FR2208901A1 - Alpha-(4-substd pyridino)-4-benzyloxypropiophenones - as inters for cardiovascular 1-(4-hydroxy-phenyl)-2-(4-substd piperidino) propan-1-ols - Google Patents

Alpha-(4-substd pyridino)-4-benzyloxypropiophenones - as inters for cardiovascular 1-(4-hydroxy-phenyl)-2-(4-substd piperidino) propan-1-ols

Info

Publication number
FR2208901A1
FR2208901A1 FR7243053A FR7243053A FR2208901A1 FR 2208901 A1 FR2208901 A1 FR 2208901A1 FR 7243053 A FR7243053 A FR 7243053A FR 7243053 A FR7243053 A FR 7243053A FR 2208901 A1 FR2208901 A1 FR 2208901A1
Authority
FR
France
Prior art keywords
substd
alpha
cardiovascular
benzyloxypropiophenones
inters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7243053A
Other languages
French (fr)
Other versions
FR2208901B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Priority to FR7243053A priority Critical patent/FR2208901A1/en
Priority to JP13365673A priority patent/JPS5824435B2/en
Publication of FR2208901A1 publication Critical patent/FR2208901A1/en
Application granted granted Critical
Publication of FR2208901B1 publication Critical patent/FR2208901B1/fr
Priority to JP21590781A priority patent/JPS5824434B2/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Cpds. of formula: (where R is alkyl, aralkyl, aryl; X circled negative is a halide anion) may be prepd. by reaction of 4-subst-pyridines with 4-benzyloxyphenyl-alpha-halopropiophenones. The products may be hydrogenated, e.g. in presence of Pd catalysts to give the cardiovascular agents (known).
FR7243053A 1972-12-04 1972-12-04 Alpha-(4-substd pyridino)-4-benzyloxypropiophenones - as inters for cardiovascular 1-(4-hydroxy-phenyl)-2-(4-substd piperidino) propan-1-ols Granted FR2208901A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR7243053A FR2208901A1 (en) 1972-12-04 1972-12-04 Alpha-(4-substd pyridino)-4-benzyloxypropiophenones - as inters for cardiovascular 1-(4-hydroxy-phenyl)-2-(4-substd piperidino) propan-1-ols
JP13365673A JPS5824435B2 (en) 1972-12-04 1973-11-30 Die 4 Ammonium Enno Seizouhouhou
JP21590781A JPS5824434B2 (en) 1972-12-04 1981-12-28 Method for producing piperidino-propanol derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7243053A FR2208901A1 (en) 1972-12-04 1972-12-04 Alpha-(4-substd pyridino)-4-benzyloxypropiophenones - as inters for cardiovascular 1-(4-hydroxy-phenyl)-2-(4-substd piperidino) propan-1-ols

Publications (2)

Publication Number Publication Date
FR2208901A1 true FR2208901A1 (en) 1974-06-28
FR2208901B1 FR2208901B1 (en) 1976-08-20

Family

ID=9108152

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7243053A Granted FR2208901A1 (en) 1972-12-04 1972-12-04 Alpha-(4-substd pyridino)-4-benzyloxypropiophenones - as inters for cardiovascular 1-(4-hydroxy-phenyl)-2-(4-substd piperidino) propan-1-ols

Country Status (2)

Country Link
JP (2) JPS5824435B2 (en)
FR (1) FR2208901A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471374A1 (en) * 1979-12-07 1981-06-19 Cosmos Enterprise NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS
FR2534580A1 (en) * 1982-10-13 1984-04-20 Synthelabo PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM
WO1998022444A1 (en) * 1996-11-15 1998-05-28 Hoechst Schering Agrevo Gmbh Quaternary nitrogen heterocycles, method for their production and their use as pesticides

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS547205A (en) * 1977-06-20 1979-01-19 Nippon Telegr & Teleph Corp <Ntt> Privacy circuit
JPS6034951B2 (en) * 1979-09-13 1985-08-12 東洋フアルマ−株式会社 Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2471374A1 (en) * 1979-12-07 1981-06-19 Cosmos Enterprise NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS
DE3045916A1 (en) * 1979-12-07 1981-09-03 Kabushiki Kaisha Cosmos Enterprise, Osaka METHOD FOR PRODUCING 4-BENZYL- (ALPHA) - (P-HYDROXYPHENYL) - (BETA) -METHYL-1-PIPERIDINAETHANOL AND ITS SALTS WITH ACIDS
FR2534580A1 (en) * 1982-10-13 1984-04-20 Synthelabo PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM
EP0109317A2 (en) * 1982-10-13 1984-05-23 Synthelabo Phenyl-1-piperidino-2-propanol derivatives, their preparation and medicaments containing them
EP0109317A3 (en) * 1982-10-13 1984-08-08 Synthelabo Phenyl-1-piperidino-2-propanol derivatives, their preparation and medicaments containing them
WO1998022444A1 (en) * 1996-11-15 1998-05-28 Hoechst Schering Agrevo Gmbh Quaternary nitrogen heterocycles, method for their production and their use as pesticides

Also Published As

Publication number Publication date
JPS504081A (en) 1975-01-16
JPS57188569A (en) 1982-11-19
JPS5824435B2 (en) 1983-05-20
JPS5824434B2 (en) 1983-05-20
FR2208901B1 (en) 1976-08-20

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Legal Events

Date Code Title Description
ST Notification of lapse