FR2283690B1 - - Google Patents

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Publication number
FR2283690B1
FR2283690B1 FR7527132A FR7527132A FR2283690B1 FR 2283690 B1 FR2283690 B1 FR 2283690B1 FR 7527132 A FR7527132 A FR 7527132A FR 7527132 A FR7527132 A FR 7527132A FR 2283690 B1 FR2283690 B1 FR 2283690B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7527132A
Other versions
FR2283690A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of FR2283690A1 publication Critical patent/FR2283690A1/fr
Application granted granted Critical
Publication of FR2283690B1 publication Critical patent/FR2283690B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/233Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/18Ring systems of four or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
FR7527132A 1974-09-06 1975-09-04 Nouveaux composes tetracycliques utiles comme medicaments et leur procede de preparation Granted FR2283690A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2442829A DE2442829A1 (de) 1974-09-06 1974-09-06 Tetracyclische verbindungen und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
FR2283690A1 FR2283690A1 (fr) 1976-04-02
FR2283690B1 true FR2283690B1 (fr) 1980-03-28

Family

ID=5925100

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7527132A Granted FR2283690A1 (fr) 1974-09-06 1975-09-04 Nouveaux composes tetracycliques utiles comme medicaments et leur procede de preparation

Country Status (21)

Country Link
US (1) US4024272A (fr)
JP (1) JPS5154564A (fr)
AT (1) AT344890B (fr)
BE (1) BE833048A (fr)
CA (1) CA1068285A (fr)
CS (1) CS191275B2 (fr)
DD (1) DD121637A5 (fr)
DE (1) DE2442829A1 (fr)
DK (1) DK397875A (fr)
ES (1) ES440765A1 (fr)
FR (1) FR2283690A1 (fr)
GB (1) GB1467206A (fr)
HU (2) HU173491B (fr)
IE (1) IE41675B1 (fr)
IL (1) IL48044A (fr)
IT (1) IT7948216A0 (fr)
LU (1) LU73332A1 (fr)
NL (1) NL7510505A (fr)
PL (1) PL96677B1 (fr)
SE (1) SE7509880L (fr)
ZA (1) ZA755699B (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2746044C2 (de) * 1977-10-13 1979-09-06 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur Herstellung von e-Thiatetracyclinracematen mit natürlicher Konfiguration und ihren optischen Antipoden
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
US4672138A (en) * 1980-10-20 1987-06-09 Hoechst Roussel Pharmaceuticals Inc. Phenyl substituted carbamothioic acid esters
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0416564A3 (en) * 1989-09-05 1992-03-11 Kao Corporation Novel aroyl ketone derivative, uv ray absorber comprising the same, and cosmetic composition containing the same
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
FR2795722A1 (fr) * 1999-07-02 2001-01-05 Rhodia Chimie Sa Procede de preparation d'une arylhydrazine hydroxylee, produits intermediaires et leur procede d'obtention
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP1666453A1 (fr) * 1999-09-14 2006-06-07 Trustees Of Tufts College Techniques de preparation de tetracyclines substituees avec des solutions chimiques a base de metal de transition
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EP1263442A1 (fr) * 2000-01-24 2002-12-11 Trustees Of Tufts College COMPOSES DE TETRACYCLINE POUR LE TRAITEMENT DE TROUBLES AFFERENTS AU i CRYPTOSPORIDIUM PARVUM /i
CA2404628A1 (fr) * 2000-03-31 2001-10-11 Stuart B. Levy Composes de tetracycline substitues en 7 et en 9 par carbamate, uree, thio-uree, thiocarbamate et heteroaryl-amino
AU2001259701A1 (en) 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
WO2001098236A2 (fr) * 2000-06-16 2001-12-27 Trustees Of Tufts College Composes de tetracycline 7-phenyl-substituee
US6624168B2 (en) 2000-07-07 2003-09-23 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
ATE465989T1 (de) 2000-07-07 2010-05-15 Tufts College 13-substituierte methacyclinverbindungen
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
KR101083571B1 (ko) 2000-07-07 2011-11-14 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
IL153639A0 (en) * 2000-07-07 2003-07-06 Tufts College 9-substituted minocycline compounds
WO2002072506A2 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de 7-pyrollyl tetracycline et procedes d'utilisation associes
EP1368305B1 (fr) 2001-03-13 2008-08-13 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues en position 7,9
EP1241160A1 (fr) * 2001-03-13 2002-09-18 Glaxo Group Limited Dérivés de tétracyclines et leur utilisation comme agents antibiotiques
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
CA2440757A1 (fr) 2001-03-14 2002-09-19 Michael Draper Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
JP2004530661A (ja) * 2001-03-14 2004-10-07 パラテック ファーマシューティカルズ インコーポレイテッド 抗真菌剤としての置換テトラサイクリン化合物
US20040092490A1 (en) 2001-04-24 2004-05-13 Michael Draper Substituted tetracycline compounds for the treatment of malaria
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2311798A1 (fr) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. Composés de tétracycline 4-dedimethylamino
US6730697B2 (en) * 2002-02-07 2004-05-04 Aventis Pharma Deutschland Gmbh Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid
KR101093842B1 (ko) 2002-03-08 2011-12-13 파라테크 파마슈티컬스, 인크. 아미노-메틸 치환된 테트라시클린 화합물
CA2479877C (fr) * 2002-03-21 2012-08-21 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee
EA200900540A1 (ru) * 2002-07-12 2009-12-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
EP1556007A4 (fr) 2002-10-24 2008-12-17 Paratek Pharm Innc Composes tetracycline substituee servant au traitement du paludisme
CA2531732C (fr) 2003-07-09 2012-04-10 Paratek Pharmaceuticals, Inc. Promedicaments de composes de la tetracycline substitues par 9-aminomethyle
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CA2531728A1 (fr) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitues
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族a環誘導体
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2287140A3 (fr) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués
JP2008518025A (ja) * 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド 4−アミノテトラサイクリンおよびその使用の方法
WO2006084265A1 (fr) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. Derives 11a, 12 de composes de tetracycline
CA2616224A1 (fr) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. Tetracyclines 10-substituees et leurs procedes d'utilisation
AU2007208214B2 (en) 2006-01-24 2013-02-14 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
EP2007713A2 (fr) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolement de dérivés de la tétracycline
EP2016045B1 (fr) * 2006-04-24 2014-10-29 Teva Pharmaceutical Industries, Ltd. Forme cristalline de tigecycline et procedes pour sa preparation
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
JP2009543544A (ja) * 2006-05-15 2009-12-10 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法
WO2008045507A2 (fr) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Composés de tétracycline substitués utilisés pour le traitement d'infections à bacillus anthracis
EP2236491A3 (fr) * 2006-11-29 2010-11-03 Teva Pharmaceutical Industries, Ltd. Formule cristalline de tigecycline et ses procédés de préparation
EP2084126A1 (fr) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Procédés de préparation de 9-halogénoacétamidominocyclines
CA2925939C (fr) 2006-12-21 2019-10-01 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee
AU2007338681B2 (en) 2006-12-21 2013-09-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
WO2008106234A1 (fr) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Procédés pour la purification du tigécycline
AU2008239606A1 (en) 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
CA2688662A1 (fr) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methodes de synthese et de purification de composes de type aminoalkyle de tetracycline
US9522872B2 (en) 2007-07-06 2016-12-20 Paratek Pharmaceuticals, Inc. Methods for synthesizing substituted tetracycline compounds
WO2009111064A2 (fr) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Composés de minocycline et procédés d’utilisation de ceux-ci
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
JP2011517697A (ja) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
TW202021946A (zh) 2008-05-23 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
KR20110081197A (ko) * 2008-09-19 2011-07-13 파라테크 파마슈티컬스, 인크. 류마티스 관절염의 치료를 위한 테트라시클린 화합물 및 관련된 치료 방법
JP2012523438A (ja) 2009-04-10 2012-10-04 タフツ メディカル センター インコーポレイテッド メタロプロテイナーゼ−1(mmp−1)によるpar−1活性化
CN102459153A (zh) 2009-05-08 2012-05-16 四相制药公司 四环素类化合物
EP2707003B1 (fr) 2011-05-12 2019-05-01 Paratek Pharmaceuticals, Inc. Sels cristallins d'amide de l'acide (4s,4as,5ar,12as)-4-diméthylamino- 3,10,12,12a-tétrahydroxy-7-[(méthoxy(méthyl)amino)-méthyl]- 1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphtacène-2-carboxylique et procédés d'utilisation associés
CN108329312B (zh) 2012-08-31 2021-12-31 四相制药公司 四环素化合物
JP6269300B2 (ja) * 2014-05-01 2018-01-31 国立大学法人大阪大学 スルホキシドの脱酸素用触媒、及び該脱酸素用触媒を用いたスルフィドの製造方法
CN110582486B (zh) 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式
SG11201903846TA (en) 2016-11-01 2019-05-30 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
MA49641A (fr) 2017-07-21 2021-06-02 Almirall Llc Traitement de lésions non inflammatoires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437487A1 (de) * 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES440765A1 (es) 1977-06-16
DE2442829A1 (de) 1976-03-18
BE833048A (nl) 1976-03-03
DK397875A (da) 1976-03-07
ATA689275A (de) 1977-12-15
DD121637A5 (fr) 1976-08-12
JPS5154564A (fr) 1976-05-13
SE7509880L (sv) 1976-03-08
IL48044A (en) 1978-12-17
AT344890B (de) 1978-08-10
HU176136B (en) 1980-12-28
IT7948216A0 (it) 1979-03-05
IL48044A0 (en) 1975-11-25
GB1467206A (en) 1977-03-16
IE41675L (en) 1976-03-06
CS191275B2 (en) 1979-06-29
IE41675B1 (en) 1980-02-27
PL96677B1 (pl) 1978-01-31
ZA755699B (en) 1976-08-25
AU8459975A (en) 1977-03-10
FR2283690A1 (fr) 1976-04-02
CA1068285A (fr) 1979-12-18
NL7510505A (nl) 1976-03-09
US4024272A (en) 1977-05-17
LU73332A1 (fr) 1976-04-13
HU173491B (hu) 1979-05-28

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