FR2355829A1 - Esters of nitroxoline with (poly)carboxylic or (poly)sulphonic acids - useful as antibacterials and antifungals - Google Patents

Esters of nitroxoline with (poly)carboxylic or (poly)sulphonic acids - useful as antibacterials and antifungals

Info

Publication number
FR2355829A1
FR2355829A1 FR7717431A FR7717431A FR2355829A1 FR 2355829 A1 FR2355829 A1 FR 2355829A1 FR 7717431 A FR7717431 A FR 7717431A FR 7717431 A FR7717431 A FR 7717431A FR 2355829 A1 FR2355829 A1 FR 2355829A1
Authority
FR
France
Prior art keywords
poly
nitroxoline
antifungals
carboxylic
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7717431A
Other languages
French (fr)
Inventor
Jacques Debat
Jean Lemoine
Andre Chardon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Debat SA
Original Assignee
Laboratoire Debat SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Debat SA filed Critical Laboratoire Debat SA
Publication of FR2355829A1 publication Critical patent/FR2355829A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esters of nitroxoline with mono- or poly-carboxylic or sulphonic acids, esp. of formula (I), are new cpds. (where X is CO or SO2; R is =17C opt. unsatd., (branched) hydrocarbyl, aryl or aralkyl in which each phenyl ring can be substd. by >=1.1-4C alkyl, F, Cl, Br, NO2 or CN, a gp.-AXOY, or adamantyl; A is 2-20C opt. unsatd. hydrocarbyl; Y is H, 1-4C alkyl or 5-nitroquinolin-8-yl). (I) are prepd. by reacting nitroxoline (II) with the appropriate acid or its deriv. (I) are useful antibacterials and antifungals at least as effective as (II) but with a longer-lasting effect and better oil solubility. Toxicity is low e.g. the LDo=>=1.1g/kg orally in rats. Specific cpd. is 5-nitroquinolin-8-yl undecylinate.
FR7717431A 1976-06-24 1977-06-07 Esters of nitroxoline with (poly)carboxylic or (poly)sulphonic acids - useful as antibacterials and antifungals Withdrawn FR2355829A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2639176 1976-06-24

Publications (1)

Publication Number Publication Date
FR2355829A1 true FR2355829A1 (en) 1978-01-20

Family

ID=10242908

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7717431A Withdrawn FR2355829A1 (en) 1976-06-24 1977-06-07 Esters of nitroxoline with (poly)carboxylic or (poly)sulphonic acids - useful as antibacterials and antifungals

Country Status (5)

Country Link
BE (1) BE855851A (en)
DE (1) DE2728248A1 (en)
ES (1) ES459976A1 (en)
FR (1) FR2355829A1 (en)
ZA (1) ZA773797B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429207B1 (en) 1997-11-21 2002-08-06 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
JP2001524468A (en) * 1997-11-21 2001-12-04 エヌピーエス ファーマシューティカルズ インコーポレーテッド Metabotropic glutamate receptor antagonists for treating central nervous system disorders
US20210363165A1 (en) * 2018-09-29 2021-11-25 Jiangsu Yahong Meditech Co., Ltd. Nitroxoline prodrug and use thereof
CN111514142B (en) * 2020-05-29 2021-04-06 江苏亚虹医药科技股份有限公司 Pharmaceutical composition containing nitroxoline prodrug and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2237903A1 (en) * 1972-08-02 1974-03-28 Basf Ag 8-Acyloxyquinoline derivs prepn - with antibacterial and antifungal activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2237903A1 (en) * 1972-08-02 1974-03-28 Basf Ag 8-Acyloxyquinoline derivs prepn - with antibacterial and antifungal activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1966 *

Also Published As

Publication number Publication date
ZA773797B (en) 1978-05-30
DE2728248A1 (en) 1978-01-05
ES459976A1 (en) 1978-05-01
BE855851A (en) 1977-12-20

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Legal Events

Date Code Title Description
ST Notification of lapse