FR2302101A1 - New 4-chloro 5-substd. sulphamoyl anthranilic acid - useful as diuretic and prepd. from new 2,4-dichloro benzoic acid - Google Patents

New 4-chloro 5-substd. sulphamoyl anthranilic acid - useful as diuretic and prepd. from new 2,4-dichloro benzoic acid

Info

Publication number
FR2302101A1
FR2302101A1 FR7506177A FR7506177A FR2302101A1 FR 2302101 A1 FR2302101 A1 FR 2302101A1 FR 7506177 A FR7506177 A FR 7506177A FR 7506177 A FR7506177 A FR 7506177A FR 2302101 A1 FR2302101 A1 FR 2302101A1
Authority
FR
France
Prior art keywords
new
substd
prepd
useful
opt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7506177A
Other languages
French (fr)
Other versions
FR2302101B1 (en
Inventor
Maur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joullie International SA
Original Assignee
Joullie International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joullie International SA filed Critical Joullie International SA
Priority to FR7506177A priority Critical patent/FR2302101A1/en
Publication of FR2302101A1 publication Critical patent/FR2302101A1/en
Application granted granted Critical
Publication of FR2302101B1 publication Critical patent/FR2302101B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

New sulphonamides are of formulae (I) and (II) (where X is O or S; R is H, lower alkyl or aryl; R1 is H, lower alkyl, aralkyl or aryl opt. ring-substd.; R2 is aralkyl (opt. ring-substd.), heterocyclyl-substd. alkyl, alkoxyalkyl or hydroxyalkyl; n=1-2; and is H or alkali cation esp. Na or K). (I) are prepd. from (II) by reacting with NH2R2 and opt. converting the obtd. (I; Z=H) to a salt. (I) are diuretics useful e.g. in treating essential hypertension which may be complicated by cardiac, renal or hepatic insufficienty and to create a negative sodium balance. They canbe given p.o. or i.v. and are active for several hrs., the usual dose being 1-8 mg/kg/day (adult) or 1-4 mg/kg/day (child).
FR7506177A 1975-02-27 1975-02-27 New 4-chloro 5-substd. sulphamoyl anthranilic acid - useful as diuretic and prepd. from new 2,4-dichloro benzoic acid Granted FR2302101A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7506177A FR2302101A1 (en) 1975-02-27 1975-02-27 New 4-chloro 5-substd. sulphamoyl anthranilic acid - useful as diuretic and prepd. from new 2,4-dichloro benzoic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7506177A FR2302101A1 (en) 1975-02-27 1975-02-27 New 4-chloro 5-substd. sulphamoyl anthranilic acid - useful as diuretic and prepd. from new 2,4-dichloro benzoic acid

Publications (2)

Publication Number Publication Date
FR2302101A1 true FR2302101A1 (en) 1976-09-24
FR2302101B1 FR2302101B1 (en) 1978-08-04

Family

ID=9151827

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7506177A Granted FR2302101A1 (en) 1975-02-27 1975-02-27 New 4-chloro 5-substd. sulphamoyl anthranilic acid - useful as diuretic and prepd. from new 2,4-dichloro benzoic acid

Country Status (1)

Country Link
FR (1) FR2302101A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB936417A (en) * 1959-12-28 1963-09-11 Hoechst Ag Benzene-sulphonamides and process of preparing them
FR2146249A1 (en) * 1971-07-20 1973-03-02 Teva Middle East Pharm
FR2201096A1 (en) * 1972-09-29 1974-04-26 Hoechst Ag 5-Alkoxymethyl sulphamoyl-anthranilic acid derivs - diuretics and salure-tics from corresp 5-sulphamoyl-cpds with formaldehyde and alcohols

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB936417A (en) * 1959-12-28 1963-09-11 Hoechst Ag Benzene-sulphonamides and process of preparing them
FR2146249A1 (en) * 1971-07-20 1973-03-02 Teva Middle East Pharm
FR2201096A1 (en) * 1972-09-29 1974-04-26 Hoechst Ag 5-Alkoxymethyl sulphamoyl-anthranilic acid derivs - diuretics and salure-tics from corresp 5-sulphamoyl-cpds with formaldehyde and alcohols

Also Published As

Publication number Publication date
FR2302101B1 (en) 1978-08-04

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