FR2322871A1 - Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins - Google Patents

Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins

Info

Publication number
FR2322871A1
FR2322871A1 FR7527412A FR7527412A FR2322871A1 FR 2322871 A1 FR2322871 A1 FR 2322871A1 FR 7527412 A FR7527412 A FR 7527412A FR 7527412 A FR7527412 A FR 7527412A FR 2322871 A1 FR2322871 A1 FR 2322871A1
Authority
FR
France
Prior art keywords
proteins
soln
fraction
denaturation
anionic ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7527412A
Other languages
French (fr)
Other versions
FR2322871B3 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New Zealand Inventions Development Authority
Original Assignee
New Zealand Inventions Development Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Zealand Inventions Development Authority filed Critical New Zealand Inventions Development Authority
Priority to FR7527412A priority Critical patent/FR2322871A1/en
Publication of FR2322871A1 publication Critical patent/FR2322871A1/en
Application granted granted Critical
Publication of FR2322871B3 publication Critical patent/FR2322871B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Prepn. of blood albumin (I) comprises first sepg. a (I)-contg. fraction from blood protein, serum or plasma by treatment with a anionic ion-exchange resin having amino, alkylamino, guanidino or quat. ammonium exchanging gps. An aq. soln. of this separated fraction is prepd., an agent (II) capable of stabilising (I) against heat-denaturation is added, then the soln. heated to denature proteins other than (I). The denaturated proteins are removed leaving a soln. of (I). The stabiliser is >=1 of acetyltryptophan; middle chainlength fatty acids or the salts of these cpds. (esp. Na octanoate). Pref. the resin is crosslinked regenerated cellulose or crosslinked dextran contg. diethylaminoethyl gps. I) is used as a plasma-volume extender and to treat hypoproteinaemia. Using the ion exchange treatment gives a more conc. (I) fraction almost completely free of gamma-globulins (which tend to resist the heat-denaturation step), so less unwanted protein has to be removed.
FR7527412A 1975-09-08 1975-09-08 Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins Granted FR2322871A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7527412A FR2322871A1 (en) 1975-09-08 1975-09-08 Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7527412A FR2322871A1 (en) 1975-09-08 1975-09-08 Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins

Publications (2)

Publication Number Publication Date
FR2322871A1 true FR2322871A1 (en) 1977-04-01
FR2322871B3 FR2322871B3 (en) 1978-04-28

Family

ID=9159695

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7527412A Granted FR2322871A1 (en) 1975-09-08 1975-09-08 Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins

Country Status (1)

Country Link
FR (1) FR2322871A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2364925A1 (en) * 1976-09-20 1978-04-14 Monsanto Co SERUM ALBUMIN PRODUCTION PROCESS AND NEW PRODUCT THUS OBTAINED
EP0402205A1 (en) * 1989-06-08 1990-12-12 Centre Regional De Transfusion Sanguine De Lille Process for the preparation of purified albumin solutions
EP2788033A4 (en) * 2011-12-05 2015-08-26 Factor Bioscience Inc Methods and products for transfecting cells
CN110339209A (en) * 2019-07-18 2019-10-18 上海泰坦科技股份有限公司 A kind of preparation method for the calf serum going Thyroid binding protein

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2364925A1 (en) * 1976-09-20 1978-04-14 Monsanto Co SERUM ALBUMIN PRODUCTION PROCESS AND NEW PRODUCT THUS OBTAINED
EP0402205A1 (en) * 1989-06-08 1990-12-12 Centre Regional De Transfusion Sanguine De Lille Process for the preparation of purified albumin solutions
FR2648048A1 (en) * 1989-06-08 1990-12-14 Lille Transfusion Sanguine PROCESS FOR THE PREPARATION OF PURIFIED ALBUMIN SOLUTIONS
HRP920769A2 (en) * 1989-06-08 1994-04-30 Centre Regional De Transfusion Sanguine De Lille Process for the preparation of purified albumin solutions
EP2788033A4 (en) * 2011-12-05 2015-08-26 Factor Bioscience Inc Methods and products for transfecting cells
US11692203B2 (en) 2011-12-05 2023-07-04 Factor Bioscience Inc. Methods and products for transfecting cells
US11708586B2 (en) 2011-12-05 2023-07-25 Factor Bioscience Inc. Methods and products for transfecting cells
CN110339209A (en) * 2019-07-18 2019-10-18 上海泰坦科技股份有限公司 A kind of preparation method for the calf serum going Thyroid binding protein
CN110339209B (en) * 2019-07-18 2023-06-06 上海泰坦科技股份有限公司 Preparation method of calf serum for removing thyroxine binding protein

Also Published As

Publication number Publication date
FR2322871B3 (en) 1978-04-28

Similar Documents

Publication Publication Date Title
DK0447585T4 (en) Process for the preparation of an intravenously tolerant immunoglobulin G preparation
ES8303094A1 (en) Process for heat treatment of aqueous solution containing cold insoluble globulin.
KR860006478A (en) Virus-inactivation heat treatment method of γ-globulin aqueous solution
FR2322871A1 (en) Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins
IT1041598B (en) Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins
NL7510058A (en) Albumin recovery from blood fractions - by first treating with an anionic ion exchanger, then selective denaturation of other proteins
KR840000474A (en) Method to remove aspartic acid and glutamic acid in whole or in part from protein hydrolysate and amino acid mixture
GB1501700A (en) Lactose hydrolysis using ion exchange resins
ES8304449A1 (en) Method of selectively removing adsorbed calcium and magnesium from cation exchange resins.
ES2068827T3 (en) PROTEIN PRODUCTION IN ACTIVE FORM.
JPS5598117A (en) Purification of gamma-globulin derivative
Cann Effect of binding of ions and other small molecules on protein structure. VII. The role of aliphatic acid binding and of convection in the electrophoresis of serum albumin at low pH
GB1369488A (en) Method of removing organic materials bacteria or viruses from aqueous solutions thereof
KR900015748A (en) Purification Method of Antithrombin-III and Antithrombin-III Formulation Containing the Antithrobin-III
GB941019A (en) Improvements in and relating to the stability of anti-haemophilic globulin (factor viii)
US2955074A (en) Heat sterilization of iron-binding globulin and adding radioactive iron thereto
SE8403375L (en) NEW PLASMINOGEN ACTIVATOR, MANUFACTURING PROCESS FOR THIS AND A THROMBOLYTIC AGENT CONTAINING ITS
Morr Effect of urea upon the physical properties of β-lactoglobulins A and B
FR2345939A1 (en) Lactalbumin and lactoglobulin recovery from milk serum - involves forming required pH by passing part through cation exchange resin
GB1076776A (en) Process for the extraction of elastase
GB913519A (en) Process for the production of stable non-heat coagulable protein preparations
GB1508922A (en) Method for obtaining urokinase
GB1092754A (en) Blood purification
KR940013339A (en) Products containing active milk protein components and preparation method thereof
GB883549A (en) Improvements in and relating to the purification of antihaemophilic globulin

Legal Events

Date Code Title Description
ST Notification of lapse