1991-01-16 | 1993-04-21 | Toyo Boseki Kabushiki Kaisha | A material compatible with blood |
US5541305A (en) * | 1991-01-16 | 1996-07-30 | Toyo Boseki Kabushiki Kaisha | Composition compatible with blood |
Also Published As
Publication number | Publication date |
---|---|
FR2364939B2 (en) | 1981-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
CD | Change of name or company name |