FR2254331B1 - - Google Patents

Info

Publication number: FR2254331B1
Authority: FR; France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

FR7441005A

Other versions

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-12-12

Filing date

1974-12-12

Publication date

1978-07-21

1974-12-12 Application filed by Hoechst AG filed Critical Hoechst AG

1975-07-11 Publication of FR2254331A1 publication Critical patent/FR2254331A1/fr

1978-07-21 Application granted granted Critical

1978-07-21 Publication of FR2254331B1 publication Critical patent/FR2254331B1/fr

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1742—Unsaturated ethers containing halogen containing six-membered aromatic rings with halogen atoms bound to the aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

FR7441005A 1973-12-12 1974-12-12 Expired FR2254331B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42411773A	1973-12-12	1973-12-12
US05/502,650 US3959475A (en)	1973-12-12	1974-09-03	Substituted 1,3-dihydrospiro(isobenzofuran)s

Publications (2)

Publication Number	Publication Date
FR2254331A1 FR2254331A1 (fr)	1975-07-11
FR2254331B1 true FR2254331B1 (fr)	1978-07-21

Family

ID=27026243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR7441005A Expired FR2254331B1 (fr)	1973-12-12	1974-12-12

Country Status (18)

Country	Link
US (1)	US3959475A (fr)
JP (1)	JPS5833876B2 (fr)
CA (1)	CA1051428A (fr)
CH (3)	CH617938A5 (fr)
DE (1)	DE2458177A1 (fr)
DK (1)	DK144214C (fr)
EG (1)	EG12110A (fr)
FI (1)	FI58128C (fr)
FR (1)	FR2254331B1 (fr)
GB (1)	GB1465999A (fr)
HU (1)	HU169546B (fr)
IE (1)	IE40298B1 (fr)
IL (1)	IL46201A (fr)
LU (1)	LU71461A1 (fr)
NL (1)	NL7416115A (fr)
NO (1)	NO146062C (fr)
OA (1)	OA04852A (fr)
SE (1)	SE419761B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4024263A (en) *	1975-04-30	1977-05-17	American Hoechst Corporation	1,3-Dihydrospiro[isobenzofuran-1,4'-piperidine]s
US3980786A (en) *	1975-07-15	1976-09-14	American Hoechst Corporation	1,3-Dihydro-3-phenyl-1'-(2-propynyl)spiro[isobenzofuran]s
US3980787A (en) *	1975-08-25	1976-09-14	American Hoechst Corporation	3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives
US3996354A (en) *	1976-01-26	1976-12-07	American Hoechst Corporation	1,3-Dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro(isobenzofuran)s
US4031224A (en) *	1976-04-29	1977-06-21	American Hoechst Corporation	1,3-Dihydro-heteroarylspiro (isobenzofuran)s
US4241071A (en) *	1977-01-27	1980-12-23	American Hoechst Corporation	Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
US4409229A (en) *	1977-12-02	1983-10-11	Hoechst-Roussel Pharmaceuticals, Inc.	Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
EG13536A (en) *	1977-12-02	1981-12-31	Hoechst Ag	Substituted 1,3-dihydrospiro(benzo(c)thiophene)s
US4166119A (en) *	1978-04-14	1979-08-28	American Hoechst Corporation	Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166120A (en) *	1978-04-14	1979-08-28	American Hoechst Corporation	Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4301292A (en) *	1979-09-06	1981-11-17	Hoechst-Roussel Pharmaceuticals, Incorporated	1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol
US4263317A (en) *	1979-09-06	1981-04-21	Hoechst-Roussel Pharmaceuticals, Inc.	Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US4260623A (en) *	1979-11-26	1981-04-07	Warner-Lambert Company	Hexahydro-1-arylspiro(3H-oxazolo(3,4-A)pyridine-3,4'-piperidene) antidepressants, pharmaceutical compositions thereof and method of use thereof
US4268515A (en) *	1980-02-04	1981-05-19	Hoechst-Roussel Pharmaceuticals Inc.	Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceutical compositions thereof and methods of use thereof
US4304941A (en) *	1980-08-01	1981-12-08	Hoechst Roussel Pharmaceuticals, Inc.	Method of preparing poly-substituted acylbenzenes
US4404221A (en) *	1981-10-19	1983-09-13	Hoechst-Roussel Pharmaceuticals Inc.	2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use
US4517311A (en) *	1981-10-19	1985-05-14	Hoechst-Roussel Pharmaceuticals Inc.	2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions
US4524207A (en) *	1981-10-20	1985-06-18	Hoechst-Roussel Pharmaceuticals Inc.	Process for preparing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
CA1315279C (fr) *	1987-01-12	1993-03-30	Nancy Grace Bollinger	Agents antiinflammatoires
IL96507A0 (en) *	1989-12-08	1991-08-16	Merck & Co Inc	Nitrogen-containing spirocycles and pharmaceutical compositions containing them
CA2037287A1 (fr) *	1990-03-02	1991-09-03	Ben E. Evans	Antagonistes de l'oxytocine spirocyclique
EP0445974A3 (en) *	1990-03-05	1992-04-29	Merck Sharp & Dohme Ltd.	Spirocyclic antipsychotic agents
US5693643A (en) *	1991-09-16	1997-12-02	Merck & Co., Inc.	Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
DE59308382D1 (de) *	1992-11-29	1998-05-14	Clariant Gmbh	Neue asymmetrische, halogenierte Benzophenone und Verfahren zu ihrer Herstellung
US6374762B1 (en) *	1997-10-27	2002-04-23	Correct Craft, Inc.	Water sport towing apparatus
US6433196B1 (en) *	2000-02-17	2002-08-13	Sumika Fine Chemicals Co., Ltd.	Production method of citalopram, intermediate therefor and production method of the intermediate
GB0213715D0 (en) *	2002-06-14	2002-07-24	Syngenta Ltd	Chemical compounds
AU2005277126A1 (en) *	2004-08-19	2006-03-02	Vertex Pharmaceuticals, Incorporated	Modulators of muscarinic receptors
US7786141B2 (en) *	2004-08-19	2010-08-31	Vertex Pharmaceuticals Incorporated	Dihydrospiroindene modulators of muscarinic receptors
EP1817036B1 (fr) *	2004-11-29	2012-07-04	Vertex Pharmaceuticals Incorporated	Modulateurs des recepteurs muscariniques
JP2009507800A (ja) *	2005-09-09	2009-02-26	ユーロ−セルティークエス．エイ．	縮合およびスピロ環化合物ならびにその使用
US7858635B2 (en) *	2005-12-22	2010-12-28	Vertex Pharmaceuticals Incorporated	Spiro compounds as modulators of muscarinic receptors
ATE517106T1 (de) *	2006-02-22	2011-08-15	Vertex Pharma	Kondensierte spiropiperidine als modulatoren muskarinartiger rezeptoren
RU2008137593A (ru) *	2006-02-22	2010-03-27	Вертекс Фармасьютикалз Инкорпорейтед (Us)	Модуляторы мускариновых рецепторов
EP1847542A1 (fr) *	2006-04-21	2007-10-24	Laboratorios del Dr. Esteve S.A.	Dérivés de spiro[benzopyran] ou de spiro[benzofuran] comme antagonistes du récepteur sigma
JP2009542670A (ja) *	2006-06-29	2009-12-03	バーテックスファーマシューティカルズインコーポレイテッド	ムスカリン受容体の調節剤
WO2008021375A2 (fr) *	2006-08-15	2008-02-21	Vertex Pharmaceuticals Incorporated	Modulateurs de récepteurs muscariniques
WO2008021545A2 (fr) *	2006-08-18	2008-02-21	Vertex Pharmaceuticals Incorporated	Modulateurs des récepteurs muscariniques
JP2010540640A (ja) *	2007-10-03	2010-12-24	バーテックスファーマシューティカルズインコーポレイテッド	ムスカリン作用性レセプターのモジュレーター
WO2011137024A1 (fr) *	2010-04-26	2011-11-03	Merck Sharp & Dohme Corp.	Nouveaux inhibiteurs de spiropipéridine prolylcarboxypeptidase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3686186A (en) *	1970-10-05	1972-08-22	William J Houlihan	Substituted isochroman or phthalan piperidenes

1974
- 1974-09-03 US US05/502,650 patent/US3959475A/en not_active Expired - Lifetime
- 1974-12-06 IL IL7446201A patent/IL46201A/xx unknown
- 1974-12-09 DE DE19742458177 patent/DE2458177A1/de not_active Withdrawn
- 1974-12-10 FI FI3554/74A patent/FI58128C/fi active
- 1974-12-11 DK DK644974A patent/DK144214C/da active
- 1974-12-11 HU HUHO1754A patent/HU169546B/hu unknown
- 1974-12-11 CH CH1647074A patent/CH617938A5/de not_active IP Right Cessation
- 1974-12-11 LU LU71461A patent/LU71461A1/xx unknown
- 1974-12-11 SE SE7415521A patent/SE419761B/xx unknown
- 1974-12-11 OA OA55362A patent/OA04852A/fr unknown
- 1974-12-11 CA CA215,786A patent/CA1051428A/fr not_active Expired
- 1974-12-11 EG EG546/74A patent/EG12110A/xx active
- 1974-12-11 NL NL7416115A patent/NL7416115A/xx not_active Application Discontinuation
- 1974-12-11 NO NO744471A patent/NO146062C/no unknown
- 1974-12-11 IE IE2648/74A patent/IE40298B1/xx unknown
- 1974-12-12 FR FR7441005A patent/FR2254331B1/fr not_active Expired
- 1974-12-12 JP JP49142997A patent/JPS5833876B2/ja not_active Expired
- 1974-12-12 GB GB5374474A patent/GB1465999A/en not_active Expired
1979
- 1979-09-05 CH CH800079A patent/CH619228A5/de not_active IP Right Cessation
- 1979-09-05 CH CH800179A patent/CH619229A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
LU71461A1 (fr)	1976-11-11
CH619229A5 (fr)	1980-09-15
FI58128C (fi)	1980-12-10
GB1465999A (en)	1977-03-02
DK644974A (fr)	1975-08-18
FI58128B (fi)	1980-08-29
SE419761B (sv)	1981-08-24
IL46201A (en)	1982-04-30
IE40298B1 (en)	1979-04-25
NO146062B (no)	1982-04-13
NO146062C (no)	1982-08-11
OA04852A (fr)	1980-10-31
AU7624674A (en)	1976-06-10
DE2458177A1 (de)	1976-09-30
IL46201A0 (en)	1975-03-13
FI355474A (fr)	1975-06-13
DK144214B (da)	1982-01-18
CA1051428A (fr)	1979-03-27
CH619228A5 (fr)	1980-09-15
NL7416115A (nl)	1975-06-16
CH617938A5 (fr)	1980-06-30
DK144214C (da)	1982-06-21
JPS50100052A (fr)	1975-08-08
JPS5833876B2 (ja)	1983-07-22
SE7415521L (fr)	1975-06-13
HU169546B (fr)	1976-12-28
FR2254331A1 (fr)	1975-07-11
NO744471L (fr)	1975-07-07
EG12110A (en)	1981-03-31
US3959475A (en)	1976-05-25

Legal Events

Date	Code	Title	Description
1984-10-19	ST	Notification of lapse

Publication	Publication Date	Title
FR2254332B1 (fr)	1978-07-21
FR2254331B1 (fr)	1978-07-21
AR195948A1 (fr)	1973-11-15
AR196382A1 (fr)	1973-12-18
AR195311A1 (fr)	1973-09-28
JPS5038402U (fr)	1975-04-21
AR196123Q (fr)	1973-11-30
AR196212Q (fr)	1973-12-10
BG23039A1 (fr)	1977-07-12
BG19410A1 (fr)	1975-06-25
CH565360A5 (fr)	1975-08-15
CH561036A5 (fr)	1975-04-30
CH423773A4 (fr)	1975-07-15
CH565595A5 (fr)	1975-08-29
AU470923A (fr)	1976-04-01
CH1327374A4 (fr)	1975-12-31
CH565655A5 (fr)	1975-08-29
BG20976A1 (fr)	1976-01-20
BG20427A1 (fr)	1975-12-05
BG19976A1 (fr)	1975-10-30
BG19456A1 (fr)	1975-06-25
CH563887A5 (fr)	1975-07-15
BG19283A1 (fr)	1975-06-15
BG19048A1 (fr)	1975-04-30
AU480497A (fr)	1975-01-30