FR2285855A1 - 2,2'-Anhydro-1-beta-D-arabinofuranosyl-cytosine salts prepns - obtd by freeze drying aq solns. contg specified additives, for parenteral leukaemia treatment - Google Patents
2,2'-Anhydro-1-beta-D-arabinofuranosyl-cytosine salts prepns - obtd by freeze drying aq solns. contg specified additives, for parenteral leukaemia treatmentInfo
- Publication number
- FR2285855A1 FR2285855A1 FR7432321A FR7432321A FR2285855A1 FR 2285855 A1 FR2285855 A1 FR 2285855A1 FR 7432321 A FR7432321 A FR 7432321A FR 7432321 A FR7432321 A FR 7432321A FR 2285855 A1 FR2285855 A1 FR 2285855A1
- Authority
- FR
- France
- Prior art keywords
- prepns
- solns
- contg
- arabinofuranosyl
- anhydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Abstract
Freeze-dried prepns. contg. 2,2'-anhydro-1-beta-D-arabinofuranosyl-cytosine salts (I) are prepd. by freeze-drying an aq. soln. of (I) contg. (a) 0.1-6 wt.%, based on (I), of a saccharide, (b) 0.1-6 wt.% of polyvinylpyrrolidone (PVP), (c) 0.1-6 wt.% of sodium carboxymethylcellulose (NaCMC) and/or (d) 0.01-0.05 wt.% of a nonionic wetting agent. The products can be used to prepare injectable solns. for use in leukaemia treatment. The prepns. have good storage stability, can be prepd. by conventional rapid freeze-drying, and have a water-solubility of >=1 g/10 ml, forming clear solns.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7432321A FR2285855A1 (en) | 1974-09-25 | 1974-09-25 | 2,2'-Anhydro-1-beta-D-arabinofuranosyl-cytosine salts prepns - obtd by freeze drying aq solns. contg specified additives, for parenteral leukaemia treatment |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7432321A FR2285855A1 (en) | 1974-09-25 | 1974-09-25 | 2,2'-Anhydro-1-beta-D-arabinofuranosyl-cytosine salts prepns - obtd by freeze drying aq solns. contg specified additives, for parenteral leukaemia treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2285855A1 true FR2285855A1 (en) | 1976-04-23 |
FR2285855B1 FR2285855B1 (en) | 1978-07-28 |
Family
ID=9143415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7432321A Granted FR2285855A1 (en) | 1974-09-25 | 1974-09-25 | 2,2'-Anhydro-1-beta-D-arabinofuranosyl-cytosine salts prepns - obtd by freeze drying aq solns. contg specified additives, for parenteral leukaemia treatment |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2285855A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0012523A1 (en) * | 1978-11-20 | 1980-06-25 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability and process for their preparation |
US4344934A (en) * | 1978-11-20 | 1982-08-17 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability |
FR2577437A1 (en) * | 1985-02-21 | 1986-08-22 | Corbiere Jerome | New process for dissolving chemical compounds and aqueous preparations thus obtained |
EP0306312A1 (en) * | 1987-09-01 | 1989-03-08 | Yamanouchi Pharmaceutical Co. Ltd. | Lyophilized pharmaceutical composition of neocarzinostatin derivative |
EP0317281A2 (en) * | 1987-11-19 | 1989-05-24 | The Wellcome Foundation Limited | Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydrochloride and processes for preparing them |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3397268A (en) * | 1965-09-01 | 1968-08-13 | Upjohn Co | Process of treating herpes simplex with 1-beta-d-arabinofuranosylcytosine |
US3444294A (en) * | 1961-01-23 | 1969-05-13 | Upjohn Co | Aiding the regression of acute leukemia with 1 - beta - d - arabinofuranosylcytosine |
-
1974
- 1974-09-25 FR FR7432321A patent/FR2285855A1/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3444294A (en) * | 1961-01-23 | 1969-05-13 | Upjohn Co | Aiding the regression of acute leukemia with 1 - beta - d - arabinofuranosylcytosine |
US3397268A (en) * | 1965-09-01 | 1968-08-13 | Upjohn Co | Process of treating herpes simplex with 1-beta-d-arabinofuranosylcytosine |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0012523A1 (en) * | 1978-11-20 | 1980-06-25 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability and process for their preparation |
US4344934A (en) * | 1978-11-20 | 1982-08-17 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability |
FR2577437A1 (en) * | 1985-02-21 | 1986-08-22 | Corbiere Jerome | New process for dissolving chemical compounds and aqueous preparations thus obtained |
EP0306312A1 (en) * | 1987-09-01 | 1989-03-08 | Yamanouchi Pharmaceutical Co. Ltd. | Lyophilized pharmaceutical composition of neocarzinostatin derivative |
US5026772A (en) * | 1987-09-01 | 1991-06-25 | Yamanouchi Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical composition of neocarzinostatin derivative |
EP0317281A2 (en) * | 1987-11-19 | 1989-05-24 | The Wellcome Foundation Limited | Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydrochloride and processes for preparing them |
EP0317281A3 (en) * | 1987-11-19 | 1989-08-09 | The Wellcome Foundation Limited | Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydrochloride and processes for preparing them |
US4997651A (en) * | 1987-11-19 | 1991-03-05 | Poole Stephen W | Pharmaceutical formulations |
Also Published As
Publication number | Publication date |
---|---|
FR2285855B1 (en) | 1978-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |