FR2262533A2 - Cholera vaccine prepn. - by lysing culture of the organism, or lysate, e.g. by pptn with trichloroacetic acid, then centrifugation - Google Patents

Cholera vaccine prepn. - by lysing culture of the organism, or lysate, e.g. by pptn with trichloroacetic acid, then centrifugation

Info

Publication number
FR2262533A2
FR2262533A2 FR7406983A FR7406983A FR2262533A2 FR 2262533 A2 FR2262533 A2 FR 2262533A2 FR 7406983 A FR7406983 A FR 7406983A FR 7406983 A FR7406983 A FR 7406983A FR 2262533 A2 FR2262533 A2 FR 2262533A2
Authority
FR
France
Prior art keywords
culture
organism
centrifugation
pptn
prepn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7406983A
Other languages
French (fr)
Other versions
FR2262533B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7406983A priority Critical patent/FR2262533A2/en
Publication of FR2262533A2 publication Critical patent/FR2262533A2/en
Application granted granted Critical
Publication of FR2262533B2 publication Critical patent/FR2262533B2/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Antigenic fraction is prepd. from a portion of a culture of pathogens e.g. Vibro cholerae, Salmonella typhimurium, Malleomyces mallei or Pseudomonas mallei, the portion corresponding to the peak of 280 nm on the u.v. absorption spectrum, and which, opposed to an immune serum produced in an animal from the same culture, give the band or pair of bands of precipitation nearest the antigen source in the diffusion test in a gel medium and the immuno-electrophoretic analysis test, in which one cultivates the organism; lyses the culture obtained and centrifuges the liberated products after purification. Product is used as a vaccine against cholera. The organisms are pref. lysed using Gallut's method or by ultrasonics. Precipitation by CCl3. CO2H purifies the product. After centrifugation, the supernatant is neutralized then dialysed against distilled water.
FR7406983A 1974-03-01 1974-03-01 Cholera vaccine prepn. - by lysing culture of the organism, or lysate, e.g. by pptn with trichloroacetic acid, then centrifugation Granted FR2262533A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7406983A FR2262533A2 (en) 1974-03-01 1974-03-01 Cholera vaccine prepn. - by lysing culture of the organism, or lysate, e.g. by pptn with trichloroacetic acid, then centrifugation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7406983A FR2262533A2 (en) 1974-03-01 1974-03-01 Cholera vaccine prepn. - by lysing culture of the organism, or lysate, e.g. by pptn with trichloroacetic acid, then centrifugation

Publications (2)

Publication Number Publication Date
FR2262533A2 true FR2262533A2 (en) 1975-09-26
FR2262533B2 FR2262533B2 (en) 1977-12-02

Family

ID=9135646

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7406983A Granted FR2262533A2 (en) 1974-03-01 1974-03-01 Cholera vaccine prepn. - by lysing culture of the organism, or lysate, e.g. by pptn with trichloroacetic acid, then centrifugation

Country Status (1)

Country Link
FR (1) FR2262533A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2537725A1 (en) * 1982-12-09 1984-06-15 Pasteur Institut METHOD FOR THE IMMUNOBACTERIOLOGICAL DETECTION OF PATHOGENIC GERMS IN CONTAMINATED BIOLOGICAL ENVIRONMENTS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2537725A1 (en) * 1982-12-09 1984-06-15 Pasteur Institut METHOD FOR THE IMMUNOBACTERIOLOGICAL DETECTION OF PATHOGENIC GERMS IN CONTAMINATED BIOLOGICAL ENVIRONMENTS
EP0116793A1 (en) * 1982-12-09 1984-08-29 INSTITUT PASTEUR Fondation reconnue d'utilité publique Immunobacteriological method for the detection of pathogenic germs in biologically contaminated media

Also Published As

Publication number Publication date
FR2262533B2 (en) 1977-12-02

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