FR2217009A1 - 2-Tetrazole analogs of prostaglandins - with bronchodilatory, antihyperten-sive and gastric secretion inhibiting activity - Google Patents
2-Tetrazole analogs of prostaglandins - with bronchodilatory, antihyperten-sive and gastric secretion inhibiting activityInfo
- Publication number
- FR2217009A1 FR2217009A1 FR7404126A FR7404126A FR2217009A1 FR 2217009 A1 FR2217009 A1 FR 2217009A1 FR 7404126 A FR7404126 A FR 7404126A FR 7404126 A FR7404126 A FR 7404126A FR 2217009 A1 FR2217009 A1 FR 2217009A1
- Authority
- FR
- France
- Prior art keywords
- antihyperten
- bronchodilatory
- sive
- prostaglandins
- inhibiting activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- PZJFUNZDCRKXPZ-UHFFFAOYSA-N 2,5-dihydro-1h-tetrazole Chemical class C1NNN=N1 PZJFUNZDCRKXPZ-UHFFFAOYSA-N 0.000 title 1
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 230000003182 bronchodilatating effect Effects 0.000 title 1
- 230000002496 gastric effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
New cpds of formula (I) (where D is a gp. of formula (IIa)-(IId): n=3-5; R1 is H or lower alkyl, R2 and R3 are lower alkyl) are pref. prepd by reacting a cpd (III) with a cpd (IV): (where E is a gp. of formula (Va, (Vb) or (Vc): R4 and R5 are trialkylsilyl or tetrahydropyranyl; R6 is H or trialkylsilyl; X is halogen), opt. oxidising the prod and then removing the protecting gps.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH180573 | 1973-02-08 | ||
| CH1618273 | 1973-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2217009A1 true FR2217009A1 (en) | 1974-09-06 |
Family
ID=25688718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7404126A Withdrawn FR2217009A1 (en) | 1973-02-08 | 1974-02-07 | 2-Tetrazole analogs of prostaglandins - with bronchodilatory, antihyperten-sive and gastric secretion inhibiting activity |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS49109380A (en) |
| AU (1) | AU6539574A (en) |
| DD (1) | DD110878A5 (en) |
| DE (1) | DE2405255A1 (en) |
| FR (1) | FR2217009A1 (en) |
| IL (1) | IL44154A0 (en) |
| NL (1) | NL7401493A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102209719B (en) | 2008-09-10 | 2014-05-14 | 旭硝子株式会社 | Novel prostaglandin i2 derivative |
| TWI555744B (en) | 2010-03-08 | 2016-11-01 | Kaken Pharma Co Ltd | Novel EP4 agonists |
-
1974
- 1974-02-04 NL NL7401493A patent/NL7401493A/xx unknown
- 1974-02-04 DE DE19742405255 patent/DE2405255A1/en active Pending
- 1974-02-06 IL IL44154A patent/IL44154A0/en unknown
- 1974-02-06 DD DD176410A patent/DD110878A5/xx unknown
- 1974-02-06 JP JP49014657A patent/JPS49109380A/ja active Pending
- 1974-02-07 FR FR7404126A patent/FR2217009A1/en not_active Withdrawn
- 1974-02-08 AU AU65395/74A patent/AU6539574A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL44154A0 (en) | 1974-05-16 |
| DD110878A5 (en) | 1975-01-12 |
| DE2405255A1 (en) | 1974-08-15 |
| AU6539574A (en) | 1975-08-14 |
| NL7401493A (en) | 1974-08-12 |
| JPS49109380A (en) | 1974-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |