FR2334355A2 - Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876) - Google Patents
Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876)Info
- Publication number
- FR2334355A2 FR2334355A2 FR7538063A FR7538063A FR2334355A2 FR 2334355 A2 FR2334355 A2 FR 2334355A2 FR 7538063 A FR7538063 A FR 7538063A FR 7538063 A FR7538063 A FR 7538063A FR 2334355 A2 FR2334355 A2 FR 2334355A2
- Authority
- FR
- France
- Prior art keywords
- thiazolyl
- alkyl
- derivs
- isocyantaates
- carbmate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Carbamate derivs. of formula (I) (where R1 is 1-5C alkyl; R2 is NH2, 1-4C alkylamino, di(1-4C alkyl) amino, anilino or diphenylamino; and n is 1-6), e.g. 2-methyl-5-(N-methylcarbamoyloxymethyl)thiazole, and their addition salts with mineral acids or organic sulphonic acids are new cpds. (I) have antiliopolytic properties, reducing plasma free fatty acid levels Certain cpds. (I) have peripheral vasodilatory and anti-bradykinin activity. (I) are useful for the treatment of acute or chronic hyperlipaemia, coronary insufficiency or atheromatous origin, chronic angina and functional hypertensive disorders.
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7538063A FR2334355A2 (en) | 1975-12-12 | 1975-12-12 | Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876) |
AR262223A AR208020A1 (en) | 1975-02-14 | 1976-01-01 | PROCEDURE FOR THE PREPARATION OF 2-ALKYL-5 - ((N-SUBSTITUTED CARBAMOYLOXY) ALKYL) -THAZOLE |
US05/654,630 US4032643A (en) | 1975-02-14 | 1976-02-02 | Novel thiazole derivatives |
IL48970A IL48970A (en) | 1975-02-14 | 1976-02-04 | 2alkyl-5-thiazolylakyl carbamates, process for preparing them and pharmaceutical compositions containing them |
HU76RO00000876A HU171952B (en) | 1975-02-14 | 1976-02-05 | Process for producing thiazole derivatives |
AT99576A AT350557B (en) | 1975-02-14 | 1976-02-12 | PROCESS FOR PRODUCING NEW THIAZOLE DERIVATIVES AND THEIR SALTS |
DD191211A DD124980A5 (en) | 1975-02-14 | 1976-02-12 | |
BE164264A BE838490A (en) | 1975-02-14 | 1976-02-12 | NEW THIAZOLIC DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION |
LU74340A LU74340A1 (en) | 1975-02-14 | 1976-02-12 | |
SE7601591A SE7601591L (en) | 1975-02-14 | 1976-02-12 | WAY TO PRODUCE NEW TIAZOLE DERIVATIVES |
IE295/76A IE42775B1 (en) | 1975-02-14 | 1976-02-13 | Thiazole derivatives |
DE19762605840 DE2605840A1 (en) | 1975-02-14 | 1976-02-13 | NEW THIAZOLE DERIVATIVES, PROCEDURES FOR THEIR MANUFACTURING AND PHARMACEUTICAL COMPOSITIONS |
AU11107/76A AU498500B2 (en) | 1975-02-14 | 1976-02-13 | Thiazoles |
PT64803A PT64803B (en) | 1975-02-14 | 1976-02-13 | PROCESS FOR THE PREPARATION OF NEW THIAZOLIC DERIVATIVES |
CH180976A CH610314A5 (en) | 1975-02-14 | 1976-02-13 | |
DK58676*#A DK58676A (en) | 1975-02-14 | 1976-02-13 | PROCEDURE FOR THE PREPARATION OF THIAZOLE DERIVATIVES |
ES445150A ES445150A1 (en) | 1975-02-14 | 1976-02-13 | Novel thiazole derivatives |
GB5820/76A GB1535267A (en) | 1975-02-14 | 1976-02-13 | Thiazole derivatives |
JP51014120A JPS51105058A (en) | 1975-02-14 | 1976-02-13 | |
NL7601563A NL7601563A (en) | 1975-02-14 | 1976-02-16 | PROCESS FOR PREPARING NEW THIAZOLE COMPOUNDS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7538063A FR2334355A2 (en) | 1975-12-12 | 1975-12-12 | Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876) |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2334355A2 true FR2334355A2 (en) | 1977-07-08 |
FR2334355B2 FR2334355B2 (en) | 1978-08-25 |
Family
ID=9163664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7538063A Granted FR2334355A2 (en) | 1975-02-14 | 1975-12-12 | Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876) |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2334355A2 (en) |
-
1975
- 1975-12-12 FR FR7538063A patent/FR2334355A2/en active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2334355B2 (en) | 1978-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE156123T1 (en) | CYCLIC UREAS AND ANALOGUES USABLE AS RETROVIRAL PROTEASE INHIBITORS | |
IS3651A7 (en) | Amino acid derivatives and process for their production | |
NO180718C (en) | Analogous Process for Preparation of Therapeutically Active Mercaptoacetylamide Derivatives | |
NO179638C (en) | Analogous process for the preparation of thiazole derivatives | |
ES2037768T3 (en) | PROCEDURE FOR PREPARING N- (FENYL (2,6-DISSTITUTED)) - UREAS AND CARBAMATES INHIBITING ACIL-COA: CHOLESTEROL ACIL-TRANSFERASE. | |
ATE87005T1 (en) | HYDROXAMIC ACIDS. | |
YU21100A (en) | Isoquinolines as urokinase inhibitors | |
NO904801L (en) | PROCEDURE FOR MANUFACTURING ACAT INHIBITORS. | |
IE36716L (en) | Cyclic ureas | |
US3159617A (en) | Production of penicillins | |
FR2334355A2 (en) | Antilipolytic thiazolyl-alkyl-carbmate derivs. - prepd. by reacting thiazolyl-alkanols with isocyantaates or carbamoyl halides (BE120876) | |
JPS5285174A (en) | Novel urea or thiourea derivatives | |
DK102892A (en) | PURIN DERIVATIVES, PHARMACEUTICAL PREPARATIONS COMPREHENSIVE, AND INTERNAL USE RELATIONS | |
ATE84043T1 (en) | AMINO ACID DERIVATIVES. | |
FR2334366A2 (en) | 9-Antimonic-(21)-tungsto-sodate heteropolyanions - pref. as the ammonium or metal salts are antivirals synergistic with interferon, active against leukaemia and sarcoma viruses | |
ES2001944A6 (en) | Xanthine derivatives, processes for their production and their use as pharmaceuticals. | |
ATE58532T1 (en) | (2-AMINO-4-ARYL-THIAZOLE-5-YL)AETHANOL AND THEIR DERIVATIVES WITH DIURETIC ACTIVITY AND PROCESS FOR THEIR PRODUCTION. | |
GB1407856A (en) | Anti-inflammatory thiazole compositions and methods for using same | |
GB1533129A (en) | Process for producing a peptide in the presence of an enzyme | |
FI812724L (en) | PROCEDURE FOR THE FRAMSTATION OF AV 7-ACYLAMINO-3- (THIO-SUBSTITUTES) METHYL-3-KEFEM-4-CARBOXYLSYRA-1-OXIDE DERIVATIVES | |
Supuran et al. | Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties | |
GB1299887A (en) | New penicillin derivatives | |
IE35122B1 (en) | Amino-propionic acid derivatives and process for their manufacture | |
GB863451A (en) | New sulphonyl-ureas and preparations containing them | |
ATE92077T1 (en) | ENZYM INHIBITOR AND METHOD OF PRODUCTION. |