FR2244498A1 - N-(4-or 5-nitro-2-imidazolyl)-N,N'-alkylene-(thio)ureas - prepd. by e.g. reacting 2-sulphonyl-imidazoles with N,N'-alkylene-(thio)ureas - Google Patents
N-(4-or 5-nitro-2-imidazolyl)-N,N'-alkylene-(thio)ureas - prepd. by e.g. reacting 2-sulphonyl-imidazoles with N,N'-alkylene-(thio)ureasInfo
- Publication number
- FR2244498A1 FR2244498A1 FR7431471A FR7431471A FR2244498A1 FR 2244498 A1 FR2244498 A1 FR 2244498A1 FR 7431471 A FR7431471 A FR 7431471A FR 7431471 A FR7431471 A FR 7431471A FR 2244498 A1 FR2244498 A1 FR 2244498A1
- Authority
- FR
- France
- Prior art keywords
- alkylene
- lower alkyl
- sulphonyl
- ureas
- thio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivs. of formula (I): (where one of R1 and R2 is H or lower alkyl and the other is NO2; R3 is lower alkyl, hydroxyalkyl, alkoxyalkyl, alkyl-sulphonyl-alkyl or aminoalkyl; R4 is O or S; X is CO and R5 is lower alkoxy, NH2 or mono- or di(lower alkyl)-amino or X is CS, SO or SO2 and R5 is lower alkyl, aryl, NH2 or mono- or di-(lower alkyl)-amino; and "alk" is lower alkylene with 2-4 C-atoms in the alkylene chain) (e. g. 1-(methyl-thiocarbamoyl)-2-oxo-3-(1-methyl-5-nitro-2-imidazolyl)-- tetrahydroimidazole) and their salts and N-oxides are new cpds. They may be prepd. e.g. by reacting a cpd. of formula (II) (where Z is a reactive esterified or etherified hydroxy gp., a free or etherified mercapto group, an ammonium gp. or a sulphonyl gp.) with a cpd. of formula (III). (I) are antimicrobial and anthelmintic agents active against bacteria (esp. gram-negative bacteria), protozoa and worms such as trichomonads, schistosomes, coccidia and, especially, amoebae. (I) may thus be used for therapeutic purposes, as animal feed additives, and for protecting organic materials against microbial degradation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1366773A CH592653A5 (en) | 1973-09-24 | 1973-09-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2244498A1 true FR2244498A1 (en) | 1975-04-18 |
| FR2244498B1 FR2244498B1 (en) | 1978-07-21 |
Family
ID=4394325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7431471A Granted FR2244498A1 (en) | 1973-09-24 | 1974-09-18 | N-(4-or 5-nitro-2-imidazolyl)-N,N'-alkylene-(thio)ureas - prepd. by e.g. reacting 2-sulphonyl-imidazoles with N,N'-alkylene-(thio)ureas |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5910347B2 (en) |
| AR (2) | AR212578A1 (en) |
| AT (1) | AT337692B (en) |
| BE (1) | BE820206A (en) |
| BG (2) | BG22823A3 (en) |
| CH (1) | CH592653A5 (en) |
| CS (1) | CS195689B2 (en) |
| DD (1) | DD114814A5 (en) |
| DE (1) | DE2444070A1 (en) |
| DK (1) | DK447474A (en) |
| DO (1) | DOP1981002973A (en) |
| ES (1) | ES430352A1 (en) |
| FI (1) | FI62293C (en) |
| FR (1) | FR2244498A1 (en) |
| HU (1) | HU171562B (en) |
| IE (1) | IE40003B1 (en) |
| IL (1) | IL45536A (en) |
| NL (1) | NL7412482A (en) |
| NO (1) | NO141895C (en) |
| OA (1) | OA04828A (en) |
| PH (1) | PH13743A (en) |
| PL (3) | PL95691B1 (en) |
| RO (1) | RO70190A (en) |
| SE (1) | SE416300B (en) |
| SU (3) | SU542473A3 (en) |
| YU (3) | YU37337B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5956254U (en) * | 1982-10-05 | 1984-04-12 | 住友金属鉱山株式会社 | retaining wall block |
| JPH0423998Y2 (en) * | 1985-02-01 | 1992-06-04 | ||
| DE4426757A1 (en) * | 1994-07-28 | 1996-02-01 | Bayer Ag | 2-imidazolidinone derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2944061A (en) * | 1957-09-20 | 1960-07-05 | Acyl derivatives and process | |
| IL39283A (en) * | 1971-05-03 | 1976-01-30 | Ciba Geigy Ag | Substituted 2-oxo or thioxo-3-(5-nitro-imidazol-2-yl)-tetrahydroimidazoles and their manufacture |
| BE795068A (en) * | 1972-02-08 | 1973-08-07 | Ciba Geigy | NEW 4- OR 5-NITRO-INMIDAZOLES AND METHODS FOR THEIR PREPARATION |
-
1973
- 1973-09-24 CH CH1366773A patent/CH592653A5/xx not_active IP Right Cessation
-
1974
- 1974-08-21 DK DK447474A patent/DK447474A/da not_active Application Discontinuation
- 1974-08-22 IE IE1746/74A patent/IE40003B1/en unknown
- 1974-08-26 IL IL45536A patent/IL45536A/en unknown
- 1974-09-06 SE SE7411296A patent/SE416300B/en not_active IP Right Cessation
- 1974-09-12 FI FI2669/74A patent/FI62293C/en active
- 1974-09-14 DE DE2444070A patent/DE2444070A1/en not_active Ceased
- 1974-09-18 FR FR7431471A patent/FR2244498A1/en active Granted
- 1974-09-20 NL NL7412482A patent/NL7412482A/en not_active Application Discontinuation
- 1974-09-20 NO NO743395A patent/NO141895C/en unknown
- 1974-09-21 OA OA55302A patent/OA04828A/en unknown
- 1974-09-23 PL PL1974185103A patent/PL95691B1/en unknown
- 1974-09-23 SU SU2063056A patent/SU542473A3/en active
- 1974-09-23 AR AR255685A patent/AR212578A1/en active
- 1974-09-23 YU YU2559/74A patent/YU37337B/en unknown
- 1974-09-23 PL PL1974185100A patent/PL95689B1/en unknown
- 1974-09-23 PH PH16324A patent/PH13743A/en unknown
- 1974-09-23 DD DD181273A patent/DD114814A5/xx unknown
- 1974-09-23 BE BE148776A patent/BE820206A/en not_active IP Right Cessation
- 1974-09-23 BG BG27754A patent/BG22823A3/xx unknown
- 1974-09-23 AT AT762174A patent/AT337692B/en not_active IP Right Cessation
- 1974-09-23 RO RO7487513A patent/RO70190A/en unknown
- 1974-09-23 BG BG29300A patent/BG22813A3/xx unknown
- 1974-09-23 PL PL1974174285A patent/PL96510B1/en unknown
- 1974-09-24 ES ES430352A patent/ES430352A1/en not_active Expired
- 1974-09-24 HU HU74CI00001509A patent/HU171562B/en unknown
- 1974-09-24 CS CS746554A patent/CS195689B2/en unknown
- 1974-09-24 JP JP49110385A patent/JPS5910347B2/en not_active Expired
-
1975
- 1975-01-01 AR AR258970A patent/AR207980A1/en active
- 1975-07-02 SU SU7502149413A patent/SU564812A3/en active
- 1975-07-02 SU SU7502149414A patent/SU571191A3/en active
-
1980
- 1980-11-24 YU YU2983/80A patent/YU37339B/en unknown
- 1980-11-24 YU YU2982/80A patent/YU37338B/en unknown
-
1981
- 1981-02-09 DO DO1981002973A patent/DOP1981002973A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |