FR2266506A1 - Anti-inflammatory, cardio-vascular pyridine derivs. - prepd. by refluxing halopyridine sulphonic acids with alkylpiperazine - Google Patents
Anti-inflammatory, cardio-vascular pyridine derivs. - prepd. by refluxing halopyridine sulphonic acids with alkylpiperazineInfo
- Publication number
- FR2266506A1 FR2266506A1 FR7510222A FR7510222A FR2266506A1 FR 2266506 A1 FR2266506 A1 FR 2266506A1 FR 7510222 A FR7510222 A FR 7510222A FR 7510222 A FR7510222 A FR 7510222A FR 2266506 A1 FR2266506 A1 FR 2266506A1
- Authority
- FR
- France
- Prior art keywords
- cardio
- inflammatory
- vascular
- halopyridine
- alkylpiperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Pyridine derivs. of general formula (I): in which R1 = -CN, -CONR3R4 or -SO2NR3-R4 at posn. 3 or 5; R3 and R4 are indep. H or alkyl(1-3C), opt.substd. with alkoxy (1-2 C) or methylpiperazinyl; R3+R4+N may form pyrrolidine, piperidine, methylpiperidine, morpholine, methylpiperazine or homopiperidine; R2 = alkylpiperazinyl or hydroxyethylpiperazinyl at posns. 2,4 or 6, and their acid-addn. salts have anti-inflammatory, antipyretic and cardio-vascular activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1509474 | 1974-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2266506A1 true FR2266506A1 (en) | 1975-10-31 |
Family
ID=10052924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7510222A Withdrawn FR2266506A1 (en) | 1974-04-04 | 1975-04-02 | Anti-inflammatory, cardio-vascular pyridine derivs. - prepd. by refluxing halopyridine sulphonic acids with alkylpiperazine |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS50140469A (en) |
BE (1) | BE827326A (en) |
CA (1) | CA1051888A (en) |
DE (1) | DE2514334A1 (en) |
ES (1) | ES436109A1 (en) |
FR (1) | FR2266506A1 (en) |
LU (1) | LU72195A1 (en) |
NL (1) | NL7503975A (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994456A (en) * | 1989-03-01 | 1991-02-19 | Nisshin Flour Milling Co., Ltd. | Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same |
DE19918021C1 (en) * | 1999-04-21 | 2000-06-29 | Ruetgers Organics Gmbh | Preparation of chlorinated pyridine sulfonic acid chloride derivatives from hydroxypyridine sulfonic acids and phosphorus trichloride/chlorine gas; useful as intermediates for drugs, e.g. torasemide |
CA2403382A1 (en) | 2000-03-20 | 2001-09-27 | Teva Pharmaceutical Industries Ltd. | Novel processes for preparing torsemide intermediate |
WO2005097751A2 (en) | 2004-03-31 | 2005-10-20 | Janssen Pharmaceutica, N.V. | Non-imidazole heterocyclic compounds as histamine h3-receptor ligands |
WO2005118543A1 (en) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | Kinase inhibitor and use thereof |
JP2007031391A (en) * | 2005-07-29 | 2007-02-08 | Koei Chem Co Ltd | Method for producing alkylaminopyridine carbonitrile |
MX2008015365A (en) | 2006-05-30 | 2008-12-16 | Janssen Pharmaceutica Nv | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor. |
AU2008326561B2 (en) | 2007-11-20 | 2013-12-05 | Janssen Pharmaceutica N.V. | Cycloalkyloxy-and heterocycloalky-loxypyridine compounds as modulators of the histamine H3 receptor |
-
1975
- 1975-03-27 ES ES436109A patent/ES436109A1/en not_active Expired
- 1975-03-28 BE BE154892A patent/BE827326A/en unknown
- 1975-04-02 LU LU72195A patent/LU72195A1/xx unknown
- 1975-04-02 CA CA223,696A patent/CA1051888A/en not_active Expired
- 1975-04-02 FR FR7510222A patent/FR2266506A1/en not_active Withdrawn
- 1975-04-02 DE DE19752514334 patent/DE2514334A1/en not_active Withdrawn
- 1975-04-03 NL NL7503975A patent/NL7503975A/en not_active Application Discontinuation
- 1975-04-04 JP JP4175475A patent/JPS50140469A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE2514334A1 (en) | 1975-10-09 |
LU72195A1 (en) | 1975-08-20 |
CA1051888A (en) | 1979-04-03 |
JPS50140469A (en) | 1975-11-11 |
ES436109A1 (en) | 1977-01-01 |
NL7503975A (en) | 1975-10-07 |
BE827326A (en) | 1975-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |