FR2272683A1 - Anti inflammatory acidic polypeptide fraction - isolated by chromatography from total hepatic extract - Google Patents
Anti inflammatory acidic polypeptide fraction - isolated by chromatography from total hepatic extractInfo
- Publication number
- FR2272683A1 FR2272683A1 FR7501946A FR7501946A FR2272683A1 FR 2272683 A1 FR2272683 A1 FR 2272683A1 FR 7501946 A FR7501946 A FR 7501946A FR 7501946 A FR7501946 A FR 7501946A FR 2272683 A1 FR2272683 A1 FR 2272683A1
- Authority
- FR
- France
- Prior art keywords
- chromatography
- isolated
- elution
- total hepatic
- eluate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
Abstract
Novel acidic polypeptide fraction (I) isolated from total hepatic extract is practically free from toxicity and is prepared from total hepatic fraction, pref. that suitable for parenteral administration according to "Farmacopea Ufficiale della Republica Italian, 7th Edition" by the following process (a) chromatography on an acid ion exchange column, (b) chromatography of the eluate on a basic ion exchange column, which retains (I), (c) elution of the column with water and alkaline solutions to eliminate weakly acidic material, (d) elution with strong mineral or organic acids, (e) chromatography of the eluate by filtration on gel and elimination of the lower band by elution, and (f) dessication of lyophilisation of the eluate containing the lower band from (e).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT720974 | 1974-01-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2272683A1 true FR2272683A1 (en) | 1975-12-26 |
FR2272683B1 FR2272683B1 (en) | 1978-07-21 |
Family
ID=11124690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7501946A Granted FR2272683A1 (en) | 1974-01-22 | 1975-01-22 | Anti inflammatory acidic polypeptide fraction - isolated by chromatography from total hepatic extract |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2272683A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002104A1 (en) * | 1992-07-21 | 1994-02-03 | Nikolaenko Alexandr N | Biologically active agent having immunomodulating properties, method for its obtaining and pharmaceutical preparation based on it |
-
1975
- 1975-01-22 FR FR7501946A patent/FR2272683A1/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994002104A1 (en) * | 1992-07-21 | 1994-02-03 | Nikolaenko Alexandr N | Biologically active agent having immunomodulating properties, method for its obtaining and pharmaceutical preparation based on it |
Also Published As
Publication number | Publication date |
---|---|
FR2272683B1 (en) | 1978-07-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |