FR2262976A1 - Xanthinoxidase-inhibitory substd. formamidrazones - prepd. by reacting 4-pyrimidinone and amine - Google Patents

Xanthinoxidase-inhibitory substd. formamidrazones - prepd. by reacting 4-pyrimidinone and amine

Info

Publication number
FR2262976A1
FR2262976A1 FR7506629A FR7506629A FR2262976A1 FR 2262976 A1 FR2262976 A1 FR 2262976A1 FR 7506629 A FR7506629 A FR 7506629A FR 7506629 A FR7506629 A FR 7506629A FR 2262976 A1 FR2262976 A1 FR 2262976A1
Authority
FR
France
Prior art keywords
methyl
pentamethylene
ethyl
esp
formamidrazones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7506629A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of FR2262976A1 publication Critical patent/FR2262976A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

N-Acyl-N''-(3-amino-2-cyano-acryloyl) formamidrazones of formula (I) : and their tautomers and salts with (in)org. acids (in which R1 and R2 are same or different H or opt. branched 1-7C alkyl, with proviso that R1 and R2 are not both H, R1+R2 may form 2-5C alkylene in which one methylene group is opt. replaced by -O, -S or -NR7 forming . e.g. 3-aza-, 3-thia-, 3-oxo-pentamethylene and pentamethylene, R1 and R2 are pref. methyl or together from 3-oxo-pentamethylene R7=H or 1-7C alkyl; R3 = 4- N,N-dipropylsulphamoyl - phenyl, pyridyl-(3), pyridyl-(4), 1,3,5-triphenylpyrazolyl -(4) -methyl, 1,2,3,6-tetrahydro-2,6-dioxopyrimidinyl-(4), thiazolidinyl-(4), 1- 6-methoxynaphthyl-(2) -ethyl, 1-methyl-1-(4- 1,2,3,4-tetrahydronaphthyl-(1) -phenoxy) -ethyl, (3-trifluoromethyl phenoxy)-(4-chlorophenyl)-methyl, 3-acetyl-thiazoliol-inyl-(4) and esp. 1-methyl-1-(4-chlorophenoxy)-ethyl) have xanthinoxidase inhibitory activity and may be used against gout, coronary insufficiency and anti-arrhythmia. Depending on R3 cpds. (I) also have lipid-lowering-, uricosuric-, antiphlogistic-, esp. anti-rheumatic- and liver-protecting activity. (I) are also inters. for other active cpds. such as 4(1H)-pyrimidinones used esp. against gout.
FR7506629A 1974-03-04 1975-03-04 Xanthinoxidase-inhibitory substd. formamidrazones - prepd. by reacting 4-pyrimidinone and amine Withdrawn FR2262976A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK115374A DK115374A (en) 1974-03-04 1974-03-04

Publications (1)

Publication Number Publication Date
FR2262976A1 true FR2262976A1 (en) 1975-10-03

Family

ID=8101605

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7506629A Withdrawn FR2262976A1 (en) 1974-03-04 1975-03-04 Xanthinoxidase-inhibitory substd. formamidrazones - prepd. by reacting 4-pyrimidinone and amine

Country Status (4)

Country Link
BE (1) BE826258A (en)
DE (1) DE2509049A1 (en)
DK (1) DK115374A (en)
FR (1) FR2262976A1 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2608507A (en) 1949-08-20 1952-08-26 Sharp & Dohme Inc Dialkyl sulfamyl benzoic acids
GB860303A (en) 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
DE1904894U (en) 1964-03-28 1964-11-19 Karl Dipl Ing Gruendig CARRYING AND FASTENING DEVICE FOR SAFETY BELTS.
US3517050A (en) 1966-10-03 1970-06-23 Merck & Co Inc Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid
GB1252435A (en) 1968-02-02 1971-11-03
AT289743B (en) 1968-10-08 1971-05-10 Byk Gulden Lomberg Chem Fab Process for the preparation of 1-dimethylamino-2-cyano-chloro-4-azapenta-1,3-diene-5-dimethylimmonium perchlorate
BE755924A (en) 1969-09-12 1971-02-15 Byk Gulden Lomberg Chem Fab PYRAZOLE-4-ACETIC ACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND MEDICINAL PRODUCTS CONTAINING
LU66036A1 (en) 1972-09-08 1974-03-14

Also Published As

Publication number Publication date
DE2509049A1 (en) 1975-09-11
BE826258A (en) 1975-09-04
DK115374A (en) 1975-11-03

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